Journal of pediatric neuroradiology最新文献_第6页

Does MRS Lactate Peak Correlate with Lactate in the CSF and Blood? MRS乳酸峰值与脑脊液和血液中的乳酸相关吗?

Journal of pediatric neuroradiology Pub Date : 2015-03-01 DOI: 10.1055/s-0035-1564663

Simone Shibao, M. Otaduy, F. Kok, C. Leite

{"title":"Does MRS Lactate Peak Correlate with Lactate in the CSF and Blood?","authors":"Simone Shibao, M. Otaduy, F. Kok, C. Leite","doi":"10.1055/s-0035-1564663","DOIUrl":"https://doi.org/10.1055/s-0035-1564663","url":null,"abstract":"Abstract Purpose Cerebrospinal fluid (CSF) or brain parenchyma lactate detection is important for the diagnosis of some diseases with aerobic cellular metabolism compromise. Our purpose is to correlate intraventricular magnetic resonance spectroscopy (MRS) lactate detection and quantification to CSF and blood lactate concentration. Methods Twenty-one patients (13 females; mean age 5 years) suspected of having mitochondrial disorders underwent proton MRS with point-resolved spectroscopy (TE = 144 ms). The volume of interest was positioned in the lateral ventricles, and LCModel was used for the MRS lactate peak detection and quantification. CSF and venous blood samples were obtained for lactate quantification immediately after MRS. Comparisons between MRS, CSF, and blood lactate detection and quantification were performed. p < 0.05 was considered significant. Results In our series, CSF lactate levels were high in 11 patients (52%) and blood serum lactate levels were high in 3 patients (14%). MRS was able to detect a lactate peak in all patients. A positive correlation between MRS lactate quantification and CSF lactate was observed (Pearson correlation coefficient = 0.750; p < 0.0001). Blood lactate did not correlate with lactate levels in the lateral ventricle measured by MRS or direct determinations of CSF lactate concentration. When noting the lactate quantification obtained by MRS, only 8 patients (as opposed to 14) presented higher values than the established normality threshold of 1.7 mmol/L. Considering CSF puncture concentration as the gold standard, we obtained 64% of sensitivity and 90% of specificity for MRS quantification. Conclusion If MRS shows increased lactate levels in the ventricles, CSF puncture is not needed for lactate increase confirmation.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"82 1","pages":"001 - 006"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76112933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Contributing Reviewers in 2014 2014年投稿审稿人

Journal of pediatric neuroradiology Pub Date : 2015-03-01 DOI: 10.1055/s-0035-1566158

引用次数: 0

Intracranial Calcifications in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) Syndrome: A Case Report and Literature Review 自身免疫性多内分泌病念珠菌病外表皮营养不良(APECED)综合征颅内钙化一例报告及文献复习

Journal of pediatric neuroradiology Pub Date : 2015-03-01 DOI: 10.1055/s-0035-1564661

M. Alkaphoury, H. Kamel, R. Abujarir, T. Ben-Omran

{"title":"Intracranial Calcifications in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) Syndrome: A Case Report and Literature Review","authors":"M. Alkaphoury, H. Kamel, R. Abujarir, T. Ben-Omran","doi":"10.1055/s-0035-1564661","DOIUrl":"https://doi.org/10.1055/s-0035-1564661","url":null,"abstract":"Abstract Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED [MIM 240300]), also known as autoimmune polyglandular syndrome type I (APS I), is a rare, debilitating autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene. The clinical spectrum of the disease is variable and includes several autoimmune endocrine and non-endocrine manifestations, which may lead to acute metabolic alterations and eventually life-threatening events. The clinical diagnosis requires the presence of two out of three major criteria; chronic mucocutaneous candidiasis, autoimmune hypoparathyroidism, and autoimmune adrenal failure. Brain calcifications secondary to hypoparathyroidism have been reported in many patients with APECED. These tend to be extensive, bilateral and symmetrical and have characteristic predilection to the basal ganglia. The calcifications may extend to affect the cerebellum and subcortical white matter. The aim of this work is to describe intracranial calcifications in APECED and to report a new feature of pontine calcification expanding the phenotype of this rare condition.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"36 1","pages":"014 - 018"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83021951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

