Stromal cells and epigenetics: emerging key players of chronic inflammatory skin diseases.

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
BMB Reports Pub Date : 2024-09-02
Jihye Kim, Michael Detmar
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引用次数: 0

Abstract

Epigenetic alterations play a crucial role in developmental processes, tissue regeneration, and cellular differentiation. Epigenetic changes are dynamically reversible. Various drugs that target DNA methyltransferases or histone deacetylases have demonstrated their ability to restore normal epigenetic patterns in a number of diseases. While the involvement of epigenetic modifications has been identified in chronic inflammatory diseases, their specific impact on skin inflammation in stromal cells remains unclear. This mini-review explores the role of stromal cells in chronic inflammatory skin diseases, focusing on epigenetic modifications of stromal cells such as fibroblasts, lymphatic, and blood vascular endothelial cells in both healthy and diseased skin. We also provide an overview of recent findings that highlight the contribution of stromal cells, including fibroblasts, to inflammatory and remodeling processes through epigenetic changes in the context of chronic inflammatory conditions. Investigating epigenetic reprogramming of stromal cells might lead to novel strategies for treating chronic inflammatory skin diseases.

基质细胞和表观遗传学:慢性炎症性皮肤病的新兴关键角色。
表观遗传改变在发育过程、组织再生和细胞分化中起着至关重要的作用。表观遗传变化是动态可逆的。以 DNA 甲基转移酶或组蛋白去乙酰化酶为靶点的各种药物已证明能够在多种疾病中恢复正常的表观遗传模式。虽然已发现表观遗传修饰参与了慢性炎症性疾病,但它们对基质细胞皮肤炎症的具体影响仍不清楚。这篇微型综述探讨了基质细胞在慢性炎症性皮肤病中的作用,重点是健康和患病皮肤中基质细胞(如成纤维细胞、淋巴细胞和血管内皮细胞)的表观遗传修饰。我们还概述了近期的研究成果,这些研究成果强调了基质细胞(包括成纤维细胞)在慢性炎症情况下通过表观遗传学变化对炎症和重塑过程的贡献。研究基质细胞的表观遗传学重编程可能会为治疗慢性炎症性皮肤病带来新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMB Reports
BMB Reports 生物-生化与分子生物学
CiteScore
5.10
自引率
7.90%
发文量
141
审稿时长
1 months
期刊介绍: The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.
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