Metallomics最新文献_第4页

Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics. 从突触动力学中的双向 Zn2+ 信号透视脑金属硫蛋白

IF 2.9 3区生物学

Metallomics Pub Date : 2024-09-05 DOI: 10.1093/mtomcs/mfae039

Atsushi Takeda, Haruna Tamano

{"title":"Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics.","authors":"Atsushi Takeda, Haruna Tamano","doi":"10.1093/mtomcs/mfae039","DOIUrl":"10.1093/mtomcs/mfae039","url":null,"abstract":"The basal levels as the labile Zn2+ pools in the extracellular and intracellular compartments are in the range of ∼10 nM and ∼100 pM, respectively. The influx of extracellular Zn2+ is used for memory via cognitive activity and is regulated for synaptic plasticity, a cellular mechanism of memory. When Zn2+ influx into neurons excessively occurs, however, it becomes a critical trigger for cognitive decline and neurodegeneration, resulting in acute and chronic pathogenesis. Aging, a biological process, generally accelerates vulnerability to neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). The basal level of extracellular Zn2+ is age relatedly increased in the rat hippocampus, and the influx of extracellular Zn2+ contributes to accelerating vulnerability to the AD and PD pathogenesis in experimental animals with aging. Metallothioneins (MTs) are Zn2+-binding proteins for cellular Zn2+ homeostasis and involved in not only supplying functional Zn2+ required for cognitive activity, but also capturing excess (toxic) Zn2+ involved in cognitive decline and neurodegeneration. Therefore, it is estimated that regulation of MT synthesis is involved in both neuronal activity and neuroprotection. The present report provides recent knowledge regarding the protective/preventive potential of MT synthesis against not only normal aging but also the AD and PD pathogenesis in experimental animals, focused on MT function in bidirectional Zn2+ signaling in synaptic dynamics.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction of: Characterising the spatial and temporal brain metal profile in a mouse model of tauopathy. 撤回：牛磺酸病小鼠模型的脑金属空间和时间分布特征。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-09-05 DOI: 10.1093/mtomcs/mfae037

引用次数: 0

P-based referencing for correcting tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry imaging of cancer samples. 在对癌症样本进行激光烧蚀-电感耦合等离子体-质谱成像时校正组织伪影的基于 P 的参照。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-08-20 DOI: 10.1093/mtomcs/mfae034

Katharina Kronenberg, Emily Hoffmann, Lena Hiddeßen, Bastian Maus, Mirjam Gerwing, Cornelius Faber, Michael Sperling, Moritz Wildgruber, Uwe Karst

{"title":"P-based referencing for correcting tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry imaging of cancer samples.","authors":"Katharina Kronenberg, Emily Hoffmann, Lena Hiddeßen, Bastian Maus, Mirjam Gerwing, Cornelius Faber, Michael Sperling, Moritz Wildgruber, Uwe Karst","doi":"10.1093/mtomcs/mfae034","DOIUrl":"10.1093/mtomcs/mfae034","url":null,"abstract":"A referencing strategy based on the element P is presented to compensate for cryosectioning tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) data. The study examines how the gadolinium-based contrast agent Gadofosveset is distributed in murine cancer tissue, and illustrates how referenced images can compensate for tissue artifacts like folds, overlaps, and density variations. Compared to non-referenced images that provide information on the absolute distribution of the analyte, referenced images allow for the representation of the analyte distribution relative to the amount of material introduced into the instrument, which in this case is correlated to the P signal. Tissue artifacts were corrected in referenced images for both Gadofosveset and endogenous elements, such as Fe and Zn. Additionally, the referencing approach provides valuable information on the Gd uptake relative to the tissue density in necrotic compared to vital tumor areas, which is not obtained from in vivo magnetic resonance imaging (MRI) data. However, validation of in vivo MRI and ex vivo LA-ICP-MS methods was possible by establishing a mean ratio of necrotic to vital tumor areas in the T1-weighted image post Gadofosveset injection and the non-referenced LA-ICP-MS image of Gd. In summary, P-based correction of LA-ICP-MS imaging data allows for a more accurate spatial representation of certain elements, including endogenous and exogenous elements such as injected contrast agents.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of bacterial biofilms by a green synthesized artemisinin nano-copper nanomaterial. 一种绿色合成青蒿素纳米铜材料对细菌生物膜的破坏作用

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae030

Yan Zhang, Xia Hua, Xiaohu Han, Xue Fang, Peng Li, Jingbo Zhai, Lin Xie, Yanming Lv, Yonghao Lai, Chengcheng Meng, Yi Zhang, Shiwei Liu, Zeliang Chen

