Biointerface Research in Applied Chemistry最新文献_第3页

In Silico Interactions of Some of the Triazole Derivatives with the Main Protease of Coronavirus 某些三唑衍生物与冠状病毒主要蛋白酶的硅内相互作用

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.382

E. Salarrezaei, K. Harismah, M. Mirzaei

{"title":"In Silico Interactions of Some of the Triazole Derivatives with the Main Protease of Coronavirus","authors":"E. Salarrezaei, K. Harismah, M. Mirzaei","doi":"10.33263/briac134.382","DOIUrl":"https://doi.org/10.33263/briac134.382","url":null,"abstract":"This work was done to assess in silico interactions of some of the 1,2,4-triazole derivatives with the main protease (MPro) of coronavirus to approach insights into enzymatic activity inhibition. Fifteen models of triazole derivatives (T2-T16) were investigated in this work to examine such benefits of structural modifications of T1 for approaching better ligand structures. The density functional theory (DFT) calculations indicated that the derivative ligand models were in their new characteristic specifications compared with the original T1 ligand and other T ligands. One important point was that the derivatives ligands were in higher levels of activity in comparison with the original T1 affirming the benefits of employing such structural modifications. Next, the results of molecular docking simulations indicated the potential of derivative ligands for participating in efficient interactions with the MPro target of coronavirus. As a result, the ligand models were stabilized. Their interactions with the MPro of coronavirus revealed that the investigated triazole derivatives could be considered possible inhibitors of MPro of coronavirus.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41387772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Pistachio (Pistacia) Shell Use to Remove Pollutants from Aqua Media 开心果壳去除水中污染物的研究进展

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.389

引用次数: 1

Resistin, a Multipotential Therapeutic Target 抵抗素，一个多潜能治疗靶点

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.384

J. L. Vique‐Sánchez

{"title":"Resistin, a Multipotential Therapeutic Target","authors":"J. L. Vique‐Sánchez","doi":"10.33263/briac134.384","DOIUrl":"https://doi.org/10.33263/briac134.384","url":null,"abstract":"Being overweight and obese are risk factors that have increased during the COVID-19 pandemic; these factors increase the white adipose tissue (WAT) that increases the release of adipokines (adiponectin, leptin, and resistin). So, obesity provokes the expansion of adipose tissue; it induces changes in their macrophages of pro-inflammatory cytokines (M2 to M1). These changes increase the resistin levels with effects on the metabolism, inflammation process, glucose homeostasis, and insulin resistance, promote cell proliferation and migration, and even serve as a biomarker for tumorigenesis. Therefore, resistin is proposed as a multipotential therapeutic target to treat different diseases, between chronic-degenerative and some types of cancer, because resistin has characteristics that give it a high probability to be a therapeutic target to attend to and prevent various diseases. In different ways, developing new drugs by molecular docking to use molecules with pharmacological characteristics capable of interacting in the regions of resistin to hinder/block the interaction between resistin and their receptors (Δ-DCN, TLR4, and CAP-1) and by promoting health to reduce overweight and obesity, and this could generate lower plasma serum resistin values, so this review remarks the potential of resistin as multipotential therapeutic target.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43921731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different Dimensions of the Effects of SARS-CoV-2 in Causing Fluctuations in the Blood Pressure of Patients SARS-CoV-2对患者血压波动影响的不同维度

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.377

M. A. Ozma, E. Nabizadeh, M. R. Valiollahzadeh, J. Rashedi, B. M. Poor, V. Asgharzadeh, H. Kafil, E. Khodadadi, Z. Taghinejad, A. Abbasi, A. Esmaeili, M. Asgharzadeh

