ISRN allergy最新文献_第3页

Unscrambling Egg Allergy: The Diagnostic Value of Specific IgE Concentrations and Skin Prick Tests for Ovomucoid and Egg White in the Management of Children with Hen's Egg Allergy. 解读鸡蛋过敏:卵泡样蛋白特异性IgE浓度及皮肤点刺试验对儿童鸡蛋过敏的诊断价值

ISRN allergy Pub Date : 2012-02-09 Print Date: 2012-01-01 DOI: 10.5402/2012/627545

D E Marriage, M Erlewyn-Lajeunesse, D J Unsworth, A J Henderson

引用次数: 10

Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense). 表皮免疫疗法与舌下免疫疗法对花粉致敏小鼠的比较。

ISRN allergy Pub Date : 2012-02-02 Print Date: 2012-01-01 DOI: 10.5402/2012/375735

Lucie Mondoulet, Vincent Dioszeghy, Mélanie Ligouis, Véronique Dhelft, Emilie Puteaux, Christophe Dupont, Pierre-Henri Benhamou

{"title":"Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense).","authors":"Lucie Mondoulet, Vincent Dioszeghy, Mélanie Ligouis, Véronique Dhelft, Emilie Puteaux, Christophe Dupont, Pierre-Henri Benhamou","doi":"10.5402/2012/375735","DOIUrl":"https://doi.org/10.5402/2012/375735","url":null,"abstract":"Background. The aim of this study was to compare the efficacy of epicutaneous immunotherapy (EPIT) to sublingual immunotherapy (SLIT) in a model of mice sensitized to Phleum pratense pollen. Methods. BALB/c mice were sensitized by sub-cutaneous route to pollen protein extract mixed treated for 8 weeks, using sham, EPIT, or SLIT. Measurements involved the serological response and cytokine profile from reactivated splenocytes, plethysmography after aerosol challenge to pollen, cell, and cytokine contents in the bronchoalveolar lavages (BALs). Results. After immunotherapy, sIgE was significantly decreased in the treated groups compared to sham (P < 0.001), whereas sIgG2a increased with EPIT and SLIT (P < 0.001 and P < 0.005 versus sham). Reactivated splenocytes secreted higher levels of Th2 cytokines with sham (P < 0.01). Penh values were higher in sham than EPIT and SLIT. Eosinophil recruitment in BAL was significantly reduced only by EPIT (P < 0.01). Conclusion. In this model of mice sensitized to pollen, EPIT was at least as efficient as SLIT.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2012 ","pages":"375735"},"PeriodicalIF":0.0,"publicationDate":"2012-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

The Relationship of Allergy Severity to Depressive and Anxious Symptomatology: The Role of Attitude toward Illness. 变态反应严重程度与抑郁、焦虑症状的关系:疾病态度的作用。

ISRN allergy Pub Date : 2012-01-12 Print Date: 2011-01-01 DOI: 10.5402/2011/765309

Elizabeth S Molzon, Kristina I Suorsa, Stephanie E Hullmann, Jamie L Ryan, Larry L Mullins

引用次数: 5

Do other components of bedding dust affect sensitisation to house dust mites? 床上用品粉尘的其他成分会影响对室内尘螨的致敏吗?

ISRN allergy Pub Date : 2012-01-11 Print Date: 2011-01-01 DOI: 10.5402/2011/426941