CT and MRI Features of a Solid Hemangioblastoma of Cerebellar Vermis in a Child: A Case Report 儿童小脑蚓实性血管母细胞瘤的CT和MRI表现:1例报告

Journal of pediatric neuroradiology Pub Date : 2015-03-01 DOI: 10.1055/s-0035-1564662

Ling Sun, Heng Liu, Wu Li, Lin Jiang, C. Tian, Xinyu Wang, Yihua Zhou, Tijiang Zhang, Q. Gong

引用次数: 1

Limitations of functional magnetic resonance imaging in mapping function near a vascular lesion: A case study 功能性磁共振成像在血管病变附近定位功能的局限性:一个案例研究

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14188

Kristen Berry, Kevin Shuh, K. Blackmon, O. Devinsky, Chad E. Carlson, R. Kuzniecky, W. Doyle, T. Thesen

{"title":"Limitations of functional magnetic resonance imaging in mapping function near a vascular lesion: A case study","authors":"Kristen Berry, Kevin Shuh, K. Blackmon, O. Devinsky, Chad E. Carlson, R. Kuzniecky, W. Doyle, T. Thesen","doi":"10.3233/PNR-14188","DOIUrl":"https://doi.org/10.3233/PNR-14188","url":null,"abstract":"Abstract We present a case of functional reorganization of the somatosensory system in a 15 year-old female with a history of perinatal stroke of the middle cerebral artery. The patient presented with hemiparesis and epilepsy and underwent comprehensive pre-surgical evaluation for epilepsy surgery, including mapping of somatosensory function with functional magnetic resonance imaging (fMRI). The fMRI results indicated inter-hemispheric reorganization of somatosensory function from the left to the right hemisphere, and showed no residual somatosensory function in the peri-lesional area of the affected left hemisphere. However, following implantation of subdural electroencephalography (EEG) electrodes, recordings from left hemisphere lesional and peri-lesional areas showed evoked electrophysiological responses to tactile stimulation. Bedside and intra-operative stimulation mapping confirmed multiple somatosensory responsive sites in the left hemisphere in or near the lesion, in contradiction of the fMRI results. Since the BOLD signal is a measure of the local ratio of oxygenated to deoxygenated blood, fMRI represents only an indirect measure of neuronal activity. Modeling of fMRI activation depends on intact neurovascular coupling and adequate signal to noise ratios, which may be altered in the presence of a vascular lesion. Our results suggest that pre-surgical mapping of cortical function with fMRI can be unreliable in the presence of a vascular lesion and can lead to false-negative results. In such cases, direct measures of electrophysiological activity, such as electrocorticography, scalp EEG and MEG should be preferred.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"35 1","pages":"197 - 202"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74610912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antenatal detection of an intraglossal ranula on ultrasound and magnetic resonance imaging 超声和磁共振成像产前检测耳蜗内小瘘管

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14192

H. Cohen, A. Choudhri, A. Raju, J. Samson, Lisa M. Mabry, Jerome W. Thompson

引用次数: 0

Multiple intracranial dural arterivenous fistulas in a girl with Cowden Syndrome – a case report 多发性颅内硬脑膜动静脉瘘的女孩考登综合征- 1例报告

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14187

Vineeta Singh, T. Neil, S. Hetts, J. English

引用次数: 0

Pediatric pedicle screw (In)accuracy based on postoperative computed tomography 基于术后计算机断层扫描的小儿椎弓根螺钉(In)准确性

