Journal of biomedical graphics and computing最新文献

{"title":"Primary intracranial meningeal melanocytoma","authors":"M. Kumar, M. Gokden","doi":"10.5430/JBGC.V3N3P14","DOIUrl":"https://doi.org/10.5430/JBGC.V3N3P14","url":null,"abstract":"Primary intracranial meningeal melanocytoma (PIMM) is an uncommon, neoplasm of the central nervous system. It is a relatively benign entity and needs to be considered in the differential diagnosis of pigmented, melanin containing intracranial lesions. A case of a 25 year old right handed male, who presented with right side facial numbness, tingling and headaches, is presented. MRI findings suggested a diagnosis of primary meningeal melanocytoma, which was surgically and pathologically confirmed.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2013-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N3P14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71214269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of wound healing process based on texture image analysis","authors":"C. Loizou, T. Kasparis, Michalis Polyviou","doi":"10.5430/JBGC.V3N3P1","DOIUrl":"https://doi.org/10.5430/JBGC.V3N3P1","url":null,"abstract":"Wound healing rate remains an interesting and important issue, in which modern imaging techniques have not yet given a definitive answer. In order to guide better therapeutic interventions, a better understanding of the fundamental mechanisms driving tissue repair are required. The wound healing rate is primarily quantified by the rate of change of the wound’s surface area. The objective of this work is to establish a standardized and objective technique to assess the progress of wound healing in wounds appearing on patient’s feet, by means of texture image analysis. Image pre-processing, segmentation, texture and geometrical analysis together with visual expert’s evaluation were used to assess the wound healing process. A total of 77 digital images from 11 different subjects with foot wounds were taken every third day, for 21 days, by an inexpensive digital camera under different lighting conditions. The images were intensity normalized, and wounds were automatic segmented using a segmentation system based on snakes. From the segmented wounds, 56 different texture features and 4 different geometrical measures were extracted in order to identify features that quantify the rate of wound healing. Texture features that may indicate the progression of wound healing process were identified. More specifically, certain texture features increase (mean, contrast, roughness and radial sum), while some other texture features decrease (sum of squares variance, sum variance, sum average, entropy, coarseness, EE-laws texture energy measures and the Hurst coefficients for fractal dimension one and two analysis) with the progression of the wound healing process. These features were found to be significantly different at an observed time point during the wound healing process, when compared to previous different time points, and this could be used to indicate the rate of wound healing. No significant differences were found for all geometrical measures extracted from the wounds between different time points. Based on the results of this study, it is suggested that some texture features might be used to monitor the wound healing process, thus reducing the workload of experts, provide standardization, reduce costs, and improve the treatment quality for patients. The simplicity of the method also suggests that it may be a valuable tool in clinical wound evaluation. A larger scale study is needed to establish the application in clinical practice and for computing texture features and geometrical measures that may provide information for better and earlier differentiation of the wound healing process. Future work will incorporate additional texture features and geometrical measures for assessing the wound healing process in order to be used in the real clinical practice.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2013-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N3P1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71214196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparent dysfunction of one leaflet of a bileaflet mitral valve prosthesis due to collection of blood behind left atrium following cox maze III procedure and mitral valve replacement","authors":"D. Ho, M. Elahi, K. Zehr","doi":"10.5430/JBGC.V3N2P78","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P78","url":null,"abstract":"Immediate postcardiotomy tamponade is a known surgical complication predominantly by ventricular compression due to accumulation of ongoing bleeding or clot within the pericardial space. Transeosophageal echocardiography (TEE) is a useful tool in understanding such acute pathology; especially when the clot behind the heart would cause mechanical distortion of the prosthetic valve leaflets in mitral position. The main aim here is to present intraoperative TEE comparison findings to rule out leaflet mechanical obstruction of prosthetic valve during cardiac tamponade, shortly after cut and sew Cox-Maze III procedure, mitral valve replacement and tricuspid valve repair.