M. Raets, P. Govaert, T. G. Goos, I. Reiss, R. Jonge, J. Dudink
{"title":"Preterm cerebral microcirculation assessed with color Doppler: A pilot study","authors":"M. Raets, P. Govaert, T. G. Goos, I. Reiss, R. Jonge, J. Dudink","doi":"10.3233/PNR-14190","DOIUrl":"https://doi.org/10.3233/PNR-14190","url":null,"abstract":"Abstract AIM: Pilot study to explore feasibility of a color Doppler technique for monitoring cerebral perfusion at the level of microvessels. METHODS: Between March 1st, 2011, and January 30th, 2013, all admitted infants born before 29 weeks of gestation were eligible for Doppler imaging. Perfusion images were acquired in a standard coronal plane. Image quality was assessed by two authors (MR, PG). The region of interest (ROI) was manually selected. A segmentation tool was developed to separate color data from the greyscale 2D images, leading to a percentage and number of color pixels in the image (Doppler color index; DCI). Intra- and inter-observer agreement was analyzed. RESULTS: Intra- and inter-observer agreement for placement of ROIs was good (bias −0.24 resp. −0.74 percentage points). Color Doppler was able to depict microvessels in cortex, white matter and deep grey matter. The median DCI in a region of cortex-white matter was 7.8% with a wide range (1.4%–25.6%). There was no significant difference between the left and right hemisphere (Mann-Whitney U, P-value 0.61). Clinically relevant observations were tabulated, e.g. distant effect of germinal matrix hemorrhage (GMH) on regional perfusion. CONCLUSION: Sonographic small vessel visualisation may help understand pathogenetic mechanisms related to perfusion and is valuable to monitor effects of treatment.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"10 1","pages":"155 - 160"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91058281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guillain Barre syndrome – Spinal MR findings","authors":"Saurabh Kumar","doi":"10.3233/PNR-14180","DOIUrl":"https://doi.org/10.3233/PNR-14180","url":null,"abstract":"A 10 yr old male child presented with history of acute onset rapidly progressive weakness of bilateral lower limbs. There was no history of associated fever or trauma. No bowel or bladder involvement was noted. On examination there was bilateral lower limb areflexia with little sensory involvement. The rest of the systemic examination was unremarkable. Cerebrospinal Fluid (CSF) examination revealed elevated protein level (800 mg/dl, normal range is 20–40 mg/dl) consistent with albumin cytological dissociation with nerve conduction study showing slow conduction consistent with demyelinating polyneuropathy. Based on clinical signs, symptoms and lab investigation diagnosis of Guillain Barre syndrome (GBS) was made and patient was put on intravenous immunoglobulin therapy. Before starting the treatment magnetic resonance imaging (MRI) spine was performed to rule out compressive myelopathy or myelitis. Pre contrast images were normal however post contrast images of spine revealed enhancement of cauda equina nerve roots and conus medullaris (Fig. 1) with preferential enhancement of ventral spinal nerve roots as compared to dorsal nerve roots (Fig. 2) GBS is an acute symmetrical inflammatory demyelinating polyneuropathy [1] that involves the peripheral nervous system. Patients generally present with acute","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"28 1","pages":"153 - 154"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85341075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Maud, T. Chacón-Quesada, L. Ramos-Duran, S. Cruz-Flores, P. Espinosa, G. Rodriguez
{"title":"Symptomatic focal cerebral arteriopathy in a young man","authors":"A. Maud, T. Chacón-Quesada, L. Ramos-Duran, S. Cruz-Flores, P. Espinosa, G. Rodriguez","doi":"10.3233/PNR-14186","DOIUrl":"https://doi.org/10.3233/PNR-14186","url":null,"abstract":"Abstract Arteriopathy is the leading cause of acute ischemic stroke in children and young adults, with intracranial arterial dissection (IAD) and transient cerebral arteriopathy (TCA) most commonly reported. The etiology and pathophysiology of childhood cerebral arteriopathies are not completely understood. The diagnosis is mainly based on clinical presentation and neuroimaging findings with considerable overlapping and discrepancy between diagnoses. We report the case of a young man who presented with an acute right basal ganglia infarct, and was found to have a focal cerebral arteriopathy of the intracranial right internal carotid artery that fluctuated clinically but resolved in four weeks with conservative management. The diagnoses of IAD and TCA were considered. We review and discuss the literature and the difficulties with the current terminology and classifications. In order to better understand the natural history and management there is a need to standardize the terminology and classifications of cerebral arteriopathies of the children and young adults.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"19 1","pages":"147 - 151"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86777688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pearls in pediatric shunted brain CT evaluation","authors":"N. Kadom, S. Narayanan, A. Trofimova","doi":"10.3233/PNR-14183","DOIUrl":"https://doi.org/10.3233/PNR-14183","url":null,"abstract":"Abstract This article presents pearls in interpretation of pediatric shunt computed tomography with emphasis on the utility of multi-detector computed tomography (CT) reformatted and three-dimensional (3D) surface reconstructions.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"54 1","pages":"107 - 120"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72652496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kadom, N. Hai, R. Udyavar, A. Noor, R. Packer, G. Vezina, M. Acosta
