Bioequivalence & Bioavailability International Journal最新文献_第4页

Bioequivalence Study Comparing a Generic and Innovator Drug of Rosuvastatin 20 mg 瑞舒伐他汀20mg仿制药与创新药的生物等效性研究

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000189

Dewi Ou

{"title":"Bioequivalence Study Comparing a Generic and Innovator Drug of Rosuvastatin 20 mg","authors":"Dewi Ou","doi":"10.23880/beba-16000189","DOIUrl":"https://doi.org/10.23880/beba-16000189","url":null,"abstract":"The bioequivalence study was conducted to compare the bioavailability of two rosuvastatin 20 mg film-coated tablet formulations (test and reference formulation). This study was an open-label, randomized, single-dose, two-periods, twotreatments, and crossover study which included 32 healthy adult male and female subjects under fasting conditions. Each of the two study periods was separated by a 7 days washout period. A single oral dose of test or reference drug was administered to the subject in each period based on the randomization scheme. Plasma concentrations of the drug were determined by LC-MS/MS method. The pharmacokinetic parameters assessed in this study were the area under the plasma concentration-time curve from time zero to 72 h (AUC0-72h), area under the plasma concentration-time curve from time zero to infinity (AUC0-∞), the peak plasma concentration of the drug (Cmax), time needed to achieve the peak plasma concentration (Tmax), and the elimination half-life (T1/2). The geometric mean ratio (GMR) and 90% Confidence Interval (90% CI) for AUC0-72h and Cmax of test/reference drug for rosuvastatin were 97.05 % (89.07%– 105.74%) and 101.15% (89.53%– 114.26%). Since the 90% CI with α 0.05% for AUC0-72h and Cmax of rosuvastatin were within the standard bioequivalence range (80.00– 125.00%), it was concluded that the two rosuvastatin film-coated tablets (test and reference drug) were bioequivalence in terms of the rate and extent of absorption.","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82745564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioavailability – Challenges and Advances in Drug Targeting 生物利用度-药物靶向的挑战和进展

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000186

V. M.

引用次数: 0

Evaluation of the Participation of Phenolic Compounds Naturally Present in Food in Stimulating the Health of the Organism 评价食品中天然存在的酚类化合物对促进机体健康的作用

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000187

Mancini-Filho J

引用次数: 0

A Mini Review on Bioequivalence & the Bioavailability Study on Anticancer Drugs 抗癌药物生物等效性及生物利用度研究综述

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000188

Behera A

引用次数: 0

Covid-19 Vaccinations and Menstrual Cycle Alteration Covid-19疫苗接种与月经周期改变

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000182

Hussain S

引用次数: 0

Determination of Caffeine and Chlorogenic Acid (CGA) in the Methanolic Extracts Coffee (C. arabica. L) To seeds and peels (Unroasted and Roasted) Cultivars Grown in Yemen by High Performance Liquid Chromatography (HPLC) 阿拉比卡咖啡甲醇提取物中咖啡因和绿原酸含量的测定。L)通过高效液相色谱法(HPLC)检测也门种植的种子和果皮(未烘烤和烘烤)

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000180

Ali Sa

{"title":"Determination of Caffeine and Chlorogenic Acid (CGA) in the Methanolic Extracts Coffee (C. arabica. L) To seeds and peels (Unroasted and Roasted) Cultivars Grown in Yemen by High Performance Liquid Chromatography (HPLC)","authors":"Ali Sa","doi":"10.23880/beba-16000180","DOIUrl":"https://doi.org/10.23880/beba-16000180","url":null,"abstract":"In this study methanolic extract of one plant namely Arabic coffee, were screened for the presence of analysis Constituents and tested for their of liquid chromatographic separation (HPLC). The quantitative HPLC analysis revealed the results showed presence of Caffeine, chlorogenic acid (CGA) is the concentration of the contents Seeds, peels (unroasted) samples is higher than their contents in the Seeds, and peels (roasted) samples. The highest concentration of Caffeine was 5,334 % in unroasted Arabica coffee peels (Udaini) in Ibb (Kafr) region, while the highest value of chlorogenic acid was 68,460% in unroasted Arabica coffee peels (Tufahi) in Ibb (Kafr). The highest concentration of Caffeine was 9,948% in unroasted Arabic coffee seeds (Udaini) in Ibb (Kafr) region, while the highest concentration of chlorogenic acid was 97,280% in unroasted Arabic coffee seeds (Udaini) in Ibb (Kafr) region. The highest concentration of Caffeine was 1,964 % in roasted Arabica coffee peels (Udaini) in Ibb (Kafr) region, while the highest value of chlorogenic acid was 26,260% in roasted Arabica coffee peels (Bura’ai.) in Sana'a (Haraz). The highest concentration of Caffeine was 2,324% in roasted Arabic coffee seeds (Udaini) in Al- Mahweet (Hufash) region, while the highest concentration of chlorogenic acid was 47,09% in roasted Arabic coffee seeds (Dawairi) in Al- Mahweet (Hufash).","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85656018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Monitoring-Guided Dosing of Factor Viii in Hemophilia A: From Pharmacodynamics and Pharmacokinetics toward Precision Therapy 血友病A的治疗监测引导因子Viii的剂量:从药效学和药代动力学到精确治疗

