ISRN endocrinology最新文献_第4页

Four Hour Temporal Relation of 5-HTP and L-DOPA Induces Inhibitory Responses in Recrudescing Gonad of Indian Palm Squirrel (Funambulus pennantii). 5-HTP和L-DOPA的4小时时间关系诱导棕榈松鼠生殖腺再生的抑制反应。

ISRN endocrinology Pub Date : 2013-07-01 Print Date: 2013-01-01 DOI: 10.1155/2013/206876

Ranjana Jaiwal, C M Chaturvedi

{"title":"Four Hour Temporal Relation of 5-HTP and L-DOPA Induces Inhibitory Responses in Recrudescing Gonad of Indian Palm Squirrel (Funambulus pennantii).","authors":"Ranjana Jaiwal, C M Chaturvedi","doi":"10.1155/2013/206876","DOIUrl":"https://doi.org/10.1155/2013/206876","url":null,"abstract":"Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 4 h after 5-hydroxytryptophan (5-HTP, serotonin precursor) induced inhibitory responses in recrudescing gonad (in the first week of December) of Indian palm squirrel, a seasonally breeding subtropical animal. Other temporal relations (L-DOPA given at 0, 8, 12, 16, and 20 h after 5-HTP administration) did not show any effect on the recrudescing gonad. This inhibitory effect of 4 h was evident under short day length (6 : 18) group but was masked by the increasing day length of nature (NDL, late December onwards) and increased photoperiod of long day group (16 : 8). It is apparent that seasonal testicular recrudescence of Indian palm squirrel during short day length by 4 h relation of 5-HTP and L-DOPA is not a pharmacological effect but actually is an alteration of seasonality in this annually breeding mammal. It seems that endogenous mechanism controlling seasonal testicular recrudescence of Indian palm squirrel is reset by timed daily injections of these neurotransmitter drugs. It is suggested that in spite of different environmental factors (photoperiod, humidity, etc.) used by different species to time their annual reproduction, basic mechanism of seasonality appears to be the same, that is, the temporal synergism of neurotransmitter activity. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"206876"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/206876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Autoimmune thyroid disorders. 自身免疫性甲状腺疾病。

ISRN endocrinology Pub Date : 2013-06-26 Print Date: 2013-01-01 DOI: 10.1155/2013/509764

M A Iddah, B N Macharia

{"title":"Autoimmune thyroid disorders.","authors":"M A Iddah, B N Macharia","doi":"10.1155/2013/509764","DOIUrl":"https://doi.org/10.1155/2013/509764","url":null,"abstract":"Purpose of Review. Studies have been published in the field of autoimmune thyroid diseases since January 2005. The review is organized into areas of etiology, autoimmune features, autoantibodies, mechanism of thyroid cell injury, B-cell responses, and T-cell responses. Also it reviews the diagnosis and the relationship between autoimmune thyroid disease, neoplasm, and kidney disorders. Recent Findings. Autoimmune thyroid diseases have been reported in people living in different parts of the world including North America, Europe, Baalkans, Asia, Middle East, South America, and Africa though the reported figures do not fully reflect the number of people infected per year. Cases are unrecognized due to inaccurate diagnosis and hence are treated as other diseases. However, the most recent studies have shown that the human autoimmune thyroid diseases (AITDs) affect up to 5% of the general population and are seen mostly in women between 30 and 50 years. Summary. Autoimmune thyroid disease is the result of a complex interaction between genetic and environmental factors. Overall, this review has expanded our understanding of the mechanism involved in pathogenesis of AITD and the relationship between autoimmune thyroid disease, neoplasm, and kidney disease. It has opened new lines of investigations that will ultimately result in a better clinical practice. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"509764"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/509764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31601103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus. 波兰系统性红斑狼疮患者维生素D受体基因BsmI多态性

ISRN endocrinology Pub Date : 2013-06-18 Print Date: 2013-01-01 DOI: 10.1155/2013/427818

