ISRN allergy最新文献_第2页

Identification of T- and B-Cell Subsets That Expand in the Central and Peripheral Lymphoid Organs during the Establishment of Nut Allergy in an Adjuvant-Free Mouse Model. 在无佐剂小鼠坚果过敏模型中，中央和外周淋巴器官中扩增的T细胞和b细胞亚群的鉴定

ISRN allergy Pub Date : 2013-04-11 Print Date: 2013-01-01 DOI: 10.1155/2013/509427

Babu Gonipeta, David Duriancik, Eunjung Kim, Elizabeth Gardner, Venu Gangur

{"title":"Identification of T- and B-Cell Subsets That Expand in the Central and Peripheral Lymphoid Organs during the Establishment of Nut Allergy in an Adjuvant-Free Mouse Model.","authors":"Babu Gonipeta, David Duriancik, Eunjung Kim, Elizabeth Gardner, Venu Gangur","doi":"10.1155/2013/509427","DOIUrl":"https://doi.org/10.1155/2013/509427","url":null,"abstract":"Nut allergies are potentially fatal and rarely outgrown for reasons that are not well understood. Phenotype of T- and B-cell subsets that expand during the early stages of nut allergy is largely unknown. Here we studied this problem using a novel mouse model of nut allergy. Mice were rendered hazelnut allergic by a transdermal sensitization/oral elicitation protocol. Using flow cytometry, the T- and B-cell phenotype in the bone marrow (BM), spleen, and the mesenteric lymph node (MLN) of allergic and control mice was analyzed. Nut allergic mice exhibited an expansion of CD4+ CD62L- T cells in BM and spleen; a similar trend was noted in the MLN. There was expansion of CD80+ B cells in BM and spleen and MLN and CD62L- cells in BM and spleen. Interestingly, among CD80+ B cells, significant proportion was CD73- particularly in the MLN. These data demonstrate that during the early establishment of hazelnut allergy there is (i) expansion of CD4+CD62L- T-cell subsets in both the BM and the periphery, (ii) expansion of CD80+ and CD62L- B-cell subsets in BM and the periphery, and (iii) a significant downregulation of CD73 on a subset of B cells in MLN.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2013 ","pages":"509427"},"PeriodicalIF":0.0,"publicationDate":"2013-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/509427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Innate immune responses in house dust mite allergy. 屋尘螨过敏的先天免疫反应。

ISRN allergy Pub Date : 2013-02-28 Print Date: 2013-01-01 DOI: 10.1155/2013/735031

Alain Jacquet

引用次数: 93

Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation. 胸腺基质淋巴生成素在蛋白酶过敏原诱导的气道炎症中增强Th2/Th22并降低IL-17A。

ISRN allergy Pub Date : 2013-02-07 Print Date: 2013-01-01 DOI: 10.1155/2013/971036

Dieudonnée Togbe, Louis Fauconnier, Fahima Madouri, Tiffany Marchiol, Pauline Chenuet, Nathalie Rouxel, Aurélie Ledru, François Erard, Valerie Quesniaux, Bernhard Ryffel

{"title":"Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation.","authors":"Dieudonnée Togbe, Louis Fauconnier, Fahima Madouri, Tiffany Marchiol, Pauline Chenuet, Nathalie Rouxel, Aurélie Ledru, François Erard, Valerie Quesniaux, Bernhard Ryffel","doi":"10.1155/2013/971036","DOIUrl":"https://doi.org/10.1155/2013/971036","url":null,"abstract":"Background. Thymic stromal lymphopoietin (TSLP) is induced in allergic skin and lung inflammation in man and mice. Methods. Allergic lung inflammation induced by two proteases allergens HDM and papain and a classical allergen ovalbumin was evaluated in vivo in mice deficient for TSLPR. Eosinophil recruitment, Th2 and Th17 cytokine and chemokine levels were determined in bronchoalveolar lavage fluid, lung homogenates and lung mononuclear cells ex vivo. Results. Here we report that mice challenged with house dust mite extract or papain in the absence of TSLPR have a drastic reduction of allergic inflammation with diminished eosinophil recruitment in BAL and lung and reduced mucus overproduction. TSLPR deficient DCs displayed diminished OVA antigen uptake and reduced capacity to activate antigen specific T cells. TSLPR deficient mice had diminished proinflammatory IL-1 β , IL-13, and IL-33 chemokines production, while IL-17A, IL-12p40 and IL-10 were increased. Together with impaired Th2 cytokines, IL-17A expressing TCR β (+) T cells were increased, while IL-22 expressing CD4(+) T cells were diminished in the lung. Conclusion. Therefore, TSLPR signaling is required for the development of both Th2 and Th22 responses and may restrain IL-17A. TSLP may mediate its effects in part by increasing allergen uptake and processing by DCs resulting in an exacerbated asthma.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2013 ","pages":"971036"},"PeriodicalIF":0.0,"publicationDate":"2013-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/971036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31483830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa. 南非比勒陀利亚母亲特应性反应与儿童哮喘的关系

