Bone health among premenopausal female alcoholics: A pilot study

Clynes, G. Robinson, H. Denison, G. Evans, M. Gilmour, E. Dennison
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引用次数: 2

Abstract

We report a pilot study of bone health of alcohol dependent women. Women admitted to an alcohol-withdrawal unit (cases) and a convenience sample of controls (nursing staff) were recruited and asked to complete a lifestyle questionnaire before undergoing heel ultrasound measurements. Fasting blood samples were obtained on the day of admission (day 1) and at 5 days. Bone turnover markers (P1NP and CTX) and vitamin D levels were measured in a subset of the alcohol dependent population. Cases were less physically active than controls. Alcoholic women had lower heel ultrasound derived Stiffness Index scores (mean 85.2 (17.6)) compared with controls (mean 95.5 (18.7)) (p=0.07). P1NP rose significantly over the detoxification programme (day 1: 28.35 � g/l (12.25); day 5: 34.19 � g/l (13.16), p=0.003) but CTX change was not significant. Lifestyle factors associated with poor bone health are prevalent in female alcoholics. Significant increase in bone formation was observed 5 days after alcohol withdrawal.
绝经前女性酗酒者的骨骼健康:一项初步研究
我们报告了一项酒精依赖妇女骨骼健康的初步研究。在接受足跟超声测量之前,研究人员招募了进入戒酒室的妇女(病例)和方便的对照样本(护理人员),并要求她们完成一份生活方式问卷。在入院当天(第1天)和第5天采集空腹血样。骨转换标志物(P1NP和CTX)和维生素D水平在一部分酒精依赖人群中进行了测量。与对照组相比,病例的体力活动较少。与对照组(平均95.5(18.7))相比,酗酒女性的足跟硬度指数评分(平均85.2(17.6))较低(p=0.07)。P1NP在解毒过程中显著升高(第1天:28.35 μ g/l (12.25);第5天:34.19 g/l (13.16), p=0.003),但CTX变化不显著。与骨骼健康不良相关的生活方式因素在女性酗酒者中普遍存在。戒酒5天后观察到骨形成显著增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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