Biological research for nursing最新文献

{"title":"Frailty and In-Hospital Mortality Risk Using EHR Nursing Data.","authors":"Deborah Lekan,&nbsp;Thomas P McCoy,&nbsp;Marjorie Jenkins,&nbsp;Somya Mohanty,&nbsp;Prashanti Manda","doi":"10.1177/10998004211060541","DOIUrl":"https://doi.org/10.1177/10998004211060541","url":null,"abstract":"<p><p>PurposeThe purpose of this study was to evaluate four definitions of a Frailty Risk Score (FRS) derived from EHR data that includes combinations of biopsychosocial risk factors using nursing flowsheet data or International Classification of Disease, 10th revision (ICD-10) codes and blood biomarkers and its predictive properties for in-hospital mortality in adults ≥50 years admitted to medical-surgical units. <b>Methods</b> In this retrospective observational study and secondary analysis of an EHR dataset, survival analysis and Cox regression models were performed with sociodemographic and clinical covariates. Integrated area under the ROC curve (iAUC) across follow-up time based on Cox modeling was estimated. <b>Results</b> The 46,645 patients averaged 1.5 hospitalizations (SD = 1.1) over the study period and 63.3% were emergent admissions. The average age was 70.4 years (SD = 11.4), 55.3% were female, 73.0% were non-Hispanic White (73.0%), mean comorbidity score was 3.9 (SD = 2.9), 80.5% were taking 1.5 high risk medications, and 42% recorded polypharmacy. The best performing FRS-NF-26-LABS included nursing flowsheet data and blood biomarkers (Adj. HR = 1.30, 95% CI [1.28, 1.33]), with good accuracy (iAUC = .794); the reduced model with age, sex, and FRS only demonstrated similar accuracy. The poorest performance was the ICD-10 code-based FRS. <b>Conclusion</b> The FRS captures information about the patient that increases risk for in-hospital mortality not accounted for by other factors. Identification of frailty enables providers to enhance various aspects of care, including increased monitoring, applying more intensive, individualized resources, and initiating more informed discussions about treatments and discharge planning.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39649707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-analysis of Randomized Controlled Trials of Stabilizing Exercises for Lumbopelvic Region Impact in Postpartum Women With Low Back and Pelvic Pain","authors":"Zohreh Moheboleslam, Nasser Mohammad Rahimi, R. Aminzadeh","doi":"10.1177/10998004221081083","DOIUrl":"https://doi.org/10.1177/10998004221081083","url":null,"abstract":"Background Countless women experience lumbopelvic pain (LBPP) after pregnancy. Physical activity is revealed as a beneficial procedure to alleviate LBPP, yet it appears that individual investigations report mixed conclusions about its effectiveness. Objective: This systematic review and meta-analysis examined the impact of stabilizing exercises on pain intensity, disability, and quality of life (QoL) in postpartum women. Data sources: A systematic search was conducted in PubMed, MEDLINE, Google Scholar, Scopus, and reference lists of included studies up to September, 2021. Study selection: Eleven studies comprising 623 participants were included and analyzed using a random-effects model. Results: Data displayed that stabilizing exercises significantly reduced pain (standard mean difference; SMD: −0.76, 95% confidence interval (CI): −1.26 to −0.27, p = .002), and disability (SMD: −1.19, 95% CI: −1.7 to −0.68, p < .001). However, our study found no significant change in QoL following stabilizing exercises (MD: 4.42, 95% CI: −5.73, 14.57, p = .39). Conclusion: Our systematic review and meta-analysis demonstrated that stabilizing interventions had some benefits in postpartum women. While there is some evidence to display the efficacy of stabilizing exercises for relieving LBPP, additional longer-term and high-quality studies are required to confirm the current findings.","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46936676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility and Acceptability of In-Home Saliva Collection for Stress in Persons With Dementia and Their Family Caregivers","authors":"A. Emami, Helena Hallinder, T. Theorell, Hyejin Kim, G. Engström","doi":"10.1177/10998004221076554","DOIUrl":"https://doi.org/10.1177/10998004221076554","url":null,"abstract":"Background Although increasing attention is being paid to cortisol and the sulfated form of dehydroepiandrosterone (DHEA-S) as stress biomarkers, the feasibility of saliva collection of such biomarkers has yet to be investigated among dementia care dyads (persons with dementia [PWD] and family caregivers) living in a home setting. We explored the feasibility and acceptability of in-home saliva collection for cortisol and DHEA-S as stress biomarkers among dementia care dyads. Methods Dementia care dyads were recruited from a memory evaluation center. After pre-evaluation and education sessions, participants collected their saliva 3 times a day, 5 days a week, for 8 consecutive weeks. We calculated frequency counts and percentages to assess enrollment rate, retention rate, the completion rate of saliva collection, and valid samples of