BJOG: An International Journal of Obstetrics & Gynaecology最新文献_第8页

A Core Outcome Set for Studies of Intrahepatic Cholestasis of Pregnancy: Results of International e-Delphi and Consensus Processes. 妊娠期肝内胆汁淤积研究的核心结果集：国际e-Delphi和共识过程的结果。

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2026-01-09 DOI: 10.1111/1471-0528.70144

Nadejda Capatina,William Hague,Jenny Chambers,Catherine Williamson,Caroline Ovadia

{"title":"A Core Outcome Set for Studies of Intrahepatic Cholestasis of Pregnancy: Results of International e-Delphi and Consensus Processes.","authors":"Nadejda Capatina,William Hague,Jenny Chambers,Catherine Williamson,Caroline Ovadia","doi":"10.1111/1471-0528.70144","DOIUrl":"https://doi.org/10.1111/1471-0528.70144","url":null,"abstract":"OBJECTIVETo define standardised outcomes, the Core Outcome Set (COS) for reporting in studies of Intrahepatic Cholestasis of Pregnancy (ICP).DESIGNe-Delphi survey and consensus process.SETTINGInternational.POPULATION155 individuals from Asia, Europe, Oceania, North and South America: 31 patients (20%), 121 clinicians (78%), and 3 researchers (2%).METHODSMaternal and perinatal outcomes reported in studies of ICP were collated. Stakeholders in ICP research and clinical care scored the importance of each outcome using a 9-point Likert scale over three rounds; short-listed outcomes were ranked during face-to-face consensus meetings. The final COS was agreed by the Study Steering Committee. The study was registered prospectively with Core Outcome Measures in Effectiveness Trials. Ethical approval was granted by the King's College London Research Ethics Committee (KCL MRA-23/24-39574).MAIN OUTCOME MEASURESFrom 54 manuscripts, 97 individual clinical outcomes were attributed to ICP. Twenty three outcomes were shortlisted by the e-Delphi surveys, the ranking of which enabled selection of 10 core outcomes.RESULTSMaternal core outcomes comprise: total maternal bile acid (BA) concentration (maximum), gestational age at peak BA concentration, and itch impact on maternal wellbeing. Birth core outcomes comprise: stillbirth, gestational age at birth, and spontaneous preterm birth versus induced preterm birth. Neonatal core outcomes comprise: perinatal death within 7 days of birth, perinatal asphyxia, neonatal unit admission, and mechanical ventilation.CONCLUSIONSGiven the heterogeneity of reported outcomes, we have confirmed the need for a COS in ICP, standardising the minimum reported outcomes to reduce outcome reporting bias and research wastage.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Interpreting Maternal Myo‐Inositol Intake and Congenital Heart Defects: Methodological Considerations 解释母体肌醇摄入与先天性心脏缺陷：方法学考虑

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2026-01-09 DOI: 10.1111/1471-0528.70146

Rüyam Ercenk, Selma Beyza Bilgiç, İbrahim Karaca

引用次数: 0

Infertility Burden Attributable to Maternal Sepsis and Other Infections With Projections to 2050 预测到2050年由产妇败血症和其他感染引起的不孕负担

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2026-01-05 DOI: 10.1111/1471-0528.70140

Run Miao, Ning Zhang, Yuzhou Gao, Haoyu He, Dongmei Ji

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Clarifying Time‐to‐Event Methods for Delivery Timing After PPROM 澄清PPROM后交货时间的时间到事件方法

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2026-01-05 DOI: 10.1111/1471-0528.70134

Arash Mohazzab, Safdar Masoumi

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Temporal Bias in Predicting Adverse Perinatal Outcomes in Dichorionic Twins 预测双绒毛膜双胞胎不良围产期结局的时间偏差

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-12-27 DOI: 10.1111/1471-0528.70102

David Wright, Alan Wright, Kypros H. Nicolaides

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Risk Factors for Readmission Following Minimally Invasive Hysterectomy for Benign Indications in the United States—Outpatient and Inpatient Setting 美国微创子宫切除术良性适应症后再入院的危险因素-门诊和住院情况

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-12-22 DOI: 10.1111/1471-0528.70123

Raanan Meyer, Susie Lau, Shannon Salvador, Yosef Nasseri, Moshe Barnajian, Gabriel Levin

