BJU International最新文献

{"title":"Reply to 'Comment on Bertini et al.: area deprivation and PSA screening disparities' and 'Comment on socioeconomic disparities in prostate cancer screening: the impact of the Area Deprivation Index on PSA screening frequency'.","authors":"Alessandro Bertini,Giuseppe Ottone Cirulli,Alex Stephens,Alessio Finocchiaro,Silvia Viganò,Giovanni Lughezzani,Nicolò Buffi,Vincenzo Ficarra,Andrea Salonia,Alberto Briganti,Francesco Montorsi,Akshay Sood,Craig Rogers,Firas Abdollah","doi":"10.1111/bju.16924","DOIUrl":"https://doi.org/10.1111/bju.16924","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"112 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal, bladder and prostate cancer surgery outcomes with respect to team familiarity.","authors":"Imogen A Roberts,Marcus G Cumberbatch,James W F Catto","doi":"10.1111/bju.16920","DOIUrl":"https://doi.org/10.1111/bju.16920","url":null,"abstract":"OBJECTIVESTo investigate outcomes in urological oncology according to team membership and familiarity.SUBJECTS/PATIENTSWe assessed peri-operative times, lengths of stay and re-admission rates in all patients undergoing surgery for prostate, bladder and kidney cancer at Sheffield Teaching Hospitals from 2021 to September 2024. Our analysis was performed with respect to staff pairs and a validated familiarity score (FS) derived using seven team members.RESULTSIn total, 1043 patients, 319 staff members and 3791 staff combinations were included. The mean (sd) FS for all cases was 14.2 (7.2), and was 13.7 (7.3), 9.3 (4.1) and 16.7 (7.1) for renal, bladder and prostate surgeries (anova, P < 0.001), respectively. Teams with higher familiarity had shorter times for all peri-operative intervals (anova, P < 0.041), shorter lengths of stay (1.94 vs 5.3 days; anova, P < 0.001) and fewer readmissions within 30 days (4.1% vs 8.0%; chi-squared test, P = 0.01). Greater familiarity led to savings of 26.2, 44.2 and 12.8 min for renal, bladder and prostate surgeries, respectively. In multiple regression, using preoperative features, greater familiarity was associated with fewer total case min (each 1-unit increase in FS equated to -1.88 min; 95% confidence interval -2.25 to -1.29; P < 0.001). Regarding team dyads, the greatest difference in total case duration was for the Surgeon #1/Surgeon #2 combination (average 40.8-min saving). Increased anaesthetic familiarity (with anaesthetic assistant) was associated with shorter anaesthetic room durations (anova, P = 0.007) and shorter delays leaving theatre (P < 0.001).CONCLUSIONGreater team familiarity was associated with faster surgical times and shorter lengths of stay. The time savings could be used to improve theatre usage and efficiency.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"8 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Dorsal- vs ventral-onlay buccal mucosal graft urethroplasty: a meta-analysis'.","authors":"Sherryn Sherryn, Bacilius Agung Priyosantoso, Jie Sun","doi":"10.1111/bju.16907","DOIUrl":"https://doi.org/10.1111/bju.16907","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter by Masali and Özbey","authors":"Niklas Pakkasjärvi, Annaleena Anttila, Seppo Taskinen","doi":"10.1111/bju.16917","DOIUrl":"https://doi.org/10.1111/bju.16917","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon footprint and staff demands of surgery and chemoradiation for muscle-invasive bladder cancer.","authors":"Vera C Rutten, Simone A W Hesseling, Martine Franckena, Tahlita C M Zuiverloon, Debbie G J Robbrecht, Maarten J IJzerman, Wenxin Lin, Daan Mes, Nicole Hunfeld, Joost L Boormans","doi":"10.1111/bju.16876","DOIUrl":"10.1111/bju.16876","url":null,"abstract":"<p><strong>Objective: </strong>To calculate the environmental and labour impact of two complete care pathways for patients with muscle-invasive bladder cancer (MIBC) with similar oncological outcomes: radical cystectomy (RC) and chemoradiation (CRT), by quantifying the total carbon footprint and staff demands.