{"title":"Different Dimensions of the Effects of SARS-CoV-2 in Causing Fluctuations in the Blood Pressure of Patients","authors":"M. A. Ozma, E. Nabizadeh, M. R. Valiollahzadeh, J. Rashedi, B. M. Poor, V. Asgharzadeh, H. Kafil, E. Khodadadi, Z. Taghinejad, A. Abbasi, A. Esmaeili, M. Asgharzadeh","doi":"10.33263/briac134.377","DOIUrl":"https://doi.org/10.33263/briac134.377","url":null,"abstract":"In late 2019, SARS-CoV-2 was transmitted from animal to human in China. Subsequently, the virus spread rapidly throughout the world by human-to-human transmission and caused high mortality the people with underlying diseases, especially hypertension. This virus binds to its receptor, angiotensin-converting enzyme-2 (ACE2), via the S protein. ACE2 has a negative regulatory function in the renin-angiotensin system (RAS) and degrades angiotensin 2 (Ang II) as a vasoconstrictor which causes blood pressure regulation. It also converts Ang II to Ang1-7, which has anti-inflammatory and anti-oxidative effects. SARS-CoV-2 infection in patients with hypertension reduces ACE2 levels due to virus binding, which decreases Ang II degradation. Consequently, the complications associated with hypertension are raised, and blood pumping from the lungs into the left atrium lowers. On the other hand, the final product, Ang1-7, is reduced, and its related anti-inflammatory activity is also eliminated. The virus multiplies and damages lung cells, causing inflammation and edema of the lung tissue through the function of immune cells and cytokines, which eventually leads to lung damage, reduced oxygen delivery, and death. Careful care of patients with hypertension can prevent their infection and reduce their death with appropriate oxygen therapy and possibly using exogenous ACE2 supplements.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42556618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrosion Inhibition Investigation of Small Organic Inhibitor on API5LX60 Steel in 3.5% NaCl Solution with CO2 Saturation 小型有机缓蚀剂对API5LX60钢在3.5%NaCl饱和CO2溶液中的缓蚀性能研究

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.380

引用次数: 0

Newly Modified Nanoformulation of Quercetin as Promising Chemotherapeutic Anticancer Agent 新改性槲皮素纳米制剂作为抗癌化疗药物的研究进展

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.387

{"title":"Newly Modified Nanoformulation of Quercetin as Promising Chemotherapeutic Anticancer Agent","authors":"","doi":"10.33263/briac134.387","DOIUrl":"https://doi.org/10.33263/briac134.387","url":null,"abstract":"Previous studies have demonstrated the potential anticancer effect of quercetin (QUR). However, water insolubility and less bioavailability of QUR reduce its efficiency in cancer therapy. So, this study aims to develop a nanoformulation of quercetin (QURnp) and evaluate its anticancer effect against Ehrlich ascites carcinoma (EAC)-bearing mice compared with native QUR. QUR- loaded pluronic nanoparticles (QURnp) were prepared and characterized. To investigate the anticancer effect of QUR and QURnp, histopathological, ultrastructural, immunohistochemical, cell cycle analysis, western blot, and qRT-PCR studies were performed on EAC tumor cells, as well as antioxidant biomarkers. The results showed that QURnp destroyed tumor cells and significantly elevated antioxidant status with the reduction in MDA and NO levels. QURnp caused mitochondrial degeneration in tumor cells. Furthermore, QURnp completely reduced tumor growth by inhibiting the IL-6/STAT3 signaling pathway, inducing cell cycle arrest at the G1/S phase via overexpression of p27 and suppression of angiogenesis via downregulation in VEGF gene expression. Moreover, immunohistochemical studies indicated that QURnp showed significant inhibition of proliferation marker Ki-67 and anti-apoptotic marker Bcl-2. This study demonstrated that QURnp is a promising anticancer agent superior to native QUR.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45201873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis, Characterization, and Dye Removal Applications of Graphene Oxide-Gold Nanocomposite 氧化石墨烯-金纳米复合材料的合成、表征及除染应用

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI: 10.33263/briac134.385

引用次数: 0

Strengthening the Clumping Paper Properties using Hydroxypropyl Cellulose Applied on a Historical manuscript 13th Century AD. 在公元13世纪的一份历史手稿上应用羟丙基纤维素增强成团纸的性能。

