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Journal of neuroinfectious diseases最新文献

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Alzheimers Disease: The Novel Finding of Intracellular Biofilms 阿尔茨海默病:细胞内生物膜的新发现
Journal of neuroinfectious diseases Pub Date : 2017-05-12 DOI: 10.4172/2314-7326.1000247
H. Allen, R. Allawh, A. Touati, C. Katsetos, S. Joshi
{"title":"Alzheimers Disease: The Novel Finding of Intracellular Biofilms","authors":"H. Allen, R. Allawh, A. Touati, C. Katsetos, S. Joshi","doi":"10.4172/2314-7326.1000247","DOIUrl":"https://doi.org/10.4172/2314-7326.1000247","url":null,"abstract":"We previously have found biofilms in the hippocampi of Alzheimer’s disease (AD) post mortem brain specimens. We had seen them in an extracellular location and noted them to be present in the areas of pathological plaque formation. Other investigators have found the presence of spirochetes (Lyme and dental) in affected (AD) brains, and these have been correlated with Treponema pallidum. In a recent historical comparison of the pathology of syphilis, the histological findings of syphilis and AD were shown to be exactly the same. Further, spirochetes have been cultured from the affected brains and have been found to make biofilms and beta amyloid precursor protein. Utilizing the same pathological methods as in our prior study, we have found biofilms in an intracellular location. The similarity of this finding to other diseases has been presented; and, the impact of the “intra” versus the “extra” cellular location is discussed.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72542226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Pathogenesis of An Intracranial Mycotic Aneurysm in An Immunocompromised Patient 免疫功能低下患者颅内真菌性动脉瘤的发病机制
Journal of neuroinfectious diseases Pub Date : 2017-05-06 DOI: 10.4172/2314-7326.1000245
Neelan J. Marianayagam, Sagi Harnoff, S. Michowiz, G. Rajz
{"title":"Pathogenesis of An Intracranial Mycotic Aneurysm in An Immunocompromised Patient","authors":"Neelan J. Marianayagam, Sagi Harnoff, S. Michowiz, G. Rajz","doi":"10.4172/2314-7326.1000245","DOIUrl":"https://doi.org/10.4172/2314-7326.1000245","url":null,"abstract":"Mycotic intracranial aneurysms are rare entities that can be rapidly fatal. The pathology of these lesions are usually due to bacterial infections however in exceptional cases such as immunocompromise, fungal agents are also found to be the cause. In this study, we present the case of a 43-year old, immunocompromised, male patient who suffered from a ruptured mycotic aneurysm after undergoing surgical evacuation of a basal ganglia brain abscess. Pathological analysis of the lesion showed that Aspergillus fumigatis was the causative agent. Since these types of lesions are rare, there are few clinical guidelines for treatment. We emphasize that in an immunocompromised patient with sudden neurological deterioration, mycotic intracranial aneurysm should be in the differential diagnosis.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79243581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HHV6 Encephalitis in Children After Hematopoietic Stem Cell Transplantation 儿童造血干细胞移植后的HHV6脑炎
Journal of neuroinfectious diseases Pub Date : 2017-04-20 DOI: 10.4172/2314-7326.1000244
L. Oevermann, P. Lang, M. Kumpf
{"title":"HHV6 Encephalitis in Children After Hematopoietic Stem Cell Transplantation","authors":"L. Oevermann, P. Lang, M. Kumpf","doi":"10.4172/2314-7326.1000244","DOIUrl":"https://doi.org/10.4172/2314-7326.1000244","url":null,"abstract":"HHV-6 is a roseolovirus, existing in two distinct genetic subsets, HHV-6a and HHV-6b. Most infections are due to HHV6b. The primary infection normally happens during the first 3 years of life and the virus develops lifelong latency. Typical symptoms as exanthema, fever, lymphadenopathy and cough resolve within a week. Secondary infections as e.g. bronchopneumia are rare in immunecompetent patients.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80801453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dynamic Nature of Cerebral Mycotic Aneurysms 脑真菌性动脉瘤的动力学性质
Journal of neuroinfectious diseases Pub Date : 2017-04-15 DOI: 10.4172/2314-7326.1000I001
P. Panni