Claire Smith, Thorsten Stanley, Julian Crane, Robert Siebers

{"title":"Do other components of bedding dust affect sensitisation to house dust mites?","authors":"Claire Smith, Thorsten Stanley, Julian Crane, Robert Siebers","doi":"10.5402/2011/426941","DOIUrl":"https://doi.org/10.5402/2011/426941","url":null,"abstract":"Bedding dust is a mixture of many components, of which the house dust mite (HDM) allergen, Der p 1, is the most allergenic. There has been little work to investigate the effect of other bedding dust components on HDM sensitisation. The objective of the study was to determine the effect of endotoxin in bedding dust on the allergic response in HDM-sensitised individuals. Twenty-nine house dust mite-sensitised adults were skin prick and allergen patch tested against a sterile solution of their own bedding dust and against a solution containing the same concentration of Der p 1 as the bedding solution for comparison. There was no significant difference in wheal size between the diluted house dust mite solution and the bedding dust in spite of their high levels of endotoxin. Symptomatic subjects had larger, but not statistically significant, responses to commercial house dust mite solution than asymptomatic subjects. Allergen patch test responses were negative in 22/29 of subjects using either bedding dust solutions or comparable diluted house dust mite solutions. An individual's own bedding dust does not appear to contain factors that enhance skin prick test or atopy patch test responses to house dust mites.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2011 ","pages":"426941"},"PeriodicalIF":0.0,"publicationDate":"2012-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement of Horse Allergen (Equ cx) in Schools. 测量学校中的马过敏原 (Equ cx)。

ISRN allergy Pub Date : 2012-01-04 Print Date: 2011-01-01 DOI: 10.5402/2011/574258

Anne-Sophie Merritt, Gunnel Emenius, Lena Elfman, Greta Smedje

{"title":"Measurement of Horse Allergen (Equ cx) in Schools.","authors":"Anne-Sophie Merritt, Gunnel Emenius, Lena Elfman, Greta Smedje","doi":"10.5402/2011/574258","DOIUrl":"10.5402/2011/574258","url":null,"abstract":"Background. The presence of horse allergen in public places is not well-known, unlike for instance cat and dog allergens, which have been studied extensively. The aim was to investigate the presence of horse allergen in schools and to what extent the influence of number of children with regular horse contact have on indoor allergen levels. Methods. Petri dishes were used to collect airborne dust samples during one week in classrooms. In some cases, vacuumed dust samples were also collected. All samples were extracted, frozen and analysed for Equ cx content shortly after sampling, and some were re-analysed six years later with a more sensitive ELISA assay. Results. Horse allergen levels were significantly higher in classrooms, in which many children had horse contact, regardless of sampling method. Allergen levels in extracts from Petri dish samples, which had been kept frozen, dropped about 53% over a six-year period. Conclusion. Horse allergen was present in classrooms and levels were higher in classrooms where many children had regular horse contact in their leisure time. This suggests that transfer of allergens takes place via contaminated clothing. Measures should be taken to minimize possible transfer and deposition of allergens in pet-free environments, such as schools.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2011 ","pages":"574258"},"PeriodicalIF":0.0,"publicationDate":"2012-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Airway epithelium in atopic and nonatopic asthma: similarities and differences. 特应性和非特应性哮喘的气道上皮:异同。

ISRN allergy Pub Date : 2011-12-29 Print Date: 2011-01-01 DOI: 10.5402/2011/195846

Prathap Pillai, Chris J Corrigan, Sun Ying

引用次数: 25

Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes. Th2细胞因子水平扭曲了IL-10和IFN-γ与过敏表型的关系。

ISRN allergy Pub Date : 2011-12-28 Print Date: 2011-01-01 DOI: 10.5402/2011/405813

Guicheng Zhang, Catherine M Hayden, Jack Goldblatt, Patrick Holt, Peter N Le Souëf

{"title":"Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes.","authors":"Guicheng Zhang, Catherine M Hayden, Jack Goldblatt, Patrick Holt, Peter N Le Souëf","doi":"10.5402/2011/405813","DOIUrl":"https://doi.org/10.5402/2011/405813","url":null,"abstract":"The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10. These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes. In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-γ) on allergic phenotypes after adjusting for the correlations with Th2 cytokines. After adjusting for Th2 cytokines, IL-10 and IFN-γ were protective against atopy. Adjusted levels of IL-10 and IFN-γ stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P = 0.002), IL-13 (P = 0.012), IL-9 (P = 0.016), and IL-4 (P = 0.043), and for IFN-γ adjusting for IL-5 (P = 0.005), IL-13 (P = 0.005), and IL-9 (P = 0.037). IL-10 and IFN-γ levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern. The adjusted levels of IL-10 and IFN-γ stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-γ stimulated with SEB. Levels of Th2 cytokines distort the associations of IL-10 and IFN-γ with allergic phenotypes. Removing the covariance with Th2 cytokines, both IL-10 and IFN-γ were protective against atopy.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2011 ","pages":"405813"},"PeriodicalIF":0.0,"publicationDate":"2011-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31563719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histone deacetylase inhibition and dietary short-chain Fatty acids. 组蛋白去乙酰化酶抑制与膳食短链脂肪酸。