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Effect of Targeted Aspirin After First‐Trimester Preeclampsia Screening on Preterm Birth: Interpreting a Neutral Signal 早三个月子痫前期筛查后靶向阿司匹林对早产的影响：解读中性信号

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-12-16 DOI: 10.1111/1471-0528.70117

Ruijuan Chen, Jingni Zhao, Binglin Li

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ERAP2 as a Potential Marker for Ovarian Ageing and Spontaneous Ovulation Recovery in Women With Premature Ovarian Insufficiency. ERAP2作为卵巢衰老和卵巢功能不全女性自发排卵恢复的潜在标志物

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-12-04 DOI: 10.1111/1471-0528.70105

Tingting Meng,Yunju Jo,Shibo Wei,Hanbing Zhu,Changjing Wang,Shutong Meng,Hyun Joo Lee,Jongkil Joo,Jiangtao Zhang,Daimin Wei,Zi-Jiang Chen,Dongryeol Ryu,Yingying Qin,Xue Jiao

{"title":"ERAP2 as a Potential Marker for Ovarian Ageing and Spontaneous Ovulation Recovery in Women With Premature Ovarian Insufficiency.","authors":"Tingting Meng,Yunju Jo,Shibo Wei,Hanbing Zhu,Changjing Wang,Shutong Meng,Hyun Joo Lee,Jongkil Joo,Jiangtao Zhang,Daimin Wei,Zi-Jiang Chen,Dongryeol Ryu,Yingying Qin,Xue Jiao","doi":"10.1111/1471-0528.70105","DOIUrl":"https://doi.org/10.1111/1471-0528.70105","url":null,"abstract":"OBJECTIVETo explore novel biomarkers for clinical prognosis in patients with ovarian ageing, especially in premature ovarian insufficiency (POI).DESIGNProspective Cohort Study.SETTINGReproductive Hospital Affiliated with Shandong University, China.POPULATIONSixty POI patients and 60 control women recruited from 2018 to 2019.METHODSMachine learning algorithms were used to screen features of ovarian ageing from public ovarian transcriptome data. The candidate serum biomarker, endoplasmic reticulum aminopeptidase-2 (ERAP2), was compared between 60 POI patients and 60 control women. A prospective follow-up of 4 years was conducted on POI patients, and prediction models were established for intermittent recovery of ovarian function and clinical pregnancy based on serum ERAP2 levels.MAIN OUTCOME MEASURESIntermittent recovery of ovarian function and clinical pregnancy.RESULTSMachine learning models identified ERAP2 as a novel biomarker associated with ovarian ageing. POI patients exhibited significantly elevated serum ERAP2 levels compared to controls (5.78 ± 2.29 ng/mL vs. 4.81 ± 2.20 ng/mL, p = 0.018). With a prospective follow-up of these POI patients, ERAP2 was found to be a new biomarker for predicting intermittent recovery of ovarian function (AUROC = 0.763, 95% CI 0.734-0.792) and clinical pregnancy (AUROC = 0.768, 95% CI 0.749-0.787). Integrating ERAP2 into existing indices significantly improved their prediction accuracy both in predicting intermittent recovery of ovarian function (IDI = 0.166, p = 0.008) and in clinical pregnancy (NRI = 0.442, p = 0.034; IDI = 0.208, p = 0.018).CONCLUSIONSSerum ERAP2 can serve as a biomarker for intermittent recovery of ovarian function and clinical pregnancy in patients with POI. Combining ERAP2 with other clinical indicators may facilitate personalised intervention strategies for patients with POI in clinic.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"365 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145664282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Metformin and Hyperemesis Gravidarum: Reframing a Metabolic Disorder Through the Lens of Placental Adaptation 二甲双胍和妊娠剧吐：通过胎盘适应镜头重构代谢紊乱

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-11-11 DOI: 10.1111/1471-0528.70086

Nav La, Schawanya K. Rattanapitoon, Chutharat Thanchonnang, Nathkapach K. Rattanapitoon

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Evaluating Fetal Well‐Being at Labor Onset: Is Intermittent Auscultation Enough? 评估分娩时胎儿的健康状况：间歇听诊是否足够？

BJOG: An International Journal of Obstetrics & Gynaecology Pub Date : 2025-11-11 DOI: 10.1111/1471-0528.70085

Charles Garabedian, Paul Guerby, Paul Berveiller

引用次数: 0