ISRN endocrinology最新文献

Lipoprotein ratios as surrogate markers for insulin resistance in South indians with normoglycemic nondiabetic acute coronary syndrome. 脂蛋白比率作为南印度人血糖正常的非糖尿病急性冠状动脉综合征胰岛素抵抗的替代标志物。

ISRN endocrinology Pub Date : 2014-05-18 eCollection Date: 2014-01-01 DOI: 10.1155/2014/981524

Medha Rajappa, M G Sridhar, J Balachander, K R Sethuraman, Kalai Selvi Rajendiran

{"title":"Lipoprotein ratios as surrogate markers for insulin resistance in South indians with normoglycemic nondiabetic acute coronary syndrome.","authors":"Medha Rajappa, M G Sridhar, J Balachander, K R Sethuraman, Kalai Selvi Rajendiran","doi":"10.1155/2014/981524","DOIUrl":"10.1155/2014/981524","url":null,"abstract":"Background. Insulin resistance has been associated with dyslipidemia and cardiovascular disease. Even though homeostasis model assessment of insulin resistance (HOMA-IR) is a well-known insulin resistance predictor, estimation of serum lipoprotein ratios has been recently suggested as a surrogate marker for insulin resistance. Here, we evaluated the relationship between lipoprotein ratios and insulin resistance in normoglycemic nondiabetic south Indians with acute coronary syndrome. Methods. 100 normoglycemic nondiabetic ACS patients and 140 controls were enrolled in the study. Levels of fasting glucose, fasting insulin, and lipid profile [total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C)], lipoprotein(a) [Lp(a)] levels were measured and lipoprotein ratios were computed. HOMA-IR was used to calculate the insulin resistance. Receiver operating characteristic curves (ROC) analysis was used to compare the power of these lipoprotein ratios to predict insulin resistance. Results. Lipoprotein ratios were significantly higher in normoglycemic nondiabetic ACS patients, as compared to healthy controls, and were significantly correlated with HOMA-IR by Spearman's rank correlation analysis. ROC curve showed that Lp(a)/HDL-C and TG/HDL-C ratios were the best surrogate predictors of insulin resistance in normoglycemic nondiabetic ACS. Conclusion. This study demonstrates that serum lipoprotein ratios significantly correlate with insulin resistance in normoglycemic nondiabetic ACS. Lp(a)/HDL-C and TG/HDL-C ratios could be used as surrogate markers of insulin resistance in atherosclerosis-prone south Indians with normoglycemic nondiabetic ACS. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"981524"},"PeriodicalIF":0.0,"publicationDate":"2014-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/981524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32451568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Antihyperglycaemic effect of tetracarpidium conophorum nuts in alloxan induced diabetic female albino rats. 四叶参果对四氧嘧啶诱导的糖尿病雌性白化大鼠的降糖作用。

ISRN endocrinology Pub Date : 2014-05-06 eCollection Date: 2014-01-01 DOI: 10.1155/2014/124974

Donatus Onukwufor Onwuli, Holy Brown, Harrison Anaezichukwuolu Ozoani

{"title":"Antihyperglycaemic effect of tetracarpidium conophorum nuts in alloxan induced diabetic female albino rats.","authors":"Donatus Onukwufor Onwuli, Holy Brown, Harrison Anaezichukwuolu Ozoani","doi":"10.1155/2014/124974","DOIUrl":"10.1155/2014/124974","url":null,"abstract":"The antihyperglycaemic activity of Tetracarpidium conophorum nut (walnut) was investigated in albino rats. A total of 20 albino rats were used for the study. The rats were divided into five groups (A-E) of four rats each. Diabetes were induced in the rats except four which served as the positive control group A. Groups B (negative control), C, D, and E contain diabetic rats each with blood sugar level ≥17.00 mmol/L. Groups A and B were fed on 85.2 g of top feed grower over the test period. Test groups C, D, and E were fed on 21.3 g, 42.6 g, and 85.2 g of walnuts, respectively, and their fasting blood sugar (FBS) levels were checked on daily basis. Fasting blood glucose levels of the test groups were significantly lower than negative control P < 0.05, for 3rd, 7th, and 10th days of the test. There were also significant increase in the body weight and hemoglobin concentration and a decreased urine output of the test group compared with the controls. These results indicate that Tetracarpidium conophorum nut (walnut) has an antihyperglycemic effect in diabetic rats. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"124974"},"PeriodicalIF":0.0,"publicationDate":"2014-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/124974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32436741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Effect of Aerobic Training on Glucose Control and Blood Pressure in T2DDM East African Males. 有氧训练对T2DDM东非男性血糖控制和血压的影响。

