The Open bone journal最新文献_第3页

Discrimination of Cervical and Trochanteric Hip Fractures Using Radiography-Based Two-Dimensional Finite Element Models 基于x线摄影的二维有限元模型鉴别颈椎和股骨粗隆骨折

The Open bone journal Pub Date : 2009-09-11 DOI: 10.2174/1876525400901010016

J. Thevenot, P. Pulkkinen, Janne E. M. Koivumäki, V. Kuhn, F. Eckstein, T. Jämsä

{"title":"Discrimination of Cervical and Trochanteric Hip Fractures Using Radiography-Based Two-Dimensional Finite Element Models","authors":"J. Thevenot, P. Pulkkinen, Janne E. M. Koivumäki, V. Kuhn, F. Eckstein, T. Jämsä","doi":"10.2174/1876525400901010016","DOIUrl":"https://doi.org/10.2174/1876525400901010016","url":null,"abstract":"Introduction: Predictors of fracture risk differ between cervical and trochanteric hip fractures. The aim of this experimental study was therefore to investigate whether two-dimensional (2D) finite element (FE) models, generated from standard radiographs, are able to predict and discriminate fracture types, originating from a simulated fall on the greater trochanter. Methods: A semi-automatic custom algorithm was applied to segment cortical and trabecular bone contours from radiographs of 49 female cadaver femora (mean age 80.7±10.3 years). Two types of 2D FE models were generated, either one or four material properties assigned to the trabecular bone. The cartilage and soft tissue were also simulated, and the boundary conditions were mimicking the experiment. VonMises stress distributions within the trabecular bone were evaluated and the regions of maximum continuous stress patterns were determined. Results: The best fracture type prediction was obtained with the criterion that a cervical fracture was predicted if the maximum stress in trabecular bone was located at the superior part of the femoral neck and the maximum continuous stress pattern through the neck region; and in all other cases a trochanteric fracture was predicted. The two different models predicted 79.6% and 85.7% of the fracture cases correctly, in comparison with the actual failure type. Conclusion: Our results suggest that the cervical and trochanteric hip fractures can be discriminated with a satisfactory level of accuracy, using a relatively simple radiography- based 2D model. Based on the current experimental findings, the predictive power of these models should now be tested in clinical studies.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"1 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2009-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

EPAS1, a Dexamethasone-Inducible Gene in Osteoblasts, Inhibits Osteoblastic Differentiation 成骨细胞中地塞米松诱导基因EPAS1抑制成骨细胞分化

The Open bone journal Pub Date : 2009-09-07 DOI: 10.2174/1876525400901010028

N. Ijichi, K. Ikeda, M. Fujita, T. Usui, T. Urano, Kotaro Azuma, Y. Ouchi, Kuniko Horie-Inoue, S. Inoue

引用次数: 3

Celiac Disease and Osteoporosis: A Review 乳糜泻和骨质疏松症:综述

The Open bone journal Pub Date : 2009-08-11 DOI: 10.2174/1876525400901010023

J. Pérez-Castrillón, M. Andres-Calvo, E. Izquierdo-Delgado, M. Mendo, Daniel De Luis, A. Dueñas-Laita

引用次数: 5

Hypophosphatasia – Recent Advances in Diagnosis and Treatment 低磷酸盐症的诊断和治疗的最新进展

The Open bone journal Pub Date : 2009-05-07 DOI: 10.2174/1876525400901010008

Beck C, Morbach H, Stenzel M, Collmann H, Schneider P, Girschick H J

{"title":"Hypophosphatasia – Recent Advances in Diagnosis and Treatment","authors":"Beck C, Morbach H, Stenzel M, Collmann H, Schneider P, Girschick H J","doi":"10.2174/1876525400901010008","DOIUrl":"https://doi.org/10.2174/1876525400901010008","url":null,"abstract":"Hypophosphatasia (HP) is a rare inborn error of bone and mineral metabolism transmitted as an autosomal- recessive trait. It is characterized by a reduced activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSAP) and elevated concentrations of its substrates including pyrophosphates. Clinical symptoms include defective bone mineralisation with bone deformities, fractures and recently defined chronic non-bacterial osteomyelitis. Renal damage due to calcification, dental abnormalities with premature loss of dentition and craniosynostosis are further symptoms. Knowledge on the mechanisms underlying cell activation leading to inflammation and tissue destruction is still limited in HP. Recent investigations have provided evidence that calcium pyrophosphate crystals are essentially involved in activating inflammatory signal transduction pathways via different receptors of the innate immune system. Further studies are needed to improve our understanding of the pathophysiological mechanisms leading to inflammation and tissue destruction associated with deposition of microcrystals. They might support the development of new therapeutic strategies for crystal-induced inflammation. Laboratory assays, genetic analysis and radiographic imaging can confirm the diagnosis. Since clinical symptoms are highly variable patients should be followed by a HP-experienced multidisciplinary team (paediatrician, radiologist, orthopedic surgeon, neurosurgeon, dentist, nutritional specialist). At the moment symptomatic treatment is most important because curative or causative therapies, like gene transfer or enzyme replacement therapy, are not yet available.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"29 21 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2009-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Effect of Bone Morphogenetic Protein-2 and Doxycycline on the Differentiation of Osteoprogenitors from Human Femoral Bone 骨形态发生蛋白-2和强力霉素对人股骨成骨细胞分化的影响

