Biological research for nursing最新文献

{"title":"Six Weeks Effects of Dynamic Neuromuscular Stabilization (DNS) Training in Obese Postpartum Women With Low Back Pain: A Randomized Controlled Trial.","authors":"Vajihe Ghavipanje,&nbsp;Nasser Mohammad Rahimi,&nbsp;Farideh Akhlaghi","doi":"10.1177/10998004211044828","DOIUrl":"https://doi.org/10.1177/10998004211044828","url":null,"abstract":"<p><strong>Background: </strong>The worldwide prevalence of obesity and low back pain (LBP) has recently dramatically increased and is mainly indicated among postpartum women, leading to a range of adverse health consequences.</p><p><strong>Objective: </strong>This study aimed to investigate the effects of 6 weeks of Dynamic Neuromuscular Stabilization training (DNS) in obese postpartum women with LBP.</p><p><strong>Method: </strong>This was a pretest-posttest study design. The study was conducted with 40 obese postpartum women with LBP randomized to receive DNS (<i>n</i> = 20) or General Exercise (GE, <i>n</i> = 20) 6 times a week for 6 weeks. The data were gathered before and after the 6-week intervention.</p><p><strong>Results: </strong>Forty participants completed the study (mean ± <i>SD</i>, age 29.30 ± 3.77 years; weight 88.10 ± 6.09 kg; height 165.40 ± 6.31 cm; and BMI, 32.19 ± 1.07 kg/m²). The overall group-by-time interaction was significant for Numeric Pain-Rating Scale, Modified Oswestry Disability Questionnaire, Fear-Avoidance Beliefs Questionnaire, Inspiration and Expiration Breath Hold Time, and Respiratory Rate outcomes. The global rating of change was significantly different between groups (<i>p</i> < .05). The rate of improvement was higher in the DNS group compared to the GE group in all 6 tests.</p><p><strong>Conclusion: </strong>The present study confirms that DNS is applicable in obese postpartum women with LBP and effectively improved NPRS, MODQ, FABQ, BHT, and RR. It is clinically suggested that DNS is imperative based on ideal ontogenetic patterns to attain optimal results for obese postpartum women with LBP.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"106-114"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39464924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population.","authors":"Ilhem Gouissem,&nbsp;Fatma Midani,&nbsp;Hayet Soualmia,&nbsp;Meryem Bouchemi,&nbsp;Sana Ouali,&nbsp;Ameni Kallele,&nbsp;Neila Ben Romdhane,&nbsp;Mohamed Sami Mourali,&nbsp;Moncef Feki","doi":"10.1177/10998004211029376","DOIUrl":"https://doi.org/10.1177/10998004211029376","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the association of angiotensin-converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population.</p><p><strong>Materials and methods: </strong>The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively.</p><p><strong>Results: </strong>The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants (<i>p</i> < 0.01 and <i>p</i> < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39-8.34]; <i>p</i> < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48-21.98]; <i>p</i> < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62-8.27]; <i>p</i> < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22-5.86]; <i>p</i> < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08-11.77]; <i>p</i> < 0.03). Furthermore, the haplotype-based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF.</p><p><strong>Conclusion: </strong>Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"31-39"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211029376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39153892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Home-Based Exercise on Frailty in Patients With End-Stage Renal Disease: Systematic Review.","authors":"Jongwon Yoo,&nbsp;Todd Ruppar,&nbsp;JoEllen Wilbur,&nbsp;Arlene Miller,&nbsp;Jennifer C Westrick","doi":"10.1177/10998004211033031","DOIUrl":"https://doi.org/10.1177/10998004211033031","url":null,"abstract":"<p><strong>Background: </strong>New or worsening frailty is a common problem in patients with end-stage renal disease (ESRD) during the prolonged time awaiting kidney transplantation. Structured physical activity in the dialysis setting has been shown to mitigate frailty, but little is known about the benefits of home-based exercise. The purpose of this systematic review was to summarize the effects of home-based exercise interventions on indicators of frailty (weakness, slowness, low physical activity, perceived exhaustion, and shrinking) among patients diagnosed with ESRD.