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14193

D. Sahni, Prashant K Prasad, C. Hadley, Brandon H Tran, D. Fulkerson, Steven W. Hwang, A. Jea

{"title":"Pediatric pedicle screw (In)accuracy based on postoperative computed tomography","authors":"D. Sahni, Prashant K Prasad, C. Hadley, Brandon H Tran, D. Fulkerson, Steven W. Hwang, A. Jea","doi":"10.3233/PNR-14193","DOIUrl":"https://doi.org/10.3233/PNR-14193","url":null,"abstract":"Abstract Though pedicle screws are widely used in spinal stabilization, studies evaluating the variables affecting placement accuracy and effects of accuracy on outcome are limited. Using computed tomography (CT), we evaluated the accuracy of pedicle screw placement in pediatric and transitional patient populations. We evaluated screw placement in a series of 276 thoracic, lumbar, and sacral pedicle screws implanted in 41 patients with the assistance of fluoroscopy by a single surgeon at a single institution from September 1, 2007 to December 31, 2012. Postoperative CT was performed and each screw was graded based on relation to neurologic, osseous, and intra thoracic and intra-abdominal landmarks by an independent neuro radiologist: Grade I, entirely intra pedicular; Grade II, violates lateral pedicle but screw tip entirely within the vertebral body; Grade III, tip penetrates the anterior or lateral vertebral body; Grade IV, breaches medial or inferior pedicle; and Grade V, violates pedicle or vertebral body and threatens spinal cord, nerve root, or great vessels, requires immediate revision or removal. The accuracy rate (Grades I and II) was lower than expected (76.8%). Screw misplacements (Grades III, IV, and V) were numerous (23.2%), although the overall complication rate remained low. There was no statistically significant difference in pedicle screw accuracy as a function of surgeon experience, patient age, or patient diagnosis. This suggests the need for advanced intraoperative imaging, such as neuronavigation or CT, to aid placement of spinal instrumentation in the pediatric and transitional patient population. While postoperative CT should be considered gold standard for evaluating pedicle screw placement, further study is warranted to evaluate overall accuracy and assess the need for more extensive intraoperative imaging to improve accuracy.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"44 1","pages":"161 - 169"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84849575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vein of Galen Malformations: Long-term functional outcome in 6 cases 盖伦静脉畸形6例远期功能分析

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14191

Maggie L Chow, D. Cooke, H. Fullerton, M. Amans, J. Narvid, C. Dowd, R. Higashida, V. Halbach, S. Hetts

{"title":"Vein of Galen Malformations: Long-term functional outcome in 6 cases","authors":"Maggie L Chow, D. Cooke, H. Fullerton, M. Amans, J. Narvid, C. Dowd, R. Higashida, V. Halbach, S. Hetts","doi":"10.3233/PNR-14191","DOIUrl":"https://doi.org/10.3233/PNR-14191","url":null,"abstract":"Abstract PURPOSE: Vein of Galen Malformations (VOGMs) are rare congenital arteriovenous fistulas that were previously associated with high mortality and morbidity prior to the advent of endovascular treatment approaches. The long-term functional outcome and quality of life of infants and children treated with these approaches, however, are not well characterized. METHODS: The long-term outcomes of a cohort of pediatric patients treated at University of California at San Francisco from 1986–2013 (N = 39) for their VOGMs were assessed using a self-report survey-based approach. The Pediatric Quality of life Inventory (PedsQL), the Functional Disability Inventory (FDI) and the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) were employed. The results of the surveys were analyzed. RESULTS: We received six surveys from three male and three female patients with a median age of 17.5 years (range 7–22 years). The median length of follow-up since first treatment was 17 years (range 5–19 years). The PedsQL summary scores of the patients in our sample were only slightly lower than norms from healthy controls (78.4 vs. 83.0). The cases in our sample were on an average mildly affected in the domains of physical health, emotional health, social functioning and school functioning. The FDI and WHODAS results revealed that survey respondents had minimal or no disability. CONCLUSION: The long-term neurodevelopmental outcomes of children with VOGM may be good following endovascular treatment. Better long-term follow up is needed, as evidenced by the low rate of survey response.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"4 1","pages":"181 - 189"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85031345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent torticollis: Think about Grisel's syndrome 持续性斜颈:想想Grisel综合征

Journal of pediatric neuroradiology Pub Date : 2014-12-01 DOI: 10.3233/PNR-14189

R. Franceschi, Nivedita Agarwal, V. Savona, Evelina Maines, M. Bellizzi, A. Palma

引用次数: 0