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Feasibility of robotic-assisted surgery in advanced rectal cancer: a multicentre prospective phase II study (VITRUVIANO trial). 机器人辅助手术治疗晚期直肠癌的可行性:多中心前瞻性 II 期研究(VITRUVIANO 试验)。
IF 3.5 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae048
Atsushi Hamabe, Ichiro Takemasa, Masanori Kotake, Daisuke Nakano, Suguru Hasegawa, Akio Shiomi, Masakatsu Numata, Kazuhiro Sakamoto, Kei Kimura, Tsunekazu Hanai, Takeshi Naitoh, Yosuke Fukunaga, Yusuke Kinugasa, Jun Watanabe, Junichiro Kawamura, Mayumi Ozawa, Koji Okabayashi, Shuichiro Matoba, Yoshinao Takano, Mamoru Uemura, Yukihide Kanemitsu, Yoshiharu Sakai, Masahiko Watanabe
{"title":"Feasibility of robotic-assisted surgery in advanced rectal cancer: a multicentre prospective phase II study (VITRUVIANO trial).","authors":"Atsushi Hamabe, Ichiro Takemasa, Masanori Kotake, Daisuke Nakano, Suguru Hasegawa, Akio Shiomi, Masakatsu Numata, Kazuhiro Sakamoto, Kei Kimura, Tsunekazu Hanai, Takeshi Naitoh, Yosuke Fukunaga, Yusuke Kinugasa, Jun Watanabe, Junichiro Kawamura, Mayumi Ozawa, Koji Okabayashi, Shuichiro Matoba, Yoshinao Takano, Mamoru Uemura, Yukihide Kanemitsu, Yoshiharu Sakai, Masahiko Watanabe","doi":"10.1093/bjsopen/zrae048","DOIUrl":"10.1093/bjsopen/zrae048","url":null,"abstract":"<p><strong>Background: </strong>The potential benefits of robotic-assisted compared with laparoscopic surgery for locally advanced cancer have not been sufficiently proven by prospective studies. One factor is speculated to be the lack of strict surgeon criteria. The aim of this study was to assess outcomes for robotic surgery in patients with locally advanced rectal cancer with strict surgeon experience criteria.</p><p><strong>Methods: </strong>A criterion was set requiring surgeons to have performed more than 40 robotically assisted operations for rectal cancer. Between March 2020 and May 2022, patients with rectal cancer (distance from the anal verge of 12 cm or less, cT2-T4a, cN0-N3, cM0, or cT1-T4a, cN1-N3, cM0) were registered. The primary endpoint was the rate positive circumferential resection margin (CRM) from the pathological specimen. Secondary endpoints were surgical outcomes, pathological results, postoperative complications, and longterm outcomes.</p><p><strong>Results: </strong>Of the 321 registered patients, 303 were analysed, excluding 18 that were ineligible. At diagnosis: stage I (n = 68), stage II (n = 84) and stage III (n = 151). Neoadjuvant therapy was used in 56 patients. There were no conversions to open surgery. The median console time to rectal resection was 170 min, and the median blood loss was 5 ml. Fourteen patients had a positive CRM (4.6%). Grade III-IV postoperative complications were observed in 13 patients (4.3%).</p><p><strong>Conclusion: </strong>Robotic-assisted surgery is feasible for locally advanced rectal cancer when strict surgeon criteria are used.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger. 为 60 岁或以下的 DeBakey 1 型主动脉夹层患者实施主动脉弓手术。
IF 3.5 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae047
Fausto Biancari, Javier Rodriguez Lega, Giovanni Mariscalco, Sven Peterss, Joscha Buech, Antonio Fiore, Andrea Perrotti, Andreas Rukosujew, Angel G Pinto, Till Demal, Konrad Wisniewski, Marek Pol, Giuseppe Gatti, Igor Vendramin, Mauro Rinaldi, Robert Pruna-Guillen, Dario Di Perna, Zein El-Dean, Hiwa Sherzad, Francesco Nappi, Mark Field, Matteo Pettinari, Mikko Jormalainen, Angelo M Dell'Aquila, Francesco Onorati, Eduard Quintana, Tatu Juvonen, Timo Mäkikallio
