BMB Reports最新文献_第6页

Development of a highly effective recombinant protein from human collagen type III Alpha 1 (COL3A1) to enhance human skin cell functionality. 开发一种高效的人胶原蛋白 III 型α1（COL3A1）重组蛋白，以增强人皮肤细胞的功能。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-09-01

Young Un Kim, HyunJoon Gi, Eun Kyung Jeong, Seokwon Han, Woo-Young Seo, Young Jun Kim, Sang Bae Lee, KyeongJin Kim

{"title":"Development of a highly effective recombinant protein from human collagen type III Alpha 1 (COL3A1) to enhance human skin cell functionality.","authors":"Young Un Kim, HyunJoon Gi, Eun Kyung Jeong, Seokwon Han, Woo-Young Seo, Young Jun Kim, Sang Bae Lee, KyeongJin Kim","doi":"","DOIUrl":"","url":null,"abstract":"Collagen type III, a member of the fibrillar collagen group, is a major component of the extracellular matrix in various internal organs, the vascular systems, and skin. It is essential to maintain the structural integrity and functionality of these tissues, and plays a significant role in wound healing, often found alongside collagen type I. Despite being the second most abundant collagen in human tissues after type I, its biological functions on various skin properties have not been thoroughly studied. In this study, we have isolated and developed an effective recombinant protein derived from human collagen type III alpha 1 chain (hCOL3A1). Our findings demonstrate that the recombinant proteins hCOL3A1-THR-M1 and M4 stimulate cell proliferation and collagen biosynthesis in human dermal fibroblasts (HDFs), and enhance wound healing. Notably, hCOL3A1-THR- M1 (referred to as HUCOLLATIN3) specifically penetrates both the epidermal and dermal layers in a full-thickness skin model. These results collectively indicate that hCOL3A1-THR-M1 holds promise as a potential biomaterial to prevent skin aging. [BMB Reports 2024; 57(9): 424-429].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"424-429"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy. 对肿瘤微环境进行代谢重编程，以增强免疫疗法。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-09-01

Seon Ah Lim

{"title":"Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy.","authors":"Seon Ah Lim","doi":"","DOIUrl":"","url":null,"abstract":"Immunotherapy represents a promising treatment strategy for targeting various tumor types. However, the overall response rate is low due to the tumor microenvironment (TME). In the TME, numerous distinct factors actively induce immunosuppression, restricting the efficacy of anticancer immune reactions. Recently, metabolic reprogramming of tumors has been recognized for its role in modulating the tumor microenvironment to enhance immune cell responses in the TME. Furthermore, recent elucidations underscore the critical role of metabolic limitations imposed by the tumor microenvironment on the effectiveness of antitumor immune cells, guiding the development of novel immunotherapeutic approaches. Hence, achieving a comprehensive understanding of the metabolic requirements of both cancer and immune cells within the TME is pivotal. This insight not only aids in acknowledging the current limitations of clinical practices but also significantly shapes the trajectory of future research endeavors in the domain of cancer immunotherapy. In addition, therapeutic interventions targeting metabolic limitations have exhibited promising potential as combinatory treatments across diverse cancer types. In this review, we first discuss the metabolic barriers in the TME. Second, we explore how the immune response is regulated by metabolites. Finally, we will review the current strategy for targeting metabolism to not simply inhibit tumor growth but also enhance antitumor immune responses. Thus, we could suggest potent combination therapy for improving immunotherapy with metabolic inhibitors. [BMB Reports 2024; 57(9): 388-399].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"388-399"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway. 葡萄糖依赖性胰岛素多肽（GIP）通过Epac/Rap1信号通路缓解衰老诱导的脑损伤中的铁蛋白沉积。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-09-01

Jiwon Ko, Soyoung Jang, Soyeon Jang, Song Park, Junkoo Yi, Dong Kyu Choi, Seonggon Kim, Myoung Ok Kim, Su-Geun Lim, Zae Young Ryoo