{"title":"Dynamic Nature of Cerebral Mycotic Aneurysms","authors":"P. Panni","doi":"10.4172/2314-7326.1000I001","DOIUrl":"https://doi.org/10.4172/2314-7326.1000I001","url":null,"abstract":"A 53 years old female was admitted to our department in coma (GCS 5/15) after abrupt onset of headache. Plain CT scan showed left acute subdural hematoma which was emergently evacuated.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86916178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired Quality of Life One Year After Neuro-Chikungunya: A BrazilianExperience 神经基孔肯雅病后一年的生活质量受损:巴西的经验
Journal of neuroinfectious diseases Pub Date : 2017-04-14 DOI: 10.4172/2314-7326.1000243
H. A. Martins, Camila Cordeiro dos Santos, Valdenilson Ribeiro Ribas, Carla Lima, Deyse Cristine da Silva Albuquerque, M. Valença
{"title":"Impaired Quality of Life One Year After Neuro-Chikungunya: A BrazilianExperience","authors":"H. A. Martins, Camila Cordeiro dos Santos, Valdenilson Ribeiro Ribas, Carla Lima, Deyse Cristine da Silva Albuquerque, M. Valença","doi":"10.4172/2314-7326.1000243","DOIUrl":"https://doi.org/10.4172/2314-7326.1000243","url":null,"abstract":"Chikungunya virus (CHIKV) is a positive-strand RNA arthropod-borne virus that was first described in Africa about 65 years ago, and has now spread worldwide, mostly in underdeveloped countries. This study assessed 42 patients (34 women) with ages ranging from 30 to 78 years 12 months after the acute phase of CHIKV fever. A control group of 40 volunteers (27 women) with similar social and demographic features as the patients was used for comparison. Although the patients presented some neurologic symptoms during the acute phase of CHIKV infection, recovery was considered complete. They were evaluated using the Medical Outcome Study Short-Form 36 Health Survey (SF-36) in respect to their quality of life 12 months after the acute phase of the disease. In the comparison of the scores between groups, all domains were shown to be statistically significant showing a lower quality of life for the patients who had suffered neuro-chikungunya, although no patient had any apparent neurological sequela of CHIKV infection.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80303135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloid-ò Oligomers and Aluminum Co-Aggregate to Form Toxic Amyloid Channels in Alzheimers Disease Brain: A New Amyloid-ò Channel-Aluminum Hypotheses 淀粉样蛋白-ò低聚物和铝共同聚集形成阿尔茨海默病大脑中的有毒淀粉样蛋白通道:一个新的淀粉样蛋白-ò通道-铝假说
Journal of neuroinfectious diseases Pub Date : 2017-03-31 DOI: 10.4172/2314-7326.1000241
Y. Kuroda
{"title":"Amyloid-ò Oligomers and Aluminum Co-Aggregate to Form Toxic Amyloid Channels in Alzheimers Disease Brain: A New Amyloid-ò Channel-Aluminum Hypotheses","authors":"Y. Kuroda","doi":"10.4172/2314-7326.1000241","DOIUrl":"https://doi.org/10.4172/2314-7326.1000241","url":null,"abstract":"Large numbers of senile plaques are thought to be characteristic of Alzheimer’s disease (AD), but these deposits are also a by-product of normal senescence. In AD and normal brains, senile plaques are primarily composed of amyloid-s peptides (As P) with aluminum (Al). Evidence suggests the oligomerization of As P is part of the molecular mechanism of AD pathogenesis by forming neurotoxic amyloid channels. However, the relationship between Al and AD has been a subject of scientific debate for many years. The complex nature of Al bioavailability has made it difficult to evaluate its toxicity to the human brain. In 2004, Al concentration in CSF of AD patients analyzed to be 1.6 ± 0.4 times higher than normal people. Importantly, AD patients with more Al in CSF showed less MMSE score, indicating Al may decrease cognitive ability. Recently, Al accumulations in sporadic AD and familial AD brains were reported to be much higher than in normal control brains. Above its neurotoxicity, Al3+ has a crucial role as a cross-linker in s-amyloid oligomerization. Therefore, I propose a hypothesis that s-amyloid oligomerizes with Al, forming non-specific cation amyloid channels in cell membranes, which allows calcium to enter cells and finally causes neuronal death by together with Al’s own neurotoxicity.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76847614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Adult Acute Disseminated Encephalomyelitis Associated with a Falsely Positive HIV Elisa Test 成人急性播散性脑脊髓炎与HIV Elisa检测假阳性相关
Journal of neuroinfectious diseases Pub Date : 2017-03-30 DOI: 10.4172/2314-7326.1000242
M. Wahba, D. Alsbrook, M. McCormack, George-Rudolph M. Tamula, H. Sherif
