Endocrine disruptors (Austin, Tex.)最新文献_第4页

Expanding the structural footprint of xenoestrogens 扩大异种雌激素的结构足迹

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.967138

M. Baker

引用次数: 9

Estrogenicity of soybeans (Glycine max) varies by plant organ and developmental stage 大豆(Glycine max)的雌激素原性因植物器官和发育阶段而异

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/endo.28490

Howard Morgan, Dylan N. Dillaway, T. M. Edwards

{"title":"Estrogenicity of soybeans (Glycine max) varies by plant organ and developmental stage","authors":"Howard Morgan, Dylan N. Dillaway, T. M. Edwards","doi":"10.4161/endo.28490","DOIUrl":"https://doi.org/10.4161/endo.28490","url":null,"abstract":"Phytoestrogens are a broad group of environmentally labile plant molecules that can influence development and reproduction of animals by binding estrogen and ecdysone receptors. In plants, phytoestrogens regulate physiological mechanisms such as auxin transport and mediate ecological interactions including attraction of symbionts. Most analytical phytoestrogen studies focus on quantifying particular phytoestrogen compounds (e.g., genistein) rather than measuring the accompanying biological estrogenic activity, and studies that evaluate temporal or spatial estrogenic variation in plants are rare. Therefore, in the present study, variation in estrogenic activity of field-grown soybeans (Glycine max cv Shirofumi) was examined across plant parts and life stages. Ethanolic organ extracts were analyzed for estrogenicity in a yeast reporter assay expressing human estrogen receptors α (ERα) or β (ERβ). All tissues were significantly more active with ERβ than ERα. The estrogenicity of roots, leaves, and shoots varied significantly across growth stages. Roots were the most estrogenic organ, being one order of magnitude more estrogenic than leaves, and up to two orders of magnitude higher than shoots, immature seeds, stems, flowers, and pods. We propose that estrogenic molecules are abundant where they participate in a plant’s outreach activities: recruitment of mutualists, allelopathy, defense, or synthesis for systemic distribution. Estrogenic activity is lower in plant organs that use phytoestrogens mainly for local regulation. We interpret our results in the context of plant chemical ecology to explain how and why plants vary their estrogenic activity and what this means for plant–animal co-evolution.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.28490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70627826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Cross-training of biologists and chemists–new book entitled “Endocrine Disruptors in the Environment” 生物学家和化学家的交叉培训——新书《环境中的内分泌干扰物》

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.967600

C. Watson

{"title":"Cross-training of biologists and chemists–new book entitled “Endocrine Disruptors in the Environment”","authors":"C. Watson","doi":"10.4161/23273739.2014.967600","DOIUrl":"https://doi.org/10.4161/23273739.2014.967600","url":null,"abstract":"Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Versions of published Taylor & Francis and Routledge Open articles and Taylor & Francis and Routledge Open Select articles posted to institutional or subject repositories or any other third-party website are without warranty from Taylor & Francis of any kind, either expressed or implied, including, but not limited to, warranties of merchantability, fitness for a particular purpose, or non-infringement. Any opinions and views expressed in this article are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor & Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23273739.2014.967600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70554613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microbiome as a target for endocrine disruptors: Novel chemicals may disrupt androgen and microbiome-mediated autoimmunity 微生物组作为内分泌干扰物的靶标:新的化学物质可能会破坏雄激素和微生物组介导的自身免疫

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.964539

M. Baker

引用次数: 1

PBDE flame retardants PBDE阻燃剂

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/endo.29430

P. Noyes, H. Stapleton

引用次数: 31

Chronic exposures to low levels of estradiol and their effects on the ovaries and reproductive hormones: Comparison with aging 长期暴露于低水平雌二醇及其对卵巢和生殖激素的影响:与衰老的比较

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.967127

E. Gilbreath, S. MohanKumar, P. Balasubramanian, D. Agnew, PS Mohankumar

{"title":"Chronic exposures to low levels of estradiol and their effects on the ovaries and reproductive hormones: Comparison with aging","authors":"E. Gilbreath, S. MohanKumar, P. Balasubramanian, D. Agnew, PS Mohankumar","doi":"10.4161/23273739.2014.967127","DOIUrl":"https://doi.org/10.4161/23273739.2014.967127","url":null,"abstract":"Aging in female rats is characterized by a state called “constant estrous” in which rats are unable to ovulate, have polycystic ovaries and moderately elevated estrogen levels. We hypothesized that chronic exposure of young animals to low levels of E2 can produce reproductive changes similar to that seen in aging animals. Adult female rats were sham-implanted (control) or implanted with slow-release E2 (20 ng/day) pellets for 30, 60, or 90 days. Old constant estrous (OCE) rats were used for comparison. Estrous cyclicity was monitored periodically. At the end of treatment, animals were sacrificed, trunk blood was collected for hormone measurements and ovaries for immunohistochemistry. Young animals became acyclic with increasing duration of E2 exposure while OCE rats were in a state of acyclicity. Ovaries became increasingly more cystic with E2 exposure, and were comparable to OCE rats; however, there was a marked reduction in interstitial tissue with exogenous E2 treatment. Exogenous E2 also decreased Mullerian inhibiting substance expression, increased infiltration of macrophages without much impact on apoptosis in the ovaries. Serum testosterone levels decreased in E2-treated young animals, while it increased significantly in OCE rats. There was a marked reduction in LH but not FSH levels with E2 exposure in both young and old animals. These results indicate that even very low doses of E2 are capable of inducing aging-like changes in young animals.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23273739.2014.967127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70554427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Non-monotonic dose responses in EDSP Tier 1 guideline assays EDSP 1级指南试验中的非单调剂量反应

