{"title":"Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance.","authors":"Tarja Malm, Johanna Magga, Jari Koistinaho","doi":"10.1007/s13670-011-0004-z","DOIUrl":"https://doi.org/10.1007/s13670-011-0004-z","url":null,"abstract":"<p><p>Glial cells in Alzheimer's disease (AD) have been shown to be capable of clearing or at least restricting the accumulation of toxic amyloid beta (Aβ) deposits. Recently, bone marrow (BM)-derived monocytic cells have been recognized in experimental studies to be superior in their phagocytic properties when compared to their brain endogenous counterparts. In human AD, BM-derived monocytic cells may have deficiencies in their capacity to restrict plaque growth. Therefore, enhancement of phagocytic properties of cells of monocyte origin, both brain endogenous microglia and BM-derived monocytic cells, offers an attractive therapeutic approach to fight off AD. Transgenic mouse models with aberrant Aβ deposition offer a valuable tool for discovery of novel pathways to facilitate cell-mediated Aβ uptake. This article reviews the most recent findings on the phagocytic capacity of cells with monocytic origin in various transgenic AD models and describes the methods to study phagocytic activity of these cells.</p>","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0004-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31264013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cognitive Deficits in Schizophrenia","authors":"Deborah J. Kayman, M. Goldstein","doi":"10.1007/s13670-012-0006-5","DOIUrl":"https://doi.org/10.1007/s13670-012-0006-5","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2012-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0006-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cognitive Deficits in Early Parkinson’s Disease: New Areas of Research","authors":"S. Mason, R. Barker","doi":"10.1007/s13670-011-0003-0","DOIUrl":"https://doi.org/10.1007/s13670-011-0003-0","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0003-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroscience-based Tests for Assessing Cognitive Changes in Normal Aging and in the Prodromal Phase of Alzheimer’s Disease","authors":"D. Woodruff-Pak, J. Raber","doi":"10.1007/s13670-011-0001-2","DOIUrl":"https://doi.org/10.1007/s13670-011-0001-2","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2012-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0001-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53295900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Animal Models of Aging and Cognition","authors":"J. McQuail, M. Nicolle","doi":"10.1007/s13670-011-0002-1","DOIUrl":"https://doi.org/10.1007/s13670-011-0002-1","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2012-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cognitive Deficits in Huntington’s Disease: Insights from Animal Models","authors":"Elizabeth A. Wang, C. Cepeda, M. Levine","doi":"10.1007/s13670-011-0005-y","DOIUrl":"https://doi.org/10.1007/s13670-011-0005-y","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2012-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0005-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance","authors":"T. Malm, Johanna Magga, J. Koistinaho","doi":"10.1007/s13670-012-0008-3","DOIUrl":"https://doi.org/10.1007/s13670-012-0008-3","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"13 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0008-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}