ISRN endocrinology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/864897

Huimin Yan, Antonio Prista, Sushant M Ranadive, Albertino Damasceno, Paula Caupers, Jill A Kanaley, Bo Fernhall

{"title":"Effect of Aerobic Training on Glucose Control and Blood Pressure in T2DDM East African Males.","authors":"Huimin Yan, Antonio Prista, Sushant M Ranadive, Albertino Damasceno, Paula Caupers, Jill A Kanaley, Bo Fernhall","doi":"10.1155/2014/864897","DOIUrl":"https://doi.org/10.1155/2014/864897","url":null,"abstract":"Background. Exercise training intervention is underused in the management of type 2 diabetes mellitus in East Africa. Methods. 41 physically-active males with type 2 diabetes mellitus living in Mozambique were recruited and randomly assigned to 12 weeks of supervised exercise of low intensity exercise (LEX), vigorous intensity exercise (VEX), or to a control group (CON). Since there were no differences for any outcome variables between the exercise groups, VEX and LEX were combined into one exercise group (EX). Results. Age and baseline body weight were similar between EX and CON. Plasma glucose at 120 min following glucose load (Glu 120) was significantly reduced in the EX group after training (Glu 120 : 17.3 mmol/L to 15.0 mmol/L, P < 0.05), whereas Glu 120 remained unchanged in the CON (Glu 120 : 16.6 mmol/L to 18.7 mmol/L). After controlling for baseline blood pressure (BP), posttraining systolic BP and diastolic BP were lower in the EX group than in the CON group (EX: 129/77 mm Hg, CON: 152/83 mm Hg, P < 0.05). Conclusion. Adding exercise to already active African men with type 2 diabetes improved glucose control and BP levels without concomitant changes in weight. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"864897"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/864897","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32259958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Correlation between Body Mass Index and Waist Circumference in Patients with Metabolic Syndrome. 代谢综合征患者的体重指数与腰围之间的相关性。

ISRN endocrinology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/514589

Marcin Gierach, Joanna Gierach, Marlena Ewertowska, Adam Arndt, Roman Junik

{"title":"Correlation between Body Mass Index and Waist Circumference in Patients with Metabolic Syndrome.","authors":"Marcin Gierach, Joanna Gierach, Marlena Ewertowska, Adam Arndt, Roman Junik","doi":"10.1155/2014/514589","DOIUrl":"10.1155/2014/514589","url":null,"abstract":"Metabolic syndrome is defined as a group of coexisting metabolic risk factors, such as central obesity, lipid disorders, carbohydrate disorders, and arterial hypertension. According to the 2005 IDF criteria, subsequently revised in 2009, abdominal obesity is identified as the waist circumference of ≥80 cm in women and ≥94 cm in men. It is responsible for the development of insulin resistance. The aim of our study was to demonstrate a correlation between waist circumference (WC) and body mass index (BMI) in patients with metabolic syndrome in relation with hypertension, lipid disorders, and carbohydrate disorders. A cross-sectional two-site study was conducted in the Kuyavian-Pomeranian Voivodeship for 24 months. The study group consisted of 839 patients with diagnosed metabolic syndrome: 345 men (41.1%) and 494 women (58.9%) aged 32-80. In the study group, WC was found to be significantly correlated with BMI (R = 0.78, P < 0.01). The presence of overweight in men (BMI 25, 84 kg/m(2)) and even normal body weight in women (BMI 21,62 kg/m(2)) corresponds to an increased volume of visceral tissue in the abdomen. Introduction of primary prophylaxis in those people to limit the development of diabetes mellitus type 2 and cardiovascular diseases should be considered. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"514589"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32261099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower plasma creatinine and urine albumin in individuals at increased risk of type 2 diabetes with factor v leiden mutation. 2型糖尿病伴因子v leen突变风险增高者血浆肌酐和尿白蛋白降低

