Current translational geriatrics and experimental gerontology reports最新文献

Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility. 热量限制适度衰老:机制和临床应用。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-12-13 DOI: 10.1007/s13670-013-0062-5

Stephen D Anton, Christy Karabetian, Kacey Heekin, Christiaan Leeuwenburgh

{"title":"Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility.","authors":"Stephen D Anton, Christy Karabetian, Kacey Heekin, Christiaan Leeuwenburgh","doi":"10.1007/s13670-013-0062-5","DOIUrl":"https://doi.org/10.1007/s13670-013-0062-5","url":null,"abstract":"As life expectancy in the United States continues to increase, the maintenance of physical independence among older Americans has emerged as a major clinical and public health priority. Therefore, there is an urgent need to identify interventions that can maintain or enhance cognitive and physical function with the goal of preventing or delaying the onset of disability. To date, caloric restriction (CR) is the only method that has been consistently found to increase lifespan and delay the onset of age-associated diseases such as cancer and diabetes across multiple species. The promise of calorie restriction as an intervention to improve health and/or maintain function in humans, however, only holds if individuals are able to adhere to this intervention over the long-term. Unfortunately, long-term adherence to CR regimens is notoriously poor likely due to complex interactions between behavioral, physiological, psychological, and environmental variables. Thus, a current challenge for both researchers and clinicians is to identify methods that can assist individuals in maintaining CR over the long-term.","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"2 4","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2013-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-013-0062-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32065558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Interventions to Improve Walking in Older Adults. 改善老年人步行的干预措施。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-12-01 DOI: 10.1007/s13670-013-0059-0

Jennifer S Brach, Jessie M Vanswearingen

引用次数: 77

Cardiac Hegemony of Senescence. 衰老的心脏霸权。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-12-01 DOI: 10.1007/s13670-013-0064-3

Sailay Siddiqi, Mark A Sussman

引用次数: 0

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications 老年心血管钙化:机制和临床意义

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-10-12 DOI: 10.1007/s13670-013-0063-4

F. Giallauria, C. Vigorito, N. Ferrara, L. Ferrucci

引用次数: 12

Mechanisms of Cardiovascular Aging 心血管老化的机制

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-10-09 DOI: 10.1007/s13670-013-0061-6

F. Paneni, S. Costantino, F. Cosentino, T. Lüscher

引用次数: 2

Functions and Mechanisms of Arginase in Age-Associated Cardiovascular Diseases 精氨酸酶在年龄相关性心血管疾病中的作用及机制

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-10-05 DOI: 10.1007/s13670-013-0060-7

X. Ming, Zhihong Yang

引用次数: 6

UPDATE ON DEMENTIA WITH LEWY BODIES. 路易体痴呆的最新进展。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-09-01 DOI: 10.1007/s13670-013-0053-6

Stella Karantzoulis, James E Galvin

引用次数: 24

RELATIONSHIP OF GAIT AND COGNITION IN THE ELDERLY. 老年人步态与认知的关系。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-09-01 DOI: 10.1007/s13670-013-0052-7

Raminder Parihar, Jeannette R Mahoney, Joe Verghese

引用次数: 65

Vascular Dementia. 血管性痴呆。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-09-01 DOI: 10.1007/s13670-013-0054-5

Alberto R Ramos, Salim I Dib, Clinton B Wright

{"title":"Vascular Dementia.","authors":"Alberto R Ramos, Salim I Dib, Clinton B Wright","doi":"10.1007/s13670-013-0054-5","DOIUrl":"https://doi.org/10.1007/s13670-013-0054-5","url":null,"abstract":"The purpose of this review is to highlight existing literature on the epidemiology, pathophysiology, and novel risk factors for vascular dementia. We further examine the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular diseases to the development of vascular dementia. In the elderly, in whom cerebral perfusion is diminished by the aging process, additional reduction in cerebral blood flow stemming from exposure to potentially modifiable vascular risk factors increases the probability of developing vascular dementia. Finally, we discuss the association between obstructive sleep apnea, an underrecognized risk factor for stroke, and vascular dementia. Obstructive sleep apnea is linked to cerebrovascular disease through many intermediary vascular risk factors and may directly cause cerebrovascular damage through microvacular disease. Insight into how cardiovascular risk factors induce vascular dementia offers an enhanced understanding of the multifactorial pathophysiology by this disorder and ways of preventing and managing the cerebrovascular precursors of vascular dementia. Many vital questions about the relation of obstructive sleep apnea with stroke and vascular dementia are still unanswered and await future well-designed studies.","PeriodicalId":89757,"journal":{"name":"Current translational geriatrics and experimental gerontology reports","volume":"2 3","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13670-013-0054-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33869969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Treatment of Alzheimer's Disease: Current Management and Experimental Therapeutics. 阿尔茨海默病的治疗:目前的管理和实验性治疗。

Current translational geriatrics and experimental gerontology reports Pub Date : 2013-09-01 DOI: 10.1007/s13670-013-0056-3

Lawrence S Honig, Clara D Boyd

引用次数: 11