{"title":"Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway.","authors":"Jiwon Ko, Soyoung Jang, Soyeon Jang, Song Park, Junkoo Yi, Dong Kyu Choi, Seonggon Kim, Myoung Ok Kim, Su-Geun Lim, Zae Young Ryoo","doi":"","DOIUrl":"","url":null,"abstract":"Glucose-dependent insulinotropic polypeptide (GIP), a 42-aminoacid hormone, exerts multifaceted effects in physiology, most notably in metabolism, obesity, and inflammation. Its significance extends to neuroprotection, promoting neuronal proliferation, maintaining physiological homeostasis, and inhibiting cell death, all of which play a crucial role in the context of neurodegenerative diseases. Through intricate signaling pathways involving its cognate receptor (GIPR), a member of the G protein-coupled receptors, GIP maintains cellular homeostasis and regulates a defense system against ferroptosis, an essential process in aging. Our study, utilizing GIP-overexpressing mice and in vitro cell model, elucidates the pivotal role of GIP in preserving neuronal integrity and combating age-related damage, primarily through the Epac/Rap1 pathway. These findings shed light on the potential of GIP as a therapeutic target for the pathogenesis of ferroptosis in neurodegenerative diseases and aging. [BMB Reports 2024; 57(9): 417-423].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"417-423"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential role of ANGPTL4 in cancer progression, metastasis, and metabolism: a brief review. ANGPTL4 在癌症进展、转移和新陈代谢中的潜在作用：简要回顾。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Min Seok Park, Sang Eun Kim, Pureunchowon Lee, Ju-Hee Lee, Kyung Hee Jung, Soon-Sun Hong

{"title":"Potential role of ANGPTL4 in cancer progression, metastasis, and metabolism: a brief review.","authors":"Min Seok Park, Sang Eun Kim, Pureunchowon Lee, Ju-Hee Lee, Kyung Hee Jung, Soon-Sun Hong","doi":"","DOIUrl":"","url":null,"abstract":"Angiopoietin-like 4 (ANGPTL4) has been identified as an adipokine involved in several non-metabolic and metabolic diseases, including angiogenesis, glucose homeostasis, and lipid metabolism. To date, the role of ANGPTL4 in cancer growth and progression, and metastasis, has been variable. Accumulating evidence suggests that proteolytic processing and posttranslational modifications of ANGPTL4 can significantly alter its function, and may contribute to the multiple and conflicting roles of ANGPTL4 in a tissue-dependent manner. With the growing interest in ANGPTL4 in cancer diagnosis and therapy, we aim to provide an up-to-date review of the implications of ANGPTL4 as a biomarker/oncogene in cancer metabolism, metastasis, and the tumor microenvironment (TME). In cancer cells, ANGPTL4 plays an important role in regulating metabolism by altering intracellular glucose, lipid, and amino acid metabolism. We also highlight the knowledge gaps and future prospect of ANGPTL4 in lymphatic metastasis and perineural invasion through various signaling pathways, underscoring its importance in cancer progression and prognosis. Through this review, a better understanding of the role of ANGPTL4 in cancer progression within the TME will provide new insights into other aspects of tumorigenesis and the potential therapeutic value of ANGPTL4. [BMB Reports 2024; 57(8): 343-351].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"343-351"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural stability for surface display of antigen 43 and application to bacterial outer membrane vesicles production. 抗原 43 表面显示的结构稳定性以及在细菌外膜囊泡生产中的应用。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Gna Ahn, Hyo-Won Yoon, Jae-Won Choi, Woo-Ri Shin, Jiho Min, Yang-Hoon Kim, Ji-Young Ahn

引用次数: 0

miR-328-5p functions as a critical negative regulator in early endothelial inflammation and advanced atherosclerosis. miR-328-5p 在早期内皮炎症和晚期动脉粥样硬化中发挥关键负调控因子的作用。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Yangxia Zhang, Yingke Li, Zhisheng Han, Qingyang Huo, Longkai Ji, Xuejia Liu, Han Li, Xinxing Zhu, Zhipeng Hao

