Current translational geriatrics and experimental gerontology reports最新文献

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Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance. 阿尔茨海默病动物模型:利用转基因阿尔茨海默病模型研究β淀粉样蛋白清除。
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-03-01 Epub Date: 2012-01-19 DOI: 10.1007/s13670-011-0004-z
Tarja Malm, Johanna Magga, Jari Koistinaho
{"title":"Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance.","authors":"Tarja Malm,&nbsp;Johanna Magga,&nbsp;Jari Koistinaho","doi":"10.1007/s13670-011-0004-z","DOIUrl":"https://doi.org/10.1007/s13670-011-0004-z","url":null,"abstract":"<p><p>Glial cells in Alzheimer's disease (AD) have been shown to be capable of clearing or at least restricting the accumulation of toxic amyloid beta (Aβ) deposits. Recently, bone marrow (BM)-derived monocytic cells have been recognized in experimental studies to be superior in their phagocytic properties when compared to their brain endogenous counterparts. In human AD, BM-derived monocytic cells may have deficiencies in their capacity to restrict plaque growth. Therefore, enhancement of phagocytic properties of cells of monocyte origin, both brain endogenous microglia and BM-derived monocytic cells, offers an attractive therapeutic approach to fight off AD. Transgenic mouse models with aberrant Aβ deposition offer a valuable tool for discovery of novel pathways to facilitate cell-mediated Aβ uptake. This article reviews the most recent findings on the phagocytic capacity of cells with monocytic origin in various transgenic AD models and describes the methods to study phagocytic activity of these cells.</p>","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0004-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31264013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Cognitive Deficits in Schizophrenia 精神分裂症的认知缺陷
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-02-08 DOI: 10.1007/s13670-012-0006-5
Deborah J. Kayman, M. Goldstein
{"title":"Cognitive Deficits in Schizophrenia","authors":"Deborah J. Kayman, M. Goldstein","doi":"10.1007/s13670-012-0006-5","DOIUrl":"https://doi.org/10.1007/s13670-012-0006-5","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2012-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0006-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Cognitive Deficits in Early Parkinson’s Disease: New Areas of Research 认知缺陷在早期帕金森病:新的研究领域
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-02-01 DOI: 10.1007/s13670-011-0003-0
S. Mason, R. Barker
{"title":"Cognitive Deficits in Early Parkinson’s Disease: New Areas of Research","authors":"S. Mason, R. Barker","doi":"10.1007/s13670-011-0003-0","DOIUrl":"https://doi.org/10.1007/s13670-011-0003-0","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0003-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Neuroscience-based Tests for Assessing Cognitive Changes in Normal Aging and in the Prodromal Phase of Alzheimer’s Disease 评估正常衰老和阿尔茨海默病前驱期认知变化的神经科学测试
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-01-25 DOI: 10.1007/s13670-011-0001-2
D. Woodruff-Pak, J. Raber
{"title":"Neuroscience-based Tests for Assessing Cognitive Changes in Normal Aging and in the Prodromal Phase of Alzheimer’s Disease","authors":"D. Woodruff-Pak, J. Raber","doi":"10.1007/s13670-011-0001-2","DOIUrl":"https://doi.org/10.1007/s13670-011-0001-2","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2012-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0001-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53295900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Animal Models of Aging and Cognition 衰老和认知的动物模型
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-01-18 DOI: 10.1007/s13670-011-0002-1
J. McQuail, M. Nicolle
{"title":"Animal Models of Aging and Cognition","authors":"J. McQuail, M. Nicolle","doi":"10.1007/s13670-011-0002-1","DOIUrl":"https://doi.org/10.1007/s13670-011-0002-1","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2012-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cognitive Deficits in Huntington’s Disease: Insights from Animal Models 亨廷顿氏病的认知缺陷:来自动物模型的见解
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-01-17 DOI: 10.1007/s13670-011-0005-y
Elizabeth A. Wang, C. Cepeda, M. Levine
{"title":"Cognitive Deficits in Huntington’s Disease: Insights from Animal Models","authors":"Elizabeth A. Wang, C. Cepeda, M. Levine","doi":"10.1007/s13670-011-0005-y","DOIUrl":"https://doi.org/10.1007/s13670-011-0005-y","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"1 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2012-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-011-0005-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Erratum to: Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance 阿尔茨海默病动物模型的勘误:利用转基因阿尔茨海默病模型研究淀粉样蛋白清除
Current translational geriatrics and experimental gerontology reports Pub Date : 2012-01-01 DOI: 10.1007/s13670-012-0008-3
T. Malm, Johanna Magga, J. Koistinaho
{"title":"Erratum to: Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance","authors":"T. Malm, Johanna Magga, J. Koistinaho","doi":"10.1007/s13670-012-0008-3","DOIUrl":"https://doi.org/10.1007/s13670-012-0008-3","url":null,"abstract":"","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"13 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-012-0008-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53296713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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