</p><p><strong>Methods: </strong>We searched PubMed, MEDLINE, Scopus, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Google Scholar using Medical Subject Heading terms and free text keywords including kidney failure, exercise, and frailty. We identified 13 relevant articles (eight randomized controlled trials, five quasi-experimental studies).</p><p><strong>Results: </strong>Our review found potential effectiveness of home-based exercise interventions on mitigating or preventing selected indicators of frailty (e.g., weakness, slowness, low physical activity, perceived exhaustion), particularly when the interventions combined aerobic walking, resistance exercise, and behavioral components and were delivered for at least 6 months. However, no published studies measured the effect of home-based exercise interventions on frailty as a whole.</p><p><strong>Conclusions: </strong>While existing studies suggest likely benefits of home-based exercise interventions among patients with ESRD, future research is warranted to develop and test home-based physical activity interventions that address all indicators of frailty.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"48-63"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211033031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39215587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Systolic Blood Pressure Mediates the Relationship Between Urate and Gout Risk in Indonesia: A Novel Application of a Partial Least Squares-Structural Equation Model.","authors":"Maria Dyah Kurniasari,&nbsp;Ferry Fredy Karwur,&nbsp;Rosiana Eva Rayanti,&nbsp;Andrian Dolfriandra Huruta,&nbsp;Yu Huei Lin,&nbsp;Shuen Fu Weng,&nbsp;Hsiu Ting Tsai","doi":"10.1177/10998004211029044","DOIUrl":"https://doi.org/10.1177/10998004211029044","url":null,"abstract":"<p><strong>Background: </strong>Most Indonesians with hyperuricemia are less than 40 years old, which suggests an increasing gout risk in the country. Meanwhile, untreated hyperuricemia was also suggested to lead to hypertension. Yet, it is unclear whether blood pressure (BP) plays a mediating role between urate and gout.</p><p><strong>Objective: </strong>We investigated the mediating effect of BP between urate and gout risk in Indonesians using a partial least squares-structural equation model.</p><p><strong>Method: </strong>A community-based retrospective case-control study was conducted between July 1 and August 31, 2019 in Indonesia. We randomly recruited 397 participants, including 86 patients with gout and 311 healthy controls from seven community health service centers. Multivariate logistic regression was employed to analyze the adjusted odds ratios of the association between risk factors, such as urate level and BP, and gout risk after controlling for other covariates. A path analysis was utilized to analyze the mediating effect of systolic BP between urate and gout. The STROBE reporting guideline for the observational study is adopted in our reporting.</p><p><strong>Result: </strong>We found that a 1 mg/dL increase of urate level significantly increased gout risk with an OR of 4.97 (95% CI: 3.48-7.09) and an AOR of 4.44 (95% CI: 3.07<i>-</i>6.42) after adjusting for covariates. The association between urate and gout was also significantly mediated by systolic BP (β = 0.05; 95% CI Bias Corrected [0.02-0.08], <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Urate was significantly associated with gout risk and was possibly mediated by increased systolic BP in Indonesians. Controlling systolic BP could be one of the strategies to decrease the risk of gout for individuals with hyperuricemia. Health education can be carried out by community health nurses to individuals on controlling their urate level and systolic BP to decrease the gout risk among Indonesian.