Endocrine disruptors (Austin, Tex.)最新文献_第5页

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.27347

L. Casati

{"title":"Epigenetics and PCBs","authors":"L. Casati","doi":"10.4161/endo.27347","DOIUrl":"https://doi.org/10.4161/endo.27347","url":null,"abstract":"Epigenetic links genetics and environment in shaping several physiological mechanisms including endocrine functions. Growing evidences suggest an interplay among endocrine system, environment, and epigenetics in the etiology of many complex diseases, including some neuropsychiatric disorders. We have demonstrated that a prenatal exposure to polychlorinated biphenyls (PCBs) is able to modulate some epigenetic marks related to the steroid receptors, which (in particular androgen receptor, AR) are cofactors of histone remodeling enzymes; in our recent paper we focused on the interaction between PCBs–AR and the demethylase Jarid1b. Our studies indicate that PCBs induce AR transactivation in a dose-dependent way. Jarid1b potentiates transcriptional activity independently of ligand and of cell phenotype; in particular, Jarid1b increase the AR transactivation in the isoforms with a short polyQ expansion, which are normally present in the population. Since an inverse relationship appears to exist between the AR transcriptional activity and the polyQ repeat length, it is possible to hypothesize that Jarid1b–AR interaction strength depends on the polyQ lenght. PCBs auto-downregulate AR expression and this negative feedback is potentiated by Jarid1b and depends on AR promoter length. These results open new perspectives in the PCBs/AR/Jarid1b interplay possibly occurring in the pathogenesis of some neurological diseases like autism.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.27347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Is female reproductive aging programmed in the womb? 女性的生殖衰老是在子宫里就被设定好的吗?

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.27086

D. Walker

{"title":"Is female reproductive aging programmed in the womb?","authors":"D. Walker","doi":"10.4161/endo.27086","DOIUrl":"https://doi.org/10.4161/endo.27086","url":null,"abstract":"Polychlorinated Biphenyls (PCBs) are industrial contaminants and a class of endocrine disrupting chemicals (EDCs) that are known to interact with the reproductive system (estrogenic and androgenic) as well as other endocrine systems. Our lab and others have shown that perinatal exposure to estrogenic PCBs alters numerous aspects of the reproductive physiology and behavior in adulthood. In our current study published in Endocrinology, we extended this work further into the lifecycle to understand how gestational exposure to EDCs might affect the process of reproductive aging. In females, we found that exposure to a PCB mixture, Aroclor 1221 (A1221), altered the progression of reproductive aging and gene expression profiles in two brain regions important for regulating reproductive physiology and function: the arcuate nucleus (ARC) and median eminence (ME). Fewer effects were found in males and were largely limited to the ARC. Here I expand upon the ideas presented in the original article to discuss how exposure to EDCs and early life history can inform treatment for the symptoms of menopause, explore new hypotheses regarding circadian alterations involved in the process of reproductive aging, and examine how different models of reproductive senescence may inform our understanding of the underlying cellular and molecular mechanisms involved in these physiological processes.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":"2143"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.27086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phthalates in our food 我们食物中的邻苯二甲酸盐

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.25078

L. Birnbaum, T. Schug

{"title":"Phthalates in our food","authors":"L. Birnbaum, T. Schug","doi":"10.4161/endo.25078","DOIUrl":"https://doi.org/10.4161/endo.25078","url":null,"abstract":"Phthalates are a group of chemicals used to make plastics softer and more flexible. They are used in hundreds of products, such as vinyl flooring, adhesives, detergents, lubricating oils, automotive plastics, plastic clothes (raincoats) and personal-care products (soaps, shampoos, hair sprays and nail polishes). People are exposed to phthalates by eating and drinking foods that have been in contact with containers and products containing phthalates. To a lesser extent, exposure can occur from breathing in air that contains vapors or dust contaminated with phthalate particles. Once phthalates enter a person's body, they are converted into breakdown products that pass out quickly in urine. However, biomonitoring studies that measure urine metabolites in humans show widespread exposure to phthalates. Phthalates have been labeled as potential endocrine disrupting chemicals (EDCs) because studies have demonstrated that they interfere with hormones of the reproductive system. Recently, we reported for the first time concentrations of phthalates in United States food and used these finding to estimate dietary phthalate intake.1 The estimated intakes for individual phthalates in our study were more than an order of magnitude lower than EPA Reference Doses (RfDs), but more studies are needed to evaluate cumulative exposure to phthalates as byproducts of food consumption.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.25078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health. 尿中含磷阻燃剂代谢物与男性生殖健康指标关系的探索性分析。

