BJOG: An International Journal of Obstetrics & Gynaecology最新文献

{"title":"Metformin for the Prevention of Hyperemesis Gravidarum: An Observational Cohort Study","authors":"Laure Sillis, Essi Whaites Heinonen, Michael Ceulemans, Diana Johnson, Yunjun Luo, Christina D. Chambers","doi":"10.1111/1471-0528.18238","DOIUrl":"https://doi.org/10.1111/1471-0528.18238","url":null,"abstract":"To evaluate if metformin treatment prior to pregnancy reduces the likelihood of nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) compared to no exposure.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Aspirin Adherence for Effective Pre-Eclampsia Prevention","authors":"Raya Vinogradov, Stephen Robson","doi":"10.1111/1471-0528.18236","DOIUrl":"https://doi.org/10.1111/1471-0528.18236","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Anaemia Among Women of Childbearing Age: Temporal Trends, Inequalities and Projections Using the Global Burden of Disease 2021.","authors":"Jianjun Bai,Junyan Xi,Yining Xiang,Yongyue Wei,Xiao Lin,Yuantao Hao","doi":"10.1111/1471-0528.18223","DOIUrl":"https://doi.org/10.1111/1471-0528.18223","url":null,"abstract":"OBJECTIVETo analyse temporal trends, inequalities and projections in anaemia burden among women of childbearing age (WCBA).DESIGNPopulation-based study.SETTINGData from the Global burden of Disease (GBD) Study.POPULATIONWCBA (ages 15-49) diagnosed with anaemia.METHODSAccording to the GBD study, original data sources, including population-based surveys, scientific studies and government reports, were synthesised to estimate WCBA anaemia prevalence and years lived with disability (YLD). We extracted annual estimates with 95% uncertainty intervals (UIs) from 1990 to 2021 and assessed relative prevalence risks by age, period and cohort. Inequality was evaluated via sociodemographic index (SDI). The Bayesian age-period-cohort model was used to predict progress toward the 2030 prevalence halving target.MAIN OUTCOMES MEASURESThe burden of WCBA anaemia.RESULTSDespite population growth increasing total case numbers, the global age-standardised prevalence rate of WCBA anaemia declined from 35.64% (95% UI: 34.16 to 37.37) in 1990 to 33.77% (32.10-35.55) in 2021. Socioeconomic disparities persisted, with a stable concentration index around -0.21 over time, indicating sustained inequality disadvantaging lower-SDI countries, especially in Western and Central Sub-Saharan Africa and South Asia. Despite reductions in period/cohort prevalence risks, projections indicated insufficient progress toward the 2030 target.CONCLUSIONThe persistent global burden, inequalities and insufficient progress in addressing WCBA anaemia continue to call for improving anaemia management, contextually tailored, multisectoral nutritional and non-nutritional interventions to achieve the 2030 target.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Diagnosis of Foetal Structural Anomalies Using Medium-Coverage Whole Genome Sequencing (CMA-Seq): A Large-Scale Comparative Study With CMA in 3973 Pregnancies.","authors":"Yan Jiang,Fang Liu,Lijuan Zhong,Rong Zhong,Mingxing Liang,Lin Ma,Victor Wei Zhang,Baixue Chen,Qian Zhang,Lei Xu,Wei Zhou","doi":"10.1111/1471-0528.18222","DOIUrl":"https://doi.org/10.1111/1471-0528.18222","url":null,"abstract":"OBJECTIVETo evaluate the feasibility and effectiveness of medium-coverage whole genome sequencing (CMA-seq) for prenatal diagnosis of foetal structural anomalies, and to compare its performance with conventional chromosomal microarray analysis (CMA).DESIGNA prospective clinical study combined with a systematic meta-analysis.SETTINGA tertiary maternal and child health hospital in Chongqing, China.POPULATION OR SAMPLE3973 pregnant women with ultrasound-detected foetal structural anomalies or other high-risk indications.METHODSSpecimens were collected through amniocentesis, followed by CMA-seq to identify a wide range of chromosomal abnormalities. Meta-analysis was used to study the application and effectiveness of CMA in prenatal diagnosis. Clinical studies were screened in Chinese and English databases, and a meta-analysis was performed.MAIN OUTCOME MEASURESDetection rates for chromosomal abnormalities, including mosaic aneuploidy, small copy number variants (CNVs < 100 kb) and absence of heterozygosity.RESULTSCMA-seq identified chromosomal abnormalities in 24.72% (982/3973) of cases. Mosaic aneuploidy was detected in 6.5% of samples (42 cases < 30% mosaicism). A total of 670 cases were presented with CNVs, including 40 below 100 kb. AOH was found in 112 cases (2.82%). The meta-analysis indicated a lower pooled chimeric chromosome detection rate (1.10%), a smaller proportion of CNVs < 500 kb (2.06%), and reduced AOH detection (1.26%) with conventional CMA.CONCLUSIONCMA-seq exhibits significant advancements and superior sensitivity in detecting low-level mosaic aneuploidy, small segment CNVs and AOH.