Beata Kaleta, Jarosław Bogaczewicz, Ewa Robak, Anna Sysa-Jędrzejowska, Małgorzata Wrzosek, Weronika Szubierajska, Piotr Mróz, Jacek Lukaszkiewicz, Anna Woźniacka

{"title":"Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus.","authors":"Beata Kaleta, Jarosław Bogaczewicz, Ewa Robak, Anna Sysa-Jędrzejowska, Małgorzata Wrzosek, Weronika Szubierajska, Piotr Mróz, Jacek Lukaszkiewicz, Anna Woźniacka","doi":"10.1155/2013/427818","DOIUrl":"https://doi.org/10.1155/2013/427818","url":null,"abstract":"The hormonally active form of vitamin D3, 1,25(OH)2D3 (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affects the level of VDR gene transcription, transcript stability, and posttranscriptional modifications. It seems to be related to the systemic lupus erythematosus (SLE). Our study examined the characteristics of VDR gene BsmI polymorphism in Polish SLE patients and their relationship with clinical manifestations of the disease. We genotyped 62 patients with SLE and 100 healthy controls using the real-time PCR. There were no differences observed in the frequency of BsmI genotypes in SLE patients and in the control group. There was no significant correlation between BsmI genotypes and clinical symptoms of SLE, but the AA genotype correlates with higher levels of antinuclear antibodies (ANA) in this group (r = 0.438; P = 0.002). A larger study examining BsmI and other VDR gene polymorphisms is needed. It may allow explaining differences in the clinical picture of the disease and choosing a personalized therapy. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"427818"},"PeriodicalIF":0.0,"publicationDate":"2013-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/427818","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31580072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Routine Screening for Cushing's Syndrome Is Not Required in Patients Presenting with Obesity. 肥胖患者不需要常规筛查库欣综合征。

ISRN endocrinology Pub Date : 2013-06-11 Print Date: 2013-01-01 DOI: 10.1155/2013/321063

Serap Baydur Sahin, Hacer Sezgin, Teslime Ayaz, Emine Uslu Gur, Kadir Ilkkilic

{"title":"Routine Screening for Cushing's Syndrome Is Not Required in Patients Presenting with Obesity.","authors":"Serap Baydur Sahin, Hacer Sezgin, Teslime Ayaz, Emine Uslu Gur, Kadir Ilkkilic","doi":"10.1155/2013/321063","DOIUrl":"https://doi.org/10.1155/2013/321063","url":null,"abstract":"Background. Cushing's syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. Our aim was to evaluate the frequency of CS in obese patients. Materials and Methods. This study included 354 consecutive patients (87.9% female, age 37.8 ± 13.4 years) who presented with simple obesity. All the patients were evaluated for the clinical signs of CS. Lipid parameters, fasting glucose (FPG) and insulin, 75 gr oral glucose tolerance test, basal cortisol and ACTH were measured. 1 mg overnight DST was performed. Results. The mean weight of the patients was 102.4 ± 20.1 kg and BMI 40 ± 7.35 kg/m(2). 34.5% of the patients were hypertensive. 36.2% of the patients had central obesity, 72% dorsocervical fat accumulation, 28.8% abdominal striae and 23.2% acne. 49.4% of the women had hirsutism. 46.5% had prediabetes and 12.0% had type 2 diabetes, 72.6% had dyslipidemia. The mean cortisol and ACTH levels were as follows: 9.28 ± 3.53 μ g/dL and 17.02 ± 10.43 pg/mL. Seven patients failed to suppress plasma cortisol to less than 1.8 μ g/dL. Biochemical confirmation tests were performed in these patients and 2 of them were diagnosed glucocorticoid-secreting adrenal adenoma. Conclusions. Routine screening for CS in obese patients is not required. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"321063"},"PeriodicalIF":0.0,"publicationDate":"2013-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/321063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31568398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mouse models and techniques for the isolation of the diabetic endothelium. 糖尿病内皮细胞的小鼠模型和分离技术。

ISRN endocrinology Pub Date : 2013-06-11 Print Date: 2013-01-01 DOI: 10.1155/2013/165397

