BJOG: An International Journal of Obstetrics & Gynaecology最新文献

{"title":"Peritoneal Fluid‐Derived Small Extracellular Vesicle Proteins as Potential Biomarkers for Endometriosis: A Case–Control Study","authors":"Hannah M. Nazri, Roman Fischer, Joel Steele, Sanjiv Manek, Kavita S. Subramaniam, Benedikt M. Kessler, Krina T. Zondervan, Thomas T. Tapmeier, Christian M. Becker","doi":"10.1111/1471-0528.70334","DOIUrl":"https://doi.org/10.1111/1471-0528.70334","url":null,"abstract":"Objective To demonstrate the presence of peritoneal fluid (PF)‐derived small extracellular vesicles (sEVs) in endometriosis and control samples, to characterise their protein content and to define endometriosis‐specific biomarkers within the sEV proteome. Design Case–control experimental study. Setting Academic endometriosis centre. Sample PF samples from women between 18 and 49 years old ( <jats:italic>n</jats:italic> = 63). Methods sEVs were enriched using size exclusion chromatography (SEC), and characterised by nanoparticle tracking analysis (NTA), immunoblotting and mass spectrometry, according to surgically‐defined disease stage and cycle phase (control, rASRM stages I–II and III–IV endometriosis, in proliferative, secretory, and menstrual phases). FragPipe was used for protein identification. Main Outcome Measures Protein content of sEVs from control and endometriosis PF samples. Results sEVs were identified in PF of women by NTA, immunoblotting and mass spectrometry. Four proteins were significantly different across all samples: fructose‐bisphosphate aldolase A (ALDOA: 3.12‐fold increase in control samples, <jats:italic>p</jats:italic> = 0.0164), heat shock protein 90‐alpha (HSP90AA1: 2.14‐fold increase in control samples, <jats:italic>p</jats:italic> = 0.0245), collagen alpha‐1 (XV) chain (COL15A1: 1.83‐fold increase in control samples, <jats:italic>p</jats:italic> = 0.0421), and protein S100‐A10 (2.54‐fold increase in endometriosis samples, <jats:italic>p</jats:italic> = 0.0421). Conclusions PF‐derived sEVs differ between endometriosis and control patients. Concentrations vary regardless of cycle phase and disease stage, and this difference appears to be reflected in the proteomics analysis. However, higher sampling numbers are needed to confirm findings and functional assays to be performed delineate sEV function in endometriosis pathophysiology. Correlating PF‐derived sEV proteins with those in blood or urine could help further understand endometriosis and lead to the identification of biomarkers for diagnosis.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Term Birth in First Nations Women: A Retrospective Cohort Study","authors":"Kate Jarrett, Kylie Crawford, Jesrine Hong, Davina Smith, Kym M. Rae, Vicki Clifton, Vicki Flenady, Nicole Hewlett, Sailesh Kumar","doi":"10.1111/1471-0528.70336","DOIUrl":"https://doi.org/10.1111/1471-0528.70336","url":null,"abstract":"Objective To ascertain factors that predict term birth in a large cohort of First Nations women in their first pregnancy. We also developed a prenatal clinical scoring rule to facilitate calculation of personalized probabilities for term birth. Design Retrospective cohort study. Setting 2000–2022 in Queensland, Australia. Population 1 350 473 births over the study period, of which 30 509 were First Nations nulliparous women. Methods We ascertained factors predicting term birth exclusively within nulliparous First Nations women. Candidate predictors were clinically relevant information available antenatally. We developed an internally validated logistic regression model allocating points for the presence of clinical predictors, facilitating personalized probability of term birth. Main Outcome Measures Term birth (≥ 37 weeks). Results There were 27 310 term births and 3489 preterm births. After excluding stillbirths, 89% (27 255/30509) had a term birth and 11% (3254/30509) had preterm birth. Of the preterm births, 57% (1865/3254) were spontaneous and 