The Open bone journal最新文献

Bone health among premenopausal female alcoholics: A pilot study 绝经前女性酗酒者的骨骼健康:一项初步研究

The Open bone journal Pub Date : 2015-02-25 DOI: 10.2174/1876525401507010014

Clynes, G. Robinson, H. Denison, G. Evans, M. Gilmour, E. Dennison

引用次数: 2

The Fate of a Total Talar Allograft to Treat Traumatic Talar Enucleation, Fifteen Years after Transplantation in Teenage Patients 全距骨异体移植治疗创伤性距骨剜出的命运，移植15年后的青少年患者

The Open bone journal Pub Date : 2015-01-21 DOI: 10.2174/1876525401507010001

R. Piet, Dobre Cristina

引用次数: 0

B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice. 老年小鼠B细胞中OPG和RANKL的生成均显著增加。

The Open bone journal Pub Date : 2014-01-01 DOI: 10.2174/1876525401406010008

Yan Li, Masakazu Terauchi, Tatyana Vikulina, Susanne Roser-Page, M N Weitzmann

{"title":"B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice.","authors":"Yan Li, Masakazu Terauchi, Tatyana Vikulina, Susanne Roser-Page, M N Weitzmann","doi":"10.2174/1876525401406010008","DOIUrl":"https://doi.org/10.2174/1876525401406010008","url":null,"abstract":"Aging is a risk factor for osteoclastic bone loss and bone fracture. Receptor activator of NF-κB ligand (RANKL) is the key effector cytokine for osteoclastogenesis and bone resorption, and is moderated by its decoy receptor osteoprotegerin (OPG). The development of an inflammatory environment during aging leads to increased bone resorption and loss of bone mineral density (BMD). Interestingly, animal and clinical studies show that OPG is actually increased in aging but fails to fully compensate for endogenous RANKL. Osteoblast- and B-lineage cells are significant sources of physiological OPG, however osteoblast OPG production declines with age, suggesting that elevated OPG in aging may be a consequence of changes in B cell function. In this study we examined BMD and indices of trabecular bone structure during aging, and B cell production of both RANKL and OPG in young and aged mice. Our data reveal significant loss of BMD and trabecular structure with age commensurate with significantly elevated concentrations of both OPG and RANKL in aged mice, and a decline in B cell populations in aged animals. Taken together our data suggest that B cells may be responsible for the elevated concentrations of OPG during aging and are essential to counteract excessive age-associated bone resorption. Paradoxically, B cells themselves likely contribute RANKL in aging and the loss of B cells with age may further contribute to the imbalance in OPG relative to RANKL that predisposes age-associated bone loss.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"6 ","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/46/nihms670722.PMC4429037.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33313038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Evidence that Osteoblasts are Specialized Citrate-producing Cells that Provide the Citrate for Incorporation into the Structure of Bone. 证据表明成骨细胞是专门生产柠檬酸盐的细胞，提供柠檬酸盐并入骨结构。

The Open bone journal Pub Date : 2014-01-01 DOI: 10.2174/1876525401406010001

Renty B Franklin, Meena Chellaiah, Jing Zou, Mark A Reynolds, Leslie C Costello

{"title":"Evidence that Osteoblasts are Specialized Citrate-producing Cells that Provide the Citrate for Incorporation into the Structure of Bone.","authors":"Renty B Franklin, Meena Chellaiah, Jing Zou, Mark A Reynolds, Leslie C Costello","doi":"10.2174/1876525401406010001","DOIUrl":"https://doi.org/10.2174/1876525401406010001","url":null,"abstract":"Citrate is a major component of bone in all vertebrates, but its implications in bone have remained largely unknown. Recent studies identified that citrate is incorporated into the structure of the hydroxyapatite nanocrystal/collagen complex; and is essential for the important biomechanical properties of bone. This raises the important question, \"What is the source of citrate for incorporation into bone?\"; A question that heretofore had remained unresolved. Studies in this report were designed to determine the plausibility of our concept that the osteoblasts are specialized citrate-producing cells, which provide the citrate that is incorporated into the structure of bone; and that osteogenic differentiation of mesenchyme cells leads to the development of the citrate-producing osteoblasts. The results demonstrated that primary human osteoblasts exhibit the capability of citrate-production. Undifferentiated mesenchyme cells do not exhibit the capability of citrate production; and osteogenic differentiation results in citrate-producing osteoblasts. The up-regulation of zinc uptake transporter ZIP1 is essential for the manifestation of the citrate-producing capability of the osteoblasts. We determined that osteoblast transport of citrate from plasma is not a likely source of citrate in bone. Thus, this study establishes for the first time that the osteoblasts are specialized citrate-producing cells that provide the citrate for incorporation into the structure of bone; and that mesenchyme cell osteogenesis leads to differentiated citrate-producing osteoblasts. This is a new understanding; which must include the osteogenic development of citrate-producing osteoblasts, and the process of \"citration\" in concert with mineralization during bone formation. It also provides a new understanding of the role of bone in the homeostatic maintenance of plasma citrate concentration.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"6 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1876525401406010001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33108064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Effect of Tibial Tray Malalignment on Micromotion and Subsidence: A Preliminary Report 胫骨托板错位对微动和沉降的影响:初步报告