{"title":"Disruption of bacterial biofilms by a green synthesized artemisinin nano-copper nanomaterial.","authors":"Yan Zhang, Xia Hua, Xiaohu Han, Xue Fang, Peng Li, Jingbo Zhai, Lin Xie, Yanming Lv, Yonghao Lai, Chengcheng Meng, Yi Zhang, Shiwei Liu, Zeliang Chen","doi":"10.1093/mtomcs/mfae030","DOIUrl":"10.1093/mtomcs/mfae030","url":null,"abstract":"Bacterial biofilms are associated with antibiotic resistance and account for ∼80% of all bacterial infections. In this study, we explored novel nanomaterials for combating bacteria and their biofilms. Artemisinin nano-copper (ANC) was synthesized using a green synthesis strategy, and its shape, size, structure, elemental composition, chemical valence, zeta potential, and conductivity were characterized using transmission electron microscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, zeta potential, and dynamic light scattering. The results showed that ANC was successfully synthesized utilizing a liquid phase chemical reduction method using chitosan as a modified protectant and l-ascorbic acid as a green reducing agent. The stability of ANC was evaluated using dynamic light scattering. The results showed that the particle size of ANC at different concentrations was comparable to that of the original solution after 7 days of storage, and there was no significant change in the polydispersity index (P > 0.05). The antibacterial effects of ANC on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were determined by disc diffusion and broth dilution methods. The results demonstrated that ANC inhibited and killed E. coli and S. aureus. The effect of ANC on bacterial biofilms was investigated using crystal violet staining, scanning electron microscopy, laser confocal microscopy, and quantitative polymerase chain reaction. The results showed that ANC treatment was able to destroy bacterial biofilms and downregulate biofilm- and virulence-related genes in E. coli (HlyA, gyrA, and F17) and S. aureus (cna, PVL, ClfA, and femB). Green-synthesized ANC possesses excellent antibiofilm properties and is expected to exhibit antibacterial and antibiofilm properties.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141464456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter. 在缺乏 SLC30A10 转运体的小鼠（而非大鼠）体内，甲状腺锰升高会减少甲状腺碘，从而诱发甲状腺功能减退症。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae029

Steven Hutchens, Ashvini Melkote, Thomas Jursa, William Shawlot, Leonardo Trasande, Donald R Smith, Somshuvra Mukhopadhyay

{"title":"Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter.","authors":"Steven Hutchens, Ashvini Melkote, Thomas Jursa, William Shawlot, Leonardo Trasande, Donald R Smith, Somshuvra Mukhopadhyay","doi":"10.1093/mtomcs/mfae029","DOIUrl":"10.1093/mtomcs/mfae029","url":null,"abstract":"Elevated manganese (Mn) accumulates in the brain and induces neurotoxicity. SLC30A10 is an Mn efflux transporter that controls body Mn levels. We previously reported that full-body Slc30a10 knockout mice (1) recapitulate the body Mn retention phenotype of humans with loss-of-function SLC30A10 mutations and (2) unexpectedly develop hypothyroidism induced by Mn accumulation in the thyroid, which reduces intra-thyroid thyroxine. Subsequent analyses of National Health and Nutrition Examination Survey data identified an association between serum Mn and subclinical thyroid changes. The emergence of thyroid deficits as a feature of Mn toxicity suggests that changes in thyroid function may be an underappreciated, but critical, modulator of Mn-induced disease. To better understand the relationship between thyroid function and Mn toxicity, here we further defined the mechanism of Mn-induced hypothyroidism using mouse and rat models. Slc30a10 knockout mice exhibited a profound deficit in thyroid iodine levels that occurred contemporaneously with increases in thyroid Mn levels and preceded the onset of overt hypothyroidism. Wild-type Mn-exposed mice also exhibited increased thyroid Mn levels, an inverse correlation between thyroid Mn and iodine levels, and subclinical hypothyroidism. In contrast, thyroid iodine levels were unaltered in newly generated Slc30a10 knockout rats despite an increase in thyroid Mn levels, and the knockout rats were euthyroid. Thus, Mn-induced thyroid dysfunction in genetic or Mn exposure-induced mouse models occurs due to a reduction in thyroid iodine subsequent to an increase in thyroid Mn levels. Moreover, rat and mouse thyroids have differential sensitivities to Mn, which may impact the manifestations of Mn-induced disease in these routinely used animal models.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of barium deficiency with Type 2 diabetes mellitus incident risk was mediated by mitochondrial DNA copy number (mtDNA-CN): a follow-up study. 线粒体DNA拷贝数（mtDNA-CN）介导钡缺乏症与2型糖尿病发病风险的关系：随访研究。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae027