43% (1389/3254) were medically indicated. Term birth was significantly associated with singleton pregnancies (OR 24.64, 95% CI 20.13–30.17), absence of major fetal abdominal wall (OR 11.19, 95% CI 6.62–18.91) or cardiac abnormalities (OR 2.51, 95% CI 1.90–3.31), maternal age &lt; 30 years, spontaneous conception, nil substance use, non‐small for gestational age fetus, female infant sex, absence of amniotic fluid abnormalities, chorioamnionitis (OR 11.22, 95% CI 8.20–15.34), antepartum placental abruption (OR 10.93, 95% CI 8.12–14.70) and major medical co‐morbidities. Term birth was associated with ≥ 5 antenatal visits, residence in a metropolitan area and higher socioeconomic status. Conclusions Many factors that influence term birth in First Nations women are amenable to culturally safe and responsive supports.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuity of Maternity Care","authors":"Emily J. Callander, Joanne Enticott, Helena J. Teede","doi":"10.1111/1471-0528.70317","DOIUrl":"https://doi.org/10.1111/1471-0528.70317","url":null,"abstract":"","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Proteinuria and Pregnancy Outcomes in Women With Preterm Pre‐Eclampsia Undergoing Expectant Management: Secondary Analysis of Two Randomised Trials","authors":"Amy van Rooyen, Lina Bergman, Henrik Imberg, Denise Sproul, Susan P. Walker, Stephen Tong, Catherine A. Cluver","doi":"10.1111/1471-0528.70335","DOIUrl":"https://doi.org/10.1111/1471-0528.70335","url":null,"abstract":"Objective Evaluate whether proteinuria levels, in women undergoing expectant management for pre‐eclampsia, are associated with pregnancy latency and adverse outcomes. Design Secondary analysis of data from two randomised trials. Setting Tygerberg Hospital, Cape Town, South Africa. Population Women undergoing expectant management for pre‐eclampsia diagnosed between 26 and 32 weeks. Methods Latency was analysed using parametric time‐to‐event methods to estimate increases. Composite outcomes were assessed using Poisson regression. Main Outcome Measures Pregnancy latency Composite adverse maternal or perinatal outcomes. Results Two hundred and ninety‐one women were included. Women with &lt; 3 g/24 h had a median prolongation of 15.3 days (interquartile range (IQR) 4.3 to 25.6), compared to 10.0 days (IQR 5.0 to 19.6) with proteinuria between 3 to 5 g/24 h; and 4.9 days (IQR 3.8 to 11.7) for those with ≥ 5 g/24 h. Increasing levels were also associated with increases in subsequent adverse composite maternal outcomes: 8.8% of women with &lt; 3 g/24 h experienced maternal complications, compared to 16.1% with 3 to 5 g/24 h, and 27.9% with ≥ 5 g/24 h. There was no association with composite perinatal adverse outcomes. The sFlt‐1/PIGF ratio performed slightly better in predicting latency (area under the receiver operating characteristic curve (AUC) 0.78 vs. 0.67) but similarly in predicting adverse composite maternal outcomes (AUC 0.67 vs. 0.64). Both had poor performance for predicting composite adverse perinatal outcomes (AUC 0.61 vs. 0.56). Conclusion Levels of proteinuria strongly correlate with pregnancy latency and adverse maternal outcomes, but not perinatal outcomes, in women with pre‐eclampsia undergoing expectant management. They perform similarly to angiogenic markers. Proteinuria levels may confer useful prognostic information to assist clinical decision‐making.