Neuroembryology and aging最新文献_第8页

Differential Localization of Metabotropic Glutamate Receptors 1α and 2/3 in the Rat Striatum during Early Postnatal Development 大鼠出生后早期纹状体中代谢性谷氨酸受体1α和2/3的差异定位

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085403

R. Lam, Y. Chan, K. Yung

{"title":"Differential Localization of Metabotropic Glutamate Receptors 1α and 2/3 in the Rat Striatum during Early Postnatal Development","authors":"R. Lam, Y. Chan, K. Yung","doi":"10.1159/000085403","DOIUrl":"https://doi.org/10.1159/000085403","url":null,"abstract":"Metabotropic glutamate receptors (mGluRs) are a group of G-protein-coupled receptors that play important roles in mediation of glutamatergic transmission in the rat striatum. mGluR1α and mGluR2/3 are major mGluRs found in the striatum. The present study investigated the changes in expression of mGluR1α and mGluR2/3 during postnatal development. Rats at postnatal day (PND) 1, PND 7, PND 14 and adult stage were employed. Results of the immunofluorescence showed that mGluR1α immunoreactivity was primarily found in the neuropil, and an increasing trend was observed. An intense level of mGluR2/3 immunoreactivity was observed in the fiber bundles of the striatum of PND 1 rats but not in rats of other ages. A large proportion of mGluR2/3 but not mGluR1α immunoreactivities were found to be colocalized with synaptic vesicle protein two immunoreactive glutamatergic terminals. The present results demonstrate that mGluR2/3 is primarily expressed in glutamatergic axonal terminals in the striatum, but mGluR1α is expressed in postsynaptic elements in the striatum. There is a differential expression of mGluR1α and mGluR2/3 in rat striatum during postnatal developmental stages.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"36 - 41"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000085403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65286700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Apoptosis – A Brief Review 细胞凋亡-简要回顾

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085404

Aiqun Zhang, Yan Wu, H. Lai, D. Yew

引用次数: 68

Pathogenesis and Prevention of Pontosubicular Necrosis 桥骨下坏死的发病机制及预防

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085565

S. Takashima, A. Ichinohe, M. Itoh

引用次数: 0

Chiari Type 2 Anomaly Associated with a Thyroglossal Cyst 伴有甲状舌囊肿的Chiari 2型异常

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085406

Ş. Orguc, Ozum Tuncyurek, S. Serter, S. Tarhan, C. Goktan

引用次数: 0

Aberrant Chromosome 21 Gene Products: Explaining the Down Syndrome Phenotype? 21号染色体异常基因产物:解释唐氏综合征表型?

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085398

R. Ferrando-Miguel, M. Cheon, G. Lubec

引用次数: 4

Histological Analysis of Vascular Patterns and Connections in the Ganglionic Eminence of Premature Neonates 早产儿神经节隆起血管形态及连接的组织学分析

Neuroembryology and aging Pub Date : 2005-06-01 DOI: 10.1159/000085399

J. Anstrom, C. Thore, D. Moody, V. Challa, S. M. Block, W. Brown

{"title":"Histological Analysis of Vascular Patterns and Connections in the Ganglionic Eminence of Premature Neonates","authors":"J. Anstrom, C. Thore, D. Moody, V. Challa, S. M. Block, W. Brown","doi":"10.1159/000085399","DOIUrl":"https://doi.org/10.1159/000085399","url":null,"abstract":"Capillaries of the ganglionic eminence (GE) are reported to display structural features, such as an unusually large diameter and thin walls that support the widely held notion that these vessels are immature, and an important factor in the pathogenesis of germinal matrix hemorrhage. In this study, structural characteristics of vessels in the GE of preterm neonates were studied with either collagen IV immunohistochemistry, which labels all vessels, or alkaline phosphatase enzyme histochemistry, a marker of arterioles and capillaries but not venules. Brains from 17 preterm neonates ranging in age from 24 to 38.5 weeks postconception were used to test the hypothesis that GE arterioles connect to a peculiar capillary bed that includes large sinusoidal vessels. Clearly identifiable arterioles were traced to their terminal branch points. We found that arterioles connected directly to alkaline phosphatase-positive capillaries with a diameter of approximately 5 µm, and not to large-diameter thin-walled sinusoids. The average diameter of GE capillaries measured only 0.30 µm, greater than that of capillaries in the cortex of the same specimen. Although it is commonly held that GE capillaries are structurally immature, our results indicate that arterial blood reaching the GE is delivered to a typical capillary bed.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"4 - 12"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000085399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65286505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Contents Vol. 4, 2003 目录2003年第4卷