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"40-47"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39271039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth.","authors":"Anita Barišić,&nbsp;Aleksandra Stanković,&nbsp;Ljiljana Stojković,&nbsp;Nina Pereza,&nbsp;Saša Ostojić,&nbsp;Ana Peterlin,&nbsp;Borut Peterlin,&nbsp;Jadranka Vraneković","doi":"10.1177/10998004211043571","DOIUrl":"https://doi.org/10.1177/10998004211043571","url":null,"abstract":"<p><p>Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth (SPTB), it remains the leading cause of infant mortality and morbidity. The aim of this study was to evaluate maternal LINE-1 DNA methylation (DNAm), along with <i>DNMT</i> polymorphisms and factors proposed to modulate DNAm, in patients who delivered early preterm. This case-control study included women who delivered spontaneously early preterm (23-33⁶^/7 weeks of gestation), and control women. DNAm was analyzed in peripheral blood lymphocytes by quantification of LINE-1 DNAm using the MethyLight method. There was no significant difference in LINE-1 DNAm between patients with early PTB and controls. Among the investigated predictors, only the history of previous PTB was significantly associated with LINE-1 DNAm in PTB patients (β = -0.407; R² = 0.131; <i>p</i> = 0.011). The regression analysis showed the effect of DNMT3B rs1569686 TT+TG genotypes on LINE-1 DNAm in patients with familial PTB (β = -0.524; R² = 0.275; <i>p</i> = 0.037). Our findings suggest novel associations of maternal LINE-1 DNA hypomethylation with DNMT3B rs1569686 T allele. These results also contribute to the understanding of a complex (epi)genetic and environmental relationship underlying the early PTB.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"85-93"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39584016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lifestyle Intervention on Inflammatory Markers and Waist Circumference in Overweight/Obese Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Gholam Rasul Mohammad Rahimi,&nbsp;Heidar Alizaei Yousefabadi,&nbsp;Arghavan Niyazi,&nbsp;Nasser Mohammad Rahimi,&nbsp;Yaser Alikhajeh","doi":"10.1177/10998004211044754","DOIUrl":"https://doi.org/10.1177/10998004211044754","url":null,"abstract":"<p><strong>Background: </strong>Physical inactivity and an imbalanced diet could lead to some cardio metabolic risk factors.</p><p><strong>Objective: </strong>The objective of this meta-analysis was to investigate the effects of lifestyle modification on inflammatory indicators and waist circumference (WC) in overweight/obese subjects with metabolic syndrome (MS).</p><p><strong>Data sources: </strong>A systematic search was conducted in PubMed, CINAHL, MEDLINE, Cochrane, Google Scholar, and Web of Science.</p><p><strong>Study selection: </strong>The selection criteria were randomized controlled trials (RCTs) investigating the effects of lifestyle interventions on inflammation and WC from inception to 20 December 2020. The weighted mean difference (WMD) and 95% confidence interval (CI) between interventions were computed using a random or fixed-effects model.</p><p><strong>Results: </strong>Six RCTs (including 1246 MS patients who had, on average, overweight/obesity) met all inclusion criteria. Interventions lasted 6 to 12 months (2-5 sessions per week). Lifestyle intervention significantly reduced C-reactive protein (WMD: -0.52 mg/ml, 95% CI: -0.72, -0.33), IL-6 (WMD: -0.50 pg/ml, 95% CI: -0.56, -0.45), and increased adiponectin (WMD: 0.81 µg/ml, 95% CI, 0.64, 0.98). Moreover, lifestyle modification significantly decreased WC (WMD: -3.12 cm, 95% CI, -4.61, -1.62).</p><p><strong>Conclusion: </strong>Our findings provide evidence that lifestyle alterations, including physical activity and diet, can lead to significant improvement in abdominal obesity, measured by WC and some inflammation markers among overweight/obese individuals with MS. Further high-quality research is needed to clarify the mechanisms underlying the effect of such interventions on this population's inflammatory markers.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"94-105"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39569847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Exercise Interventions to Improve Psychosocial Aspects and Glycemic Control in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Gholam Rasul Mohammad Rahimi,&nbsp;Reza Aminzadeh,&nbsp;Amin Azimkhani,&nbsp;Vahid Saatchian","doi":"10.1177/10998004211022849","DOIUrl":"https://doi.org/10.1177/10998004211022849","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) patients have a raised risk of developing depression compared with non-diabetic people.</p><p><strong>Objective: </strong>The objective of this meta-analysis was to investigate the impacts of exercise training interventions to improve psychosocial aspects and glycemic control in T2DM patients.