Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.

IF 2.4 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2024-12-03 DOI:10.1186/s12868-024-00916-6

Da Chang, Xiu Wang, Yaojing Chen, Zhuo Rachel Han, Yin Wang, Bing Liu, Zhanjun Zhang, Xi-Nian Zuo

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引用次数: 0

Abstract

Background: Entropy trajectories remain unclear for the aging process of human brain system due to the lacking of longitudinal neuroimaging resource.

Results: We used open data from an accelerated longitudinal cohort (PREVENT-AD) that included 24 healthy aging participants followed by 4 years with 5 visits per participant to establish cortical entropy aging curves and distinguish with the effects of age and cohort. This reveals that global cortical entropy decreased with aging, while a significant cohort effect was detectable that people who were born earlier showed higher cortical entropy. Such entropy reductions were also evident for large-scale cortical networks, although with different rates of reduction for different networks. Specifically, the primary and intermediate networks reduce their entropy faster than the higher-order association networks.

Conclusions: Our study confirmed that cortical entropy decreases continually in the aging process, both globally and regionally, and we conclude two specific characteristics of the entropy of the human cortex with aging: the shift of the complexity hierarchy and the diversity of complexity strengthen.

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衰老是有序的：皮层自发活动的熵减少标志着健康的衰老。

背景：由于缺乏纵向神经成像资源，人类大脑系统衰老过程的熵轨迹尚不清楚。结果：我们使用来自加速纵向队列（prevention - ad）的开放数据，包括24名健康的老年受试者，随访4年，每位受试者随访5次，建立皮质熵老化曲线，并区分年龄和队列的影响。这表明整体皮质熵随着年龄的增长而下降，而显著的队列效应是出生较早的人表现出更高的皮质熵。这种熵的减少在大规模皮质网络中也很明显，尽管不同网络的减少率不同。具体来说，初级和中间网络比高阶关联网络减少熵的速度更快。结论：在衰老过程中，皮层熵在整体和区域上呈持续下降趋势，并总结出人类皮层熵随年龄增长的两个特征：复杂性层次的转移和复杂性多样性的增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.