April L Darrow, J Gregory Maresh, Ralph V Shohet

{"title":"Mouse models and techniques for the isolation of the diabetic endothelium.","authors":"April L Darrow, J Gregory Maresh, Ralph V Shohet","doi":"10.1155/2013/165397","DOIUrl":"https://doi.org/10.1155/2013/165397","url":null,"abstract":"Understanding the molecular mechanisms underlying diabetic endothelial dysfunction is necessary in order to improve the cardiovascular health of diabetic patients. Previously, we described an in vivo, murine model of insulin resistance induced by feeding a high-fat diet (HFD) whereby the endothelium may be isolated by fluorescence-activated cell sorting (FACS) based on Tie2-GFP expression and cell-surface staining. Here, we apply this model to two new strains of mice, ScN/Tie2-GFP and ApoE(-/-)/Tie2-GFP, and describe their metabolic responses and endothelial isolation. ScN/Tie2-GFP mice, which lack a functional toll-like receptor 4 (TLR4), display lower fasting glucose and insulin levels and improved glucose tolerance compared to Tie2-GFP mice, suggesting that TLR4 deficiency decreases susceptibility to the development of insulin resistance. ApoE(-/-)/Tie2-GFP mice display elevated glucose and cholesterol levels versus Tie2-GFP mice. Endothelial isolation by FACS achieves a pure population of endothelial cells that retain GFP fluorescence and endothelial functions. Transcriptional analysis of the aortic and muscle endothelium isolated from ApoE(-/-)/Tie2-GFP mice reveals a reduced endothelial response to HFD compared to Tie2-GFP mice, perhaps resulting from preexisting endothelial dysfunction in the hypercholesterolemic state. These mouse models and endothelial isolation techniques are valuable for assessing diabetic endothelial dysfunction and vascular responses in vivo. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"165397"},"PeriodicalIF":0.0,"publicationDate":"2013-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/165397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31568397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Human Serum PCSK9 Is Elevated at Parturition in Comparison to Nonpregnant Subjects While Serum PCSK9 from Umbilical Cord Blood is Lower Compared to Maternal Blood. 人血清PCSK9在分娩时比未怀孕的人升高，而脐带血的血清PCSK9比母血低。

ISRN endocrinology Pub Date : 2013-06-05 Print Date: 2013-01-01 DOI: 10.1155/2013/341632

Patricia Peticca, Angela Raymond, Andrée Gruslin, Marion Cousins, Ejibunmi Adetola, Hussein Abujrad, Janice Mayne, Teik Chye Ooi

{"title":"Human Serum PCSK9 Is Elevated at Parturition in Comparison to Nonpregnant Subjects While Serum PCSK9 from Umbilical Cord Blood is Lower Compared to Maternal Blood.","authors":"Patricia Peticca, Angela Raymond, Andrée Gruslin, Marion Cousins, Ejibunmi Adetola, Hussein Abujrad, Janice Mayne, Teik Chye Ooi","doi":"10.1155/2013/341632","DOIUrl":"https://doi.org/10.1155/2013/341632","url":null,"abstract":"Background. Serum lipids including total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C) are increased in pregnancy. Serum proprotein convertase subtilisin kexin 9 (PCSK9) is a significant player in lipoprotein metabolism. Circulating PCSK9 downregulates the LDL receptor on the surface of the liver, inhibiting clearance of LDL-C. Therefore, our study assessed serum PCSK9 concentrations at parturition (Maternal) compared to a nonpregnant (Control) cohort, as well as between mother and newborn (Maternal and Newborn). Methods. Blood was collected from women at parturition and from umbilical cords. Serum lipids and PCSK9 were measured and data were analysed for significance by Mann-Whitney U test at P < 0.05 and presented as median levels. Spearman's correlations were made at a 95% confidence interval. Results. Serum PCSK9 was significantly higher in Maternal versus Control cohorts (493.1 versus 289.7 ng/mL; P < 0.001, resp.), while the Newborn cohort was significantly lower than Maternal (278.2 versus 493.1 ng/mL; P < 0.0001, resp.). PCSK9 was significantly correlated with TC and HDL-C in Maternal and with TC, LDL-C, and HDL-C in Newborn cohorts. Conclusions. Our study provides the first quantitative report on PCSK9 in pregnancy (at parturition) and in umbilical cord blood. Further research will determine how these changes may affect lipoprotein levels during this physiological state. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"341632"},"PeriodicalIF":0.0,"publicationDate":"2013-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/341632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31586297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Placental HSD2 Expression and Activity Is Unaffected by Maternal Protein Consumption or Gender in C57BL/6 Mice. C57BL/6小鼠胎盘HSD2的表达和活性不受母体蛋白摄入或性别的影响