</p><p><strong>Data sources: </strong>PubMed, CINAHL, Medline, Google Scholar, and Scopus databases and reference lists of included studies were searched.</p><p><strong>Study selection: </strong>The selection criteria were randomized controlled trials (RCTs) using an exercise intervention with or without dietary advice on psychological aspects and glycemic control in T2DM patients, up to January 2021. Meta-analyses were performed using the random-effects model. The analysis included 17 RCTs with 2,127 participants.</p><p><strong>Results: </strong>In the pooled analysis, improvements were seen in depression, standard mean difference (SMD) -0.65 (95% confidence interval (CI) -1.03 to -0.28, <i>p</i> = 0.0006), mental health SMD: 0.53 (95% CI 0.31 to 0.76, <i>p</i> < 0.00001), and HbA1c, weighted mean difference (WMD) -0.51% (95% CI -0.97 to -0.04, <i>p</i> = 0.03). There were no significant differences between the intervention and control groups for bodily pain, social functioning, and fasting glucose (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Our systematic review and meta-analysis displayed that exercise training interventions decreased depression and HbA1c and increased mental health in individuals with T2DM. Further longer-term and high-quality clinical trials are required to additional assess and confirm the findings presented here.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10-23"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211022849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Persistent Pain and Inflammatory Biomarkers in Sickle Cell Disease: An Exploratory Study.","authors":"Mitchell R Knisely,&nbsp;Paula J Tanabe,&nbsp;Julia K L Walker,&nbsp;Qing Yang,&nbsp;Nirmish R Shah","doi":"10.1177/10998004211027220","DOIUrl":"10.1177/10998004211027220","url":null,"abstract":"<p><strong>Background: </strong>Severe pain is among the most common and deleterious symptoms experienced by individuals with sickle cell disease (SCD), of whom more than 50% report chronic pain. Despite this, the understanding of the biological contributors to persistent severe SCD pain is limited. This exploratory study sought to describe pain phenotypes based on frequency of severe pain experienced over 6 months and identify inflammatory biomarkers associated with pain phenotypes among individuals with SCD.</p><p><strong>Methods: </strong>This study used self-report and electronic health record data collected from 74 individuals enrolled in the Duke Sickle Cell Disease Implementation Consortium Registry. Plasma from previously collected blood specimens was used to generate inflammatory biomarker data using the Inflammation 20-plex ProcartaPlex^TM panel. Descriptive statistics were used to describe the occurrence of severe pain over the past 6 months, and bi-variate analyses were used to evaluate the relationship between inflammatory biomarkers and pain phenotypes.</p><p><strong>Results: </strong>Among the 74 participants included in this study, 33.8% reported severe pain occurring never or rarely, 40.5% reported severe pain occurring sometimes, and 25.7% reported severe pain occurring often or always. Soluble E-selectin (sE-selectin) was the only inflammatory biomarker significantly associated with the pain phenotype groups (<i>p</i> = 0.049). Post hoc comparisons identified that participants in the often/always severe pain group had significantly higher plasma concentrations of sE-selectin compared to those in the sometimes severe pain group (<i>p</i> = 0.040).</p><p><strong>Conclusions: </strong>Our findings provide preliminary evidence of the frequent occurrence of severe pain and that sE-selectin may be an objective biomarker for the frequent occurrence of severe pain in this population.