ISRN endocrinology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/530830

Andreas Peter, Andreas Fritsche, Fausto Machicao, Peter P Nawroth, Hans-Ulrich Häring, Berend Isermann

{"title":"Lower plasma creatinine and urine albumin in individuals at increased risk of type 2 diabetes with factor v leiden mutation.","authors":"Andreas Peter, Andreas Fritsche, Fausto Machicao, Peter P Nawroth, Hans-Ulrich Häring, Berend Isermann","doi":"10.1155/2014/530830","DOIUrl":"https://doi.org/10.1155/2014/530830","url":null,"abstract":"The factor V Leiden (FVL) mutation is the most frequent genetic cause of venous thrombosis in Caucasians. However, protective effects have been suggested to balance the disadvantages. We have recently observed protective effects of FVL mutation on experimental diabetic nephropathy in mice as well as an association with reduced albuminuria in two human cohorts of diabetic patients. In the present study we aimed to reevaluate these findings in an independent, larger cohort of 1905 Caucasians at risk of developing type 2 diabetes and extend possible associations to earlier disease stages of nephropathy. Carriers of FVL mutation had a significantly lower urine albumin excretion (P = 0.03) and tended to have lower plasma creatinine concentrations (P = 0.07). The difference in plasma creatinine concentrations was significant after adjustment for the influencing factors: age, gender, and lean body mass (P = 0.048). These observations at a very early \"disease\" stage are an important extension of previous findings and suggest that modification of glomerular dysfunction by FVL mutation is relevant during very early stages of diabetic nephropathy. This makes the underlying mechanism an interesting therapeutic target and raises the question whether FVL mutation may also exert protective effects in other glomerulopathies. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"530830"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/530830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32261100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients. 白藜芦醇促进2型糖尿病患者足部溃疡缩小。

ISRN endocrinology Pub Date : 2014-02-20 eCollection Date: 2014-01-01 DOI: 10.1155/2014/816307

Yuriy K Bashmakov, Samir H Assaad-Khalil, Myriam Abou Seif, Ruzan Udumyan, Magdy Megallaa, Kamel H Rohoma, Mohamed Zeitoun, Ivan M Petyaev

{"title":"Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients.","authors":"Yuriy K Bashmakov, Samir H Assaad-Khalil, Myriam Abou Seif, Ruzan Udumyan, Magdy Megallaa, Kamel H Rohoma, Mohamed Zeitoun, Ivan M Petyaev","doi":"10.1155/2014/816307","DOIUrl":"https://doi.org/10.1155/2014/816307","url":null,"abstract":"Objective. The effect of a proprietary formulation of trans-resveratrol (t-RSV) on manifestations of diabetic foot syndrome (DFS) was studied in type 2 diabetic patients with newly diagnosed diabetic foot ulcers. Method. Placebo-controlled, examiner-blinded, parallel-group randomized controlled pilot clinical trial (ACTRN Clinical Trial Registry number 12610000629033) involving 24 patients with DFS (15 males and 9 females, average age of 56.4 ± 9.1 years) divided into the placebo and RSV-treatment groups was performed. 50 mg of t-RSV or placebo capsules was given to each patient twice a day over a 60-day time period. Results. Reduction in the parameters reflecting diabetic ulcer size was more profound in the RSV group as compared to placebo. RSV-treated patients also had a marginally improved performance in the foot pressure test. A statistically significant decline in the plasma fibrinogen level, but not CRP, was also found in the RSV-treated patients. Some improvement in the plasma lipid profile and fasting glucose levels were not related to RSV-treatment, since they have been seen on both the RSV and placebo groups, revealing the effectiveness of medical supervision and education in the newly diagnosed patients with DFS. Conclusion. t-RSV supplementation promotes reduction of the foot ulcer size and reduces plasma fibrinogen level in type 2 diabetic patients. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"816307"},"PeriodicalIF":0.0,"publicationDate":"2014-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/816307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32234717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

Thyroid hormone status interferes with estrogen target gene expression in breast cancer samples in menopausal women. 甲状腺激素状态干扰绝经期妇女乳腺癌样本中雌激素靶基因的表达。

ISRN endocrinology Pub Date : 2014-02-20 eCollection Date: 2014-01-01 DOI: 10.1155/2014/317398

Sandro José Conde, Renata de Azevedo Melo Luvizotto, Maria Teresa de Síbio, Célia Regina Nogueira