ISRN allergy Pub Date : 2013-01-27 Print Date: 2013-01-01 DOI: 10.1155/2013/164063

Salome Abbott, Piet Becker, Robin J Green

{"title":"The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa.","authors":"Salome Abbott, Piet Becker, Robin J Green","doi":"10.1155/2013/164063","DOIUrl":"https://doi.org/10.1155/2013/164063","url":null,"abstract":"Introduction. Asthma is the commonest chronic condition of children. Diagnosis of this condition remains difficult. Many surrogate markers are used, such as documenting evidence of atopy. Method. A random sample of asthmatic children and their mothers attending the Children's Chest and Allergy Clinic at Steve Biko Academic Hospital were enrolled. Children were classified as having atopic or nonatopic asthma. Mothers completed a questionnaire to uncover atopic features. Results. Along with their mothers, 64 children with atopic asthma and 36 with nonatopic asthma were studied. The proportion of children with atopic asthma does not differ for mothers with and without a positive SPT (P = 0.836), a history of asthma (P = 0.045), symptoms suggestive of an allergic disease (P = 1.000), or who were considered to be allergic (P = 0.806). The odds ratio of a child having atopic asthma when having a mother with a doctor diagnosed history of asthma is 4.76, but the sensitivity is low (21.9%). Conclusion. The data demonstrates that all maternal allergic or asthmatic associations are poor predictors of childhood atopic asthma. Despite the increased risk of atopic asthma in a child to a mother that has a doctor diagnosis of asthma (OR 4.76 P = 0.045), this is a poor predictor of atopic asthma (sensitivity 21.9%).","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2013 ","pages":"164063"},"PeriodicalIF":0.0,"publicationDate":"2013-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/164063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Perinatal pet exposure, faecal microbiota, and wheezy bronchitis: is there a connection? 围产期宠物暴露，粪便微生物群和喘息性支气管炎:有联系吗?

ISRN allergy Pub Date : 2013-01-09 Print Date: 2013-01-01 DOI: 10.1155/2013/827934

Merja Nermes, Katri Niinivirta, Lotta Nylund, Kirsi Laitinen, Jaakko Matomäki, Seppo Salminen, Erika Isolauri

{"title":"Perinatal pet exposure, faecal microbiota, and wheezy bronchitis: is there a connection?","authors":"Merja Nermes, Katri Niinivirta, Lotta Nylund, Kirsi Laitinen, Jaakko Matomäki, Seppo Salminen, Erika Isolauri","doi":"10.1155/2013/827934","DOIUrl":"https://doi.org/10.1155/2013/827934","url":null,"abstract":"Background. The hygiene hypothesis suggests that high hygiene standards have led to an immune dysfunction and an increase in allergic diseases. Farming-related exposures are associated with a decreased risk of asthma. Since the gut microbiota may be a pivotal component in the hygiene hypothesis, we studied whether perinatal exposure to pets, doctor's diagnosed wheezy bronchitis (WB), and compositional changes in the gut microbiota are interrelated among urban infants. Methods. Data were collected prospectively from a mother-infant nutrition study. Data on perinatal pet ownership, WB, and the microbiota composition of faecal samples of the infants assessed by quantitative PCR at 1 month were compared. Results. None of the 30 infants exposed to pets had suffered from WB by 24 months, whereas 15 of the 99 (15%) nonexposed infants had had WB (P = 0.03). The counts of Bifidobacterium longum were higher in samples (n = 17) from nonwheezing infants with pet exposure compared to those (n = 10) in wheezing infants without pet exposure (8.59/10.44 versus 5.94/9.86, resp. (median/upper limit of range, bacteria(log)/g of stool); P = 0.02). B. breve was more abundant in the wheezing infants (P = 0.02).","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2013 ","pages":"827934"},"PeriodicalIF":0.0,"publicationDate":"2013-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/827934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Effect of Activated Charcoal Fibers on the Survival of the House Dust Mite, Dermatophagoides pteronyssinus: A Pilot Study. 活性炭纤维对室内尘螨生存影响的初步研究。

ISRN allergy Pub Date : 2012-10-24 Print Date: 2012-01-01 DOI: 10.5402/2012/868170

Hae-Seon Nam, Sun-Hwa Lee, Young-Jin Choi, Joon-Soo Park, Moon-Kyun Cho, Sang-Han Lee, Julian Crane, Robert Siebers