ISRN endocrinology Pub Date : 2013-05-28 Print Date: 2013-01-01 DOI: 10.1155/2013/867938

Mark R Garbrecht, Fred S Lamb

{"title":"Placental HSD2 Expression and Activity Is Unaffected by Maternal Protein Consumption or Gender in C57BL/6 Mice.","authors":"Mark R Garbrecht, Fred S Lamb","doi":"10.1155/2013/867938","DOIUrl":"https://doi.org/10.1155/2013/867938","url":null,"abstract":"The placenta acts as a physiological barrier, preventing the transfer of maternal glucocorticoids to the developing fetus. This is accomplished via the oxidation, and subsequent inactivation, of endogenous glucocorticoids by the 11-β hydroxysteroid dehydrogenase type 2 enzyme (HSD2). Maternal protein restriction during pregnancy has been shown to result in a decrease in placental HSD2 expression and fetal glucocorticoid overexposure, especially late in gestation, resulting in low birth weight and “fetal programming” of the offspring. This dietary intervention impairs fetal growth and cardiovascular function in adult C57BL/6 offspring, but the impact on placental HSD2 has not been defined. The goal of the current study was to examine the effects of a maternal low-protein diet (18% versus 9% protein) on placental HSD2 gene expression and enzyme activity in mice during late gestation. In contrast to previous studies in rats, a maternal low-protein diet did not affect HSD2 protein or enzyme activity levels in the placentas of C57BL/6 mice and this was irrespective of the gender of the offspring. These data suggest that the effects of maternal protein restriction on adult phenotypes in C57BL/6 mice depend upon a mechanism that may be independent of placental HSD2 or possibly occurs earlier in gestation.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"867938"},"PeriodicalIF":0.0,"publicationDate":"2013-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/867938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31518580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Risk factors associated with benign and malignant thyroid nodules in autoimmune thyroid diseases. 自身免疫性甲状腺疾病中良性和恶性甲状腺结节的相关危险因素

ISRN endocrinology Pub Date : 2013-05-25 Print Date: 2013-01-01 DOI: 10.1155/2013/673146

Priscila Carneiro Moreira Lima, Arnaldo Moura Neto, Marcos Antonio Tambascia, Denise Engelbrecht Zantut Wittmann

{"title":"Risk factors associated with benign and malignant thyroid nodules in autoimmune thyroid diseases.","authors":"Priscila Carneiro Moreira Lima, Arnaldo Moura Neto, Marcos Antonio Tambascia, Denise Engelbrecht Zantut Wittmann","doi":"10.1155/2013/673146","DOIUrl":"https://doi.org/10.1155/2013/673146","url":null,"abstract":"Objectives. Assess the prevalence of thyroid nodules and predictors of malignant origin in patients with autoimmune thyroid diseases. Patients and Methods. Retrospective study including 275 patients, 198 with Graves' disease and 77 with Hashimoto's thyroiditis. Clinical and demographical data, ultrasonographical nodule characteristics, total thyroid volume and histological characteristics were recorded. Results. Graves' disease: the prevalence of thyroid nodules and thyroid carcinoma were 27.78% and 5.05%, respectively. Older age (OR = 1.054; 95% CI = 1.029-1.080) and larger thyroid volumes (OR = 1.013; 95% CI = 1.003-1.022) increased the chance of nodules. Younger age (OR = 1.073; 95% CI = 1.020-1.128) and larger thyroid volume (OR = 1.018; 95% CI = 1.005-1.030) predicted thyroid carcinoma. Hashimoto's thyroiditis: the prevalence of thyroid nodules and carcinomas were 50.7% and 7.8%, respectively. Nodules were predicted by thyroid volume (OR = 1.030; 95% CI = 1.001-1.062). We found higher number of nodules in patients with thyroid carcinoma than in those with benign nodules (3 versus 2; P = 0.03). Patients with Hashimoto's thyroiditis presented nodules more frequently than patients with Graves' disease (50.65% versus 27.28%; P < 0.001), while the prevalence of carcinoma was similar (P = 0.751). Conclusions. Larger goiter was associated with carcinoma in Graves' disease and Hashimoto's thyroiditis. Younger patients presented higher risk of papillary thyroid carcinoma in Graves' disease. The prevalence of carcinoma was similar in both conditions.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"673146"},"PeriodicalIF":0.0,"publicationDate":"2013-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/673146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The effect of pioglitazone on antioxidant levels and renal histopathology in streptozotocin-induced diabetic rats. 吡格列酮对链脲佐菌素诱导的糖尿病大鼠抗氧化水平及肾脏组织病理学的影响。