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a Prediction Model for Adverse Perinatal Outcomes in Foetal Growth Restriction Based on a Machine Learning Algorithm: A Retrospective Study.","authors":"Xiangli Meng,Lei Wang,Minghui Wu,Na Zhang,Xiaofei Li,Qingqing Wu","doi":"10.1111/1471-0528.18226","DOIUrl":"https://doi.org/10.1111/1471-0528.18226","url":null,"abstract":"OBJECTIVETo create and validate a machine learning (ML)-based model for predicting the adverse perinatal outcome (APO) in foetal growth restriction (FGR) at diagnosis.DESIGNA retrospective study.SETTINGMulti-centre in China.POPULATIONPregnancies affected by FGR.METHODSWe enrolled singleton foetuses with a perinatal diagnosis of FGR who were admitted between January 2021 and November 2023. A total of 361 pregnancies from Beijing Obstetrics and Gynecology Hospital were used as the training set and the internal test set. In comparison, data from 50 pregnancies from Haidian Maternal and Child Health Hospital were used as the external test set. Feature screening was performed using the random forest (RF), the Least Absolute Shrinkage and Selection Operator (LASSO) and logistic regression (LR). Subsequently, six ML methods, including Stacking, were used to construct models to predict the APO of FGR.MAIN OUTCOME MEASURESModel's performance was evaluated through indicators such as the area under the receiver operating characteristic curve (AUROC). The Shapley Additive Explanation analysis was used to rank each model feature and explain the final model.RESULTSMean ± SD gestational age at diagnosis was 32.3 ± 4.8 weeks in the absent APO group and 27.3 ± 3.7 in the present APO group. Women enrolled in the present APO group had a higher rate of hypertension related to pregnancy (74.8% vs. 18.8%, p < 0.001). Among 17 candidate predictors (including maternal characteristics, maternal comorbidities, obstetric characteristics and ultrasound parameters), the integration of RF, LASSO and LR methodologies identified maternal body mass index, hypertension, gestational age at diagnosis of FGR, estimated foetal weight (EFW) z score, EFW growth velocity and abnormal umbilical artery Doppler (defined as a pulsatility index above the 95th percentile or instances of absent/reversed diastolic flow) as significant predictors. The Stacking model demonstrated a good performance in both the internal test set [AUROC: 0.861, 95% confidence interval (CI), 0.838-0.896] and the external test set [AUROC: 0.906, 95% CI, 0.875-0.947]. The calibration curve showed high agreement between the predicted and observed risks. The Hosmer-Lemeshow test for the internal and external test sets was p = 0.387 and p = 0.825, respectively.CONCLUSIONSThe ML algorithm for APO, which integrates maternal clinical factors and ultrasound parameters, demonstrates good predictive value for APO in FGR at diagnosis. This suggested that ML techniques may be a valid approach for the early detection of high-risk APO in FGR pregnancies.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Predicting Preterm Birth: An Evolving Landscape\".","authors":"","doi":"10.1111/1471-0528.18183","DOIUrl":"https://doi.org/10.1111/1471-0528.18183","url":null,"abstract":"","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Genetic polymorphisms influencing antihypertensive drug responses”","authors":"","doi":"10.1111/bph.70013","DOIUrl":"https://doi.org/10.1111/bph.70013","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enabling Evaluation of Self-Care Post Pregnancy Hypertension.","authors":"Abi Merriel","doi":"10.1111/1471-0528.18232","DOIUrl":"https://doi.org/10.1111/1471-0528.18232","url":null,"abstract":"","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caution Needed When Applying and Interpreting Causal Decompositions.","authors":"Jeffrey N Bone","doi":"10.1111/1471-0528.18231","DOIUrl":"https://doi.org/10.1111/1471-0528.18231","url":null,"abstract":"","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy‐Related Venous Thromboembolism Risk Perception and Prevention in Risk‐Averse Times—Significant Change Required: a Commentary","authors":"Laura A. Magee, Roopen Arya, Clare Boag, Luci Buxton, Matthew A. Coleman, Fizzah Jivraj, Rebecca Scott, Kayleigh Sheen, Sergio A. Silverio, Peter von Dadelszen","doi":"10.1111/1471-0528.18229","DOIUrl":"https://doi.org/10.1111/1471-0528.18229","url":null,"abstract":"Between 2020 and 2022 in the United Kingdom (UK), there were 45 maternal deaths from venous thromboembolism (VTE), out of more than 2 million maternities. This occurred despite extensive risk assessment and prescribing of low molecular weight heparin (LMWH) thromboprophylaxis, alongside clinicians' overestimate of risk and commitment to the cause. Whilst every maternal death is a tragedy, the challenge ahead is immense—to identify, in an efficient and consistent way, those few women at risk of life‐threatening thrombosis, and then minimise that risk with a cost‐effective therapy that is acceptable to pregnant and postpartum women, and does not do more harm than good. We propose a way forward.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}