Blood vessels最新文献_第10页

Endothelium-derived hyperpolarizing factor. 内皮衍生的超极化因子。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158815

K Komori, P M Vanhoutte

引用次数: 52

EDRF in intact vascular networks. 完整血管网中的EDRF。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158814

T M Griffith, D H Edwards

引用次数: 6

Vasoactive peptides and their receptors. 血管活性肽及其受体。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158804

D Regoli, S Dion, N E Rhaleb, G Drapeau, P D'Orléans-Juste

{"title":"Vasoactive peptides and their receptors.","authors":"D Regoli, S Dion, N E Rhaleb, G Drapeau, P D'Orléans-Juste","doi":"10.1159/000158804","DOIUrl":"https://doi.org/10.1159/000158804","url":null,"abstract":"Peptides act as vasoconstrictors (for instance angiotensins, vasopressin) or vasodilators (the kinins, the neurokinins), both through direct activation of specific receptors in the vascular smooth muscles or indirectly through the release of other endogenous inhibitors of the vascular tone. Kinins and neurokinins as well as their multiple receptors have been analyzed in the present study to assess the possible contributions of peptides to vasodilatation. Kinin receptors, B1 and B2, have been characterized, using new selective agonists and antagonists. B1 and B2 receptors appear to present in endothelium (B2) and in smooth muscles (B2, B1) of a variety of isolated vessels of the dog and the rabbit, where they subserve both stimulatory and inhibitory effects. Vasodilator inhibitory mechanisms depend on the release of the endothelium-relaxing factor and/or of prostanoids from the endothelium or the smooth muscles, especially in the dog renal vessels, where both B1 and B2 receptors appear to be involved in causing vasodilatation. B2 receptors have also been shown to activate cardiovascular reflexes through a direct action on sensory fibers or on reflexogenic areas of the epicardium. Three types of receptors for neurokinins, namely NK-1, NK-2 and NK-3, have been identified by the use of naturally occurring peptides and of some analogues that act as selective agonists of a single receptor type. NK-1 receptors (particularly sensitive to substance P) have been shown to be present in endothelia where they promote the release of the endothelium relaxing factor, while NK-2 receptors (sensitive to neurokinin A) are found in the pulmonary artery of the rabbit and act directly to contract the smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13326471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Patterns of internal elastic lamina morphology in the canine common carotid artery. 犬颈总动脉内弹性板形态。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158791

K J Hutchison, E J Sanders

引用次数: 5

Endothelium-dependent relaxations and chronic vasospasm after subarachnoid hemorrhage. 蛛网膜下腔出血后内皮依赖性松弛和慢性血管痉挛。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158818

P Kim, P M Vanhoutte

引用次数: 9

Decreased activity of the sodium-calcium exchanger in tail artery of stroke-prone spontaneously hypertensive rats. 卒中易感自发性高血压大鼠尾动脉钠钙交换器活性降低。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158810

L E Thompson, G J Rinaldi, D F Bohr

{"title":"Decreased activity of the sodium-calcium exchanger in tail artery of stroke-prone spontaneously hypertensive rats.","authors":"L E Thompson, G J Rinaldi, D F Bohr","doi":"10.1159/000158810","DOIUrl":"https://doi.org/10.1159/000158810","url":null,"abstract":"The ability of the Na-Ca exchanger to modify vascular relaxation was studied in rings isolated from tail arteries of stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). The arteries were contracted with norepinephrine (NE) 1 microM and after stabilization they were transferred to a Ca-free physiological salt solution still in presence of NE. The time to 50% relaxation (T-50) in these conditions was significantly greater in SHRSP (78 +/- 7 s) than in WKY (50 +/- 7 s). When the calcium pump was stopped with vanadate (VAN), the Ca uptake by the sarcoplasmic reticulum with ryanodine (RY) and the Na-Ca exchanger with a Na-free PSS, the relaxation was slowed (T-50 increased to 198 +/- 16 s in SHRSP and to 162 +/- 14 s in WKY). Releasing the Na-Ca exchanger only (i.e. still with VAN and RY but with normal Na in the bath) the T-50 for relaxation in Ca-free PSS was, in WKY, nearly as fast as in control conditions (54 +/- 8 s). However, the Na-Ca exchanger in SHRSP was not so effective, and the T-50 for relaxation was slower than in control conditions (122 +/- 10 s). We conclude that the activity of the Na-Ca exchanger is depressed in tail arteries of SHRSP. This abnormality in resistance vessels, would contribute to the enhanced vascular tone present in hypertension.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13394662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

