International journal of biomedical nanoscience and nanotechnology最新文献_第3页

Generation of nanoparticles from technical powder of the insecticidal bacterium Bacillus thuringiensis var. kurstaki for improving efficacy 苏云金芽孢杆菌技术粉制备纳米颗粒提高杀虫效果

International journal of biomedical nanoscience and nanotechnology Pub Date : 2014-10-28 DOI: 10.1504/IJBNN.2014.065470

K. Murthy, V. Vineela, P. Devi

{"title":"Generation of nanoparticles from technical powder of the insecticidal bacterium Bacillus thuringiensis var. kurstaki for improving efficacy","authors":"K. Murthy, V. Vineela, P. Devi","doi":"10.1504/IJBNN.2014.065470","DOIUrl":"https://doi.org/10.1504/IJBNN.2014.065470","url":null,"abstract":"The technical powder of a local isolate of Bacillus thuringiensis (Bt) var. kurstaki namely DOR Bt-1 was subjected to high pressure homogenisation (HPH) to obtain nanoparticles (NPs) ranging 32–1,106 nm as determined through dynamic light scattering. NPs of Bt were also characterised for shape and size through scanning electron microscopy, field emission scanning electron microscopy and transmission electron microscopy that helped in visualising the smallest nanoparticles, i.e., less than even 50 nm. The larger particles comprised mainly Bt spores with a length and width of 1,139 and 813 nm respectively. HPH showed little effect on the spore viability. NPs had a zeta potential above +30 and were stable, resulted in higher mortality of Helicoverpa armigera larvae at a lower dose. Alkali solubilisation of the NPs resulted in higher values of protein and endotoxin quantified through Lowry’s method and ELISA respectively. This is indicative of an increased solubility of the toxin in the midgut alkaline fluid of the insect leading to higher mortality coupled with quicker kill. Thus Bt as NPs has brighter prospects for insect pest management with increased speed of kill at lower doses.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"3 1","pages":"236"},"PeriodicalIF":0.0,"publicationDate":"2014-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2014.065470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Green synthesis, characterisation and biological studies of silver nanoparticles using Dalbergia sissoides seeds and ecofriendly reduction of 4-nitrophenol 黄柏种子纳米银的绿色合成、表征和生物学研究及4-硝基酚的生态还原

International journal of biomedical nanoscience and nanotechnology Pub Date : 2014-10-28 DOI: 10.1504/IJBNN.2014.065475

N. Muniyappan, N. Nagarajan

{"title":"Green synthesis, characterisation and biological studies of silver nanoparticles using Dalbergia sissoides seeds and ecofriendly reduction of 4-nitrophenol","authors":"N. Muniyappan, N. Nagarajan","doi":"10.1504/IJBNN.2014.065475","DOIUrl":"https://doi.org/10.1504/IJBNN.2014.065475","url":null,"abstract":"Green synthesis of Ag nanoparticles (AgNPs) has been of great interest because of its potential nanomedical applications. In this study, Dalbergia sissoides seeds (DSS) served as a reducing as well as a stabilising agent simultaneously thereby necessitating no additional reagent or further treatment. Appearance of surface plasmon band at 432 nm within 35 sec of microwave irradiation indicated the formation of DSS-silver nanoparticles. TEM analysis showed the DSS-AgNPs to be almost spherical in shape with a size of 18 ± 2 nm. When evaluated for their in vitro antioxidant activity, the nanoparticles showed considerably better activity when compared to that of the standard and the plant extract. Evaluation of anti-inflammatory activity of DSS-AgNPs by in-vitro method at a concentration of 10 µg/ml showed considerably better activity (94.05%), when compared to that of the plant extract (85.45%). The synthesised silver nanoparticles were also found to be effective in catalytic reduction of 4-nitrophenol (4-NP) into 4-aminophenol (4-AP).","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"3 1","pages":"262"},"PeriodicalIF":0.0,"publicationDate":"2014-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2014.065475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The investigation of novel glucose oxidase biosensor based on graphene-clay nanocomposite 基于石墨烯-粘土纳米复合材料的新型葡萄糖氧化酶生物传感器研究

International journal of biomedical nanoscience and nanotechnology Pub Date : 2014-10-28 DOI: 10.1504/IJBNN.2014.065477

Khadijeh Eskandari, F. Gouranlou, M. Kamali, A. Morsali

引用次数: 1

Bio-based calcium carbonate (CaCO 3) nanoparticles for drug delivery applications 生物基碳酸钙(caco3)纳米颗粒药物递送应用

International journal of biomedical nanoscience and nanotechnology Pub Date : 2014-01-01 DOI: 10.1504/IJBNN.2014.065464

D. Render, V. Rangari, S. Jeelani, K. Fadlalla, T. Samuel

引用次数: 9

Nickel contamination on MWCNT is related to particle bioactivity but not toxicity in the THP-1 transformed macrophage model 在THP-1转化巨噬细胞模型中，MWCNT上的镍污染与颗粒生物活性有关，但与毒性无关