{"title":"miR-328-5p functions as a critical negative regulator in early endothelial inflammation and advanced atherosclerosis.","authors":"Yangxia Zhang, Yingke Li, Zhisheng Han, Qingyang Huo, Longkai Ji, Xuejia Liu, Han Li, Xinxing Zhu, Zhipeng Hao","doi":"","DOIUrl":"","url":null,"abstract":"Early proatherogenic inflammation constitutes a significant risk factor for atherogenesis development. Despite this, the precise molecular mechanisms driving this pathological progression largely remain elusive. Our study unveils a pivotal role for the microRNA miR-328-5p in dampening endothelial inflammation by modulating the stability of JUNB (JunB proto-oncogene). Perturbation of miR-328-5p levels results in heightened monocyte adhesion to endothelial cells and enhanced transendothelial migration, while its overexpression mitigates these inflammatory processes. Furthermore, miR-328-5p hinders macrophage polarization toward the pro-inflammatory M1 phenotype, and exerts a negative influence on atherosclerotic plaque formation in vivo. By pinpointing JUNB as a direct miR-328-5p target, our research underscores the potential of miR-328-5p as a therapeutic target for inflammatory atherosclerosis. Reintroduction of JUNB effectively counteracts the anti-atherosclerotic effects of miR-328-5p, highlighting the promise of pharmacological miR-328-5p targeting in managing inflammatory atherosclerosis. [BMB Reports 2024; 57(8): 375-380].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"375-380"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy. ASCL1 介导的直接重编程：将腹侧中脑星形胶质细胞转化为治疗帕金森病的多巴胺能神经元。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Sang Hui Yong, Sang-Mi Kim, Gyeong Woon Kong, Seung Hwan Ko, Eun-Hye Lee, Yohan Oh, Chang-Hwan Park

{"title":"ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy.","authors":"Sang Hui Yong, Sang-Mi Kim, Gyeong Woon Kong, Seung Hwan Ko, Eun-Hye Lee, Yohan Oh, Chang-Hwan Park","doi":"","DOIUrl":"","url":null,"abstract":"Parkinson's disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra, is caused by various genetic and environmental factors. Current treatment methods are medication and surgery; however, a primary therapy has not yet been proposed. In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture in iDAN convertsion medium reprogrammed the astrocytes into iDANs. After 7 days of differentiation, TH+/TUJ1+ cells emerged. After 2 weeks, the number of mature TH+/TUJ1+ dopaminergic neurons increased. Only ventral midbrain (VM) astrocytes exhibited these results, not cortical astrocytes. Thus, VM astrocytes can undergo direct iDAN reprogramming with ASCL1 alone, in the absence of transcription factors that stimulate dopaminergic neurons development. [BMB Reports 2024; 57(8): 363-368].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"363-368"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems. 造血干细胞移植的挑战与创新：探索骨髓龛位和新模型系统。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Byung-Chul Lee

{"title":"Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems.","authors":"Byung-Chul Lee","doi":"","DOIUrl":"","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) remains an indispensable therapeutic strategy for various hematological diseases. This review discusses the pivotal role of bone marrow (BM) niches in influencing the efficacy of HSCT and evaluates the current animal models, emphasizing their limitations and the need for alternative models. Traditional animal models, mainly murine xenograft, have provided significant insights, but due to species-specific differences, are often constrained from accurately mimicking human physiological responses. These limitations highlight the importance of developing alternative models that can more realistically replicate human hematopoiesis. Emerging models that include BM organoids and BM-on-a-chip microfluidic systems promise enhanced understanding of HSCT dynamics. These models aim to provide more accurate simulations of the human BM microenvironment, potentially leading to improved preclinical assessments and therapeutic outcomes. This review highlights the complexities of the BM niche, discusses the limitations of current models, and suggests directions for future research using advanced model systems. [BMB Reports 2024; 57(8): 352-362].","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"352-362"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway. 下调的 CDK10 通过激活 JNK/c-Jun 信号通路促进肺癌的癌症进展和放射抗性。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Chaojin Hong, Yimei Meng, Anchen Qiu, Haibo Zhang, Liu Yang, Yupeng Hong, Yumei Huang

引用次数: 0

Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling. Prmt7是间充质干细胞通过调节BMP信号分化成骨所必需的。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Tuan Anh Vuong, Yan Zhang, June Kim, Young-Eun Leem, Jong-Sun Kang

引用次数: 0