cortisol and DHEA-S. Independent samples t-tests were performed to compare mean differences in the total number of collected samples and valid samples between PWD and family caregivers at each time point of saliva collection. Results A total of 46 dyads were referred to this study; 32 dyads (69.6%) agreed to participate, and 26 started collecting saliva. Twenty-four dyads (75%) completed 8 weeks of saliva collection. There were no significant differences (p > 0.05) in the number of collected samples and valid samples between PWD and caregiver participants. Conclusion This study supports the feasibility of in-home saliva collection for stress biomarker assay and the need for further investigation into self-administered collection of stress biomarkers with a particular focus on dementia care dyads living at home.","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49123762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Tai Chi on Patients With Chronic Kidney Disease.","authors":"Mei Ha,&nbsp;Yuhui Yang,&nbsp;Yu Shi,&nbsp;Ya Lu,&nbsp;Kun Chen,&nbsp;Suofei Zhang,&nbsp;Yu Luo","doi":"10.1177/10998004211047993","DOIUrl":"https://doi.org/10.1177/10998004211047993","url":null,"abstract":"<p><p>Previous systematic reviews elucidate the efficacy of Tai Chi on the rehabilitation and treatment for various chronic diseases. Yet, no consensus has been reached on its efficacy and safety from those with chronic kidney disease (CKD). Therefore, we conducted a systematic review to critically summarize what is already known about the prevailing benefits of Tai Chi for CKD patients. There was no evidence that Tai Chi had adverse effects on CKD patients. Long-term Tai Chi exercises could improve quality of life, cardiorespiratory fitness, and physical motor function for the end-stage renal disease (ERSD) patients undergoing dialysis. Regular Tai Chi exercises might exert modest influences in delaying CKD progression for mild-moderate CKD patients. However, there is insufficient evidence to demonstrate positive effects of Tai Chi exercises on bone health of the ESRD patients. Accordingly, rigorously designed, longer-term studies of Tai Chi are warranted to identify its efficacy on CKD patients across different stages, especially targeting potential mechanisms in terms of Tai Chi altering biological gene profile expressions.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39661157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the Summer Institute on Symptoms and Omics.","authors":"Irene Yang,&nbsp;Marcia Holstad","doi":"10.1177/10998004211050056","DOIUrl":"https://doi.org/10.1177/10998004211050056","url":null,"abstract":"Metabolomics, a relatively recent field of research, offers nurse scientists a powerful new way to investigate physiologic pathways underlying health and disease and identify a biological basis for symptoms or health risks, as is consistent with nursing’s focus. Metabolomics methods are particularly useful because the metabolome is the final downstream product of gene transcription and the closest to the phenotype of the entire biological system (Harrigan & Goodacre, 2003). Another advantage of metabolomics methods, compared to other omics methods, is that changes in the metabolome are frequently amplified relative to changes at the level of the genome, transcriptome, and proteome (Harrigan & Goodacre, 2003). Despite its potential, metabolomics is currently underutilized by nurse researchers. A recent scoping literature review presented by Laura Kimble, PhD, RN, FNP-C, FAAN, Clinical Professor at Emory University School of Nursing and Nicole Carlson, PhD, CNM, Assistant Professor at Emory University School of Nursing (Kimble et al., 2020) suggests that while uptake is emerging, the current state of nursing science still reflects a scarcity of nurse scientists with an established program of metabolomics research. The Emory School of Nursing P30 Center for the Study of Symptom Science, Metabolomics, and Multiple Chronic Conditions (P30NR018090) is dedicated to supporting the conduct of research to identify metabolites and metabolic pathways associated with symptoms of fatigue, depression, and anxiety in African Americans with multiple chronic conditions. The center is based on a novel metabolomics framework developed by one of the center’s founders, Elizabeth Corwin, PhD, FNP-BC, now Vice Dean of Strategic and Innovative Research at Columbia University School of Nursing, to study symptoms in persons with multiple chronic conditions. This theoretical framework posits that tissue injury in individuals with multiple chronic conditions may activate metabolic pathways initiating symptoms and/or clusters of symptoms, and that a variety of covariates (i.e., clinical characteristics, sex, stress) may influence this effect (Corwin et al., 2021). The model focuses on specific symptoms such as fatigue, depression, and anxiety, all of which are known to accompany chronic conditions and impact health-related quality of life (Corwin et al., 2021). To increase exposure of nurse researchers to metabolomics methods, the Center launched its first annual Summer Institute on Symptoms and Omics (SISO), May 