G-proteins and endothelial responses. g蛋白与内皮反应。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158813

N A Flavahan, P M Vanhoutte

{"title":"G-proteins and endothelial responses.","authors":"N A Flavahan, P M Vanhoutte","doi":"10.1159/000158813","DOIUrl":"https://doi.org/10.1159/000158813","url":null,"abstract":"G-proteins are transducing proteins that couple a large number of membrane-bound receptors to a variety of intracellular effector systems. Pertussis toxin ADP-ribosylates certain G-proteins causing inhibition of their function. In porcine coronary arteries, pertussis toxin inhibited the endothelium-dependent relaxations evoked by alpha-2-adrenergic or serotonergic receptor stimulation, and by aggregating platelets or thrombin. Relaxations to nitric oxide and endothelium-dependent relaxations to bradykinin, adenosine diphosphate or A23187 were unaffected by the toxin. Therefore, certain endothelium-dependent relaxations are mediated by activation of a pertussis toxin-sensitive G-protein in the endothelial cells, most likely Gi-protein. In porcine coronary arteries with regenerated endothelium (following in vivo denudation), the endothelium-dependent relaxations caused by the pertussis toxin-sensitive stimuli were reduced and were not further affected by pertussis toxin. Relaxations to the other stimuli were not altered by the regeneration process and were still not affected by the toxin. In regenerating endothelial cells there may be a selective impairment of the G-protein-dependent mechanism for releasing EDRF, which may predispose the blood vessel to vasospasm or the initiation of vascular disease.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13277167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

Impaired dilatation of cerebral arterioles in chronic hypertension. 慢性高血压患者脑小动脉扩张受损。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158817

D D Heistad, W G Mayhan, P Coyle, G L Baumbach

引用次数: 68

The first Robert Furchgott lecture: from endothelium-dependent relaxation to the L-arginine:NO pathway. 第一个Robert Furchgott讲座:从内皮依赖性松弛到l -精氨酸:NO途径。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158812

S Moncada

引用次数: 46

Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents. 非肽血管紧张素II受体拮抗剂:一类新的抗高血压药物。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158821

P B Timmermans, D J Carini, A T Chiu, J V Duncia, W A Price, G J Wells, P C Wong, R R Wexler, A L Johnson

{"title":"Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents.","authors":"P B Timmermans, D J Carini, A T Chiu, J V Duncia, W A Price, G J Wells, P C Wong, R R Wexler, A L Johnson","doi":"10.1159/000158821","DOIUrl":"https://doi.org/10.1159/000158821","url":null,"abstract":"The most direct approach to block the function of the renin-angiotensin system would be to antagonize angiotensin II (AII) at the level of its receptor. However, the AII receptor antagonists currently available, such as saralasin, are peptides which still retain agonistic activity and lack oral bioavailability. We have identified the N-benzylimidazoles, S-8307 and S-8308, as weak, but selective nonpeptide AII receptor antagonists. These initial leads were subsequently converted into more potent compounds, such as EXP6155, EXP6803 and EXP7711, while maintaining the selectivity. The compounds displace 3H-AII from its specific binding sites in adrenal cortical membranes and smooth muscle cells. They competitively inhibit the vasoconstrictor response to AII in various in vivo and in vitro preparations, but do not influence those to KCl, norepinephrine, and vasopressin. Converting enzyme and renin are not affected by these agents. In renal hypertensive rats and sodium-depleted dogs our compounds cause a sustained decrease in arterial pressure following intravenous and oral (EXP7711) administration, and are devoid of agonistic properties. Taken together, these nonpeptide structures are true competitive AII receptor antagonists and represent a new class of effective antihypertensive agents.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13135982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16