Yiqin Zhang, Jing Ye, Lina Zhou, Xianfa Xuan, Liping Xu, Xia Cao, Tianyu Lv, Jianhua Yan, Siyu Zhang, Yuxin Wang, Qingyu Huang, Meiping Tian

{"title":"Association of barium deficiency with Type 2 diabetes mellitus incident risk was mediated by mitochondrial DNA copy number (mtDNA-CN): a follow-up study.","authors":"Yiqin Zhang, Jing Ye, Lina Zhou, Xianfa Xuan, Liping Xu, Xia Cao, Tianyu Lv, Jianhua Yan, Siyu Zhang, Yuxin Wang, Qingyu Huang, Meiping Tian","doi":"10.1093/mtomcs/mfae027","DOIUrl":"10.1093/mtomcs/mfae027","url":null,"abstract":"Accumulating evidence indicates that plasma metal levels may be associated with Type 2 diabetes mellitus (T2DM) incident risk. Mitochondrial function such as mitochondrial DNA copy number (mtDNA-CN) might be linked to metal exposure and physiological metabolism. Mediation analysis was conducted to determine the mediating roles of mtDNA-CN in the association between plasma metals and diabetes risk. In the present study, we investigated associations between plasma metals levels, mtDNA-CN, and T2DM incident in the elderly population with a 6-year follow-up (two times) study. Ten plasma metals [i.e. manganese, aluminum, calcium, iron, barium (Ba), arsenic, copper, selenium, titanium, and strontium] were measured using inductively coupled plasma mass spectrometry. mtDNA-CN was measured by real-time polymerase chain reaction. Multivariable linear regression and logistic regression analyses were carried out to estimate the relationship between plasma metal concentrations, mtDNA-CN, and T2DM incident risk in the current work. Plasma Ba deficiency and mtDNA-CN decline were associated with T2DM incident risk during the aging process. Meanwhile, plasma Ba was found to be positively associated with mtDNA-CN. Mitochondrial function mtDNA-CN demonstrated mediating effects in the association between plasma Ba deficiency and T2DM incident risk, and 49.8% of the association was mediated by mtDNA-CN. These findings extend the knowledge of T2DM incident risk factors and highlight the point that mtDNA-CN may be linked to plasma metal elements and T2DM incident risk.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial-targeted cyclometalated Ir(III)-5,7-dibromo/dichloro-2-methyl-8-hydroxyquinoline complexes and their anticancer efficacy evaluation in Hep-G2 cells. 线粒体靶向环金属化 Ir(III)-5,7- 二溴/二氯-2-甲基-8-羟基喹啉配合物及其在 Hep-G2 细胞中的抗癌效果评估。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae032

Ting Meng, Xiongzhi Shi, Hongfen Chen, Zhong Xu, Weirong Qin, Kehua Wei, Xin Yang, Jin Huang, Chuanan Liao

引用次数: 0

Enhanced axon guidance and synaptic markers in rat brains using ferric-tannic nanoparticles. 使用鞣酸铁纳米粒子增强大鼠大脑中的轴突导向和突触标记。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae031

Jantira Sanit, Jannarong Intakhad, Aiyarin Kittilukkana, Arpamas Vachiraarunwong, Rawiwan Wongpoomchai, Chalermchai Pilapong

{"title":"Enhanced axon guidance and synaptic markers in rat brains using ferric-tannic nanoparticles.","authors":"Jantira Sanit, Jannarong Intakhad, Aiyarin Kittilukkana, Arpamas Vachiraarunwong, Rawiwan Wongpoomchai, Chalermchai Pilapong","doi":"10.1093/mtomcs/mfae031","DOIUrl":"10.1093/mtomcs/mfae031","url":null,"abstract":"Ferric-tannic nanoparticles (FTs) are now considered to be new pharmaceuticals appropriate for the prevention of brain aging and related diseases. We have previously shown that FTs could activate axon guidance pathways and cellular clearance functioning in neuronal cell lines. Herein, we further investigated whether FTs could activate the two coordinated neuronal functions of axon guidance and synaptic function in rat brains and neuronal cell lines. A single intravenous injection of a safe dose of FTs has been shown to activate a protein expression of axon attractant Netrin-1 and neurotransmitter receptor GABRA4 in the cerebral cortexes of male Wistar rats. According to RNA-seq with targeted analysis, axon guidance and synapses have been enriched and Ephrin membered genes have been identified as coordinating a network of genes for such processes. In vitro, as expected, FTs are also found to activate axon guidance markers and promote neuronal tubes in neuronal cell lines. At the same time, pre-synaptic markers (synaptophysin), post-synaptic markers (synapsin), and GABRA4 neurotransmitter receptors have been found to be activated by FTs. Interestingly, synaptophysin has been found to localize along the promoted neuronal tubes, suggesting that enhanced axon guidance is associated with the formation and transportation of pre-synaptic vesicles. Preliminarily, repeated injection of FTs into adult rats every 3 days for 10 times could enhance an expression of synaptophysin in the cerebral cortex, as compared to control rats. This work demonstrates that FTs can be used for activating brain function associated with axon guidance and synaptic function.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141464457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary iron intake has long-term effects on the fecal metabolome and microbiome. 膳食铁摄入对粪便代谢组和微生物组有长期影响

