ISRN endocrinology最新文献_第5页

Thryroid hormones and hematological indices levels in thyroid disorders patients at moi teaching and referral hospital, Western kenya. 肯尼亚西部moi教学和转诊医院甲状腺疾病患者甲状腺激素和血液学指标水平。

ISRN endocrinology Pub Date : 2013-04-15 Print Date: 2013-01-01 DOI: 10.1155/2013/385940

M A Iddah, B N Macharia, A G Ng'wena, A Keter, A V O Ofulla

{"title":"Thryroid hormones and hematological indices levels in thyroid disorders patients at moi teaching and referral hospital, Western kenya.","authors":"M A Iddah, B N Macharia, A G Ng'wena, A Keter, A V O Ofulla","doi":"10.1155/2013/385940","DOIUrl":"https://doi.org/10.1155/2013/385940","url":null,"abstract":"Problem Statement. Thyroid disorders are prevalent in western Kenya, but the effects of disorders on thyroid hormones and hematological indices levels have not been documented. Study Population. Patients treated for thyroid disorders at the MTRH between January 2008 and December 2011. Objectives. To determine the thyroid hormones and hematological indices levels in thyroid disorders patients at the MTRH, western Kenya. Methodology. A retrospective study in which patient data and stored samples of patients, who presented with thyroid pathologies, underwent thyroidectomy, and histological examinations are done. Thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) blood levels, white blood cells (WBCs), red blood cells (RBCs), platelet counts, and hemoglobin (Hb) levels were analyzed. Results. Male : female ratio was 1 : 10.9 with female representing 368 (95%). The median age was 41 (IQR: 32-48) with a range of 14-89 years. HHormonal levels for immunological thyroid disease patients were higher (P = 0.0232; 0.040) for TSH and (T3) for those aged 30-39 years, respectively. The WBCs, RBCs, HGB, and platelets in immunological thyroid disease were not statistically significant with P values of 0.547, 0.205, 0.291, and 0.488 respectively. Conclusion. The presence of anaemia due to low RBCs in thyroid disease is not significantly associated with thyroid hormone with a P value of 0.512.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"385940"},"PeriodicalIF":0.0,"publicationDate":"2013-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/385940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31538620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

The BB Wistar Rat as a Diabetic Model for Fracture Healing. BB Wistar大鼠作为糖尿病骨折愈合模型。

ISRN endocrinology Pub Date : 2013-03-31 Print Date: 2013-01-01 DOI: 10.1155/2013/349604

Amit Sood, Catie Cunningham, Sheldon Lin

引用次数: 8

Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease. PI3K/AKT/PTEN通路在非酒精性脂肪肝细胞信号传导中的作用

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-01-30 DOI: 10.1155/2013/472432

Satoru Matsuda, Mayumi Kobayashi, Yasuko Kitagishi

{"title":"Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease.","authors":"Satoru Matsuda, Mayumi Kobayashi, Yasuko Kitagishi","doi":"10.1155/2013/472432","DOIUrl":"https://doi.org/10.1155/2013/472432","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver pathologies and is associated with obesity and the metabolic syndrome, which represents a range of fatty liver diseases associated with an increased risk of type 2 diabetes. Molecular mechanisms underlying how to make transition from simple fatty liver to nonalcoholic steatohepatitis (NASH) are not well understood. However, accumulating evidence indicates that deregulation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in hepatocytes is a common molecular event associated with metabolic dysfunctions including obesity, metabolic syndrome, and the NAFLD. A tumor suppressor PTEN negatively regulates the PI3K/AKT pathways through its lipid phosphatase activity. Molecular studies in the NAFLD support a key role for PTEN in hepatic insulin sensitivity and the development of steatosis, steatohepatitis, and fibrosis. We review recent studies on the features of the PTEN and the PI3K/AKT pathway and discuss the protein functions in the signaling pathways involved in the NAFLD. The molecular mechanisms contributing to the diseases are the subject of considerable investigation, as a better understanding of the pathogenesis will lead to novel therapies for a condition.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"472432"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/472432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31257132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 125

Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance. 吡格列酮治疗期间胰岛素敏感性的改善与2型糖尿病患者igf - 1和皮质醇分泌的变化以及糖耐量受损有关

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-01-15 DOI: 10.1155/2013/148497

Lisa Arnetz, Neda Rajamand Ekberg, Charlotte Höybye, Kerstin Brismar, Michael Alvarsson

{"title":"Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance.","authors":"Lisa Arnetz, Neda Rajamand Ekberg, Charlotte Höybye, Kerstin Brismar, Michael Alvarsson","doi":"10.1155/2013/148497","DOIUrl":"https://doi.org/10.1155/2013/148497","url":null,"abstract":"Background. Hypercortisolism and type 2 diabetes (T2D) share clinical characteristics. We examined pioglitazone's effects on the GH-IGF-I and HPA axes in men with varying glucose intolerance. Methods. 10 men with T2D and 10 with IGT received pioglitazone 30-45 mg for 12 weeks. OGTT with microdialysis in subcutaneous adipose tissue and 1 μg ACTH-stimulation test were performed before and after. Glucose, insulin, IGF-I, IGFBP1, and interstitial measurements were analyzed during the OGTT. Insulin sensitivity was estimated using HOMA-IR. Results. HOMA-IR improved in both groups. IGF-I was initially lower in T2D subjects (P = 0.004) and increased during treatment (-1.4 ± 0.5 to -0.5 ± 0.4 SD; P = 0.007); no change was seen in IGT (0.4 ± 39 SD before and during treatment). Fasting glycerol decreased in T2D (P = 0.038), indicating reduced lipolysis. Fasting cortisol decreased in T2D (400 ± 30 to 312 ± 25 nmol/L; P = 0.041) but increased in IGT (402 ± 21 to 461 ± 35 nmol/L; P = 0.044). Peak cortisol was lower in T2D during treatment (599 ± 32 to 511 ± 43, versus 643 ± 0.3 to 713 ± 37 nmol/L in IGT; P = 0.007). Conclusions. Pioglitazone improved adipose tissue and liver insulin sensitivity in both groups. This may explain increased IGF-I in T2D. Pioglitazone affected cortisol levels in both groups but differently, suggesting different mechanisms for improving insulin sensitivity between T2D and IGT.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"148497"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/148497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31324087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Comparison between Revised NCEP ATP III and IDF Definitions in Diagnosing Metabolic Syndrome in an Urban Sri Lankan Population: The Ragama Health Study. 修订后的NCEP ATP III和IDF定义在诊断斯里兰卡城市人群代谢综合征中的比较:Ragama健康研究

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-02-27 DOI: 10.1155/2013/320176

S Chackrewarthy, D Gunasekera, A Pathmeswaren, C N Wijekoon, U K Ranawaka, N Kato, F Takeuchi, A R Wickremasinghe

{"title":"A Comparison between Revised NCEP ATP III and IDF Definitions in Diagnosing Metabolic Syndrome in an Urban Sri Lankan Population: The Ragama Health Study.","authors":"S Chackrewarthy, D Gunasekera, A Pathmeswaren, C N Wijekoon, U K Ranawaka, N Kato, F Takeuchi, A R Wickremasinghe","doi":"10.1155/2013/320176","DOIUrl":"10.1155/2013/320176","url":null,"abstract":"Background. The prevalence of metabolic syndrome (MetS) within individual cohorts varies with the definition used. The aim of this study was to compare the prevalence of MetS between IDF and revised NCEP ATP III criteria in an urban Sri Lankan population and to investigate the characteristics of discrepant cases. Methods. 2985 individuals, aged 35-65 years, were recruited to the study. Anthropometric and blood pressure measurements and laboratory investigations were carried out following standard protocols. Results. Age and sex-adjusted prevalences of MetS were 46.1% and 38.9% by revised NCEP and IDF definitions, respectively. IDF criteria failed to identify 21% of men and 7% of women identified by the revised NCEP criteria. The discrepant group had more adverse metabolic profiles despite having a lower waist circumference than those diagnosed by both criteria. Conclusion. MetS is common in this urban Sri Lankan cohort regardless of the definition used. The revised NCEP definition was more appropriate in identifying the metabolically abnormal but nonobese individuals, especially among the males predisposed to type 2 diabetes or cardiovascular disease. Further research is needed to determine the suitability of the currently accepted Asian-specific cut-offs for waist circumference in Sri Lankan adults.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"320176"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/320176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40227421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57