{"title":"Effect of Activated Charcoal Fibers on the Survival of the House Dust Mite, Dermatophagoides pteronyssinus: A Pilot Study.","authors":"Hae-Seon Nam, Sun-Hwa Lee, Young-Jin Choi, Joon-Soo Park, Moon-Kyun Cho, Sang-Han Lee, Julian Crane, Robert Siebers","doi":"10.5402/2012/868170","DOIUrl":"https://doi.org/10.5402/2012/868170","url":null,"abstract":"House dust mites produce potent allergens that exacerbate asthma in sensitized patients, whom are recommended to practice allergen avoidance within their home environment. We tested the effect of activated charcoal impregnated fibers on house dust mite survival. One hundred live adult house dust mites (Dermatophagoides pteronyssinus) were added to eight culture dishes preequilibrated at room temperature (n = 4) and 70% humidity (n = 4) containing house dust mite food and active charcoal fibers. At 10 minute intervals, live and dead house dust mites were counted. All house dust mites instantly attached to the activated charcoal fibers and started to shrink almost immediately. There were no live house dust mites present as early as 40 minutes in some dishes while after 190 minutes all house dust mites were dead. In conclusion, activated charcoal fibers, if incorporated into bedding items, have the potential to control house dust mites in the indoor environment.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2012 ","pages":"868170"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Conditions associated with childhood asthma in north Texas. 德克萨斯州北部儿童哮喘相关疾病。

ISRN allergy Pub Date : 2012-09-24 Print Date: 2012-01-01 DOI: 10.5402/2012/823608

Patricia Newcomb, Alaina Cyr

{"title":"Conditions associated with childhood asthma in north Texas.","authors":"Patricia Newcomb, Alaina Cyr","doi":"10.5402/2012/823608","DOIUrl":"https://doi.org/10.5402/2012/823608","url":null,"abstract":"Introduction. The purpose of this study was to identify significant associations between asthma diagnosis, comorbid conditions, and social problems in children. Method. This study explored data collected in a unique, regional survey of children's health in north Texas originally administered in 2009 to a random sample of 21,530 households with children from 0 to 14 years of age. Descriptive statistics were compiled for the subsample of children with asthma, associations of interest were identified, and strengths of relevant associations were calculated. Results. The prevalence of asthma in school-aged children in the target area is 19-25%, which exceeds both national and state values. Statistically significant associations were found between asthma and allergies, sleep problems, and tonsillectomy. Significant associations were identified between asthma and school absences, academic problems, and behavior problems in school. There was a significantly greater prevalence of obesity/overweight among children with asthma than without asthma. Discussion. Children with asthma are at high risk for impairment in multiple dimensions. Thorough assessment, including comprehensive medical, social, and environmental histories, is critical in management of pediatric asthma.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2012 ","pages":"823608"},"PeriodicalIF":0.0,"publicationDate":"2012-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hormonal link to autoimmune allergies. 荷尔蒙与自身免疫过敏有关

ISRN allergy Pub Date : 2012-08-22 Print Date: 2012-01-01 DOI: 10.5402/2012/910437

Shilpa Shah

引用次数: 11

Alternative treatment for asthma: case study of success of traditional chinese medicine treatment of children from urban areas with different levels of environmental pollution. 哮喘的替代治疗:不同环境污染程度城市儿童中医治疗成功案例研究。

ISRN allergy Pub Date : 2012-08-09 Print Date: 2012-01-01 DOI: 10.5402/2012/547534

Helen Kopnina

引用次数: 6

Clinical and immunological changes of immunotherapy in patients with atopic dermatitis: randomized controlled trial. 免疫治疗对特应性皮炎患者的临床和免疫学改变:随机对照试验。

ISRN allergy Pub Date : 2012-03-07 Print Date: 2012-01-01 DOI: 10.5402/2012/183983

Jorge Mario Sánchez Caraballo, Ricardo Cardona Villa

{"title":"Clinical and immunological changes of immunotherapy in patients with atopic dermatitis: randomized controlled trial.","authors":"Jorge Mario Sánchez Caraballo, Ricardo Cardona Villa","doi":"10.5402/2012/183983","DOIUrl":"https://doi.org/10.5402/2012/183983","url":null,"abstract":"Background. Immunotherapy has proven to be an useful tool in the management of allergic respiratory diseases; however, little has been studied in atopic dermatitis. Objective. To evaluate the clinical and immunological impact of immunotherapy with mites allergen extracts in atopic dermatitis. Methods. Patients with atopic dermatitis were assigned with computer-generated randomization to either of the following groups: (a) controls received only topical treatment with steroids and/or tacrolimus and (b) actively treated patients received topical treatment plus immunotherapy. Levels of serum total IgE, mites-specific IgE and IgG4 were assessed at study start and after one year of immunotherapy. Results. 31 patients in the active group and 29 in the control group completed the study. Symptoms and medication scores were significantly reduced in the active group after six months. Three patients in the control group showed new sensitizations to mites, while 3 patients in the active group showed neosensitization to shrimp with negative oral food challenge. We observed significant increase of mites-specific IgG4 levels in active group. Conclusion. Specific allergen immunotherapy induced a tolerogenic IgG4 response to mite allergens associated with favorable clinical effects in atopic dermatitis patients.","PeriodicalId":89782,"journal":{"name":"ISRN allergy","volume":"2012 ","pages":"183983"},"PeriodicalIF":0.0,"publicationDate":"2012-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31470891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27