Blood vessels最新文献_第9页

Mechanism of the vasodilator action of pinacidil. 品酸酯血管扩张作用的机制。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158824

M J Mulvany, L M Videbaek, A D Hughes, C Aalkjaer

引用次数: 5

Role of vasopressin in cardiovascular and blood pressure regulation. 血管加压素在心血管和血压调节中的作用。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158801

F M Abboud, J S Floras, P E Aylward, G B Guo, B N Gupta, P G Schmid

引用次数: 73

Resistance artery tone is influenced independently by pressure and by flow. 阻力动脉张力受压力和流量的独立影响。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158811

J A Bevan, J L Garcia-Roldan, E H Joyce

引用次数: 25

Flow-induced constriction of rabbit resistance artery is sodium-dependent. 兔阻力动脉血流收缩是钠依赖性的。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158831

J A Bevan, G C Wellman, E H Joyce

引用次数: 14

The potassium channel openers: a new class of vasorelaxants. 钾离子通道打开剂:一类新的血管松弛剂。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158823

A H Weston, J Longmore, D T Newgreen, G Edwards, K M Bray, S Duty

{"title":"The potassium channel openers: a new class of vasorelaxants.","authors":"A H Weston, J Longmore, D T Newgreen, G Edwards, K M Bray, S Duty","doi":"10.1159/000158823","DOIUrl":"https://doi.org/10.1159/000158823","url":null,"abstract":"Cromakalim, pinacidil, nicorandil, diazoxide and RP-49356 belong to the class of drugs termed potassium channel openers. In rat portal vein diazoxide, like cromakalim, abolished spontaneous mechanical and electrical activity and in rat aorta caused an increase in 86Rb efflux and inhibited KCl(20 mM)-induced contractions. However, in contrast to cromakalim, diazoxide (greater than 100 microM) also inhibited mechanical responses evoked by 80 mM KCl in rat aorta suggesting that it possesses pharmacological properties in addition to K channel opening. Since glibenclamide can attenuate the effects of cromakalim and diazoxide in vascular tissues, it is possible that a channel resembling the ATP-sensitive K channel found in pancreatic beta-cells may be involved in the vasorelaxant effects of these agents. However, differences exist in the order of potency of cromakalim and diazoxide for producing smooth muscle relaxation and for decreasing insulin secretion in pancreatic beta-cells. Furthermore galanin (which opens ATP-sensitive K channels in beta-cells) increases mechanical activity in rat portal vein. It is anticipated that new chemical developments will produce K channel opening molecules with greater potency and tissue selectivity.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"27 2-5","pages":"306-13"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12864879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Prostanoids contribute to endothelium-dependent coronary vasodilation in guinea pigs. 前列腺素有助于豚鼠内皮依赖性冠状动脉血管舒张。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158828

L Lee, C A Bruner, R C Webb

{"title":"Prostanoids contribute to endothelium-dependent coronary vasodilation in guinea pigs.","authors":"L Lee, C A Bruner, R C Webb","doi":"10.1159/000158828","DOIUrl":"https://doi.org/10.1159/000158828","url":null,"abstract":"This study characterizes the contribution of prostanoids to endothelium-dependent responses in two vascular regions of the guinea pig. We compared the mechanisms of relaxation responses to acetylcholine and adenosine triphosphate (ATP) in the coronary vasculature and in the abdominal aorta of the guinea pig. Endothelium-dependent responses were examined in an isolated, potassium-arrested guinea pig heart utilizing a modified Langendorff preparation. Coronary vessels were constricted with prostaglandin F2 alpha and dilated with acetylcholine (10(-9)-10(-6) mol) or ATP (10(-10)-10(-7) mol) before and after exposure to indomethacin (14 microM, n = 6) or ibuprofen (150 microM, n = 5). Helically cut strips of abdominal aorta (n = 6) were suspended in isolated tissue baths for measurement of isometric force. Relaxation to acetylcholine (5.5 x 10(-7) M) and ATP (10(-5) M) was quantified in strips contracted with norepinephrine before and after exposure to indomethacin (14 microM). In addition, the endothelium was damaged by exposing vessels to free radicals generated by electrolysis of the buffer (4 Hz, 9 V, 1 ms, 5 min). Following electrolysis of the buffer, relaxation responses to acetylcholine and ATP were significantly attenuated in both preparations. In the perfused heart, endothelium-dependent dilatation to acetylcholine, but not ATP were significantly inhibited in the presence of indomethacin or ibuprofen. In contrast, acetylcholine- and ATP-induced relaxation responses in the aorta were not altered by indomethacin. We conclude that prostaglandins contribute to acetylcholine-induced dilatation in the coronary bed but not in the abdominal aorta of the guinea pig. Furthermore, in the coronary bed, different endothelial factors mediate relaxation to acetylcholine and ATP.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"27 6","pages":"341-51"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13280708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Physiological modulation of alpha-adrenoceptor and 5HT receptor expression in blood vessels. 血管中肾上腺素受体和5HT受体表达的生理调节。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158805

J C McGrath, W R Dunn, A G Templeton

引用次数: 9

Scope of vasodilatory effects of calcium antagonists. 钙拮抗剂血管舒张作用的范围。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158825

G Fleckenstein-Grün, A Fleckenstein

引用次数: 7

Mechanisms involved in serotonin-induced vasodilatation. 5 -羟色胺诱导血管扩张的机制。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158802

E J Mylecharane

{"title":"Mechanisms involved in serotonin-induced vasodilatation.","authors":"E J Mylecharane","doi":"10.1159/000158802","DOIUrl":"https://doi.org/10.1159/000158802","url":null,"abstract":"In vitro investigations have identified three major mechanisms which could contribute to the vasodilator action of serotonin (5-hydroxytryptamine, 5-HT): direct vascular smooth muscle relaxation; prejunctional inhibition of noradrenaline release from vascular sympathetic nerve terminals; and release of endothelium-derived relaxing factor (EDRF). In vivo studies have shown that in pig and cat common carotid circulations, rabbit hindquarter and mesenteric circulations, and rat systemic vasculature, direct vascular smooth muscle relaxation may be the predominant mechanism involved, but the contribution of EDRF release remains to be established. In other circulations in vivo (dog femoral and common carotid), prejunctional inhibition of vascular sympathetic tone is the predominant mechanism responsible for serotonin-induced vasodilatation. All of these actions are mediated by 5-HT1-like receptors, but different subtypes seem to be involved in each of these mechanisms. The prejunctional inhibitory receptor has been the most studied; depending on the tissue, these subtypes may resemble 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D binding sites, or the contractile receptor in dog saphenous vein.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"27 2-5","pages":"116-26"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13394661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Lymphatic innervation. 淋巴神经支配。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158803

N G McHale

引用次数: 26