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000185

Fortuna A

{"title":"Therapeutic Monitoring-Guided Dosing of Factor Viii in Hemophilia A: From Pharmacodynamics and Pharmacokinetics toward Precision Therapy","authors":"Fortuna A","doi":"10.23880/beba-16000185","DOIUrl":"https://doi.org/10.23880/beba-16000185","url":null,"abstract":"Hemophilia is a rare hypocoagulation disorder that, depending on the lacking coagulation cascade factor, has different denominations. This review focuses on Hemophilia A (HA), particularly on the FVIII concentrates that are available in clinical practice to replace the scarce levels of FVIII observed in these patients. In fact, pharmacological responses are strongly heterogenic namely due to disease evolution and FVIII concentrates pharmacokinetic profiles. Therefore, therapeutic drug monitoring (TDM) is essential to maximize FVIII effectiveness and decrease adverse event rates. We provide a critical overview of current FVIII concentrates their mechanistic and pharmacokinetic differences as well as the factors that determine those profiles. Precision dosing through therapeutic drug monitoring is expanding and is essential in populations with altered pharmacokinetics and/or pharmacodynamics. However, there is still a need for studies correlating pharmacokinetics and patient outcomes. Herein, a pharmacokinetic-based optimization of FVIII therapy was revised and in deeply explained hot it can be successfully applied in clinical practice.","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76841111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herceptin- A Revolutionary Tool among Personalized or Customized Medicines 赫赛汀——个性化或定制药物中的革命性工具

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000192

Anju Pg

{"title":"Herceptin- A Revolutionary Tool among Personalized or Customized Medicines","authors":"Anju Pg","doi":"10.23880/beba-16000192","DOIUrl":"https://doi.org/10.23880/beba-16000192","url":null,"abstract":"Our current medicinal practices are based on population averages. Medicines discovered in one research centre of a particular country and tested on animals and a broad population available there, are used for the treatment of worldwide population. Medicines are applying based on statistical averages gained from their randomized clinical trials. The drugs available in the world markets are only effective in 50% of the total population. Rest of them are taking medicines like placebo, means they do not produce any effects actually. It is due to the genetic differences. We all are different in every aspect. Our choices of food, our cloths, our dreams, ambitions, rituals, and cultures everything is different. But medical system prescribes drugs based on “one size fits to all”. How can that be sensible? Here comes the importance of personalized medicine. Personalized medicine or precise medicine (PM) is a newer approach of pharmacogenomics under progression. It is actually a customized kind of medicine meant for individual patients according to their genetic makeup. For that we thoroughly understand the patient details not only age and sex but in a detailed way including their genetical variations. So we can understand their drug responsiveness as early as possible. That’s why precise or personalised medicines are also called as genomic medicines. And it will also eliminate the time, cost and failures in the clinical trials which are serious issues that developing countries currently facing.","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78199849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Level of Awareness & Attentiveness Associated to Novel Corona Virus (Covid-19) among People of Pakistan 巴基斯坦人民对新型冠状病毒(Covid-19)的认识和关注程度

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000183

S. Alam

{"title":"Level of Awareness & Attentiveness Associated to Novel Corona Virus (Covid-19) among People of Pakistan","authors":"S. Alam","doi":"10.23880/beba-16000183","DOIUrl":"https://doi.org/10.23880/beba-16000183","url":null,"abstract":"Background: Corona viruses are huge family of viruses named for the crown-like spikes on their surface. There are seven CoV viruses which will infect humans, including the “2019 Novel Corona virus” (the infection right now making features), SARS and MERS.. Symptoms include fever, breathlessness, and coughing. The illness spreads through animals and shut contact with people that have already been infected currently the virus is spreading from person to person in China as many recent cases don't seem to be related to animal markets. Method: A cross sectional investigation about the attention of corona virus (CoV), its symptoms, diagnosis and treatment was directed in several groups of individuals i.e, literate and illiterate people of Pakistan. Data was collected by means of survey based questionnaire which was prepared by the pharmacy students of Jinnah University for Women. Result: According to demographic data obtained by the cross sectional investigation about the attention of corona virus in Pakistan which was conducted among literate and illiterate people (18-25 of age).Out of which 47.9% were medical students, among these people 92.6% knew about corona virus and 97.5% people knew about its person to person transmission, and 58.8% understand its symptoms in keeping with this survey only 23.5% people knew the treatment, 76.5% people didn’t even understand the diagnosis of corona virus. Conclusion: The motivation behind this study was to assemble the information about the extent of control of corona virus with improving knowledge awareness of CoV (COVID-19) to raised inform patients about this life threatening disease in health care systems.","PeriodicalId":8995,"journal":{"name":"Bioequivalence & Bioavailability International Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77986551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates in Gastroenterology: Acotiamide for Treatment of Functional Dyspepsia 胃肠病学最新进展:阿可替胺治疗功能性消化不良

Bioequivalence & Bioavailability International Journal Pub Date : 2023-01-04 DOI: 10.23880/beba-16000195

Bhalla A

引用次数: 0

Bioequivalence &amp; Bioavailability International Journal最新文献

Bioequivalence & Bioavailability International Journal最新文献