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.964530

Laura N. Vandenberg, A. Bowler

{"title":"Non-monotonic dose responses in EDSP Tier 1 guideline assays","authors":"Laura N. Vandenberg, A. Bowler","doi":"10.4161/23273739.2014.964530","DOIUrl":"https://doi.org/10.4161/23273739.2014.964530","url":null,"abstract":"In the fields of endocrinology and toxicology, there are ongoing debates about whether endocrine disrupting chemicals (EDCs) produce non-monotonic dose responses. This type of response is typically characterized by a U- or inverted U-shaped relationship between dose and effect. In a recent report, a US EPA panel concluded that non-monotonicity is observed for EDCs, but that these responses are not expected in vivo, and are not typically observed in apical endpoints, i.e. endpoints that are indicators of adverse effects. Here, we have analyzed the shapes of the dose response curves in an EPA report analyzing the effectiveness of the Endocrine Disruptor Screening Program (EDSP) Tier 1 assays. This report included the results of 11 guideline assays for each of 4 chemicals. We found indications of non-monotonic dose response curves (iNMDRCs) for 3 of the 4 coded chemicals. In total, 27% of assays with dose response data included at least one iNMDRC. When the endpoints from the 4 test chemicals with dose response data were considered together, 9% were consistent with non-monotonicity. Collectively, these results indicate that non-monotonic responses occur in guideline endpoints including the kinds of adverse outcomes that regulatory agencies use in chemical safety assessments such as circulating hormone concentrations and organ weights. These results should inform discussions about whether NMDRCs are ‘real’ and occur frequently enough to be important. Because risk assessments typically involve high dose testing, limited dose groups (often only 3) and extrapolation to lower doses that are not expected to have adverse effects, the presence of NMDRCs challenges this status quo.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23273739.2014.964530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70554619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Application of a targeted endocrine q-PCR panel to monitor the effects of pollution in southern California flatfish 应用定向内分泌q-PCR监测污染对南加州比目鱼的影响

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/23273739.2014.969598

M. Baker, L. J. Sprague, C. Ribecco, B. Ruggeri, Narimene Lekmine, Colleen Ludka, Ivan Wick, L. Soverchia, M. Ubaldi, R. Sásik, D. Schlenk, K. Kelley, J. Reyes, G. Hardiman

{"title":"Application of a targeted endocrine q-PCR panel to monitor the effects of pollution in southern California flatfish","authors":"M. Baker, L. J. Sprague, C. Ribecco, B. Ruggeri, Narimene Lekmine, Colleen Ludka, Ivan Wick, L. Soverchia, M. Ubaldi, R. Sásik, D. Schlenk, K. Kelley, J. Reyes, G. Hardiman","doi":"10.4161/23273739.2014.969598","DOIUrl":"https://doi.org/10.4161/23273739.2014.969598","url":null,"abstract":"Current environmental monitoring programs focus primarily on legacy contaminants identified in the past as priority pollutants. Many new chemicals including so-called contaminants of emerging concern (CECs) are being widely dispersed into the environment and the development of sensitive tools that can screen endocrine responses and monitor the harmful effects of pollutants has become a priority. We developed a focused quantitative polymerase chain reaction (q-PCR) panel containing key endocrine gene targets for investigation of the effects of contaminants on transcriptional patterns in the demersal marine flatfish, hornyhead turbot (Pleuronichthys verticalis). An additional objective was to develop this tool so that it had broad applicability for monitoring endocrine disruption in other sentinel species, including California flatfish. This endocrine q-PCR panel was validated by studying transcriptional perturbations in 2 important sentinel species, hornyhead turbot and English sole (Parophrys vetulus), both sampled from sewage outfall and reference coastal waters in Southern California. In addition, the cross species utility of the endocrine q-PCR panel was examined by its application to the study of gene expression changes in laboratory male zebrafish (Danio rerio) following exposure to 17-β estradiol and 4-nonylphenol.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23273739.2014.969598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70554285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish. 幼斑马鱼接触低水平二恶英对成年期的不良影响。

Endocrine disruptors (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/endo.28309

Tracie R Baker, Richard E Peterson, Warren Heideman

{"title":"Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish.","authors":"Tracie R Baker, Richard E Peterson, Warren Heideman","doi":"10.4161/endo.28309","DOIUrl":"https://doi.org/10.4161/endo.28309","url":null,"abstract":"There is strong evidence indicating that disease in adult humans stems from a combination of genetic and environmental factors. A problem in identifying environmental factors is that subacute exposures during early life are often unnoticed, or exposures are variable among a diverse population. This leads to a confusing pattern in adulthood. An additional problem in following exposure effects in humans is the length of time needed to study outcomes spanning a human generation. We have recently developed a zebrafish model for studying the effects of sublethal juvenile exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Although the initial exposure produces no effect at the time, we find skeletal and reproductive defects in adulthood and into subsequent generations. The short generation time of zebrafish along with the ability to maintain large cohorts of exposed individuals and their offspring allows us to overcome variation in exposure and genetic background. Here we describe progress in studying TCDD as an endocrine and developmental disruptor, and our results showing adult consequences of early exposure.","PeriodicalId":90159,"journal":{"name":"Endocrine disruptors (Austin, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/endo.28309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33909913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Estrogen receptor (ER)-mediated activation by endocrine disrupting chemicals (EDCs) 内分泌干扰物(EDCs)介导的雌激素受体(ER)激活

Endocrine disruptors (Austin, Tex.) Pub Date : 2013-10-01 DOI: 10.4161/endo.27197

Yin Li, K. A. Burns, K. Korach

引用次数: 4