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.1504/IJBNN.2013.054509

R. Hamilton, T. Girtsman, Chengcheng Xiang, N. Wu, A. Holian

{"title":"Nickel contamination on MWCNT is related to particle bioactivity but not toxicity in the THP-1 transformed macrophage model","authors":"R. Hamilton, T. Girtsman, Chengcheng Xiang, N. Wu, A. Holian","doi":"10.1504/IJBNN.2013.054509","DOIUrl":"https://doi.org/10.1504/IJBNN.2013.054509","url":null,"abstract":"The potential pathogenic effects from exposure to various MWCNT have not been adequately determined. One potential contributing factor to MWCNT bioactivity could be metal contamination that occurs during production. This study examined the toxicity and bioactivity (NLRP3 inflammasome activation), of 24 commercially available MWCNT in a macrophage-like differentiated THP-1 cell line. Inflammasome activation, via IL-1β release, was highly correlated to Ni content. Soluble NiCl2 and insoluble Ni nanopowder were tested in the same model at varying concentrations with no inflammasome activation. Ni-decorated MWCNT were also tested in the THP-1 model and the results also correlated with Ni content. These results demonstrated that Ni content correlated to NLRP3 inflammasome activation, but not toxicity. Taken together, the results suggest that Ni, when fixed to MWCNT, is highly bioactive and potentially proinflammatory. The related mechanism probably involves lysosomal rupture, release of cathepsin B, and NLRP3 activation.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"3 1","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2013-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2013.054509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Engineered nanomaterial interactions with bilayer lipid membranes: screening platforms to assess nanoparticle toxicity 工程纳米材料与双层脂质膜的相互作用:评估纳米颗粒毒性的筛选平台

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.1504/IJBNN.2013.054512

A. Negoda, Y. Liu, Wen-Che Hou, C. Corredor, B. Y. Moghadam, C. Musolff, Lin Li, William O. Walker, P. Westerhoff, A. Mason, P. Duxbury, J. Posner, R. Worden

{"title":"Engineered nanomaterial interactions with bilayer lipid membranes: screening platforms to assess nanoparticle toxicity","authors":"A. Negoda, Y. Liu, Wen-Che Hou, C. Corredor, B. Y. Moghadam, C. Musolff, Lin Li, William O. Walker, P. Westerhoff, A. Mason, P. Duxbury, J. Posner, R. Worden","doi":"10.1504/IJBNN.2013.054512","DOIUrl":"https://doi.org/10.1504/IJBNN.2013.054512","url":null,"abstract":"Engineered nanomaterials (ENMs) have attractive functional properties and are increasingly being used in commercial products. However, ENMs present health risks that are poorly understood and difficult to assess. Because ENMs must interface with cell membranes to cause biological effects, improved methods are needed to measure ENM-biomembrane interactions. The goals of this paper are to review the current status of methods to characterise interactions between ENMs and bilayer lipid membranes that mimic cell membranes, and to present example applications of the methods relevant to nanotoxicology. Four approaches are discussed: electrochemical methods that measure ENM-induced ion leakage through lipid bilayers, optical methods that measure dye leakage from liposomes, partitioning methods that measure ENM distribution coefficients between aqueous solution and immobilised lipid bilayers, and theoretical models capable of predicting fundamental molecular interactions between ENMs and biomembranes. For each approach, current literature is summarised, recent results are given, and future prospects are analysed, including the potential to be used in a high-throughput mode. The relative advantages of the various approaches are discussed, along with their synergistic potential to provide multi-dimensional characterisation of ENM-biomembrane interactions for robust health risk assessment algorithms.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"3 1","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2013-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2013.054512","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Biosynthesis of monodispersed silver nanoparticles and their activity against Mycobacterium tuberculosis 单分散纳米银的生物合成及其抗结核分枝杆菌活性研究

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.4172/2155-983X.1000110

A. Banu, V. Rathod

引用次数: 42

Using zebrafish to study the biological impact of metal and metal oxide nanoparticles 利用斑马鱼研究金属和金属氧化物纳米颗粒的生物影响

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.1504/IJBNN.2013.054505

Ofek Bar-Ilan, R. Peterson, W. Heideman

引用次数: 1

Predictive toxicological paradigm and high throughput approach for toxicity screening of engineered nanomaterials 工程纳米材料毒性筛选的预测毒理学范式和高通量方法

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.1504/IJBNN.2013.054506

Bingbing Sun, Ruibin Li, Xiang Wang, T. Xia

引用次数: 9

Aggregation behaviour of carbon nanotubes in aqueous and physiological media and its influence on toxicity 碳纳米管在水和生理介质中的聚集行为及其对毒性的影响

International journal of biomedical nanoscience and nanotechnology Pub Date : 2013-06-19 DOI: 10.1504/IJBNN.2013.054510

S. A. Ntim, F. Witzmann, S. Mitra

引用次数: 2