{"title":"Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger.","authors":"Fausto Biancari, Javier Rodriguez Lega, Giovanni Mariscalco, Sven Peterss, Joscha Buech, Antonio Fiore, Andrea Perrotti, Andreas Rukosujew, Angel G Pinto, Till Demal, Konrad Wisniewski, Marek Pol, Giuseppe Gatti, Igor Vendramin, Mauro Rinaldi, Robert Pruna-Guillen, Dario Di Perna, Zein El-Dean, Hiwa Sherzad, Francesco Nappi, Mark Field, Matteo Pettinari, Mikko Jormalainen, Angelo M Dell'Aquila, Francesco Onorati, Eduard Quintana, Tatu Juvonen, Timo Mäkikallio","doi":"10.1093/bjsopen/zrae047","DOIUrl":"10.1093/bjsopen/zrae047","url":null,"abstract":"<p><strong>Background: </strong>Extended aortic repair is considered a key issue for the long-term durability of surgery for DeBakey type 1 aortic dissection. The risk of aortic degeneration may be higher in young patients due to their long life expectancy. The early outcome and durability of aortic surgery in these patients were investigated in the present study.</p><p><strong>Methods: </strong>The subjects of the present analysis were patients under 60 years old who underwent surgical repair for acute DeBakey type 1 aortic dissection at 18 cardiac surgery centres across Europe between 2005 and 2021. Patients underwent ascending aortic repair or total aortic arch repair using the conventional technique or the frozen elephant trunk technique. The primary outcome was 5-year cumulative incidence of reoperation on the distal aorta.</p><p><strong>Results: </strong>Overall, 915 patients underwent surgical ascending aortic repair and 284 patients underwent surgical total aortic arch repair. The frozen elephant trunk procedure was performed in 128 patients. Among 245 propensity score-matched pairs, total aortic arch repair did not decrease the rate of distal aortic reoperation compared to ascending aortic repair (5-year cumulative incidence, 6.7% versus 6.7%, subdistributional hazard ratio 1.127, 95% c.i. 0.523 to 2.427). Total aortic arch repair increased the incidence of postoperative stroke/global brain ischaemia (25.7% versus 18.4%, P = 0.050) and dialysis (19.6% versus 12.7%, P = 0.003). Five-year mortality was comparable after ascending aortic repair and total aortic arch repair (22.8% versus 27.3%, P = 0.172).</p><p><strong>Conclusions: </strong>In patients under 60 years old with DeBakey type 1 aortic dissection, total aortic arch replacement compared with ascending aortic repair did not reduce the incidence of distal aortic operations at 5 years. When feasible, ascending aortic repair for DeBakey type 1 aortic dissection is associated with satisfactory early and mid-term outcomes.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04831073.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphatic spread patterns in young versus elderly patients with stage III colon cancer. 年轻与老年 III 期结肠癌患者的淋巴扩散模式。
IF 3.5 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae036
Jihyung Song, Kozo Kataoka, Manabu Inoue, Takeshi Yamada, Manabu Shiozawa, Naohito Beppu, Sho Kuriyama, Takeshi Suto, Nobuhisa Matsuhashi, Yusuke Sakura, Akiyoshi Kanazawa, Hiroyasu Kagawa, Yukihide Kanemitsu, Wim Ceelen, Masataka Ikeda
{"title":"Lymphatic spread patterns in young versus elderly patients with stage III colon cancer.","authors":"Jihyung Song, Kozo Kataoka, Manabu Inoue, Takeshi Yamada, Manabu Shiozawa, Naohito Beppu, Sho Kuriyama, Takeshi Suto, Nobuhisa Matsuhashi, Yusuke Sakura, Akiyoshi Kanazawa, Hiroyasu Kagawa, Yukihide Kanemitsu, Wim Ceelen, Masataka Ikeda","doi":"10.1093/bjsopen/zrae036","DOIUrl":"10.1093/bjsopen/zrae036","url":null,"abstract":"<p><strong>Background: </strong>The anatomical pattern of lymph nodes spread differs between young (aged 45 years or younger) and elderly (aged 80 years or older) patients with stage III colon cancer and is poorly investigated.</p><p><strong>Methods: </strong>Two groups of patients (young and elderly) with stage III colon cancer who underwent upfront extensive (D3) lymphadenectomy at eight Japanese centres between 1998 and 2018 were retrospectively analysed. The primary endpoint was the proportion of positive central lymph nodes. The lymph nodes spreading pattern and its prognostic impact on recurrence-free survival and overall survival in the two groups were also compared.