Blood vessels最新文献_第8页

Endothelium-dependent effects of beta-adrenergic blockers. 肾上腺素能阻滞剂的内皮依赖性作用。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158822

P M Vanhoutte

引用次数: 5

Endothelins. 内皮素。

Blood vessels Pub Date : 1990-01-01

E E Anggård, R M Botting, J R Vane

引用次数: 0

Modulation of the action of calcium antagonists in arteries. 动脉中钙拮抗剂作用的调节。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158809

T Godfraind, N Morel, M Wibo

引用次数: 16

Adenosine A2 receptors mediate cerebral vasodilation in the conscious goat. 腺苷A2受体介导有意识山羊的脑血管舒张。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158793

G Torregrosa, J B Salom, F J Miranda, J A Alabadí, C Alvarez, E Alborch

引用次数: 6

Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses. 内皮细胞的机械接受:压力和血流诱导的血管反应的介质和机制。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158816

G M Rubanyi, A D Freay, K Kauser, A Johns, D R Harder

{"title":"Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses.","authors":"G M Rubanyi, A D Freay, K Kauser, A Johns, D R Harder","doi":"10.1159/000158816","DOIUrl":"https://doi.org/10.1159/000158816","url":null,"abstract":"Mechanoreception, a widely distributed sensory modality, has been shown to be present in certain blood vessels. Changes in physical forces, like sudden increase of transmural pressure or flow velocity (shear stress), trigger changes in blood vessel diameter; the former reduces it while the latter increases vessel caliber. These changes in diameter, which are the result of contraction and relaxation of vascular smooth muscle in the blood vessel media, can serve the purpose of physiological regulation of blood flow (autoregulation) and protection of the intima against damages from high shear forces. The precise location of mechanosensor(s) and the mechanism of mechanoreception and signal transduction are poorly understood. Accumulating evidence suggests that the endothelium may be a site of mechanoreception and that changes in the synthesis/release of endothelium-derived relaxing (EDRF, EDHF, PGI2) and contracting factors (EDCF) result in altered vascular smooth muscle tone and vessel caliber. Increased shear stress stimulates the release of EDRF and PGI2 probably via activation of a K+ channel (inward rectifier) in endothelial cell membrane. Endothelium-dependent vascular contraction evoked by increased transmural pressure may be the result of (1) reduced release of EDRF (canine carotid artery) and (2) stimulation of the release of a still unidentified EDCF(s) (feline cerebral artery). Thus the endothelium can serve as pressure and flow sensor and is capable of transducing changes in mechanical forces into changes of vascular smooth muscle tone by modulating the release of endothelium-derived vasoactive factors. The physiological importance of the mechanoreception by endothelial cells in the intact circulation remains to be determined.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13394624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 164

Inhibitor of ATP-sensitive K+ channel alters neither hypoxic contraction nor relaxation of rat aorta. atp敏感的K+通道抑制剂既不改变大鼠主动脉的缺氧收缩也不改变主动脉的舒张。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158830

D M Rodman, K Hasunuma, J L Peach, I F McMurtry

引用次数: 7

7th international symposium on vascular neuroeffector mechanisms. A satellite symposium of the 11th International Congress of Pharmacology, Amsterdam 1990. Bonn, FRG, July 8-11, 1990. Abstracts. 第七届血管神经效应机制国际研讨会。第11届国际药理学大会卫星专题讨论会，阿姆斯特丹，1990。波恩，德国，1990年7月8-11日。摘要。

Blood vessels Pub Date : 1990-01-01

引用次数: 0

Protein kinase C as a modulator of response amplification in vascular smooth muscle. 蛋白激酶C在血管平滑肌反应放大中的调节作用。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158827

I Laher, L P Thompson, L Gagne

{"title":"Protein kinase C as a modulator of response amplification in vascular smooth muscle.","authors":"I Laher, L P Thompson, L Gagne","doi":"10.1159/000158827","DOIUrl":"https://doi.org/10.1159/000158827","url":null,"abstract":"The amplification of alpha-adrenoceptor-mediated vasoconstriction by angiotensin II was studied in femoral artery rings from rabbits. Threshold concentrations of angiotensin II (0.1 nM) increased the maximal response to clonidine to 139 +/- 8% of control and produced a 3.2-fold increase in sensitivity. These effects of angiotensin II were reversed when tissues were pretreated with staurosporine (50 nM), an inhibitor of protein kinase C. The amplification of the alpha-adrenoceptor-mediated vasoconstrictor effects of thrombin and norepinephrine by angiotensin II were also reversed by pretreatment with staurosporine. Angiotensin II induced a response amplification in vascular smooth muscle known to be a nonspecific phenomenon, implying postreceptor interaction at intracellular transducer systems. Our findings suggest that upon activation of protein kinase C by angiotensin II, arterial responses to alpha-adrenoceptor agonists are amplified. This provides for nonspecific changes in vascular sensitivity by tonic alterations in postsynaptic modulation by enzyme systems known to regulate Ca2(+)-dependent phenomena, e.g. those related to vascular excitation-contraction mechanisms.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13432059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Noradrenaline induces rhythmic contractions of feline middle cerebral artery at low extracellular magnesium concentration. 低细胞外镁浓度下，去甲肾上腺素诱导猫大脑中动脉节律性收缩。

Blood vessels Pub Date : 1990-01-01 DOI: 10.1159/000158832

C. Szabó, E. Dóra, M. Faragó, I. Horváth, A. Kovách

引用次数: 4

Mechanisms of vasodilation. Proceedings of the 5th international symposium, Strasbourg, France, July 5-7, 1989. 血管舒张的机制。第五届国际研讨会论文集，斯特拉斯堡，法国，1989年7月5-7日。

Blood vessels Pub Date : 1990-01-01

引用次数: 0