Current translational geriatrics and experimental gerontology reports最新文献_第5页

Traumatic Brain Injury: Risk Factors and Biomarkers of Alzheimer's Disease and Chronic Traumatic Encephalopathy 创伤性脑损伤:阿尔茨海默病和慢性创伤性脑病的危险因素和生物标志物

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-06-26 DOI: 10.1007/s13670-012-0020-7

R. Rubenstein

引用次数: 4

Geriatric Traumatic Brain Injury in China. 中国老年人外伤性脑损伤。

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-06-19 eCollection Date: 2012-01-01 DOI: 10.1007/s13670-012-0018-1

Xianwei Zeng, Shun Pan, Zhenbo Hu

{"title":"Geriatric Traumatic Brain Injury in China.","authors":"Xianwei Zeng, Shun Pan, Zhenbo Hu","doi":"10.1007/s13670-012-0018-1","DOIUrl":"https://doi.org/10.1007/s13670-012-0018-1","url":null,"abstract":"Traumatic brain injury (TBI) is one of the major causes of morbidity and mortality in China. The elderly population has the higher rates of TBI-related hospitalization and death. Traffic accidents are the major cause for TBI in all age groups except in the group of 75 years and older, in which stumbles occurred in nearly half of those who suffered TBI. Older age is known to negatively influence outcome after TBI. To date, investigators have identified a panel of prognostic factors that include initial Glasgow Coma Scale score, comorbidities, cerebrospinal fluid leakage, associated extracranial lesions, and other factors such as cerebral perfusion pressure on recovery after injury. However, these aspects remain understudied in elderly patients with TBI. In the absence of complete clinical data, predicting outcomes and providing good care of the elderly population with TBI remain limited. To address this significant public health issue, a refocusing of research efforts is justified to prevent TBI in this population and to develop unique care strategies for achieving better clinical outcomes of the patients with TBI.","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 ","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2012-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0018-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31716092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases. Spectrin分解产物作为神经退行性疾病的潜在生物标志物

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-06-01 DOI: 10.1007/s13670-012-0009-2

Xiao-Xin Yan, Andreas Jeromin, A Jeromin

{"title":"Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases.","authors":"Xiao-Xin Yan, Andreas Jeromin, A Jeromin","doi":"10.1007/s13670-012-0009-2","DOIUrl":"https://doi.org/10.1007/s13670-012-0009-2","url":null,"abstract":"The world's human population ages rapidly thanks to the great advance in modern medicine. While more and more body system diseases become treatable and curable, age-related neurodegenerative diseases remain poorly understood mechanistically, and are desperately in need of preventive and therapeutic interventions. Biomarker development consists of a key part of concerted effort in combating neurodegenerative diseases. In many chronic neurodegenerative conditions, neuronal damage/death occurs long before the onset of disease symptoms, and abnormal proteolysis may either play an active role or be a companying event of neuronal injury. Increased spectrin cleavage yielding elevated spectrin breakdown products (SBDPs) by calcium-sensitive proteases such as calpain and caspases has been established in conditions associated with acute neuronal damage such as traumatic brain injury (TBI). Here we review literature regarding spectrin expression and metabolism in the brain, and propose a potential use of SBDPs as biomarkers for neurodegenerative diseases such as Alzheimer's diseases.","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 2","pages":"85-93"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31459675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

An Overview of Endogenous Catechol-Isoquinolines and Their Related Enzymes: Possible Biomarkers for Parkinson’s Disease 内源性儿茶酚异喹啉及其相关酶:帕金森病可能的生物标志物综述

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-04-28 DOI: 10.1007/s13670-012-0012-7

Yulin Deng, Yanyan Zhang, Jinyan Duan, Yan Xiong, H. Qing

引用次数: 5

Biomarkers of Cognitive Training Effects in Aging. 认知训练对衰老影响的生物标志物。

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-04-19 Print Date: 2012-06-01 DOI: 10.1007/s13670-012-0014-5

Sylvie Belleville, Louis Bherer

{"title":"Biomarkers of Cognitive Training Effects in Aging.","authors":"Sylvie Belleville, Louis Bherer","doi":"10.1007/s13670-012-0014-5","DOIUrl":"10.1007/s13670-012-0014-5","url":null,"abstract":"An increasing number of studies have relied on brain imaging to assess the effects of cognitive training in healthy aging populations and in persons with early Alzheimer's disease or mild cognitive impairment (MCI). At the structural level, cognitive training in healthy aging individuals has been associated with increased brain volume, cortical thickness, and density and coherence of white matter tracts. At the functional level, task-related brain activation (using fMRI and PET) and fluorodeoxyglucose positron emission tomography (FDG-PET) were found to be sensitive to the effects of training. In persons with MCI, cognitive training increased brain metabolism and task-related brain activation, whereas healthy older adults showed patterns of increased and decreased activation. Further studies are required to generalize these findings to larger groups and to investigate more diverse training protocols. Research will also need to address important methodological issues regarding the use of biomarkers in cognitive aging, including reliability, clinical validity, and relevance to the pathophysiological process.","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 2","pages":"104-110"},"PeriodicalIF":0.0,"publicationDate":"2012-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0014-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31588768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 84

The Analytical Aspects and Regulatory Challenges of Biomarker Discovery: Examples from the Field of Neurodegeneration 生物标志物发现的分析方面和调控挑战:来自神经退行性疾病领域的例子

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-04-18 DOI: 10.1007/s13670-012-0015-4

R. Martone, R. Snyder, Arron S. L. Xu, R. Reams

引用次数: 0

Neuropsychological Parameters as Potential Biomarkers for Alzheimer’s Disease 神经心理学参数作为阿尔茨海默病的潜在生物标志物

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-04-18 DOI: 10.1007/s13670-012-0007-4

Jinglong Wu, Yinghua Yu, Jiajia Yang

引用次数: 4

Use of Telomere Length as a Biomarker for Aging and Age-Related Disease 使用端粒长度作为衰老和年龄相关疾病的生物标志物

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-04-13 DOI: 10.1007/s13670-012-0013-6

M. Fossel

引用次数: 23

Potential Blood Biomarkers in Age-related Cerebral Small Vessel Disease 与年龄相关的脑血管疾病的潜在血液生物标志物

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-03-28 DOI: 10.1007/s13670-012-0011-8

Xin Cheng, Q. Dong

引用次数: 2

Biomarkers in Mood Disorders Among the Elderly: Can They Contribute to Diagnosis and Prognosis? 老年人情绪障碍的生物标志物:是否有助于诊断和预后?

Current translational geriatrics and experimental gerontology reports Pub Date : 2012-03-28 DOI: 10.1007/s13670-012-0010-9

A. Teixeira, A. Wieck, B. Diniz, M. Bauer

引用次数: 1