</p><p><strong>Results: </strong>Two hundred and ten young patients and 348 elderly patients were identified and compared. The total number of lymph nodes harvested and the total number of invaded lymph nodes were significantly higher in younger patients compared with elderly patients (median of 31.5 (3-151) versus 21 (3-116), P < 0.001 and median of 3 (1-21) versus 2 (1-25), P < 0.001 respectively). The proportion of positive central lymph nodes were higher in younger patients than in elderly patients (9.52% (95% c.i. 6.24 to 14.2%) versus 4.59% (95% c.i. 2.84 to 7.31%), P = 0.012). In multivariate models for recurrence-free survival, central lymph nodes invasion were identified as a poor prognostic factor in younger patients (HR 5.21 (95% c.i. 1.76 to 15.39)) but not in elderly patients (HR 1.73 (95% c.i. 0.80 to 3.76)).</p><p><strong>Conclusion: </strong>Young patients with stage III colon cancer have a higher risk of central lymph nodes invasion, suggesting a more aggressive disease biology. The presence of central lymph nodes invasion are associated with a worse outcome in young patients.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic, transanal, and laparoscopic total mesorectal excision for locally advanced mid/low rectal cancer: European multicentre, propensity score-matched study. 局部晚期中/低位直肠癌的机器人、经肛门和腹腔镜全直肠系膜切除术:欧洲多中心倾向评分匹配研究。
IF 3.5 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae044
Nicola de'Angelis, Francesco Marchegiani, Aleix Martínez-Pérez, Alberto Biondi, Salvatore Pucciarelli, Carlo Alberto Schena, Gianluca Pellino, Miquel Kraft, Annabel S van Lieshout, Luca Morelli, Alain Valverde, Renato Micelli Lupinacci, Segundo A Gómez-Abril, Roberto Persiani, Jurriaan B Tuynman, Eloy Espin-Basany, Frederic Ris
{"title":"Robotic, transanal, and laparoscopic total mesorectal excision for locally advanced mid/low rectal cancer: European multicentre, propensity score-matched study.","authors":"Nicola de'Angelis, Francesco Marchegiani, Aleix Martínez-Pérez, Alberto Biondi, Salvatore Pucciarelli, Carlo Alberto Schena, Gianluca Pellino, Miquel Kraft, Annabel S van Lieshout, Luca Morelli, Alain Valverde, Renato Micelli Lupinacci, Segundo A Gómez-Abril, Roberto Persiani, Jurriaan B Tuynman, Eloy Espin-Basany, Frederic Ris","doi":"10.1093/bjsopen/zrae044","DOIUrl":"10.1093/bjsopen/zrae044","url":null,"abstract":"<p><strong>Background: </strong>Total mesorectal excision (TME) is the standard surgery for low/mid locally advanced rectal cancer. The aim of this study was to compare three minimally invasive surgical approaches for TME with primary anastomosis (laparoscopic TME, robotic TME, and transanal TME).</p><p><strong>Methods: </strong>Records of patients undergoing laparoscopic TME, robotic TME, or transanal TME between 2013 and 2022 according to standardized techniques in expert centres contributing to the European MRI and Rectal Cancer Surgery III (EuMaRCS-III) database were analysed. Propensity score matching was applied to compare the three groups with respect to the complication rate (primary outcome), conversion rate, postoperative recovery, and survival.</p><p><strong>Results: </strong>A total of 468 patients (mean(s.d.) age of 64.1(11) years) were included; 190 (40.6%) patients underwent laparoscopic TME, 141 (30.1%) patients underwent robotic TME, and 137 (29.3%) patients underwent transanal TME. Comparative analyses after propensity score matching demonstrated a higher rate of postoperative complications for laparoscopic TME compared with both robotic TME (OR 1.80, 95% c.i. 1.11-2.91) and transanal TME (OR 2.87, 95% c.i. 1.72-4.80). Robotic TME was associated with a lower rate of grade A anastomotic leakage (2%) compared with both laparoscopic TME (8.8%) and transanal TME (8.1%) (P = 0.031). Robotic TME (1.4%) and transanal TME (0.7%) were both associated with a lower conversion rate to open surgery compared with laparoscopic TME (8.8%) (P < 0.001). Time to flatus and duration of hospital stay were shorter for patients treated with transanal TME (P = 0.003 and 0.001 respectively). There were no differences in operating time, intraoperative complications, blood loss, mortality, readmission, R0 resection, or survival.</p><p><strong>Conclusion: </strong>In this multicentre, retrospective, propensity score-matched, cohort study of patients with locally advanced rectal cancer, newer minimally invasive approaches (robotic TME and transanal TME) demonstrated improved outcomes compared with laparoscopic TME.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major surgical conditions of childhood and their lifelong implications: comprehensive review. 儿童主要外科疾病及其终身影响:全面回顾。
