International journal of biomedical nanoscience and nanotechnology最新文献_第7页

Synthesis, surface architecture and biological response of superparamagnetic iron oxide nanoparticles for application in drug delivery: a review 超顺磁性氧化铁纳米颗粒的合成、表面结构和生物响应研究进展

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-08-16 DOI: 10.1504/IJBNN.2010.034651

M. Mahmoudi, A. Milani, P. Stroeve

{"title":"Synthesis, surface architecture and biological response of superparamagnetic iron oxide nanoparticles for application in drug delivery: a review","authors":"M. Mahmoudi, A. Milani, P. Stroeve","doi":"10.1504/IJBNN.2010.034651","DOIUrl":"https://doi.org/10.1504/IJBNN.2010.034651","url":null,"abstract":"The biological and medical applications of superparamagnetic iron oxide nanoparticles (SPION) are increasing fast. Therefore, the reduction of toxicity of SPION, by using various surface coatings, has become a main research area. This review article presents a summary of recent research and data on well-characterised SPION with different surface coatings (dextran, polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyethylene glycol fumarate (PEGF), alginate, chitosan, albumin) along with cytotoxicity evaluation methods for drug delivery. The effect of the surface architecture of SPION in different delivery conditions is also reviewed. Cytotoxicity data are found to vary depending on the size, size distribution and surface derivatisation of SPION. In turn, these parameters depend on the methods of particle synthesis. The use of coprecipitation, microemulsions, thermal decomposition and hydrothermal synthesis are among the reviewed synthesis methods. Statistical techniques used for the optimisation of synthesis parameters have also been addressed.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"1 1","pages":"164"},"PeriodicalIF":0.0,"publicationDate":"2010-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2010.034651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

In vivo study of genotoxicity and teratogenicity of silica nanocrystals 二氧化硅纳米晶的遗传毒性和致畸性的体内研究

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034126

A. Durnev, A. Solomina, E. Shreder, E. P. Nemova, O. Shreder, Natalya O. l' Dauge, A. Zhanataev, V. A. Veligura, L. A. Osminkina, M. Gongalsky, Victor Yu. Timoshenko, Sergey S. Seredenin

{"title":"In vivo study of genotoxicity and teratogenicity of silica nanocrystals","authors":"A. Durnev, A. Solomina, E. Shreder, E. P. Nemova, O. Shreder, Natalya O. l' Dauge, A. Zhanataev, V. A. Veligura, L. A. Osminkina, M. Gongalsky, Victor Yu. Timoshenko, Sergey S. Seredenin","doi":"10.1504/IJBNN.2010.034126","DOIUrl":"https://doi.org/10.1504/IJBNN.2010.034126","url":null,"abstract":"The potential genotoxicity of silica nanocrystals (nc-Si) (size 2-7 nm with their agglomerates 5 μm) in mice and influence of nc-Si on the embryonal and the postnatal development of the rats were evaluated. No clastogenic effects were observed in bone marrow cells of mice intraperitoneally exposed to single doses of nc-Si 5, 25 and 50 mg/kg for 24 hr or to doses 5 and 25 mg/kg for seven and 14 days. Comet assay revealed a significant increase in tail DNA percentage in the bone marrow cells of mice treated with nc-Si at a single dose 5 mg/kg for 24 h and both in bone marrow and brain cells when nc-Si was used at a dose 50 mg/kg. There was no significant increase in DNA damage after a 3 h treatment with nc-Si at doses 5 and 25 mg/kg. Also, no elevated DNA damage was observed in mice exposed to nc-Si at 5 mg/kg dose for seven days. Dose of nc-Si at 50 mg/kg caused death of 40-60% of the animals within 2-3 days that made impossible evaluation genotoxicity in this dose at long-term exposure. Nc-Si injected intraperitoneally to rats at a dose of 50 mg/kg on the 1st, 7th and 14th days of pregnancy showed no teratogenicity and had no influence on postnatal development of pups. But negative influence on body weight gain in pregnant rats and newborns at some stages of the experiment was noticed.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"1 1","pages":"70-86"},"PeriodicalIF":0.0,"publicationDate":"2010-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2010.034126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A new approach to analyse effects of nanoparticles on lipid vesicles 纳米颗粒对脂质囊泡影响的新方法研究