ISRN allergy Pub Date : 2011-12-26 Print Date: 2011-01-01 DOI: 10.5402/2011/869647

Paul V Licciardi, Katherine Ververis, Tom C Karagiannis

{"title":"Histone deacetylase inhibition and dietary short-chain Fatty acids.","authors":"Paul V Licciardi, Katherine Ververis, Tom C Karagiannis","doi":"10.5402/2011/869647","DOIUrl":"https://doi.org/10.5402/2011/869647","url":null,"abstract":"Changes in diet can also have dramatic effects on the composition of gut microbiota. Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens. Moreover, consumption of fibre and vegetables typical of a non-Western diet generates substantial quantities of short-chain fatty acids (SCFAs) which have potent anti-inflammatory properties. Dietary interventions such as probiotic supplementation have been investigated for their pleiotropic effects on microbiota composition and immune function. Probiotics may restore intestinal dysbiosis and improve clinical disease through elevated SCFA levels in the intestine. Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes. The aim of this review is to provide an overview of HDAC enzymes and to discuss the biological effects of HDACi. Further, we discuss the important relationship between diet and the balance between health and disease and how novel dietary interventions such as probiotics could be alternative approach for the prevention and/or treatment of chronic inflammatory disease through modulation of the intestinal microbiome.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2011 ","pages":"869647"},"PeriodicalIF":0.0,"publicationDate":"2011-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/869647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

Prolonged antigen ingestion by sensitized mice ameliorates airway inflammation. 致敏小鼠长期摄入抗原可改善气道炎症。

ISRN allergy Pub Date : 2011-12-01 Print Date: 2011-01-01 DOI: 10.5402/2011/818239

Maria de Lourdes Meirelles Noviello, Nathália Vieira Batista, Luana Pereira Antunes Dourado, Denise Carmona Cara

引用次数: 3

The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease. 谷蛋白敏感和克罗恩病患者体液免疫反应中涉及的小麦抗原和肽库的特征

ISRN allergy Pub Date : 2011-10-27 Print Date: 2011-01-01 DOI: 10.5402/2011/950104

Aristo Vojdani

{"title":"The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease.","authors":"Aristo Vojdani","doi":"10.5402/2011/950104","DOIUrl":"https://doi.org/10.5402/2011/950104","url":null,"abstract":"Intestinal T cells from gluten sensitivity/celiac disease patients respond to a heterogeneous array of peptides. Our study extended this heterogeneity to humoral immune response to various wheat proteins and peptides in patients with gluten sensitivity or Crohn's disease. IgG and IgA antibodies in sera from those patients and healthy control subjects were measured against an array of wheat antigens and peptides. In gluten-sensitive patients, IgG reacted most against transglutaminase, prodynorphin, wheat extract, and α-, γ-, and ω-gliadin; IgA reacted most against wheat then transglutaminase, glutenin, and other peptides. In the sera of Crohn's disease patients, IgG reacted most against wheat and wheat germ agglutinin then transglutaminase, prodynorphin, α-, and γ-gliadin; IgA reacted foremost against prodynorphin then transglutaminase and α-gliadin. These results showed a substantial heterogeneity in the magnitude of IgG and IgA response against various wheat antigens and peptides. Measurements of IgG and IgA antibodies against such an array of wheat peptides and antigens can enhance the sensitivity and specificity of serological assays for gluten sensitivity and celiac disease and may also detect silent celiac disease or its overlap with inflammatory bowel disease.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2011 ","pages":"950104"},"PeriodicalIF":0.0,"publicationDate":"2011-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16