The Open bone journal Pub Date : 2009-02-19 DOI: 10.2174/1876525400901010001

Aline Eglence, N. Colterjohn, W. Duivenvoorden, M. Ghert, G. Singh

引用次数: 8

Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone. 骨巨细胞瘤基质金属蛋白酶活性的研究。

The Open bone journal Pub Date : 2009-01-01 DOI: 10.2174/1876525400901010046

Alexander Rabinovich, Isabella W Y Mak, Robert W Cowan, Robert E Turcotte, Nigel Colterjohn, Gurmit Singh, Michelle Ghert

{"title":"Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone.","authors":"Alexander Rabinovich, Isabella W Y Mak, Robert W Cowan, Robert E Turcotte, Nigel Colterjohn, Gurmit Singh, Michelle Ghert","doi":"10.2174/1876525400901010046","DOIUrl":"10.2174/1876525400901010046","url":null,"abstract":"<p><p>Giant cell tumor of bone (GCT) is a destructive and potentially metastatic bone tumour in which the characteristic giant cells have classically been considered the culprits in bone destruction. However, the neoplastic element of the tumour consists of propagative osteoblast-like stromal cells that may play a role in bone resorption. The objectives of this study were to determine the expression and activity of the gelatinases, matrix metalloproteinase (MMP)-2 and -9, in GCT stromal cells, and to determine if these cells have bone-resorbing capabilities. We performed immunohistochemistry on clinical specimens, and real-time polymerase chain reaction (PCR) and zymography on cell lysates and conditioned media from cultured clinical GCT specimens in order to evaluate the expression and activity of MMP-2 and-9 in GCT stromal cells. Our results support the fact that GCT stromal cells express MMP-2 and MMP-9 and are capable of gelatin degradation in vitro. These cells may therefore play a role in bone destruction in GCT.</p>","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"1 ","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/55/nihms215.PMC3266943.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30421678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibial Alignment in Total Knee Replacement Surgery, Intramedullary Alignment Versus Extramedullary Alignment a Blinded Single Surgeon Study 全膝关节置换术中胫骨对齐，髓内对齐与髓外对齐:单医生盲法研究

The Open bone journal Pub Date : 1900-01-01 DOI: 10.2174/1876525401305010009

Walaa El Nahas, I. Nwachuku, K. Khan, A. Gabr, J. Hodgkinson

{"title":"Tibial Alignment in Total Knee Replacement Surgery, Intramedullary Alignment Versus Extramedullary Alignment a Blinded Single Surgeon Study","authors":"Walaa El Nahas, I. Nwachuku, K. Khan, A. Gabr, J. Hodgkinson","doi":"10.2174/1876525401305010009","DOIUrl":"https://doi.org/10.2174/1876525401305010009","url":null,"abstract":"Background: The clinical success of total knee arthroplasty is positively correlated with good component orientation. Controversy remains as to what is the best tibial alignment technique, this study compares the intramedullary versus the extramedullary surgical alignment guidance methods. Material and Methods: A retrospective study was done on 100 patients during the time period 2007 to 2010. The knee replacements were performed by the same surgeon, 49 procedures were performed via the intramedullary technique and 51 procedures were via the extramedullary technique. The tibiofemoral angle was measured pre-operatively as well as post operatively, the tibial alignment angle was measured post operatively also, the results were then statistically analysed. Results and Conclusion: There was no significant difference between both groups regarding the tibial alignment angles. Both techniques proved accurate in producing an acceptable post operative tibial component alignment angle. We advocate the surgeon may use his/her discretion when deciding upon the method of tibial alignment.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"5 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2