Biointerface Research in Applied Chemistry Pub Date : 2022-10-08 DOI: 10.33263/briac134.375

{"title":"Strengthening the Clumping Paper Properties using Hydroxypropyl Cellulose Applied on a Historical manuscript 13th Century AD.","authors":"","doi":"10.33263/briac134.375","DOIUrl":"https://doi.org/10.33263/briac134.375","url":null,"abstract":"The main objective is to find a suitable and effective solution to strengthen agglomerated paper fibers and improve their physical, mechanical, and chemical properties. Many reasons lead to petrification and sticking papers. The alone worker can't lead to petrification and damage because all deterioration factors participate in the provisions of the damage circle on papers. The possible end is the loss of parts or parts or the annihilation of the entire manuscript or book. Given the archaeological and artistic value of the paper manuscripts, hydroxypropyl cellulose was chosen because it is a paper-friendly material. The papers are subject to artificial aging to reach an age like the age of the fossilized manuscript. Then the samples were naturally aged by infecting them with A. niger until they reached adhesion and agglomeration. After that, a separation process was carried out for the leaves. The leaves were consolidated with 2% hydroxypropyl cellulose. Then, an evaluation was carried out to determine the effect of hydroxypropyl cellulose on paper using digital microscopy, scanning electron microscopy, mechanical properties measurement, color change measurement, FTIR measurement, and pH measurement. The results of the examination and evaluation revealed its success in strengthening the papers and improving their properties. Therefore, it was applied to manuscript papers dating back to the thirteenth century AD.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Calculation, Docking, ADMET and Molecular Dynamics of Ketal and Non-ketal Forms of D-glucofuranose Against Bacteria, Black & White Fungus, and Triple-Negative Breast Cancer 量子计算，对接，ADMET和分子动力学的酮型和非酮型d -葡聚糖抗细菌，黑白真菌和三阴性乳腺癌

Biointerface Research in Applied Chemistry Pub Date : 2022-10-08 DOI: 10.33263/briac134.374

{"title":"Quantum Calculation, Docking, ADMET and Molecular Dynamics of Ketal and Non-ketal Forms of D-glucofuranose Against Bacteria, Black & White Fungus, and Triple-Negative Breast Cancer","authors":"","doi":"10.33263/briac134.374","DOIUrl":"https://doi.org/10.33263/briac134.374","url":null,"abstract":"D-glucofuranose has potent bioactivity against numerous diseases and pathogens, such as bacteria, fungi, viruses, and cancer. Normally, the ketal form of D-glucofuranose is converted into the non-ketal form by drug metabolism in the human body; as a result, both the ketal and non-ketal forms of D-glucofuranose are considered. To make a comparative biological activity study of ketal and non-ketal species of nine derivatives of D-glucofuranose, two bacteria, black fungus, white fungus, and triple-negative breast cancer, were selected. Firstly, the PASS prediction data from the online PASS tool indicated the probability of pathogenic efficacy through the Pa and Pi parameters. Secondly, the computational studies, such as molecular docking, molecular dynamic, ADMET, drug-likeness, pharmacokinetic, aquatic, and non-aquatic features, were calculated with three FDA-approved drugs, including azithromycin, nystatin, and cyclophosphamide. A comparative study of computational data has been performed where the ketal forms of D-glucofuranose derivatives were found highly biologically active with the satisfaction of the pharmacokinetic parameters, ADMET parameters, and Lipinski rule.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41391910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

2D-QSAR Modeling of Chalcone Analogues as Angiotensin Converting Enzyme Inhibitor Chalcone类似物作为血管紧张素转换酶抑制剂的2D-QSAR建模

Biointerface Research in Applied Chemistry Pub Date : 2022-10-07 DOI: 10.33263/briac134.370

引用次数: 0