赫赛汀——个性化或定制药物中的革命性工具

Anju Pg
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摘要

我们目前的医疗实践是基于人口平均水平。在一个特定国家的一个研究中心发现的药物,并在那里的动物和广泛人群中进行试验,用于治疗全世界的人口。药物的应用是基于随机临床试验的统计平均值。世界市场上可获得的药物仅对50%的人口有效。其余的人服用的是安慰剂之类的药物,这意味着它们实际上不会产生任何效果。这是由于基因差异。我们在各个方面都是不同的。我们对食物的选择,我们的衣服,我们的梦想,抱负,仪式和文化一切都是不同的。但是,医疗系统开药方的基础是“一刀切”。这怎么可能是明智的呢?这就是个性化医疗的重要性。个性化医疗或精确医疗(PM)是一种正在发展的药物基因组学新方法。它实际上是一种根据个体患者的基因组成定制的药物。因此,我们不仅彻底了解患者的年龄和性别,而且还详细了解他们的基因变异。这样我们就可以尽早了解他们对药物的反应。这就是为什么精确的或个性化的药物也被称为基因组药物。它还将消除临床试验的时间、成本和失败,这些都是发展中国家目前面临的严重问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herceptin- A Revolutionary Tool among Personalized or Customized Medicines
Our current medicinal practices are based on population averages. Medicines discovered in one research centre of a particular country and tested on animals and a broad population available there, are used for the treatment of worldwide population. Medicines are applying based on statistical averages gained from their randomized clinical trials. The drugs available in the world markets are only effective in 50% of the total population. Rest of them are taking medicines like placebo, means they do not produce any effects actually. It is due to the genetic differences. We all are different in every aspect. Our choices of food, our cloths, our dreams, ambitions, rituals, and cultures everything is different. But medical system prescribes drugs based on “one size fits to all”. How can that be sensible? Here comes the importance of personalized medicine. Personalized medicine or precise medicine (PM) is a newer approach of pharmacogenomics under progression. It is actually a customized kind of medicine meant for individual patients according to their genetic makeup. For that we thoroughly understand the patient details not only age and sex but in a detailed way including their genetical variations. So we can understand their drug responsiveness as early as possible. That’s why precise or personalised medicines are also called as genomic medicines. And it will also eliminate the time, cost and failures in the clinical trials which are serious issues that developing countries currently facing.
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