ISRN endocrinology Pub Date : 2013-05-09 Print Date: 2013-01-01 DOI: 10.1155/2013/858690

Munire Kuru Karabas, Mediha Ayhan, Engin Guney, Mukadder Serter, Ibrahim Meteoglu

{"title":"The effect of pioglitazone on antioxidant levels and renal histopathology in streptozotocin-induced diabetic rats.","authors":"Munire Kuru Karabas, Mediha Ayhan, Engin Guney, Mukadder Serter, Ibrahim Meteoglu","doi":"10.1155/2013/858690","DOIUrl":"https://doi.org/10.1155/2013/858690","url":null,"abstract":"Objective. Diabetic nephropathy is the most commonly seen cause of chronic renal failure, and oxidative stress is important in etiology. In the present study, favorable effects (if any) of the treatment with a thiazolidinedione group drug, pioglitazone, on antioxidant enzyme levels in the renal tissue, renal histopathology, and inflammatory cytokine levels have been investigated. Method. Forty male Wistar rats were divided into 4 groups as the control, diabetic control, and 10 and 30 mg pioglitazone-administered diabetic groups. After 4 weeks, antioxidant enzyme levels in renal tissues and inflammatory markers were investigated. Results. Blood glucose levels did not differ between the diabetic control and drug-administered groups. In pioglitazone-administered rats, histopathological findings such as tubular dilation, necrotic tubular epithelium, glomerular focal necrosis, and vascular consolidation were observed at a lesser extent than the diabetic control group. Any difference was not detected between the diabetic groups with respect to the levels of malondialdehyde, superoxide dismutase, catalase, glutathione, nitric oxide, interleukin-6, and tumor necrosis factor-alpha. Conclusion. Pioglitazone regressed development of histopathological lesions such as glomerular focal necrosis, tubular epithelial necrosis, tubular dilation, and vascular wall consolidation. However, any favorable effect on antioxidant enzyme levels in renal tissues and inflammation markers was not detected.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"858690"},"PeriodicalIF":0.0,"publicationDate":"2013-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/858690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Effect of polyherbal mixtures on the treatment of diabetes. 中药复方治疗糖尿病的疗效观察。

ISRN endocrinology Pub Date : 2013-04-16 Print Date: 2013-01-01 DOI: 10.1155/2013/934797

Aparajeya Panda, Somanatha Jena, Pramod Kumar Sahu, Sanghamitra Nayak, Payodhar Padhi

{"title":"Effect of polyherbal mixtures on the treatment of diabetes.","authors":"Aparajeya Panda, Somanatha Jena, Pramod Kumar Sahu, Sanghamitra Nayak, Payodhar Padhi","doi":"10.1155/2013/934797","DOIUrl":"https://doi.org/10.1155/2013/934797","url":null,"abstract":"The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"934797"},"PeriodicalIF":0.0,"publicationDate":"2013-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/934797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31538621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19