</p><p><strong>Patients and methods: </strong>The RC was robot-assisted surgery with pelvic lymph node dissection and ileal conduit. CRT included 20 fractions of 2/2.75 Gy with mitomycin C (Day 1) and capecitabine every radiation day. Waste audits identified medical products (n = 284), for which a cradle-to-gate environmental impact analysis was conducted from treatment selection to first post-treatment evaluation. Energy use was based on primary data, technical specifications or literature. Patient travel was based on the average distance, assuming petrol-fuelled cars. Staff demands were assessed by timing clinical staff assignment. The carbon footprint was calculated in CO₂-equivalents using the Ecoinvent Database 3.10.</p><p><strong>Results: </strong>The carbon footprint was 208 kg CO₂-equivalents for RC vs 264 kg CO₂-equivalents for CRT. The larger footprint of CRT arose from travel movements and energy use: 5- and 1.5-fold higher than RC, respectively. Main contributors to the total footprint were medical products for RC (49%), and patient travel for CRT (74%). A hotspot analysis identified 10 medical products with the highest impact, which accounted for 60% of the total impact of all medical products. RC averaged 93.5 staff hours per patient vs 29.0 staff hours per patient for CRT.</p><p><strong>Conclusions: </strong>This is the first study to analyse the environmental impact of complete care pathways in uro-oncology. Key strategies to reduce the carbon footprint of MIBC treatment include low-impact patient travel, reviewing high-impact surgical products, and using renewable energy by hospitals. Insight into staff demands per treatment assists efficient allocation of scarce personnel.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer","authors":"Michiel Vlaming, Wouter Koole, R. Jeroen A. van Moorselaar, Eveline M.A. Bleiker, Ellen van de Geer, Hanneke W.M. van Deutekom, Marjolijn J.L. Ligtenberg, Klaartje van Engelen, C. Marleen Kets, Lizet E. van der Kolk, Gina Schijven, Niven Mehra, M. Arjen Noordzij, Richard P. Meijer, Inge M. van Oort, Lambertus A.L.M. Kiemeney, Margreet G.E.M. Ausems","doi":"10.1111/bju.16916","DOIUrl":"https://doi.org/10.1111/bju.16916","url":null,"abstract":"ObjectiveTo assess the prevalence of germline pathogenic variants (gPVs) in genes associated with female breast cancer in Dutch patients with metastatic prostate cancer (mPCa).Patients and methodsIn this prospective multicentre cohort study (<jats:italic>n</jats:italic> = 15 centres), germline genetic testing of the genes <jats:italic>BRCA1</jats:italic>, <jats:italic>BRCA2</jats:italic>, <jats:italic>ATM</jats:italic>, <jats:italic>CHEK2</jats:italic> and <jats:italic>PALB2</jats:italic> was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it to a reference population of 16 823 individuals who underwent genetic testing for non‐oncological conditions. Additionally, we identified factors that increased the likelihood of carrying a gPV.ResultsA total of 779 patients with mPCa underwent germline genetic testing, of whom 46 (5.9%) had a gPV in a DNA damage repair gene. Most gPVs were found in <jats:italic>CHEK2</jats:italic> (1100delC variant), <jats:italic>ATM</jats:italic> and <jats:italic>BRCA2</jats:italic>, all significantly more prevalent than in the reference population (odds ratios 2.4, 2.8 and 3.1, respectively). The prevalence of gPVs in <jats:italic>BRCA1</jats:italic> and <jats:italic>PALB2</jats:italic> was not significantly increased. Patients with a second primary cancer, a first‐ or second‐degree relative with breast cancer at age &lt; 50 years, or pancreatic cancer, or Jewish ancestry had the highest likelihood of carrying a gPV.ConclusionWe found that gPVs in <jats:italic>CHEK2</jats:italic>, <jats:italic>ATM</jats:italic> and <jats:italic>BRCA2</jats:italic> were associated with men presenting with mPCa. Several factors increased the likelihood of carrying such a variant and, in these cases, healthcare professionals should be aware of the need to offer germline genetic testing.