IF 3.5 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae028
Paul S Cullis, Dina Fouad, Allan M Goldstein, Kenneth K Y Wong, Ampaipan Boonthai, Pablo Lobos, Mikko P Pakarinen, Paul D Losty
{"title":"Major surgical conditions of childhood and their lifelong implications: comprehensive review.","authors":"Paul S Cullis, Dina Fouad, Allan M Goldstein, Kenneth K Y Wong, Ampaipan Boonthai, Pablo Lobos, Mikko P Pakarinen, Paul D Losty","doi":"10.1093/bjsopen/zrae028","DOIUrl":"10.1093/bjsopen/zrae028","url":null,"abstract":"<p><strong>Background: </strong>In recent decades, the survival of children with congenital anomalies and paediatric cancer has improved dramatically such that there has been a steady shift towards understanding their lifelong health outcomes. Paediatric surgeons will actively manage such conditions in childhood and adolescence, however, adult surgeons must later care for these 'grown-ups' in adulthood. This article aims to highlight some of those rare disorders encountered by paediatric surgeons requiring long-term follow-up, their management in childhood and their survivorship impact, in order that the adult specialist may be better equipped with skills and knowledge to manage these patients into adulthood.</p><p><strong>Methods: </strong>A comprehensive literature review was performed to identify relevant publications. Research studies, review articles and guidelines were sought, focusing on the paediatric management and long-term outcomes of surgical conditions of childhood. The article has been written for adult surgeon readership.</p><p><strong>Results: </strong>This article describes the aforementioned conditions, their management in childhood and their lifelong implications, including: oesophageal atresia, tracheo-oesophageal fistula, malrotation, short bowel syndrome, duodenal atresia, gastroschisis, exomphalos, choledochal malformations, biliary atresia, Hirschsprung disease, anorectal malformations, congenital diaphragmatic hernia, congenital lung lesions and paediatric cancer.</p><p><strong>Conclusion: </strong>The increasing survivorship of children affected by surgical conditions will translate into a growing population of adults with lifelong conditions and specialist healthcare needs. The importance of transition from childhood to adulthood is becoming realized. It is hoped that this timely review will enthuse the readership to offer care for such vulnerable patients, and to collaborate with paediatric surgeons in providing successful and seamless transitional care.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right tool for the right job in the right way: robotic, transanal, or laparoscopic approach for rectal cancer. 用正确的工具、正确的方法完成正确的任务:机器人、经肛门或腹腔镜方法治疗直肠癌。
IF 3.1 3区 医学
BJS Open Pub Date : 2024-05-08 DOI: 10.1093/bjsopen/zrae069
Deborah S Keller
{"title":"Right tool for the right job in the right way: robotic, transanal, or laparoscopic approach for rectal cancer.","authors":"Deborah S Keller","doi":"10.1093/bjsopen/zrae069","DOIUrl":"10.1093/bjsopen/zrae069","url":null,"abstract":"","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11170498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic cost-utility analysis of stage-directed oesophageal cancer treatment. 食道癌分期治疗的经济成本效用分析。
IF 3.1 3区 医学
BJS Open Pub Date : 2024-03-01 DOI: 10.1093/bjsopen/zrad159
Geraint L Herbert, David B T Robinson, Arfon G Powell, Tarig Abdelrahman, Usman Khalid, Wyn G Lewis
{"title":"Economic cost-utility analysis of stage-directed oesophageal cancer treatment.","authors":"Geraint L Herbert, David B T Robinson, Arfon G Powell, Tarig Abdelrahman, Usman Khalid, Wyn G Lewis","doi":"10.1093/bjsopen/zrad159","DOIUrl":"10.1093/bjsopen/zrad159","url":null,"abstract":"","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis. 食道癌根治性治疗后在肿瘤学结果、手术并发症和健康相关生活质量方面的性别差异:多中心回顾性分析。