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Prevalence and Incident HPA ‐1a Alloimmunisation in Pregnancy: A Prospective, Multi‐Ethnic, Natural History Study","authors":"Vasilis Sitras, Emilie Vander Haar, Russell Miller, Gwen Allen, Sara Alson, Roisin Armstrong, Dawn Black, Michael P. Bombara, David Dhanraj, Akash Gupta, Laura Hart, Katherine Kohari, Laura E. Lawrence, Helena Litorp, Hector Mendez‐Figueroa, Surabhi Nanda, Michael Paidas, Kristy Palomares, Robin Perry, Romy Pothof, Ekkehard Schleussner, Daniel Skupski, Eva Wiberg‐Itzel, Shauna F. Williams, Heidi Tiller, Joanne Verweij, James B. Bussel","doi":"10.1111/1471-0528.70326","DOIUrl":"https://doi.org/10.1111/1471-0528.70326","url":null,"abstract":"Objective Foetal‐neonatal alloimmune thrombocytopaenia (FNAIT) is a rare disease, most commonly caused by maternal alloantibodies to human platelet antigen (HPA)‐1a that can result in severe bleeding. The present study was designed to determine the frequency of higher risk for HPA‐1a alloimmunisation and development of FNAIT among a racially and ethnically diverse cohort of pregnant women. Design Longitudinal, prospective, non‐interventional, natural history study. Setting Conducted across 28 sites in North America and Europe. Population Pregnant women (≥ 18 years) with no history of FNAIT. Methods Blood samples were collected at 10–14 weeks' gestation and a sequential screening algorithm applied: maternal HPA‐1a/1b genotyping, human leukocyte antigen [HLA]‐DRB3*01:01 allele status, anti‐HPA‐1a antibody status and foetal HPA‐1 genotype. Main Outcome Measures Number of women at higher risk for HPA‐1a alloimmunisation (i.e., those who are HPA‐1b/b, HLA‐DRB3*01:01 positive, anti‐HPA‐1a antibody negative and carrying an HPA‐1a‐positive foetus) that alloimmunise. Results Of the 14 114 participants screened, 1.7% were HPA‐1b/1b genotype, which varied according to race and geography. Of 24 women at higher risk for FNAIT, five were lost to follow‐up with no post‐partum test for alloimmunisation. At Week 10 post‐partum, 2/19 higher risk participants (11%; 95% confidence interval [CI]: 1.3%, 33.1%) demonstrated anti‐HPA‐1a antibodies, while 17 remained negative. Pre‐existing anti‐HPA‐1a antibodies were identified in 18 other HPA‐1bb, DRB3*01:01 positive women at screening. Conclusions This prospective study confirms the rarity of a population at higher risk for HPA‐1a alloimmunisation and FNAIT, describes the risk among Black and Asian women, and establishes a rigorous methodology to assess for risk of HPA‐1a immunisation.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre‐Procedure Predictors of Six‐Month Survival After Fetoscopic Laser Ablation for Twin–Twin Transfusion Syndrome ( TTTS ): Retrospective Observational Study","authors":"Yang Huang Grace Ng, Prakesh S. Shah, Seungwoo Lee, Nimrah Abbasi, Johannes Keunen, Homero Flores‐Mendoza, Tim Van Mieghem, Rory Windrim, Greg Ryan","doi":"10.1111/1471-0528.70332","DOIUrl":"https://doi.org/10.1111/1471-0528.70332","url":null,"abstract":"Objective To determine pre‐procedure maternal, pregnancy and fetal factors associated with survival until 6 months of age and evaluate temporal trends in survival outcomes over a 25‐year period following fetoscopic laser ablation (FLA) of placental anastomoses in monochorionic twin pregnancies with twin–twin transfusion syndrome (TTTS). Design Retrospective observational study. Settings A tertiary care fetal centre in Canada. Population or Sample One thousand and five patients undergoing TTTS between 1998 and 2023. Methods Patient demographics, pregnancy, procedural and outcome details were collected. Predictors for single and dual survival were identified using multivariable logistic regression. Temporal trends in survival outcomes across the study period were also examined. Main Outcome Measures Fetal/neonatal survival at 6 months and predictors for single and dual survival. Results Of 915 included fetoscopies, 597 pregnancies (65.2%) achieved dual survival, 217 (23.9%) had a single survivor, and 101 (11%) resulted in dual demise. Survival rates improved significantly over the 25‐year study period for both single and dual survival ( <jats:italic>p</jats:italic> = 0.03 and <jats:italic>p</jats:italic> = 0.0004, respectively). Three significant pre‐procedural predictors of dual demise versus one or two survivors were: cervical length ≤ 15 mm (adjusted odds ratio [AOR] 6.1, 95% CI 2.7–14.1), earlier gestational age (GA) at intervention (AOR 1.2 per earlier week, 95% CI 1.1–1.3), and abnormal donor umbilical artery Doppler flow (AOR 5.1, 95% CI 1.7–15.6). A prediction calculator using this model achieved an area under the curve of 0.65. Conclusion Short cervical length (≤ 15 mm), presence of abnormal donor umbilical artery Doppler waveform, and early GA at time of intervention are significant predictors of fetal/neonatal survival at 6 months following FLA in TTTS and thus, are valuable parameters to consider for pre‐procedural counselling.