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"302 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydraulic and malleable female-to-male penile implants after phalloplasty in transgender individuals: a retrospective cohort analysis.","authors":"Maya Levy, Wouter B van der Sluis, Emma L van Abbema, Brechje L Ronkes, R Jeroen A van Moorselaar, Mark-Bram Bouman, Garry L S Pigot","doi":"10.1111/bju.16911","DOIUrl":"10.1111/bju.16911","url":null,"abstract":"<p><strong>Objectives: </strong>To provide a comprehensive summary of the surgical outcomes of Zephyr Surgical Implants (ZSI; Geneva, Switzerland) hydraulic and malleable female-to-male (FTM) penile implants (PIs) in transgender patients.</p><p><strong>Patients and methods: </strong>All transgender patients who underwent hydraulic (ZSI FTM 475) and malleable (ZSI FTM 100) erectile device implantation between January 2017 and March 2024 were retrospectively identified. Demographics, perioperative characteristics, postoperative complications, and re-operations were recorded. Postoperative outcomes of malleable and hydraulic PI implantation were compared and risk factors for early and late complications were identified.</p><p><strong>Results: </strong>A total of 50 transgender patients underwent 85 PI implantation procedures, including 50 primary and 35 secondary implantations. The postoperative infection rate was 15% for hydraulic PIs and 11% for malleable PIs (P = 0.83). In total, 66 hydraulic PIs and 19 malleable PIs were placed. The late complication rate encompassing dysfunction, malposition and erosion was 56% for the hydraulic PIs and 58% for the malleable PIs (P = 0.68), with a median (interquartile range) postoperative follow-up of 26±12 and 32±22 months (P = 0.22), respectively. The explantation-free survival rate at 3 years after implantation of the device was 39% for the hydraulic PIs compared to 31% for the malleable PIs (P = 0.64). Secondary PI implantations were associated with a significantly higher risk of complications compared to primary procedures (odds ratio 3.5, P = 0.03) regardless of the type of PI. Additionally, urethral lengthening increased the likelihood of late complications with a hazard ratio of 2.6 (95% confidence interval CI 1.3-5.0, P = 0.01).</p><p><strong>Conclusion: </strong>The ZSI FTM PIs display poor 3-year complication-free survival despite being tailored for implantation after phalloplasty. There were no significant differences in short- and long-term complication rates between malleable and hydraulic PIs. Notably, secondary PI implantation and urethral lengthening were linked to a significantly increased risk of late complications.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrarenal pressure and bacteraemia in ureterorenoscopy: clinical implications and future directions","authors":"Ruolan Tan, Yulin Hu","doi":"10.1111/bju.16919","DOIUrl":"https://doi.org/10.1111/bju.16919","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"118 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance avelumab in metastatic urothelial carcinoma: do tumour site and previous surgery matter?","authors":"Ruslan Zukov, Yana Gridneva, Yulia Anzhiganova, Alexander Sultanbaev, Mark Gluzman, Anastasia Mochalova, Alexey Shkurat, Edgar Israelyan, Elvira Parsadanova, Yulia Murzina, Aleksei Ivanov, Alexey Kalpinskiy, Olesia Stativko, Vladislav Petkau, Elena Karabina, Artyom Kеln, Natalya Tovbik, Sufia Safina, Maria Turganova, Evgeny Kopyltsov, Varvara Bragina, Olga Novikova, Andrei Lebedinets, Vladislav Vodolazskiy, Alexey Rumyantsev, Ilya Pokataev, Rashida Orlova, Maria Volkova, Ilya Tsimafeyeu","doi":"10.1111/bju.16921","DOIUrl":"https://doi.org/10.1111/bju.16921","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"106 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: ‘Sexual function in adolescence after childhood hypospadias repair: a patient‐reported outcome’","authors":"Burak Maşalı, Hüseyin Özbey","doi":"10.1111/bju.16918","DOIUrl":"https://doi.org/10.1111/bju.16918","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"13 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}