{"title":"Adult Acute Disseminated Encephalomyelitis Associated with a Falsely Positive HIV Elisa Test","authors":"M. Wahba, D. Alsbrook, M. McCormack, George-Rudolph M. Tamula, H. Sherif","doi":"10.4172/2314-7326.1000242","DOIUrl":"https://doi.org/10.4172/2314-7326.1000242","url":null,"abstract":"Acute disseminated encephalomyelitis (ADEM) is an acute disorder of the central nervous system that follows an infection or vaccination. It is a non-vasculitic inflammatory condition resulting in perivascular edema, inflammation, and demyelination that bears resemblance to multiple sclerosis. The diagnosis of ADEM can be challenging since there is a wide set of alternative diagnoses, including opportunistic infections, vasculitis, and central nervous system lymphoma.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74910065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sandfly Virus Encephalitis in Israel: Two Case Reports and a Review 以色列的白蛉病毒性脑炎:两例报告及综述
Journal of neuroinfectious diseases Pub Date : 2017-03-24 DOI: 10.4172/2314-7326.1000240
R. Cohen, Babushkin Frida, Shimoni Zvi, S. Maurice, L. Yaniv, Brosh-Nissimov Tal
{"title":"Sandfly Virus Encephalitis in Israel: Two Case Reports and a Review","authors":"R. Cohen, Babushkin Frida, Shimoni Zvi, S. Maurice, L. Yaniv, Brosh-Nissimov Tal","doi":"10.4172/2314-7326.1000240","DOIUrl":"https://doi.org/10.4172/2314-7326.1000240","url":null,"abstract":"Background: Infections due to Sand-fly virus (SFV) are common in the Mediterranean region, but are rarely \u0000diagnosed in Israel. Until recently, no cases of severe neuro-invasive SFV infections were reported. In this study, we \u0000describe two cases of encephalitis associated with seroconversion to SFV acquired in Israel. We further try to \u0000postulate about the infecting strain of the SFV, its local phlebotomine vector, and the reasons for the emergence of \u0000this infection in Israel. \u0000Methods: Clinical data were collected from hospital records. Laboratory diagnosis was obtained using mosaic \u0000indirect immunofluorescence tests (IFT) against several SFVs. \u0000Results: Two patients with severe encephalitis presented during the same 2014 summer season. Both have \u0000acquired their infection in Hasharon district of central coastal Israel. Their encephalitis developed after a prolonged \u0000prodrome of 7 and 14 days, and was associated with severe neurological complications. Both patients exhibited a \u0000late seroconversion beyond twenty days from symptom onset. \u0000Conclusion: SFVs are possible etiological agents of febrile illnesses and central nervous system infections in \u0000Israel. The SFV we report is suspected to be a Toscana virus-like strain, and is probably transmitted by Phlebotomus \u0000perfiliewi. A review of the spread of phlebotomine vectors is presented.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84066308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nipah Virus Infection in Thailand: Status 泰国尼帕病毒感染:现状
Journal of neuroinfectious diseases Pub Date : 2017-02-26 DOI: 10.4172/2314-7326.1000e107
V. Wiwanitkit
{"title":"Nipah Virus Infection in Thailand: Status","authors":"V. Wiwanitkit","doi":"10.4172/2314-7326.1000e107","DOIUrl":"https://doi.org/10.4172/2314-7326.1000e107","url":null,"abstract":"Dear Editor, the Nipah virus is an important emerging infectious disease that is still included in the list of disease to be surveillance by WHO. The neurological involvement in Nipah virus infection is an important clinical manifestation.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90763810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Perspective: Role of Autophagy in Neuroprotective Properties of Traditional Chinese Medicines 展望:自噬在中药神经保护作用中的作用
Journal of neuroinfectious diseases Pub Date : 2017-02-09 DOI: 10.4172/2314-7326.1000239
V. Wong, Wu Zeng, B. Law
{"title":"Perspective: Role of Autophagy in Neuroprotective Properties of Traditional Chinese Medicines","authors":"V. Wong, Wu Zeng, B. Law","doi":"10.4172/2314-7326.1000239","DOIUrl":"https://doi.org/10.4172/2314-7326.1000239","url":null,"abstract":"Autophagy is an essential degradation process that sequesters and transfers the idle cytoplasmic materials to the lysosome for digestion and recyclation via the formation of autolysosome . Although both autophagy-lysosomal and ubiquitin-proteasomal pathways are the two principal pathways for cellular protein degradation.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73840831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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