突尼斯人群ACE（rs1799752）和CYP11B2（rs1799998）基因多态性对心房颤动的贡献。

IF 1.9 4区医学 Q2 NURSING

Biological research for nursing Pub Date : 2022-01-01 Epub Date: 2021-07-06 DOI:10.1177/10998004211029376

Ilhem Gouissem, Fatma Midani, Hayet Soualmia, Meryem Bouchemi, Sana Ouali, Ameni Kallele, Neila Ben Romdhane, Mohamed Sami Mourali, Moncef Feki

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Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively.Results: The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants (p < 0.01 and p < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39-8.34]; p < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48-21.98]; p < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62-8.27]; p < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22-5.86]; p < 0.01). 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引用次数: 1

摘要

背景:本研究探讨了突尼斯人群肾素-血管紧张素-醛固酮系统(RAAS)中血管紧张素转换酶(ACE I/D)和醛固酮合成酶(CYP11B2-344C/T)基因多态性与房颤(AF)的关系。材料和方法:研究人群包括120例房颤患者和123例年龄匹配的对照组。采用聚合酶链反应(PCR)和PCR- rflp方法分别对ACE基因I/D多态性和CYP11B2基因-344C/T多态性进行基因分型。结果:AF患者ACE I/D和CYP11B2-344C/T多态性基因型分布与对照组有显著差异(p < 0.01和p < 0.006)。此外，ACE I/D使DD基因型患者发生AF的风险显著增加3.41倍(OR = 3.41;95% ci [1.39-8.34];p < 0.007)，在校正混杂因素(年龄、糖尿病、高血压和血脂异常)后，风险更高(OR = 5.71;95% ci [1.48-21.98];P < 0.01)。同样，CYP11B2-344C/T多态性增加了TT基因型AF的发病率(OR = 3.66;95% ci [1.62-8.27];p < 0.002)和CT基因型(OR = 2.68;95% ci [1.22-5.86];P < 0.01)。在校正了混杂因素(年龄、糖尿病、高血压和血脂异常)后，TT基因型的风险仍然较高(OR = 3.58;95% ci [1.08-11.77];P < 0.03)。此外，基于单倍型的ACE I/D和CYP11B2-344C/T多态性的关联表明，D-T单倍型增加了AF的风险。结论:我们的研究表明，ACE (I/D)和CYP11B2-344C/T多态性与AF在突尼斯人群中存在显著关联。

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Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population.

Background: This study investigated the association of angiotensin-converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population.

Materials and methods: The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively.

Results: The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants (p < 0.01 and p < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39-8.34]; p < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48-21.98]; p < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62-8.27]; p < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22-5.86]; p < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08-11.77]; p < 0.03). Furthermore, the haplotype-based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF.

Conclusion: Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)