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"78"},"PeriodicalIF":0.0,"publicationDate":"2013-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P78","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71214141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repair of a complex incisional hernia in the setting of palliative care","authors":"C. O’Connell, O. Cormack, F. Awan, N. Ravi, J. Reynolds","doi":"10.5430/JBGC.V3N2P73","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P73","url":null,"abstract":"Palliative surgery for cancer is mainly related to the palliation of direct or indirect causes of incurable disease. Surgery may also have to considered in patients with incurable disease for benign conditions that present significant symptoms or quality of life threats. We present here in one such case of the radiological investigation and management of a large incisional hernia at the site of a previous appendicectomy incision in a patient with terminal non-small cell lung cancer (NSCLC) and multiple co- morbidities. A significant improved quality of life was gained by this surgery despite it being high risk.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2013-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71214027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model versus non-model based left ventricular volumetry - A matter of imaging modality or quantification software?","authors":"K. Laser, P. Barth, Miriam Bunge, Gregory C. Dachner, H. Esdorn, M. Fischer, J. Gieseke, E. Sandica, D. Kececioglu, W. Burchert, H. Körperich","doi":"10.5430/JBGC.V3N2P54","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P54","url":null,"abstract":"Objective: To compare the modalities 3D-echocardiography (RT3DE) and cardiac magnetic resonance as well as semiautomatic non-model-based and model-based quantification software (SWP-MRI and SWT-MRI) regarding accuracy and agreement of left ventricular functional indices. Methods: 9 asymmetrically shaped gel phantoms (range: 20-350ml), 24 healthy children (age=11.4±3.3y) and 11 patients with abnormally shaped left ventricles (22.0±17.0y) were prospectively investigated. 3D-echocardiography was performed using a Vivid 7 ultrasound machine (V3 matrix transducer); postprocessing was done with a model-based analysis strategy (SWT-echo). CMR datasets were obtained using a multi-slice multi-phase steady‑state-free-precision acquisition (TR/TE/flip=2.8msecs/1.4msecs/60°) with a 1.5T MR system. Volume quantification was done using the same model-based software for CMR as well as non model-based software based on the summation of discs method. Agreement of EDV, ESV and EF between SWT-echo, SWP-mri vs. SWT-mri was determined by Bland Altman analysis. Results: Phantom study revealed high accuracy (<1%) for SWT-echo and SWP-mri as well as a moderate underestimation for SWT‑mri (13%). Agreement between SWP-mri and SWT-echo was superior in volunteers [mean; limits-of- agreement: EDV(5.3%; -20.1 to 30.8%), ESV(-1.3%; -41.6 to 38.9%), EF(4.0%; -12.0 to 19.9%)] with only slight underestimation by  RT3DE in patients [EDV(11.5%; ‑18.5 to 41.4%), ESV(13.0%; -5.4 to 31.5%), EF(‑6.9%; -49.9 to 36.1%)]. Comparing SWT-echo with SWT-mri revealed volume underestimation of EDV (9.8; -20.5 to 40.0%) and overestimation of ESV (-9.6; -60.1 to 41.0%) in volunteers by SWT-mri resulting in underestimation of EF (12.6;-9.6 to 34.9). In patients minor differences between SWT-echo and SWT-mri were observed [EDV (0.6%; -28.2 to 29.4%), ESV (-2.4%; -38.2 to 33.4%), EF(9.3%; -35.7 to 54.3%)]. Compared to our reference SWP-mri both model-based techniques moderately underestimated EDV (SWT-MRI 12.1%; ‑2.1 to 26.4%, SWT-echo 11.5%; -18.5 to 41.4%) and ESV (SWT-mri 10.6%; -21.2 to 42.4%, SWT-echo 13.0%; -5.4 to 31.5%)  resulting in quite precise  EF(SWT-MRI  2.4%, -23.7 to 28.5%). Conclusion: Accuracy and reliability of left ventricular indices are excellent for RT3DE assessed by model based approach compared to non-model-based CMR approach in phantoms and healthy volunteers with minor volume underestimation in atypically shaped moving ventricles. Minor agreement was present if the model-based CMR software was used for determination of ventricular volumes.