Role of vasopressin in cardiovascular and blood pressure regulation.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158801
F M Abboud, J S Floras, P E Aylward, G B Guo, B N Gupta, P G Schmid
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引用次数: 73

Abstract

At low concentrations and in physiologic states vasopressin is a potent antidiuretic hormone. Its cardiovascular effects have been more complex and their role in circulatory adjustments to hypovolemia and hypotension difficult to define with precision. Although recognized as a powerful vasoconstrictor, its pressor effect in intact animals, even at high concentrations, is minimal. The reasons for this blunted pressor response have been explored. This report is a review of previously published work from our laboratories which highlights the direct and indirect vasodilator actions of this hormone in animals and humans. The indirect vasodilator effect is caused by inhibition of sympathetic efferents, and facilitation of the baroreflex through a central action of the hormone and its sensitization of arterial baroreceptors as well as cardiac afferents.

血管加压素在心血管和血压调节中的作用。
在低浓度和生理状态下,抗利尿激素是一种有效的抗利尿激素。其对心血管的影响更为复杂,其对低血容量和低血压的循环调节作用难以精确定义。虽然它被认为是一种强大的血管收缩剂,但在完整的动物体内,即使浓度很高,它的升压作用也很小。这种迟钝的压力反应的原因已被探讨。本报告是对我们实验室先前发表的工作的回顾,这些工作强调了这种激素在动物和人类中的直接和间接血管扩张作用。间接血管舒张作用是由抑制交感神经输出和通过激素的中枢作用及其对动脉压力感受器和心脏传入神经的敏化促进压力反射引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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