Type 2 diabetes mellitus, oral diabetic medications, insulin therapy, and overall breast cancer risk. 2型糖尿病，口服糖尿病药物，胰岛素治疗和总体乳腺癌风险。

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1155/2013/181240

Hala Ahmadieh, Sami T Azar

{"title":"Type 2 diabetes mellitus, oral diabetic medications, insulin therapy, and overall breast cancer risk.","authors":"Hala Ahmadieh, Sami T Azar","doi":"10.1155/2013/181240","DOIUrl":"https://doi.org/10.1155/2013/181240","url":null,"abstract":"Breast cancer is among the most common cancers worldwide. Diabetes is an important chronic health problem associated with insulin resistance, increased insulin level, changes in growth hormones and factors, and activation of mitogen-activating protein kinase (MAPK) pathways, leading to an increased breast cancer risk. This paper looked at the epidemiologic studies of the association between type 2 diabetes and risk of breast cancer and its effect on overall cancer-specific survival. The combined evidence overall supported a modest association between type 2 diabetes and the risk of breast cancer, which was found to be more prevalent among postmenopausal women. Effect of oral diabetics and insulin therapy on breast cancer risk was also evaluated. It was found that metformin and thiazolidinones tended to have a protective role. Metformin therapy trials for its use as an adjuvant for breast cancer treatment are still ongoing. Sulfonylurea and insulin therapy were found to be mildly associated with increased overall cancers. No evidence or studies evaluated the association of DPPIV inhibitors and GLP 1 agonists with breast cancer risk because of their recent introduction into the management of diabetes.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"181240"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/181240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31231709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø. 没有维生素D缺乏症的受试者补充高剂量维生素D可能有负面影响:来自特罗姆瑟四项干预试验的汇总数据

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-03-14 DOI: 10.1155/2013/348705

Rolf Jorde, Moira Strand Hutchinson, Marie Kjærgaard, Monica Sneve, Guri Grimnes

{"title":"Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø.","authors":"Rolf Jorde, Moira Strand Hutchinson, Marie Kjærgaard, Monica Sneve, Guri Grimnes","doi":"10.1155/2013/348705","DOIUrl":"https://doi.org/10.1155/2013/348705","url":null,"abstract":"Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA1c), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6-12 months of supplementation with vitamin D 20 000 IU-40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA1c of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P < 0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA1c, or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"348705"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/348705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31351281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice. 耐受性树突状细胞单独或联合雷帕霉素免疫治疗不能逆转NOD小鼠的糖尿病

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-03-11 DOI: 10.1155/2013/346987

Irma Pujol-Autonell, Rosa M Ampudia, Pau Monge, Anna M Lucas, Jorge Carrascal, Joan Verdaguer, Marta Vives-Pi

{"title":"Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice.","authors":"Irma Pujol-Autonell, Rosa M Ampudia, Pau Monge, Anna M Lucas, Jorge Carrascal, Joan Verdaguer, Marta Vives-Pi","doi":"10.1155/2013/346987","DOIUrl":"https://doi.org/10.1155/2013/346987","url":null,"abstract":"Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. Currently, there is no effective treatment strategy to restore endogenous insulin secretion in patients with type 1 diabetes. This study aims to restore insulin secretion in diabetic mice with experimental antigen-specific immunotherapy alone or in combination with rapamycin, a compound well known for its immunomodulatory effect. Nonobese diabetic (NOD) mice develop spontaneous type 1 diabetes after 12 weeks of age. Autologous tolerogenic dendritic cells-consisting in dendritic cells pulsed with islet apoptotic cells-were administered to diabetic NOD mice alone or in combination with rapamycin. The ability of this therapy to revert type 1 diabetes was determined by assessing the insulitis score and by measuring both blood glucose levels and C-peptide concentration. Our findings indicate that tolerogenic dendritic cells alone or in combination with rapamycin do not ameliorate diabetes in NOD mice. These results suggest that alternative strategies may be considered for the cure of type 1 diabetes.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"346987"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/346987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40245867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Growth and specialized growth charts of children with congenital hypothyroidism detected by neonatal screening in isfahan, iran. 伊朗伊斯法罕新生儿筛查发现先天性甲状腺功能减退症儿童的生长和特殊生长图表。