The Open bone journal Pub Date : 2013-04-03 DOI: 10.2174/1876525401305010001

S. Patil, N. Steklov, C. Colwell, M. Kester

{"title":"Effect of Tibial Tray Malalignment on Micromotion and Subsidence: A Preliminary Report","authors":"S. Patil, N. Steklov, C. Colwell, M. Kester","doi":"10.2174/1876525401305010001","DOIUrl":"https://doi.org/10.2174/1876525401305010001","url":null,"abstract":"Malalignment of the tibial tray in total knee arthroplasty has been linked to several complications including tibial tray subsidence, leading to revision surgery. However, quantitative biomechanical evidence to directly support the mechanism of failure is not available. We developed a model to study tibial tray micromotion and subsidence in vitro under multiaxial physiological loading conditions for up to 100,000 cycles. In Phase I, we tested four cadaver knees and two surrogate bone models to determine whether the surrogate models could reproduce the fatigue damage induced by cyclic loading. In Phase II, we tested six cadaver knees in a pairwise manner under conditions representing either neutral or varus malalignment. The surrogate bone models did not reproduce the progressive damage that was seen in human cadaver specimens. The altered loading conditions used to represent varus tray alignment increased the cyclic strain at the start of the fatigue loading and increased the cyclic strain at the end of the fatigue loading as well as the subsidence of the tray. The increase in final cyclic strain was greater in the varus condition indicating reduction in stiffness due to bone damage. This in vitro testing represents the clinical reports of early tray migration that lead to eventual aseptic loosening. This study provides biomechanical evidence supporting the hypothesis that a varus tray alignment could increase the risk of failure.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Efficiency of 48h vs. 24h Injection of Parathyroid Hormone forAmelioration of Osteopenic Spine Properties in Male Rats 注射甲状旁腺激素48h与24h对改善雄性大鼠骨质减少性脊柱性能的影响

The Open bone journal Pub Date : 2012-07-27 DOI: 10.2174/1876525401204010020

M. Komrakova, E. Stuermer, A. Sturm, U. Schmelz, M. Tezval, K. Stuermer, S. Sehmisch

{"title":"Efficiency of 48h vs. 24h Injection of Parathyroid Hormone forAmelioration of Osteopenic Spine Properties in Male Rats","authors":"M. Komrakova, E. Stuermer, A. Sturm, U. Schmelz, M. Tezval, K. Stuermer, S. Sehmisch","doi":"10.2174/1876525401204010020","DOIUrl":"https://doi.org/10.2174/1876525401204010020","url":null,"abstract":"Daily application of parathyroid hormone (PTH 1-34) is used for treatment of osteoporosis. It was investigated whether orchiectomy-induced osteoporotic changes in spine can be ameliorated by every 48h administration of PTH in aged male rats. Eight-month-old male Sprague-Dawley rats were sham operated (n=24) or orchiectomized (Orx, n=36) and maintained untreated over 12 weeks. Thereafter, both tibia underwent transverse metaphyseal osteotomy (Komrakova et al. 2011, J Endocrinol; 209:9-19) and rats were divided into 5 groups treated s.c. as follows: 1) sham vehicle; 2) sham PTH every 24h (PTH/24h); 3) Orx vehicle; 4) Orx PTH/24h; 5) Orx PTH every 48h (PTH/48h). PTH dosage was 40 �g/kg BW per injection. After 5 weeks, lumbar vertebral bodies were used in computed tomographical, biomechanical, histomorphological, ashing and gene expression analyses. Cortical and trabecular densities, biomechanical properties, serum osteocalcin level increased significantly after PTH treatments in all groups (yield load, sham: 232+17N, sham PTH/24h: 376+12N, Orx: 239+16N, Orx PTH/24h: 324+31N, Orx PTH/48h: 297+17N). Bone inorganic weight enhanced after daily PTH application in Orx rats. Bone gene expression did not differ (P>0.05) among the groups. Both PTH administration regimes (24h and 48h) improved impaired bone structure in osteopenic rats. Every 48h application was less effective, however, it improved bone properties to the level observed in healthy (sham) rats. Considering limitation of daily treatments known in humans, these results may be useful for further clinical studies.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"4 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2012-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effects of Freezing on the Mechanical Properties of Bone 冷冻对骨力学性能的影响