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":"24 1","pages":"24-30"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211027220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Damage Accrual and Low Bone Mineral Density in Female Patients with Systemic Lupus Erythematosus.","authors":"María Correa-Rodríguez,&nbsp;Gabriela Pocovi-Gerardino,&nbsp;José-Luis Callejas-Rubio,&nbsp;Raquel Ríos-Fernández,&nbsp;Blanca Rueda-Medina,&nbsp;Norberto Ortego-Centeno","doi":"10.1177/10998004211005550","DOIUrl":"https://doi.org/10.1177/10998004211005550","url":null,"abstract":"<p><p>Osteoporosis is a common comorbidity in patients with systemic lupus erythematosus (SLE), but the potential contribution of disease-associated factors to bone status in SLE is not well known because the reported risk factors from different studies differ greatly. We aimed to examine frequency of reduced bone mass in women with SLE, and determine their potential associations with disease activity, damage accrual and SLE-related clinical markers. A cross-sectional study including 121 Caucasian pre-menopausal and postmenopausal women was conducted (mean age 49.2 ± 12.4 years). The SLE Disease Activity Index (SLEDAI-2 K) and the SDI Damage Index were used to assess disease activity and disease-related damage, respectively. Bone mineral density (BMD) of the left femoral neck and lumbar spine (L2-L4) were measured by dual-energy X-ray absorptiometry. Ten patients (8.3%) had osteoporosis, 63 (52.1%) patients had osteopenia and 6.8% of women had history of previous fracture. Patients with low bone mass had a significantly higher mean SDI (1.3 ± 1.2 versus 0.7 ± 1.0 <i>p =</i> 0.003). T-score at lumbar spine was inversely correlated with SDI score (r = -0.222, <i>p =</i> 0.014) and complement C3 level (<i>r</i> = -0.206, <i>p =</i> .024). SDI scores were significantly different between patients with osteoporosis, osteopenia, and normal BMD after adjusting for covariates (<i>p =</i> .004). There is a high prevalence of low BMD in Caucasian women with SLE, and this status was associated with higher damage accrual scores, supporting that disease damage may itself be a major contributor to the low BMD. Women with SLE with organ damage require regular bone status monitoring to prevent further musculoskeletal damage.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":"23 4","pages":"575-583"},"PeriodicalIF":2.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211005550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25533232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Short-Term and Low-Dose N-Acetylcysteine Affect Oxidative Stress and Inflammation in The Liver Tissues of Diabetic Rats?","authors":"Fatma Genç,&nbsp;Emine Gülçeri Güleç Peker","doi":"10.1177/10998004211003668","DOIUrl":"https://doi.org/10.1177/10998004211003668","url":null,"abstract":"<p><p>Diabetes mellitus is a serious chronic disease in which the oxidant-antioxidant balance is impaired, causing many complications, including hepatopathy. In this study, the effects of short-term and low-dose <i>N-acetylcysteine</i> (NAC) administration on the biochemical, proinflammatory, and oxidative stress parameters in the liver tissue of diabetic rats were investigated. Twenty-four adult male Wistar albino rats weighing approximately 250-300 g were divided into 4 groups (n = 6): Control, Streptozotosin (STZ)-induced diabetes (DM), NAC treatment (60 mg/kg), and STZ-induced diabetes treated with NAC (DM+NAC; 60 mg/kg). NAC treatment was administered intraperitoneally as a single daily dose for 7 days. At the end of the experiment (3 weeks), blood and liver samples were collected for biochemical parameter analysis. Lipid peroxidation, antioxidant parameters, and nitric oxide (NOx) levels were determined by spectrophotometric method. Tissue inflammation parameters were evaluated by ELISA. Lipid peroxidation, proinflammatory cytokines, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) values increased significantly with diabetes. NAC treatment significantly decreased serum ALT and AST levels and proinflammatory cytokines in the diabetic group. Liver glutathione (GSH) and NOx levels increased significantly in the DM+NAC group (<i>p <</i> 0.05). While NAC treatment reduced lipid peroxidation in the liver, it improved the inflammatory response and antioxidant status. The beneficial effect of NAC treatment may be due to its antioxidant activity and the resulting increased level of GSH. The results show that low-dose and short-term NAC treatment had a positive effect on oxidative damage and inflammation in liver tissue. NAC can be used as a potential antioxidant in diabetes to prevent hepatopathy.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":"23 4","pages":"568-574"},"PeriodicalIF":2.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211003668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25494783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}