13–14, 2021, to describe how metabolomics methods can improve symptom science research and introduce researchers to basic metabolomics methods (www.sisoconference.com). This article presents highlights of the virtual event.","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096198/pdf/10.1177_10998004211050056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10824233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population.","authors":"Ilhem Gouissem,&nbsp;Fatma Midani,&nbsp;Hayet Soualmia,&nbsp;Meryem Bouchemi,&nbsp;Sana Ouali,&nbsp;Ameni Kallele,&nbsp;Neila Ben Romdhane,&nbsp;Mohamed Sami Mourali,&nbsp;Moncef Feki","doi":"10.1177/10998004211029376","DOIUrl":"https://doi.org/10.1177/10998004211029376","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the association of angiotensin-converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population.</p><p><strong>Materials and methods: </strong>The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively.</p><p><strong>Results: </strong>The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants (<i>p</i> < 0.01 and <i>p</i> < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39-8.34]; <i>p</i> < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48-21.98]; <i>p</i> < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62-8.27]; <i>p</i> < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22-5.86]; <i>p</i> < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08-11.77]; <i>p</i> < 0.03). Furthermore, the haplotype-based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF.</p><p><strong>Conclusion: </strong>Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211029376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39153892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six Weeks Effects of Dynamic Neuromuscular Stabilization (DNS) Training in Obese Postpartum Women With Low Back Pain: A Randomized Controlled Trial.","authors":"Vajihe Ghavipanje,&nbsp;Nasser Mohammad Rahimi,&nbsp;Farideh Akhlaghi","doi":"10.1177/10998004211044828","DOIUrl":"https://doi.org/10.1177/10998004211044828","url":null,"abstract":"<p><strong>Background: </strong>The worldwide prevalence of obesity and low back pain (LBP) has recently dramatically increased and is mainly indicated among postpartum women, leading to a range of adverse health consequences.</p><p><strong>Objective: </strong>This study aimed to investigate the effects of 6 weeks of Dynamic Neuromuscular Stabilization training (DNS) in obese postpartum women with LBP.</p><p><strong>Method: </strong>This was a pretest-posttest study design. The study was conducted with 40 obese postpartum women with LBP randomized to receive DNS (<i>n</i> = 20) or General Exercise (GE, <i>n</i> = 20) 6 times a week for 6 weeks. The data were gathered before and after the 6-week intervention.</p><p><strong>Results: </strong>Forty participants completed the study (mean ± <i>SD</i>, age 29.30 ± 3.77 years; weight 88.10 ± 6.09 kg; height 165.40 ± 6.31 cm; and BMI, 32.19 ± 1.07 kg/m²). The overall group-by-time interaction was significant for Numeric Pain-Rating Scale, Modified Oswestry Disability Questionnaire, Fear-Avoidance Beliefs Questionnaire, Inspiration and Expiration Breath Hold Time, and Respiratory Rate outcomes. The global rating of change was significantly different between groups (<i>p</i> < .05). The rate of improvement was higher in the DNS group compared to the GE group in all 6 tests.</p><p><strong>Conclusion: </strong>The present study confirms that DNS is applicable in obese postpartum women with LBP and effectively improved NPRS, MODQ, FABQ, BHT, and RR. It is clinically suggested that DNS is imperative based on ideal ontogenetic patterns to attain optimal results for obese postpartum women with LBP.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39464924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Inflammatory Markers in Veterans With Multiple Sclerosis.","authors":"Pamela Newland,&nbsp;Yelyzaveta Basan,&nbsp;Ling Chen,&nbsp;Gregory Wu","doi":"10.1177/10998004211050082","DOIUrl":"https://doi.org/10.1177/10998004211050082","url":null,"abstract":"<p><p>Multiple sclerosis (MS), an inflammatory neurodegenerative disease of the central nervous system (CNS), afflicts over one per thousand people in the United States. The pathology of MS typically involves lesions in several regions, including the brain and spinal cord. The manifestation of MS is variable and carries great potential to negatively impact quality of life (QOL). Evidence that inflammatory markers are related to depression in MS is accumulating. However, there are barriers in precisely identifying the biological mechanisms underlying depression and inflammation. Analysis of cytokines provides one promising approach for understanding the mechanisms that may contribute to MS symptoms.</p><p><strong>Methods: </strong>In this pilot study, we measured salivary levels of interleukin (IL)-6, IL-1beta (β), and IL-10 in 24 veterans with MS. Descriptive statistics were reported and Pearson correlation coefficients were obtained between cytokines and depression.