BioMed Research International最新文献_第6页

RETRACTION: Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals. 撤回：地西泮增强二甲双胍在伴有应激的2型糖尿病实验动物中的抗糖尿病、抗应激和抗焦虑活性。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9821027

BioMed Research International

引用次数: 0

RETRACTION: Rhubarb Tannins Extract Inhibits the Expression of Aquaporins 2 and 3 in Magnesium Sulphate-Induced Diarrhoea Model. 撤回：大黄单宁提取物抑制硫酸镁诱导腹泻模型中水通道蛋白2和3的表达。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-31 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9768597

BioMed Research International

引用次数: 0

Corrigendum to "Berberine for Appetite Suppressant and Prevention of Obesity". “小檗碱抑制食欲及预防肥胖”的勘误表。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-31 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9876059

引用次数: 0

The Protective Effect of Omeprazole on Vancomycin Cytotoxicity in HK-2 Cells and Renal Injury in Rats. 奥美拉唑对万古霉素对大鼠HK-2细胞毒性及肾损伤的保护作用。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-31 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/3520935

Jiaxu Wu, Xikun Wu, Wenli Li, Yakun Zhang, Zhiqing Zhang

{"title":"The Protective Effect of Omeprazole on Vancomycin Cytotoxicity in HK-2 Cells and Renal Injury in Rats.","authors":"Jiaxu Wu, Xikun Wu, Wenli Li, Yakun Zhang, Zhiqing Zhang","doi":"10.1155/bmri/3520935","DOIUrl":"10.1155/bmri/3520935","url":null,"abstract":"Objective: Vancomycin is the first-line treatment for MRSA infection, and high plasma concentration can cause nephrotoxicity. The aim of the study was to determine the correlation between intracellular vancomycin concentration and HK-2 cytotoxicity and explore omeprazole's protective effect. Methods: The activity of HK-2 cells was detected, HPLC method was established and verified, and the vancomycin concentrations in the intracellular and extracellular fluids of HK-2 cells were determined. Western blot was used to investigate the expressions of P-glycoprotein (P-gp) and organic cation transporter-2 (OCT-2) transporters. Blood urea nitrogen (BUN), blood creatinine (CRE), N-acetyl-β-d-glucosaminidase (NAG), and kidney injury molecule-1 (KIM-1) of rats in the vancomycin group and drug combination group were determined; the kidney tissue pathological examination and renal injury score were performed. Results: The HPLC method met the requirements for biological sample determination. The cytotoxicity of vancomycin in HK-2 cells was concentration-dependent within 1-20 mg/mL; omeprazole could reduce the intracellular accumulation of vancomycin. Western blot assay confirmed that omeprazole increased intracellular vancomycin efflux by upregulating P-gp expression and inhibited its intracellular transport by downregulating OCT-2 expression. Vancomycin increased renal function indicators and pathological injury score in rats, while there was a significant decrease in the drug combination group, together with alleviated renal tissue damage. Conclusion: Intracellular accumulation of vancomycin can cause damage to HK-2 cells and induce vancomycin-related nephrotoxicity in rats. Omeprazole can reduce vancomycin cytotoxicity by upregulating P-gp expression and inhibiting OCT-2 expression.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3520935"},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: PEGylated Polyethylenimine Derivative-Mediated Local Delivery of the shSmad3 Inhibits Intimal Thickening after Vascular Injury. 缩回：聚乙二醇化聚乙烯亚胺衍生物介导的shSmad3局部递送抑制血管损伤后内膜增厚。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9808963

BioMed Research International

引用次数: 0

RETRACTION: "Developing a Novel Method for Estimating the Speed of Sound in Biodiesel Known as Grey Wolf Optimizer Support Vector Machine Algorithm". 撤回：“开发一种估算生物柴油声速的新方法——灰狼优化支持向量机算法”。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9864925

BioMed Research International

引用次数: 0

Corrigendum to "Clinical Clues to Differentiate Between Dermatophyte Onychomycosis (DP-OM) and Dermatophytoma-Like Traumatic Onychodystrophy (DP-TO)". “区分皮肤癣菌病（DP-OM）和皮肤癣样创伤性甲营养不良（DP-TO）的临床线索”的勘误表。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-28 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/9862803

引用次数: 0

Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis. 阴陈好汤通过miR-370-3p/TM9SF4/KIT轴预防妊娠期肝内胆汁淤积

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-26 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/3000226

Hongxiu Jiang, Wenjing Yu, Xingran Tao, Qiao Yan, Guanlun Zhou, Chao Chen, Guorong Han

{"title":"Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis.","authors":"Hongxiu Jiang, Wenjing Yu, Xingran Tao, Qiao Yan, Guanlun Zhou, Chao Chen, Guorong Han","doi":"10.1155/bmri/3000226","DOIUrl":"10.1155/bmri/3000226","url":null,"abstract":"Objective: The objective is to explore the potential pathogenesis and therapeutic mechanism of Yinchenhao decoction (YCHD) in intrahepatic cholestasis of pregnancy (ICP) by focusing on the regulatory role of exosomal miR-370-3p on target genes TM9SF4 and KIT. Methods: Exosomes were isolated from the serum samples of normal pregnant women (control), patients with ICP, HTR-8/SVneo cells, and Sprague-Dawley (SD) pregnant rats via differential centrifugation. Characterization of these exosomes was performed using electron microscopy, nanoparticle tracking analysis (NTA), and western blotting. Quantitative reverse transcription PCR (qRT-PCR) and the bioinformatics tool starBase were used to identify miR-370-3p as a candidate miRNA. Dual-luciferase reporter assays were used to confirm that TM9SF4 and KIT are direct targets of miR-370-3p. An in vitro ICP cell model was established using HTR-8/SVneo cells to investigate the interactions between miR-370-3p and its targets. An animal model was established to validate the targeted regulation of miR-370-3p on TM9SF4 and KIT, as well as the therapeutic effect of YCHD in vivo. Results: The exosomal miR-370-3p expression was significantly upregulated, whereas the TM9SF4 and KIT expressions were downregulated as demonstrated by qRT-PCR and western blot analyses. RNA pull-down assays confirmed a direct negative regulatory relationship between miR-370-3p and both TM9SF4 and KIT at the molecular level. Finally, the therapeutic potential of YCHD was verified by its ability to reverse the altered expression patterns of miR-370-3p, TM9SF4, and KIT in the animal ICP model. Conclusion: Our study demonstrates that YCHD protects against ICP through the miR-370-3p/TM9SF4/KIT axis, suggesting miR-370-3p as a potential therapeutic target for ICP.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3000226"},"PeriodicalIF":2.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Curcumin Floating Tablets for Spatial Delivery in Peptic Ulcer. 新型姜黄素漂浮片用于消化性溃疡的空间递送。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/6622146