IF 2.9 3区生物学

Metallomics Pub Date : 2024-07-01 DOI: 10.1093/mtomcs/mfae033

Anastasiia Kostenko, Simone Zuffa, Hui Zhi, Kevin Mildau, Manuela Raffatellu, Pieter C Dorrestein, Allegra T Aron

{"title":"Dietary iron intake has long-term effects on the fecal metabolome and microbiome.","authors":"Anastasiia Kostenko, Simone Zuffa, Hui Zhi, Kevin Mildau, Manuela Raffatellu, Pieter C Dorrestein, Allegra T Aron","doi":"10.1093/mtomcs/mfae033","DOIUrl":"10.1093/mtomcs/mfae033","url":null,"abstract":"Iron is essential for life, but its imbalances can lead to severe health implications. Iron deficiency is the most common nutrient disorder worldwide, and iron dysregulation in early life has been found to cause long-lasting behavioral, cognitive, and neural effects. However, little is known about the effects of dietary iron on gut microbiome function and metabolism. In this study, we sought to investigate the impact of dietary iron on the fecal metabolome and microbiome by using mice fed with three diets with different iron content: an iron deficient, an iron sufficient (standard), and an iron overload diet for 7 weeks. Additionally, we sought to understand whether any observed changes would persist past the 7-week period of diet intervention. To assess this, all feeding groups were switched to a standard diet, and this feeding continued for an additional 7 weeks. Analysis of the fecal metabolome revealed that iron overload and deficiency significantly alter levels of peptides, nucleic acids, and lipids, including di- and tri-peptides containing branched-chain amino acids, inosine and guanosine, and several microbial conjugated bile acids. The observed changes in the fecal metabolome persist long after the switch back to a standard diet, with the cecal gut microbiota composition and function of each group distinct after the 7-week standard diet wash-out. Our results highlight the enduring metabolic consequences of nutritional imbalances, mediated by both the host and gut microbiome, which persist after returning to the original standard diets.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of carbonic anhydrase I released from red blood cells with human plasma in vitro. 红细胞释放的碳酸酐酶 I 与人体血浆在体外的相互作用。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-06-04 DOI: 10.1093/mtomcs/mfae028

Maryam Doroudian, Jürgen Gailer

{"title":"Interaction of carbonic anhydrase I released from red blood cells with human plasma in vitro.","authors":"Maryam Doroudian, Jürgen Gailer","doi":"10.1093/mtomcs/mfae028","DOIUrl":"10.1093/mtomcs/mfae028","url":null,"abstract":"Red blood cells (RBCs) constitute ∼50% of the bloodstream and represent an important target for environmental pollutants and bacterial/viral infections, which can result in their rupture. In addition, diseases such as sickle cell anaemia and paroxysmal nocturnal haemoglobinuria can also result in the rupture of RBCs, which can be potentially life-threatening. With regard to the release of cytosolic metalloproteins from RBCs into the blood-organ system, the biochemical fate of haemoglobin is rather well understood, while comparatively little is known about another highly abundant Zn-metalloprotein, carbonic anhydrase (CA I). To gain insight into the interaction of CA I with human blood plasma constituents, we have employed a metallomics tool comprised of size-exclusion chromatography (SEC) coupled online with an inductively coupled plasma atomic emission spectrometer (ICP-AES), which allows to simultaneously observe all Cu, Fe, and Zn-metalloproteins. After the addition of CA I to human blood plasma incubated at 37°C, the SEC-ICP-AES analysis using phosphate buffered saline (pH 7.4) after 5 min, 1 h, and 2 h revealed that CA I eluted after all endogenous Zn-metalloproteins in the 30 kDa range. Matrix-assisted laser desorption-time of flight mass spectrometry analysis of the collected Zn-peak confirmed that CA I eluted from the column intact. Our in vitro results suggest that CA I released from RBCs to plasma remains free and may be actively involved in health-relevant adverse processes that unfold at the bloodstream-endothelial interface, including atherosclerosis and vision loss.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0