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034124

Jernej Zupanc, J. Valant, D. Drobne, V. Kralj

{"title":"A new approach to analyse effects of nanoparticles on lipid vesicles","authors":"Jernej Zupanc, J. Valant, D. Drobne, V. Kralj","doi":"10.1504/IJBNN.2010.034124","DOIUrl":"https://doi.org/10.1504/IJBNN.2010.034124","url":null,"abstract":"Manufactured nanoparticles are potentially capable of inducing defects in lipid membranes. The effects of nanoparticles on cell membranes are one of the key issues in nanomedicine, nanotoxicology, food and pharmaceutical application of products of nanomaterials and others. Our aim is to demonstrate the nanoparticle - lipid vesicle interactions and to develop a controllable experimental setup for data acquisition. We studied interactions between nanoparticles (C60) and lipid vesicles (POPC), using ZnCl2 as a positive control. Light microscopy computer aided image segmentation was developed and population differences among vesicles incubated in different media were assessed. Data obtained by statistical image analysis methods revealed that nanoparticles (C60) caused changes in vesicle size distribution in the population of lipid vesicles as well as a burst of vesicles in time and in a concentration gradient. No significant changes in shape of vesicles were recorded. The advantage of the experimental set up presented here is that it employs statistical image analysis methods and direct microscopy observation of large populations of lipid vesicles. We discuss the applicability of this in vitro approach in analysing the effects of nanoparticles on simplified biological membranes.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"1 1","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2010-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2010.034124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The characterisation of the behaviour and gill toxicity of CdS/CdTe quantum dots in rainbow trout (Oncorhynchus mykiss) CdS/CdTe量子点对虹鳟鱼的行为和鳃毒性的研究

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034125

S. Louis, F. Gagné, J. Auclair, P. Turcotte, C. Gagnon, C. Emond

{"title":"The characterisation of the behaviour and gill toxicity of CdS/CdTe quantum dots in rainbow trout (Oncorhynchus mykiss)","authors":"S. Louis, F. Gagné, J. Auclair, P. Turcotte, C. Gagnon, C. Emond","doi":"10.1504/IJBNN.2010.034125","DOIUrl":"https://doi.org/10.1504/IJBNN.2010.034125","url":null,"abstract":"The increasing commercial application of nanomaterials is raising concerns about their potential release to aquatic environments. The purpose of this study was to examine the behaviour in freshwater of capped CdS/CdTe quantum dots and the sublethal effects on gills of rainbow trout. Rainbow trout (Oncorhynchus mykiss) were exposed to increasing concentrations of CdS/CdTe or dissolved cadmium (CdSO4) for 48 h at 15°C. The initial Cd and Te concentration in the aquarium water and size fractionation were determined. After the exposure period, the gills were analysed for labile Cd content, changes in lactate and pyruvate, total and redox status of metallothioneins (MT), lipid peroxidation, protein chaperones of the heat shock protein (Hsp) 72 family and ubiquitin conjugates. QDs were mostly between 6.8 and 25 nm suggesting aggregates. Significant increases in total and metal-binding MT, gill lactate and pyruvate levels and Hsp 72 proteins were observed while ubiquitin protein conjugates were significantly decreased by the QDs only with dissolved Cd, LPO and lactate/pyruvate ratio were not affected by the QDs. A discriminant function analysis of the biomarker responses revealed that colloidal and dissolved Cd differed significantly from each other, suggesting different modes of action.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"1 1","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2010-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2010.034125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Bio-safe approach for the preparation of magnesium oxide (MgO) nanoflowers at very low temperature 低温下制备氧化镁纳米花的生物安全方法

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034122

Shah, F. Marzouki

引用次数: 4

Lead oxide (PbO) nanoparticles prepared by a new technique for biomedical applications 新技术制备的氧化铅纳米颗粒在生物医学上的应用

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034121

Shah

引用次数: 7

Characterisation of nanoparticles resulting from different braking behaviours 由不同制动行为产生的纳米颗粒的表征

International journal of biomedical nanoscience and nanotechnology Pub Date : 2010-07-19 DOI: 10.1504/IJBNN.2010.034123

A. Perrenoud, Michael Gasser, B. Rothen‐Rutishauser, P. Gehr, M. Riediker

引用次数: 16

Histopathological and biochemical correlation of antidiabetic activity of zinc oxide nanoparticles after oral administration in Wistar rats Wistar大鼠口服氧化锌纳米颗粒抗糖尿病活性的组织病理学和生化相关性

International journal of biomedical nanoscience and nanotechnology Pub Date : 1900-01-01 DOI: 10.1504/ijbnn.2020.116334

S. Raut, C. Mote, G. Kulkarni

引用次数: 0