{"title":"Thyroid hormone status interferes with estrogen target gene expression in breast cancer samples in menopausal women.","authors":"Sandro José Conde, Renata de Azevedo Melo Luvizotto, Maria Teresa de Síbio, Célia Regina Nogueira","doi":"10.1155/2014/317398","DOIUrl":"https://doi.org/10.1155/2014/317398","url":null,"abstract":"We investigated thyroid hormone levels in menopausal BrC patients and verified the action of triiodothyronine on genes regulated by estrogen and by triiodothyronine itself in BrC tissues. We selected 15 postmenopausal BrC patients and a control group of 18 postmenopausal women without BrC. We measured serum TPO-AB, TSH, FT4, and estradiol, before and after surgery, and used immunohistochemistry to examine estrogen and progesterone receptors. BrC primary tissue cultures received the following treatments: ethanol, triiodothyronine, triiodothyronine plus 4-hydroxytamoxifen, 4-hydroxytamoxifen, estrogen, or estrogen plus 4-hydroxytamoxifen. Genes regulated by estrogen (TGFA, TGFB1, and PGR) and by triiodothyronine (TNFRSF9, BMP-6, and THRA) in vitro were evaluated. TSH levels in BrC patients did not differ from those of the control group (1.34 ± 0.60 versus 2.41 ± 1.10 μ U/mL), but FT4 levels of BrC patients were statistically higher than controls (1.78 ± 0.20 versus 0.95 ± 0.16 ng/dL). TGFA was upregulated and downregulated after estrogen and triiodothyronine treatment, respectively. Triiodothyronine increased PGR expression; however 4-hydroxytamoxifen did not block triiodothyronine action on PGR expression. 4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment. Thus, our work highlights the importance of thyroid hormone status evaluation and its ability to interfere with estrogen target gene expression in BrC samples in menopausal women. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"317398"},"PeriodicalIF":0.0,"publicationDate":"2014-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/317398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32234716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Serum Levels of the Adipokine Zinc- α 2-glycoprotein Are Decreased in Patients with Hypertension. 高血压患者血清脂肪因子锌- α 2糖蛋白水平降低。

ISRN endocrinology Pub Date : 2014-02-09 eCollection Date: 2014-01-01 DOI: 10.1155/2014/374090

Hui Juan Zhu, Xiang Qing Wang, Hui Pan, Feng Ying Gong, Dian Xi Zhang, Nai Shi Li, Lin Jie Wang, Hong Bo Yang

{"title":"Serum Levels of the Adipokine Zinc- α 2-glycoprotein Are Decreased in Patients with Hypertension.","authors":"Hui Juan Zhu, Xiang Qing Wang, Hui Pan, Feng Ying Gong, Dian Xi Zhang, Nai Shi Li, Lin Jie Wang, Hong Bo Yang","doi":"10.1155/2014/374090","DOIUrl":"https://doi.org/10.1155/2014/374090","url":null,"abstract":"Objective. Zinc-α2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight regulation. The purpose of this study is to investigate serum levels of ZAG in patients with hypertension and its association with related characteristics. Methods. 32 hypertension patients and 42 normal controls were recruited and the relationship between serum ZAG, total and high molecular weight (HMW) adiponectin, and tumor necrosis factor-α (TNFα) determined by enzyme-linked immunosorbent assay (ELISA) and metabolic-related parameters was investigated. Results. Serum ZAG concentrations were significantly lowered in patients with hypertension compared with healthy controls (61.4 ± 32 versus 78.3 ± 42 μg/mL, P < 0.05). The further statistical analysis demonstrated that serum ZAG levels were negatively correlated with waist-to-hip ratio (WHR) (r = -0.241, P < 0.05) and alanine aminotransferase (ALT) (r = -0.243, P < 0.05). Additionally, serum HMW adiponectin significantly decreased, while TNFα greatly increased in hypertension patients as compared with healthy controls (2.32 ± 0.41 versus 5.24 ± 1.02 μg/mL, 3.30 ± 1.56 versus 2.34 ± 0.99 pg/mL, P < 0.05). Conclusions. Serum ZAG levels are significantly lowered in hypertension patients and negatively correlated with obesity-related item WHR, suggesting ZAG is a factor associated with hypertension. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"374090"},"PeriodicalIF":0.0,"publicationDate":"2014-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/374090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32205474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro. 吡格列酮体外抑制大鼠系膜细胞p22(phox)和p47(phox)的表达