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.26306

John D Meeker, Ellen M Cooper, Heather M Stapleton, Russ Hauser

{"title":"Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health.","authors":"John D Meeker, Ellen M Cooper, Heather M Stapleton, Russ Hauser","doi":"10.4161/endo.26306","DOIUrl":"https://doi.org/10.4161/endo.26306","url":null,"abstract":"<p><p>The use of phosphorus-containing flame retardants (PFRs) has increased over the past decade. Widespread human exposure has been reported, but information on the safety or potential health risks of PFRs is lacking. We assessed the relationship between urinary concentrations of two PFR metabolites [bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPHP)] and semen quality, sperm motion parameters, and serum hormone levels in 33 men. BDCPP and DPHP concentrations were significantly greater in urine samples collected in the afternoon compared to those collected in the morning (p <0.05). In multivariable models, a number of statistically significant or suggestive associations were observed between the reproductive health measures and both PFR metabolites. While the study was limited by a small sample size, these results warrant further investigation in a larger study population. Additional studies on sources, pathways, and routes of PFR exposure, along with research on toxicokinetics and exposure measure utility, are also needed.</p>","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":"e26306"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.26306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32314573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 87

Neurobehavioral and metabolic impacts of inhaled pollutants 吸入污染物对神经行为和代谢的影响

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.27489

Errol M. Thomson

{"title":"Neurobehavioral and metabolic impacts of inhaled pollutants","authors":"Errol M. Thomson","doi":"10.4161/endo.27489","DOIUrl":"https://doi.org/10.4161/endo.27489","url":null,"abstract":"In addition to established effects on cardiovascular and respiratory systems, recent epidemiological studies show associations between air pollutants and impacts on the central nervous system such as depression and impaired cognitive ability, and on disease states associated with dysfunctional metabolism such as metabolic syndrome and type II diabetes. Although the relative risk attributed to air pollutants is small compared with established risk factors, the widespread exposure of the population translates into a substantial societal health burden. Controlled experimental studies support the notion that these associations have a biological basis. Recently, we reported that short-term exposure of rats to two pollutants associated with adverse health effects, particulate matter and ozone, activated the hypothalamic-pituitary-adrenal (HPA) stress response axis, resulting in increased circulating levels of the glucocorticoid corticosterone and systemic impacts on a variety of biological pathways. While effects were transient after a single exposure in this healthy animal model, chronic activation and dysfunction of the HPA axis is associated with adverse neurobehavioral, metabolic, cardiovascular, immune, reproductive, and developmental effects. Here I build upon the ideas presented in the original paper to discuss the potential role that activation and dysfunction of the stress axis, a common feature of neurobehavioral and metabolic disorders, may play in mediating adverse health effects associated with air pollution.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.27489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Low dose effects of bisphenol A 双酚A的低剂量效应

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-09-30 DOI: 10.4161/endo.26490

Laura N. Vandenberg, S. Ehrlich, S. Belcher, N. Ben-Jonathan, D. Dolinoy, E. Hugo, P. Hunt, R. Newbold, B. Rubin, Katerine S. Saili, A. Soto, Hong-Sheng Wang, F. V. vom Saal

引用次数: 227

Progress in understanding endocrine disruption requires cross-disciplinary approaches and concepts 了解内分泌干扰的进展需要跨学科的方法和概念

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-09-27 DOI: 10.4161/ENDO.26646

C. Watson

引用次数: 0

Rapid estrogenic signaling activities of the modified (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A 修饰的(氯化、磺化和糖醛酸化)内分泌干扰物双酚A的快速雌激素信号活动

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-06-24 DOI: 10.4161/endo.25411

René Viñas, R. Goldblum, C. Watson

{"title":"Rapid estrogenic signaling activities of the modified (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A","authors":"René Viñas, R. Goldblum, C. Watson","doi":"10.4161/endo.25411","DOIUrl":"https://doi.org/10.4161/endo.25411","url":null,"abstract":"An automated in-vitro, medium-throughput screening method was designed to compare the rapid actions of 10−9M estradiol to those of modified bisphenol A (BPA) compounds: chlorinated (created due to waste water treatment) and phase II BPA metabolites. GH3/B6/F10 prolactinoma cells were treated with increasing concentrations (10−15‒10−7M) of BPA or modified BPA compounds for 5 min, and phospho-activated kinases assayed via a fixed-cell plate immunoassay. Mono- and di-chlorinated BPAs phospho-activated the extracellular signal-regulated kinase (ERK), while tri-chlorinated BPA dephosphorylated ERK to a level below vehicle-treated controls. When c-Jun-N-terminal kinase (JNK) was examined, mono-chlorinated compounds caused no responses (similar to unmodified BPA), while di- and tri-chlorinated BPAs caused extensive dephosphorylation. When deconjugation of di-sulfated and glucuronidated metabolites were inhibited, these stably conjugated compounds were unable to activate either ERK or JNK, but could inactivate them. This suggests that the modified versions of BPA (extensively chlorinated or conjugated metabolites) may alter the ability of membrane estrogen receptor-α (which mediates these rapid signaling responses) to partner with other signaling proteins. While other studies have examined the estrogenicity of modified (chlorinated and conjugated) BPA compounds in gene expression assays, this is the first to examine their actions via rapid, membrane-initiated signaling pathways.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.25411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46