IF 3.1 3区 医学
BJS Open Pub Date : 2024-03-01 DOI: 10.1093/bjsopen/zrae026
Styliani Mantziari, Jessie A Elliott, Sheraz R Markar, Fredrik Klevebro, Lucas Goense, Asif Johar, Pernilla Lagergren, Giovanni Zaninotto, Richard van Hillegersberg, Mark I van Berge Henegouwen, Markus Schäfer, Magnus Nilsson, George B Hanna, John V Reynolds
{"title":"Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis.","authors":"Styliani Mantziari, Jessie A Elliott, Sheraz R Markar, Fredrik Klevebro, Lucas Goense, Asif Johar, Pernilla Lagergren, Giovanni Zaninotto, Richard van Hillegersberg, Mark I van Berge Henegouwen, Markus Schäfer, Magnus Nilsson, George B Hanna, John V Reynolds","doi":"10.1093/bjsopen/zrae026","DOIUrl":"https://doi.org/10.1093/bjsopen/zrae026","url":null,"abstract":"<p><strong>Background: </strong>Oesophageal cancer, in particular adenocarcinoma, has a strong male predominance. However, the impact of patient sex on operative and oncologic outcomes and recovery of health-related quality of life is poorly documented, and was the focus of this large multicentre cohort study.</p><p><strong>Methods: </strong>All consecutive patients who underwent oncological oesophagectomy from 2009 to 2015 in the 20 European iNvestigation of SUrveillance after Resection for Esophageal cancer study group centres were assessed. Clinicopathologic variables, therapeutic approach, postoperative complications, survival and health-related quality of life data were compared between male and female patients. Multivariable analyses adjusted for age, sex, tumour histology, treatment protocol and major complications. Specific subgroup analyses comparing adenocarcinoma versus squamous cell cancer for all key outcomes were performed.</p><p><strong>Results: </strong>Overall, 3974 patients were analysed, 3083 (77.6%) male and 891 (22.4%) female; adenocarcinoma was predominant in both groups, while squamous cell cancer was observed more commonly in female patients (39.8% versus 15.1%, P < 0.001). Multivariable analysis demonstrated improved outcomes in female patients for overall survival (HRmales 1.24, 95% c.i. 1.07 to 1.44) and disease-free survival (HRmales 1.22, 95% c.i. 1.05 to 1.43), which was caused by the adenocarcinoma subgroup, whereas this difference was not confirmed in squamous cell cancer. Male patients presented higher health-related quality of life functional scores but also a higher risk of financial problems, while female patients had lower overall summary scores and more persistent gastrointestinal symptoms.</p><p><strong>Conclusion: </strong>This study reveals uniquely that female sex is associated with more favourable long-term survival after curative treatment for oesophageal cancer, especially adenocarcinoma, although long-term overall and gastrointestinal health-related quality of life are poorer in women.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of artificial intelligence for the prediction of lymph node metastases in early-stage colorectal cancer: systematic review. 利用人工智能预测早期结直肠癌淋巴结转移:系统综述。
IF 3.1 3区 医学
BJS Open Pub Date : 2024-03-01 DOI: 10.1093/bjsopen/zrae033
Nasya Thompson, Arthur Morley-Bunker, Jared McLauchlan, Tamara Glyn, Tim Eglinton
{"title":"Use of artificial intelligence for the prediction of lymph node metastases in early-stage colorectal cancer: systematic review.","authors":"Nasya Thompson, Arthur Morley-Bunker, Jared McLauchlan, Tamara Glyn, Tim Eglinton","doi":"10.1093/bjsopen/zrae033","DOIUrl":"https://doi.org/10.1093/bjsopen/zrae033","url":null,"abstract":"<p><strong>Background: </strong>Risk evaluation of lymph node metastasis for early-stage (T1 and T2) colorectal cancers is critical for determining therapeutic strategies. Traditional methods of lymph node metastasis prediction have limited accuracy. This systematic review aimed to review the potential of artificial intelligence in predicting lymph node metastasis in early-stage colorectal cancers.