ISRN endocrinology Pub Date : 2014-02-03 eCollection Date: 2014-01-01 DOI: 10.1155/2014/601352

Shan Wang, Shan-Dong Ye, Wen-Jia Sun, Yuan-Yuan Hu

{"title":"Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro.","authors":"Shan Wang, Shan-Dong Ye, Wen-Jia Sun, Yuan-Yuan Hu","doi":"10.1155/2014/601352","DOIUrl":"https://doi.org/10.1155/2014/601352","url":null,"abstract":"Aim. The purpose of this study was to investigate the effects of pioglitazone on oxidative stress and the expressions of p22(phox) and p47(phox), subunits of NADPH oxidase, in mesangial cells (MCs). Method. Rat mesangial cells were cultured and randomly divided into normal glucose (NG) group, high glucose (HG) group, and pioglitazone group. After 48 h exposure, the supernatants and cells were collected. The expressions of p22(phox) and p47(phox) in MCs were detected by RT-PCR and western blot. The levels of intracellular ROS were determined by flow cytometry. Coloimetry method was used to detect malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activities. Results. Compared with the NG group, the expression levels of p22(phox), p47(phox) and ROS significantly increased, the activity of SOD decreased in HG group, while the concentration of MDA greatly increased (P < 0.01). Pioglitazone significantly suppressed HG-induced p22(phox) and p47(phox) expressions and oxidative stress. The protein and gene expressions of p22(phox) and p47(phox) were markedly reduced after pioglitazone treatment, so did the ROS generation. The activities of SOD in MCs increased, while the concentrations of MDA in the supernatant decreased greatly by pioglitazone. Conclusions. Pioglitazone can inhibit HG-induced oxidative stress in MCs through suppressing p22(phox) and p47(phox) expressions. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"601352"},"PeriodicalIF":0.0,"publicationDate":"2014-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/601352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32184644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The response of circulating leptin levels to exercise stress testing in subjects diagnosed with metabolic syndrome. 代谢综合征患者循环瘦素水平对运动应激测试的反应。

ISRN endocrinology Pub Date : 2014-01-28 eCollection Date: 2014-01-01 DOI: 10.1155/2014/689260

Dana Pop, Alexandra Dădârlat, Gyorgy Bodizs, Liana Stanca, Dumitru Zdrenghea

{"title":"The response of circulating leptin levels to exercise stress testing in subjects diagnosed with metabolic syndrome.","authors":"Dana Pop, Alexandra Dădârlat, Gyorgy Bodizs, Liana Stanca, Dumitru Zdrenghea","doi":"10.1155/2014/689260","DOIUrl":"https://doi.org/10.1155/2014/689260","url":null,"abstract":"Aim. To assess the plasma leptin responses after exercise stress testing in patients with metabolic syndrome (MS). Material and Methods. We investigated 67 patients with MS, with mean age of 55 ± 7 years. They underwent exercise stress testing on cycloergometer. The lot was divided into three groups: group 1-10 patients with a true positive test, group 2-18 patients with a true negative test, and group 3-39 patients with a false negative test. Leptin levels were measured using the ELISA method. Results. Leptin levels decreased after effort in patients with MS (9.42 ± 11.08 ng/mL before and 8.18 ± 11.5 ng/mL after the exercise stress test, P = 0.0005, r = 0.874). In groups 1 (8.98 ± 9.09 at rest versus 5.98 ± 8.73 ng/mL after the exercise test, P = 0.002) and 3 (8.6 ± 10.53 at rest versus 6.91 ± 9.07 ng/mL, P = 0.0005), lower leptin levels were recorded immediately after exercise testing. Leptin levels were not significantly lower in group 2 before effort (9.49 ± 11.36 ng/ml) and after (9.46 ± 13.81 ng/mL). We found no correlation between leptinemia and exercise stress testing parameters, regardless of group. Conclusion. Our research showed that short-term exercise lowers leptin levels in coronary patients, without a relationship between its parameters and leptin values. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"689260"},"PeriodicalIF":0.0,"publicationDate":"2014-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/689260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40300049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3