Chitra Gupta, Girdhar Kumar Sahu, Ashish Kumar Parashar, Kalpana Singh, Sarad Pawar Naik Bukke, Godswill James Udom

{"title":"Novel Curcumin Floating Tablets for Spatial Delivery in Peptic Ulcer.","authors":"Chitra Gupta, Girdhar Kumar Sahu, Ashish Kumar Parashar, Kalpana Singh, Sarad Pawar Naik Bukke, Godswill James Udom","doi":"10.1155/bmri/6622146","DOIUrl":"10.1155/bmri/6622146","url":null,"abstract":"Background: Peptic ulcers, caused by factors like Helicobacter pylori infection and NSAID overuse, are often treated with drugs that can have significant downsides. Curcumin, a natural compound with high therapeutic potential, faces challenges due to poor solubility and instability. Innovative delivery systems are key to unlocking curcumin's full benefits for effective peptic ulcer treatment. Materials and Methods: To address the challenge of curcumin's limited bioavailability, a novel drug delivery system was developed. The system employed a twofold strategy: enhancing curcumin's solubility via complexation with methyl-β-cyclodextrin, and formulating effervescent, gastroretentive tablets composed of hypromellose and gas-generating agents. This approach is aimed at achieving sustained gastric retention and localized drug release, thereby maximizing curcumin's therapeutic potential. Results: The formulated tablets exhibited excellent pharmaceutical properties, meeting all required standards for hardness, friability, and drug content. Importantly, the tablets demonstrated rapid flotation in simulated gastric fluid (buoyancy achieved within 20 s) and maintained buoyancy for approximately 16 h, indicating successful gastroretention. In vitro dissolution studies confirmed sustained drug release (73.92% within 9 h) following a quasi-Fickian diffusion mechanism, as per the Korsmeyer-Peppas model. Conclusions: This study presents a novel approach to enhance peptic ulcer treatment using floating tablets designed to optimize curcumin delivery. These tablets leverage cyclodextrin complexation for enhanced solubility, while their effervescent, gastroretentive properties allow for prolonged gastric residence time and targeted drug release. This strategy shows promise in improving curcumin's bioavailability and therapeutic efficacy, addressing a significant unmet need in peptic ulcer management.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6622146"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Topical Folic Acid in the Healing of Deep Second-Degree Burn Wound via Redox Modulation in Rat. 外用叶酸通过氧化还原调节对大鼠深二度烧伤创面愈合的影响。

IF 2.3 3区生物学

BioMed Research International Pub Date : 2025-07-20 eCollection Date: 2025-01-01 DOI: 10.1155/bmri/7337481

Ali Dalir, Shabnam Pourmoslemi, Sara Soleimani Asl, Pari Tamri

{"title":"Efficacy of Topical Folic Acid in the Healing of Deep Second-Degree Burn Wound via Redox Modulation in Rat.","authors":"Ali Dalir, Shabnam Pourmoslemi, Sara Soleimani Asl, Pari Tamri","doi":"10.1155/bmri/7337481","DOIUrl":"10.1155/bmri/7337481","url":null,"abstract":"Folic acid, synthetic form of folate, is necessary for synthesis and for repair of DNA. Studies have shown that folic acid enhances the DNA repair capacity of skin fibroblasts following tissue damage. The research objective was to assess the efficacy of topical folic acid on the treatment of second-degree burn wound in a rat model. The second-degree burn wounds were induced on the dorsal skin of Wistar rats. Animals were randomly placed into five groups (n = 5) as follows: (1) non-treatment group, (2) cream base treated group, (3) silver sulfadiazine (SSD) 1% treated group, (4) folic acid 1% cream treated group, and (5) folic acid 4% cream treated group. The healing effects of folic acid were assessed by monitoring the wound contraction rate, measuring the tissue content of hydroxyproline, and conducting a microscopical study of wound healing in experimental groups. For evaluation of antioxidant properties of folic acid, the total antioxidant capacity (TAC) and the amount of reactive oxygen species (ROS) in tissue samples were measured. Our results revealed that topical folic acid 1% and 4% (w/w) significantly (p < 0.05) accelerated wound contraction and re-epithelialization rates, enhanced hydroxyproline content of tissue, and decreased the median time to complete wound closure compared to non-treatment and cream base treated groups. Furthermore, 1% and 4% folic acid creams significantly (p < 0.05) increased the TAC content of skin tissue and suppressed the ROS levels compared to non-treatment and cream base groups. In conclusion, folic acid is capable of accelerating the burn wound healing process possibly via modulating oxidative stress.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7337481"},"PeriodicalIF":2.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0