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-02-07 DOI: 10.1155/2013/463939

Awat Feizi, Mahin Hashemipour, Silva Hovsepian, Zeynab Amirkhani, Roya Kelishadi, Maryam Yazdi, Kamal Heydari, Ali Sajadi, Masoud Amini

{"title":"Growth and specialized growth charts of children with congenital hypothyroidism detected by neonatal screening in isfahan, iran.","authors":"Awat Feizi, Mahin Hashemipour, Silva Hovsepian, Zeynab Amirkhani, Roya Kelishadi, Maryam Yazdi, Kamal Heydari, Ali Sajadi, Masoud Amini","doi":"10.1155/2013/463939","DOIUrl":"10.1155/2013/463939","url":null,"abstract":"Objectives. The aim of the current study was to investigate the growth status of CH, generate specialized growth charts of CH infants, and compare them with their counterparts of regional normal infants. Methods. In this prospective cohort study, 760 (345 girls and 415 boys) neonates born in 2002-2009 diagnosed by neonatal CH screening program in Isfahan were followed up from the time of diagnosis. 552 healthy children were recruited as a control group. The empirical 3rd, 15th, 50th, 85th, and 97th percentiles for height, weight, and head circumference of both sexes were determined and compared with their counterpart values of the control group. The relative frequency of patients with impaired growth for each studied variable was determined. Also, specialized growth charts of CH patients were generated. Results. The percentiles of weight, height, and head circumference of studied patients are significantly different from regional healthy children (P < 0.001). The relative frequency of impaired head circumference was decreased to less than 3% at the 3rd year of age and for height it reached gradually 3% and 9% at the 5th year of age for boys and girls, respectively (P < 0.05); however for weight still it was statistically more than 3% in both sexes. Conclusion. CH patients had impaired growth development which was improved during follow up, but the catch-up time was earlier for head circumference and later for weight.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"463939"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/463939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31293889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Wound bed preparation for chronic diabetic foot ulcers. 慢性糖尿病足溃疡创面床的制备。

ISRN endocrinology Pub Date : 2013-01-01 Epub Date: 2013-02-13 DOI: 10.1155/2013/608313

Arman Zaharil Mat Saad, Teng Lye Khoo, Ahmad Sukari Halim

{"title":"Wound bed preparation for chronic diabetic foot ulcers.","authors":"Arman Zaharil Mat Saad, Teng Lye Khoo, Ahmad Sukari Halim","doi":"10.1155/2013/608313","DOIUrl":"https://doi.org/10.1155/2013/608313","url":null,"abstract":"The escalating incidence of diabetic mellitus has given rise to the increasing problems of chronic diabetic ulcers that confront the practice of medicine. Peripheral vascular disease, neuropathy, and infection contribute to the multifactorial pathogenesis of diabetic ulcers. Approaches to the management of diabetic ulcers should start with an assessment and optimization of the patient's general conditions, followed by considerations of the local and regional factors. This paper aims to address the management strategies for wound bed preparation in chronic diabetic foot ulcers and also emphasizes the importance of preventive measures and future directions. The \"TIME\" framework in wound bed preparation encompasses tissue management, inflammation and infection control, moisture balance, and epithelial (edge) advancement. Tissue management aims to remove the necrotic tissue burden via various methods of debridement. Infection and inflammation control restores bacterial balance with the reduction of bacterial biofilms. Achieving a moist wound healing environment without excessive wound moisture or dryness will result in moisture balance. Epithelial advancement is promoted via removing the physical and biochemical barriers for migration of epithelium from wound edges. These systematic and holistic approaches will potentiate the healing abilities of the chronic diabetic ulcers, including those that are recalcitrant.","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"608313"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/608313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31293890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35