</p><p><strong>Results: </strong>The anti-inflammatory cytokine IL-10 was significantly negatively associated with depression in veterans with MS (r = -0.47, <i>p</i> = .024).</p><p><strong>Conclusion: </strong>Cytokines may be useful for elucidating biological mechanisms associated with the depression and a measure for nurses caring for veterans with MS.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39578068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Home-Based Exercise on Frailty in Patients With End-Stage Renal Disease: Systematic Review.","authors":"Jongwon Yoo,&nbsp;Todd Ruppar,&nbsp;JoEllen Wilbur,&nbsp;Arlene Miller,&nbsp;Jennifer C Westrick","doi":"10.1177/10998004211033031","DOIUrl":"https://doi.org/10.1177/10998004211033031","url":null,"abstract":"<p><strong>Background: </strong>New or worsening frailty is a common problem in patients with end-stage renal disease (ESRD) during the prolonged time awaiting kidney transplantation. Structured physical activity in the dialysis setting has been shown to mitigate frailty, but little is known about the benefits of home-based exercise. The purpose of this systematic review was to summarize the effects of home-based exercise interventions on indicators of frailty (weakness, slowness, low physical activity, perceived exhaustion, and shrinking) among patients diagnosed with ESRD.</p><p><strong>Methods: </strong>We searched PubMed, MEDLINE, Scopus, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Google Scholar using Medical Subject Heading terms and free text keywords including kidney failure, exercise, and frailty. We identified 13 relevant articles (eight randomized controlled trials, five quasi-experimental studies).</p><p><strong>Results: </strong>Our review found potential effectiveness of home-based exercise interventions on mitigating or preventing selected indicators of frailty (e.g., weakness, slowness, low physical activity, perceived exhaustion), particularly when the interventions combined aerobic walking, resistance exercise, and behavioral components and were delivered for at least 6 months. However, no published studies measured the effect of home-based exercise interventions on frailty as a whole.</p><p><strong>Conclusions: </strong>While existing studies suggest likely benefits of home-based exercise interventions among patients with ESRD, future research is warranted to develop and test home-based physical activity interventions that address all indicators of frailty.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10998004211033031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39215587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Systolic Blood Pressure Mediates the Relationship Between Urate and Gout Risk in Indonesia: A Novel Application of a Partial Least Squares-Structural Equation Model.","authors":"Maria Dyah Kurniasari,&nbsp;Ferry Fredy Karwur,&nbsp;Rosiana Eva Rayanti,&nbsp;Andrian Dolfriandra Huruta,&nbsp;Yu Huei Lin,&nbsp;Shuen Fu Weng,&nbsp;Hsiu Ting Tsai","doi":"10.1177/10998004211029044","DOIUrl":"https://doi.org/10.1177/10998004211029044","url":null,"abstract":"<p><strong>Background: </strong>Most Indonesians with hyperuricemia are less than 40 years old, which suggests an increasing gout risk in the country. Meanwhile, untreated hyperuricemia was also suggested to lead to hypertension. Yet, it is unclear whether blood pressure (BP) plays a mediating role between urate and gout.</p><p><strong>Objective: </strong>We investigated the mediating effect of BP between urate and gout risk in Indonesians using a partial least squares-structural equation model.</p><p><strong>Method: </strong>A community-based retrospective case-control study was conducted between July 1 and August 31, 2019 in Indonesia. We randomly recruited 397 participants, including 86 patients with gout and 311 healthy controls from seven community health service centers. Multivariate logistic regression was employed to analyze the adjusted odds ratios of the association between risk factors, such as urate level and BP, and gout risk after controlling for other covariates. A path analysis was utilized to analyze the mediating effect of systolic BP between urate and gout. The STROBE reporting guideline for the observational study is adopted in our reporting.</p><p><strong>Result: </strong>We found that a 1 mg/dL increase of urate level significantly increased gout risk with an OR of 4.97 (95% CI: 3.48-7.09) and an AOR of 4.44 (95% CI: 3.07<i>-</i>6.42) after adjusting for covariates. The association between urate and gout was also significantly mediated by systolic BP (β = 0.05; 95% CI Bias Corrected [0.02-0.08], <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Urate was significantly associated with gout risk and was possibly mediated by increased systolic BP in Indonesians. Controlling systolic BP could be one of the strategies to decrease the risk of gout for individuals with hyperuricemia. Health education can be carried out by community health nurses to individuals on controlling their urate level and systolic BP to decrease the gout risk among Indonesian.</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39271039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}