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2013-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P54","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decision support system for stress only myocardial perfusion scintigraphy may save unnecessary rest studies","authors":"K. Tägil, D. Jakobsson, M. Lomsky, J. Marving, Svensson S-E, P. Wollmer, B. Hesse","doi":"10.5430/JBGC.V3N2P46","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P46","url":null,"abstract":"Aim: It is often a practical question whether to continue with the rest study after termination of a fairly normal stress myocardial perfusion scintigraphy (MPS), in particular for physicians with limited experience. The purpose of this study was to analyze the value of using a decision support system (DSS) to guide less experienced physicians in this situation. Methods: Nine residents from eight different nuclear medicine departments interpreted 100 MPS stress studies, first without and then with access to the advice of a DSS. Each study was interpreted regarding the necessity of adding a rest study for correct interpretation of the MPS. The patients had undergone a gated stress and rest MPS, using a Tc-99m sestamibi protocol. Interpretations made by three nuclear cardiology experts, having access to all available clinical and image information, were used as the gold standard. Results: In the cases where the gold standard interpretation wanted a rest study the 9 residents asked for it in 94% and 95% before and after having access to the DSS, respectively ( p >0.05). The residents did not want a rest study in 57% (without) and 69% (with the advice from the decision support system), in the patients, considered to have a normal stress study by the experts ( p <0.005). The DSS significantly reduced interobserver variation among the residents. Conclusion: The present study shows that with the support of a DSS less experienced physicians get closer to the decisions of highly experienced nuclear cardiologists regarding the need of adding a rest study to a stress MPS.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"50 1","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2013-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P46","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography for the diagnosis and treatment of Burkitt lymphoma","authors":"M. Alexander, James Robert Brašić","doi":"10.5430/JBGC.V3N2P67","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P67","url":null,"abstract":"Background/Objective: Burkitt lymphoma, a form of non Hodgkin lymphoma, is a rare aggressive mature B-cell neoplasm with a favorable prognosis. The objective of this article is to demonstrate that the prompt diagnosis and the application of effective treatments of Burkitt lymphoma is facilitated by the efficacious use of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography. Case Report: A 45-year-old man presented with pain in and around his joints and his bones. After multiple inconclusive diagnostic procedures, a 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography scan was obtained revealing diffuse intense radiotracer activity throughout the skeletal system with multiple areas of photopenia in multiple vertebral spine levels and the posterior iliac crest. Subsequent bone marrow biopsy showed a high Ki-67 proliferative index consistent with Burkitt lymphoma. Conclusions: This case report is of interest to all clinicians who may evaluate adults with pain in and around joints and bones. Burkitt lymphoma merits inclusion in the differential diagnosis of pain in and around joints and bones in adults. Utilization of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography will facilitate the prompt diagnosis of Burkitt lymphoma and the application of effective interventions.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"67"},"PeriodicalIF":0.0,"publicationDate":"2013-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P67","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotransmitter visualization in schizophrenia","authors":"James Robert Brašić","doi":"10.5430/JBGC.V3N2P30","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P30","url":null,"abstract":"Background: Although the history, interview, and examination of the patient provide the foundation for the diagnosis of schizophrenia, nuclear neuroimaging investigations constitute promising tools to elucidate the pathophysiology of schizophrenia and other neuropsychiatric disorders. Imaging studies of neuroreceptors constitute research tools to investigate the role of dysfunction of the acetylcholinergic, dopaminergic, glutamatergic, serotonergic, cannabinoid, opioid, and nicotinic systems in the pathogenesis and pathophysiology of schizophrenia and related conditions. People with the phenotype of the clinical syndrome of schizophrenia likely represent multiple distinct genotypes with poorly characterized biological traits. Thus, the population of people manifesting the clinical syndrome of schizophrenia likely contains several heterogeneous biological subgroups yet to be specified. The dopamine hypothesis of schizophrenia proposes that the positive symptoms result from an excess of intrasynaptic dopamine, an excitatory neurotransmitter, and the negative symptoms result from a deficit of intrasynaptic dopamine. Accordingly, a