Neuroembryology and aging Pub Date : 2004-08-01 DOI: 10.1159/000080725

R. Ferrando-Miguel, S. Bölte, F. Poustka, M. Cheon, W. Y. Tam, Fung Yip, W. Chan, M. Gimona, H. Yeung, Daniel Kwong On Chan, Chris K.C. Wong, D. Pollak, M. Fountoulakis, Gert Lubec, K. Shim, M. Furuse, C. S. Cheung, Liang Wang, M. Dong

引用次数: 0

Temporal and Spatial Expressions of Stanniocalcin mRNA in Mouse Brains 斯坦钙素mRNA在小鼠大脑中的时空表达

Neuroembryology and aging Pub Date : 2004-08-01 DOI: 10.1159/000079399

H. Yeung, Daniel Kwong On Chan, Chris K.C. Wong

引用次数: 0

Third International Symposium on Normal and Abnormal Development of the Human Fetal Brain 第三届人类胎儿大脑正常与异常发育国际研讨会

Neuroembryology and aging Pub Date : 2004-08-01 DOI: 10.1159/000079405

R. Ferrando-Miguel, S. Bölte, F. Poustka, M. Cheon, W. Y. Tam, Fung Yip, W. Chan, M. Gimona, H. Yeung, Daniel Kwong On Chan, Chris K.C. Wong, D. Pollak, M. Fountoulakis, Gert Lubec, K. Shim, M. Furuse, C. S. Cheung, Liang Wang, M. Dong

引用次数: 0

Abnormalities of Interstitial Cells of Cajal in Dominant Megacolon Mice 优势巨结肠小鼠Cajal间质细胞的异常

Neuroembryology and aging Pub Date : 2004-08-01 DOI: 10.1159/000079402

W. Y. Tam, Fung Yip, W. Chan

{"title":"Abnormalities of Interstitial Cells of Cajal in Dominant Megacolon Mice","authors":"W. Y. Tam, Fung Yip, W. Chan","doi":"10.1159/000079402","DOIUrl":"https://doi.org/10.1159/000079402","url":null,"abstract":"Interstitial cells of Cajal (ICCs) in the gastrointestinal tract are a group of cells interacting with enteric neurons and smooth muscle cells. They serve as mediators of neurotransmission and pacemakers of the peristaltic movement of the gut. Previous investigations on patients with Hirschsprung’s disease and mice with aganglionic megacolon showed contrasting results on the relationship between the abnormalities of ICCs and enteric neurons. In order to ascertain whether the development of ICCs is also perturbed in the aganglionic segment of the gut, we used Dominant megacolon (Dom) mice as an animal model and an antibody specific to c-kit (a tyrosine kinase receptor expressed in ICCs) to examine the spatial distribution of ICCs in the developing and adult colon. Our results showed that in the wild-type adult colon, ICCs were bipolar in shape in the smooth muscle layer and dense networks of ICCs were observed in the myenteric and deep muscular plexuses, whereas in the aganglionic colon of Dom heterozygous mice, no ICCs could be found in the smooth muscle layer and disrupted patterns of ICC networks were observed in the myenteric and deep muscular plexuses. On 14.5 days of development, the levels of expression of c-kit and its ligand (stem cell factor) were similar in the wild-type, heterozygous and homozygous Dom embryos. However, by 18.5 days, the numbers of ICCs were greatly reduced in the myenteric and submucosal plexuses of the terminal colon of the heterozygous embryos comparing with the wild-type counterparts. Based on our results, we postulate that the abnormal development of ICCs may disrupt the neurotransmission and pacemaker activity of the gut, leading to interrupted peristalsis.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"2 1","pages":"156 - 163"},"PeriodicalIF":0.0,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000079402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65234860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1