</p><p><strong>Methods: </strong>A comprehensive search was performed of papers that evaluated the potential of artificial intelligence in predicting lymph node metastasis in early-stage colorectal cancers. Studies were appraised using the Joanna Briggs Institute tools. The primary outcome was summarizing artificial intelligence models and their accuracy. Secondary outcomes included influential variables and strategies to address challenges.</p><p><strong>Results: </strong>Of 3190 screened manuscripts, 11 were included, involving 8648 patients from 1996 to 2023. Due to diverse artificial intelligence models and varied metrics, no data synthesis was performed. Models included random forest algorithms, support vector machine, deep learning, artificial neural network, convolutional neural network and least absolute shrinkage and selection operator regression. Artificial intelligence models' area under the curve values ranged from 0.74 to 0.9993 (slide level) and 0.9476 to 0.9956 (single-node level), outperforming traditional clinical guidelines.</p><p><strong>Conclusion: </strong>Artificial intelligence models show promise in predicting lymph node metastasis in early-stage colorectal cancers, potentially refining clinical decisions and improving outcomes.</p><p><strong>Prospero registration number: </strong>CRD42023409094.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11026097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Daily handover in surgery: systematic review and a novel taxonomy of interventions and outcomes. 外科手术中的日常交接:系统性回顾以及干预措施和结果的新分类法。
IF 3.1 3区 医学
BJS Open Pub Date : 2024-03-01 DOI: 10.1093/bjsopen/zrae011
Jessica M Ryan, Fiachra McHugh, Anastasija Simiceva, Walter Eppich, Dara O Kavanagh, Deborah A McNamara
{"title":"Daily handover in surgery: systematic review and a novel taxonomy of interventions and outcomes.","authors":"Jessica M Ryan, Fiachra McHugh, Anastasija Simiceva, Walter Eppich, Dara O Kavanagh, Deborah A McNamara","doi":"10.1093/bjsopen/zrae011","DOIUrl":"10.1093/bjsopen/zrae011","url":null,"abstract":"<p><strong>Background: </strong>Poor-quality handovers lead to adverse outcomes for patients; however, there is a lack of evidence to support safe surgical handovers. This systematic review aims to summarize the interventions available to improve end-of-shift surgical handover. A novel taxonomy of interventions and outcomes and a modified quality assessment tool are also described.</p><p><strong>Methods: </strong>Ovid MEDLINE®, PubMed, Embase, and Cochrane databases were searched for articles up to April 2023. Comparative studies describing interventions for daily in-hospital surgical handovers between doctors were included. Studies were grouped according to their interventions and outcomes.</p><p><strong>Results: </strong>In total, 6139 citations were retrieved, and 41 studies met the inclusion criteria. The total patient sample sizes in the control and intervention groups were 11 946 and 11 563 patients, respectively. Most studies were pre-/post-intervention cohort studies (92.7%), and most (73.2%) represented level V evidence. The mean quality assessment score was 53.4% (17.1). A taxonomy of handover interventions and outcomes was developed, with interventions including handover tools, process standardization measures, staff education, and the use of mnemonics. More than 25% of studies used a document as the only intervention. Overall, 55 discrete outcomes were assessed in four categories including process (n = 27), staff (n = 14), patient (n = 12) and system-level (n = 2) outcomes. Significant improvements were seen in 51.8%, 78.5%, 58.3% (n = 9761 versus 9312 patients) and 100% of these outcomes, respectively.</p><p><strong>Conclusions: </strong>Most publications demonstrate that good-quality surgical handover improves outcomes and many interventions appear to be effective; however, studies are methodologically heterogeneous. These novel taxonomies and quality assessment tool will help standardize future studies.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10905088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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