group of people with schizophrenia likely have reduced intrasynaptic dopamine in the tonic, resting, basal state, and increased intrasynaptic dopamine in the excited, aroused, phasic state. Additionally, the glutamate hypothesis of schizophrenia suggests that dysfunction of glutamate, another excitatory neurotransmitter, in the prefrontal region results in excessive concentrations of dopamine in the striata resulting in the positive symptoms of schizophrenia. Methodology/Principal Findings: Published research about the nuclear neuroimaging techniques to identify neurotrans- mitters in people with schizophrenia are reviewed. Conclusions/Significance: Future research including neuronuclear imaging and genetic evaluations is needed to characterize the biological subgroups of people with the clinical syndrome of schizophrenia. Neuronuclear imaging studies will likely refine the measurement of neurotransmitters in the presynaptic, synaptic, and postsynaptic regions in people with schizophrenia and healthy people. Imaging studies of neuroreceptors during the administration of putative therapeutic agents for schizophrenia will help determine the optimal dose. In the future the research findings summarized in this article will likely be translated into clinical practice.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2013-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of gallbladder cancer presenting with meta- stasis to bone and brain in an African American male discovered by F18-FDG PET/CT","authors":"A. Win, C. Aparici","doi":"10.5430/JBGC.V3N2P24","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P24","url":null,"abstract":"The most common site of metastasis in gallbladder cancer is the liver. To our knowledge, there are no reports in the literature of gallbladder cancer metastasizing to both the brain parenchyma and the bone.  There are only 5 prior reports of gallbladder cancer metastasis to the bone in the English Language literature. Likewise, gallbladder neoplasm metastasizing into the brain parenchyma is extremely rare. We present a rare case of gallbladder cancer presenting with metastases to both the brain parenchyma and the bone in a 71 year old African American male. This patient had early bone metastasis evidenced by hypermetabolic lesions on FDG PET/CT imaging, without density abnormalities of the bone tissue. Gastrointestinal (GI) tumors are commonly detected by CT but for metastasis, F18-FDG PET/CT has higher sensitivity and higher positive predictive value than CT. Since at the initial presentation, most patients suffering from gallbladder cancer tend to have metastatic disease, we raise a question as to whether F18-FDG PET/CT scans should be included in the routine work-up protocol.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2013-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two cone beam computed tomography multiplanar reconstruction orientation protocols","authors":"Vandana Kumar, D. Ang, K. Williams, M. Walker","doi":"10.5430/JBGC.V3N2P7","DOIUrl":"https://doi.org/10.5430/JBGC.V3N2P7","url":null,"abstract":"Objective: The utilization of cone beam computed tomographic imaging for oral implants has increased enormously for precise determination of anatomic dimensions. However, the impact of reorientation of data that influences the constructed panoramic view and thus the measurements on generated cross sectional views has not been explored. This study is undertaken to explore if differences exist in the implant height and width measurement when the whole data is reoriented from the standard manufacturer's setting to an aligned protocol (perpendicular to the implant (XYZ) settings). Material and Methods: Two different orientation protocols were set up, standard and aligned or perpendicular setting (XYZ), and implant height and width measurements derived from these were compared to the original known measurements. Results: The range of differences between actual dimensions and measurements obtained using each orientation method using McNemar's Change test in the four accuracy categories (exact, +0.20, +0.25, and +0.50) showed the aligned orientation produced larger proportion of width measurements between +0.25 and +0.50 compared to standard for width measures; however, these differences were not statistically significant. Implant length measurements varied widely and this variability was irrespective of orientation method. Conclusions: The aligned/perpendicular (XYZ) protocol produces implant width measurements more accurate than length when compared to the standard protocol.","PeriodicalId":89580,"journal":{"name":"Journal of biomedical graphics and computing","volume":"3 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2013-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/JBGC.V3N2P7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71213394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}