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends and Spatial Variation in Preterm Prelabour Rupture of Membranes: A Population‐Based Study","authors":"Marion Rouzaire, Laetitia Bénézet, Angélique Souchal, Alexia Triolaire, Vincent Sapin, Loïc Blanchon, Damien Bouvier, Aurélien Mulliez, Denis Gallot","doi":"10.1111/1471-0528.70331","DOIUrl":"https://doi.org/10.1111/1471-0528.70331","url":null,"abstract":"Objective To describe the temporal trends in Preterm prelabour rupture of membranes (PPROM) in metropolitan France and the geographical distribution at the administrative division level. Design Exploratory population‐based study using administrative data of the French National Health Data System. Setting Metropolitan France, 2015 to 2023. Population Pregnancy with a diagnosis of PROM before 37 SA. Methods Annual crude incidence of PPROM was calculated by dividing the number of pregnancies with PPROM diagnosis by the number of live births recorded during the same period. Annual trend was estimated by a binomial negative mixed model. Smoothed standardised incidence ratios were estimated based on a BYM2 model, which accounts for spatial variability between departments. Main Outcome PPROM cases, defined as pregnancies with first hospitalizations with a diagnosis of PROM before 37 weeks. Results Over the study period, we included 150 615 PPROM cases representing 16 735 (±596) per year. Incidence of PPROM cases showed an ascending trend over time (incidence rate ratio 1.023 per year; 95% CI: 1.017–1.030) with an annual crude incidence ranging from 2.2% in 2015 to 2.7% in 2023. A decrease in the incidence was observed in 2020 relative to other years (incidence rate ratio 0.903, 95% CI: 0.887–0.920). A map of smoothed SIRs of PPROM cases at the French administrative division level revealed geographical inequalities. Conclusions This first population‐based study describing PPROM cases in metropolitan France paves the way for further studies to explore environmental hypotheses. Identifying temporal and geographical disparities in PPROM incidence is relevant to public health policy and practice as such disparities argue for the development of targeted prevention strategies in high‐risk areas.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicians' Knowledge and Understanding of Pregnancy‐Related VTE Risk and Its Assessment in the UK : A Survey of Risk Perception in Complex Times","authors":"R. Scott, S. A. Silverio, R. Arya, J. P. Patel, P. von Dadelszen, M. A. Coleman, L. Buxton, C. Boag, K. S. Sheen, L. A. Magee","doi":"10.1111/1471-0528.70325","DOIUrl":"https://doi.org/10.1111/1471-0528.70325","url":null,"abstract":"","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Versus Low Transvaginal Cerclage and Pregnancy Outcomes: A Secondary Analysis of the C‐ STICH Trial","authors":"Laura van der Krogt, Nicole Pilarski, Victoria Hodgetts Morton, Alexandra Emms, Philip Toozs‐Hobson, Lee Middleton, Andrew Shennan, Catherine A. Moakes","doi":"10.1111/1471-0528.70320","DOIUrl":"https://doi.org/10.1111/1471-0528.70320","url":null,"abstract":"Objective To compare pregnancy outcomes following high versus low vaginal cerclage in women at high risk of preterm birth. Design Secondary analysis of a multi‐centre randomised control trial. Setting Obstetric units across the UK. Sample Women participating in the C‐STICH trial who received a transvaginal cerclage. Methods Cerclage height was classified as high (with bladder dissection) or low (without bladder dissection). Cerclage