The Open bone journal Pub Date : 2012-06-15 DOI: 10.2174/1876525401204010014

Bryan Kaye, C. Randall, Daniel J Walsh, P. Hansma

{"title":"The Effects of Freezing on the Mechanical Properties of Bone","authors":"Bryan Kaye, C. Randall, Daniel J Walsh, P. Hansma","doi":"10.2174/1876525401204010014","DOIUrl":"https://doi.org/10.2174/1876525401204010014","url":null,"abstract":"The serious health risks posed by bone fractures create a growing need for accurately diagnosing fracture risk. The Reference Point Indentation instrument (RPI) directly measures key mechanical properties in vivo to assess bone fracturability. There is a wealth of information that could be obtained from measuring cryopreserved bone samples with the RPI. Since it is unknown how freezing affects these key mechanical properties, measuring a cryopreserved sample gives no indication of the sample's original fracturability. Although there is research on how freezing affects the various mechanical properties of bone, this is the first paper to show how freezing effects the RPI's measurement of fracturability. Bovine femur and human tibia were tested using the RPI before freezing (-20°C, up to 20 days) and after thawing. The effect of freeze-thaw cycles varied depending on the type of the bone, but in most cases, was not measureable. When degradation did occur, the effect of freezing on the mechanical properties was smaller than the natural variation of those properties across a sample before freezing. Degradation of the mechanical properties, as measured by the RPI, was always found to be 15% or less. Subsequent freeze-thaw cycles had no effect on further degradation of the bone samples. In cases where degradation occurred, the effect from the twenty-day duration of freezing was negligible compared to the effects from phase-change. Furthermore, significant evidence was found supporting the theory that freezing degrades the organic components of the extracellular matrix.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"4 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2012-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68145051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Physical Exercise for Secondary Osteoporosis 继发性骨质疏松的体育锻炼

The Open bone journal Pub Date : 2012-01-26 DOI: 10.2174/1876525401204010001

D. Mina, S. Alibhai, A. Matthew, Crissa L. Guglietti, Shalini H Moonsammy, J. Trachtenberg, P. Ritvo

引用次数: 0

The Important Role of Osteoblasts and Citrate Production in Bone Formation: "Osteoblast Citration" as a New Concept for an Old Relationship. 成骨细胞与柠檬酸盐生成在骨形成中的重要作用:“成骨细胞柠檬酸”作为一个旧关系的新概念。

The Open bone journal Pub Date : 2012-01-01 DOI: 10.2174/1876525401204010027

Leslie C Costello, Renty B Franklin, Mark A Reynolds, Meena Chellaiah

{"title":"The Important Role of Osteoblasts and Citrate Production in Bone Formation: \"Osteoblast Citration\" as a New Concept for an Old Relationship.","authors":"Leslie C Costello, Renty B Franklin, Mark A Reynolds, Meena Chellaiah","doi":"10.2174/1876525401204010027","DOIUrl":"https://doi.org/10.2174/1876525401204010027","url":null,"abstract":"It has been known for about seventy years that bone, in all vertebrates, contains uniquely high citrate levels. However, the role of citrate, its source, its regulation, and its implication in normal bone formation and in bone disorders have remained largely unknown. For the past thirty-five years, the relationship of citrate in bone has been a neglected area of attention and research. It has recently been discovered that citrate is critical for the structure of the apatite nanocrystal, and is required to impart the important properties of bone such as its stability, strength, and resistance to fracture. This brings to focus the need for a renewed interest and research into the relationships of citrate in bone formation. A most fundamental question that must be resolved is \"What is the source of citrate in bone?\". This presentation provides a historical review of the early research to the present status of citrate implications in bone. This leads to a new concept of the role of osteoblasts as specialized citrate producing cells that provide the source of citrate in bone formation; i.e. the \"osteoblast citration\" process. This also brings into focus a new insight into the role of zinc in bone in relation to osteoblast citrate production. The genetic/hormonal/metabolic relationships of \"net citrate production\" are described. The intent of this presentation is to provide the background for a new perspective of the important implications of osteoblasts and citrate in bone formation; which, hopefully, will stimulate a renewed interest and essential research.","PeriodicalId":89634,"journal":{"name":"The Open bone journal","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1876525401204010027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31835730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 88

The Effect of Detraining on Bone 去训练对骨骼的影响

The Open bone journal Pub Date : 2011-06-30 DOI: 10.2174/1876525401103010022

A. Nordström, P. Nordström

引用次数: 4