{"title":"Cingulate Apparent Diffusion Coefficient measurements in children with Neurofibromatosis type 1","authors":"N. Kadom, N. Hai, R. Udyavar, A. Noor, R. Packer, G. Vezina, M. Acosta","doi":"10.3233/PNR-14181","DOIUrl":"https://doi.org/10.3233/PNR-14181","url":null,"abstract":"Abstract The purpose of this study was to objectively verify and study a bright magnetic resonance imaging T2 signal that was qualitatively observed in the anterior cingulate region in children with neurofibromatosis type 1 (NF1). We performed a retrospective study in children with the cingulate imaging sign with apparent diffusion coefficient (ADC) measurements in the anterior and posterior cingulate region, as well as in a reference region in the vitreous. There were 18 NF1 patients and 18 matched controls age 2–14 yr in whom ADC measurements were performed. We found significantly higher ADC values in NF1 patients in the visibly abnormal anterior cingulate, but also in the normal appearing posterior cingulate regions (p < 0.00001). Major considerations to explain the high ADC values include vasogenic edema and abnormal myelination. Given its location in the cingulate, our observed magnetic resonance imaging sign may bear relevance to cognitive symptoms in NF1 patients and warrants further investigation with correlating studies.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"17 1","pages":"121 - 126"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78300735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful venous sinus stenting for management of idiopathic intracranial hypertension in a 2 year old: A case report","authors":"S. Boddu, G. Chow, N. McConachie","doi":"10.3233/PNR-14182","DOIUrl":"https://doi.org/10.3233/PNR-14182","url":null,"abstract":"Abstract Our understanding of idiopathic intracranial hypertension is still evolving. Its management is challenging and venous sinus stenting has been reported an alternative to cerebrospinal fluid diversion in adult patients with underlying venous sinus stenosis. Out of very few patients reported with venous sinus stenting in the literature, only one has been an adolescent. We report a case of a 2-year-old with idiopathic intracranial hypertension successfully treated with transverse sinus stenting with good outcome. Venous sinus stenting is a safe treatment option in the management of refractory idiopathic intracranial hypertension even in young children. We present the youngest patient to have successfully undergone this treatment.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"26 1","pages":"133 - 137"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81135549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Duplication of pituitary gland: A rare congenital anomaly","authors":"G. Oncel, D. Oncel","doi":"10.3233/PNR-14184","DOIUrl":"https://doi.org/10.3233/PNR-14184","url":null,"abstract":"Abstract Pituitary duplication is a rare malformation, with only a few previously reported cases. It occurs most commonly in association with other complex midline craniofacial abnormalities. We present the imaging findings of a 1-year-old girl who has been diagnosed coincidentally by magnetic resonance imaging with an isolated pituitary gland duplication but no other major craniofacial malformations.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"25 1","pages":"143 - 146"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91156160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Childhood orbitotemporal neurofibromatosis with congenital glaucoma – A clinical and neuroradiological report","authors":"N. Adulkar, U. Kim","doi":"10.3233/PNR-14179","DOIUrl":"https://doi.org/10.3233/PNR-14179","url":null,"abstract":"Abstract In infants with unilateral congenital glaucoma, orbitotemporal neurofibromatosis should be included in the differential diagnosis. We present an unusual case of neurofibromatosis type-1 with unilateral congenital glaucoma, buphthalmos and spheno-orbital dysplasia. The neuroimaging features are discussed. Presence of all the syndromic features at 6 months of life have rarely been described in the literature.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"36 1","pages":"139 - 142"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83312966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suman Das, K. Chatterjee, Jayitri Majumdar, N. Sarkar, B. Aich, Sudhanshu Sekhar Jana
{"title":"Bickers-Adams syndrome with absent septum pellucidum – A case report","authors":"Suman Das, K. Chatterjee, Jayitri Majumdar, N. Sarkar, B. Aich, Sudhanshu Sekhar Jana","doi":"10.3233/PNR-14185","DOIUrl":"https://doi.org/10.3233/PNR-14185","url":null,"abstract":"Abstract A 20-year-old primigravida with no antenatal care presented to the Obstetric outpatient department at 37 wk completed gestational age. Antenatal ultrasound demonstrated isolated gross fetal ventriculomegaly with absent septum pellucidum. Adduction deformity was present in both thumbs. He had tumultuous post natal life with seizures from 2 h of life, recurrent apnea and death at 72 h of age. Postnatal computed tomography showed hydrocephalus due to aqueductal stenosis and absent septum pellucidum. The clinical and radiological features were consistent with the diagnosis of Bickers-Adams syndrome.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"74 1","pages":"127 - 131"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77712975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Alexandre, G. Napoli, A. Sanna, C. Leoni, M. Ruggiero
{"title":"Posterior reversible encephalopathy syndrome in children, epiphenomenon of a known or unknown disease","authors":"A. Alexandre, G. Napoli, A. Sanna, C. Leoni, M. Ruggiero","doi":"10.3233/PNR-14095","DOIUrl":"https://doi.org/10.3233/PNR-14095","url":null,"abstract":"Abstract Posterior reversible encephalopathy syndrome, also known as reversible posterior leukoencephalopathy syndrome or reversible posterior cerebral edema syndrome, is a recently described disorder of the cerebrovascular autoregulation system with multiple etiologies, most of which cause acute hypertension. Its clinical symptoms include headache, decreased alertness, mental abnormalities such as confusion, diminished spontaneity of speech, and changed behavior, stupor, seizures, vomiting, and abnormalities of visual perception such as cortical blindness. Radiologic appearance consists in cortical/subcortical posterior cerebral artery territory lesions. We describe two cases of this disease in pediatric patients caused by different clinical conditions but supported by the same pathophysiology. Early recognition of posterior reversible encephalopathy syndrome as a complication during different diseases and therapies in childhood may facilitate precise diagnosis and appropriate treatment.","PeriodicalId":89989,"journal":{"name":"Journal of pediatric neuroradiology","volume":"53 1","pages":"099 - 103"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88497856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}