technique was determined by clinician preference. For each outcome, regression models were fitted adjusting for pre‐specified prognostic variables. Main Outcome Measures The primary outcome was pregnancy loss defined as miscarriage and perinatal mortality (stillbirth or neonatal death within 7 days). Secondary maternal outcomes included miscarriage and previable neonatal death, stillbirth, gestational age at delivery, preterm pre labour rupture of membranes and sepsis. Secondary neonatal outcomes included early and late neonatal death and sepsis. Results Of the 2048 women randomised to C‐STICH, 1995 had details of cerclage height available: 24% received a high and 76% a low vaginal cerclage. Pregnancy loss rates were similar between the groups (6.5% vs. 7.3%; adjusted risk ratio 0.88, 95% CI: 0.57–1.34). High vaginal cerclage was associated with an increase in mean gestational age of 0.5 weeks and a lower rate of births before 32 weeks (adjusted risk ratio 0.57, 95% CI: 0.37–0.86). Conclusion Pregnancy loss rates do not differ significantly between high and low vaginal cerclage techniques. High cerclage may be associated with a small prolongation of pregnancy in women at high risk of preterm birth and reduction in preterm births &lt; 32 weeks.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Clinician Perspectives on Postpartum Thromboembolism Risk and Pharmacologic Thromboprophylaxis Use: A Qualitative Study","authors":"Ann M. Bruno, Naomi O. Riches, Erin Rothwell, Robert M. Silver, Torri D. Metz","doi":"10.1111/1471-0528.70321","DOIUrl":"https://doi.org/10.1111/1471-0528.70321","url":null,"abstract":"Objective Pregnancy‐associated venous thromboembolism (VTE) risk is highest after delivery, and many hospitals recommend pharmacologic thromboprophylaxis during this period. There is a paucity of data on patient counselling received and clinician counselling provided on VTE risk and thromboprophylaxis. We aimed to determine information needs, perspectives and priorities regarding postpartum VTE risk communication and thromboprophylaxis education among people undergoing caesarean delivery and their obstetric clinicians. Design Qualitative study. Setting Single academic medical centre. Population Postpartum individuals after caesarean delivery and obstetric clinicians. Methods Semi‐structured interviews were completed virtually by trained personnel with individuals within 12 weeks postpartum and obstetric clinicians to explore: (1) patient information needs on VTE risk communication; (2) perspectives on pharmacologic thromboprophylaxis; and (3) outcome priorities for decision‐making around VTE and future research. Transcribed interviews were imported into a qualitative analytics software program. A standardized inductive coding framework was used in duplicate to identify themes. Main Outcome Measures Qualitative data. Results Fifteen patients and 10 obstetric clinicians were interviewed. Patients were educated on the risk for VTE after caesarean delivery and rationale for thromboprophylaxis. Although patients reported discomfort (e.g., bruising, injection site pain) from prophylaxis administration, they reflected a willingness to use this therapy to reduce their risk of VTE and protect themselves. Patients identified some gaps in knowledge, opportunities for enhanced materials for education and willingness to participate in research. Clinicians endorsed providing counselling on VTE risk and thromboprophylaxis but identified barriers and recognized uncertainties on optimal management. Clinicians valued research that will improve evidence‐based guidelines. Conclusions While routine education on VTE risk and thromboprophylaxis is being provided, there are opportunities to improve communication. Patients and clinicians alike identified the necessity of research to inform precise individualized VTE risk estimates and the efficacy and risks of thromboprophylaxis.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}