ISRN endocrinology最新文献_第2页

Vitamin D and the Immune System from the Nephrologist's Viewpoint. 从肾病专家的角度看维生素D和免疫系统。

ISRN endocrinology Pub Date : 2014-01-22 eCollection Date: 2014-01-01 DOI: 10.1155/2014/105456

Cheng-Lin Lang, Min-Hui Wang, Chih-Kang Chiang, Kuo-Cheng Lu

引用次数: 30

Are plasma thyroid-stimulating hormone levels associated with degree of obesity and metabolic syndrome in euthyroid obese patients? A Turkish cohort study. 血浆促甲状腺激素水平与甲状腺功能正常肥胖患者的肥胖程度和代谢综合征相关吗?一项土耳其队列研究。

ISRN endocrinology Pub Date : 2014-01-02 eCollection Date: 2014-01-01 DOI: 10.1155/2014/803028

Okan Bakiner, Emre Bozkirli, Gulhan Cavlak, Kursad Ozsahin, Eda Ertorer

{"title":"Are plasma thyroid-stimulating hormone levels associated with degree of obesity and metabolic syndrome in euthyroid obese patients? A Turkish cohort study.","authors":"Okan Bakiner, Emre Bozkirli, Gulhan Cavlak, Kursad Ozsahin, Eda Ertorer","doi":"10.1155/2014/803028","DOIUrl":"https://doi.org/10.1155/2014/803028","url":null,"abstract":"We aimed to observe the association between degree of obesity and metabolic syndrome and plasma thyrotropin levels in obese, euthyroid Turkish patients. 947 obese and overweight patients who admitted to our outpatient clinic were assessed retrospectively. 150 healthy euthyroid cases were also recruited as the control group. Cases with metabolic syndrome were determined. Patients were divided into various subgroups as overweight, obese, morbid obese, men, and women. No statistical significance was determined when all the patients' and subgroups' plasma thyrotropin levels were compared to normal weight control group. No association was shown between the presence of metabolic syndrome and plasma thyrotropin levels for both all patients and subgroups. Also there was not any association between each component of metabolic syndrome and plasma thyrotropin levels. In conclusion, we did not found any significant association between plasma thyrotropin levels and obesity and metabolic syndrome in our euthyroid subjects. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2014 ","pages":"803028"},"PeriodicalIF":0.0,"publicationDate":"2014-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/803028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32115778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Effects of glucose control and variability on endothelial function and repair in adolescents with type 1 diabetes. 血糖控制和变异性对青少年1型糖尿病内皮功能和修复的影响

ISRN endocrinology Pub Date : 2013-12-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/876547

Robert P Hoffman, Amanda S Dye, Hong Huang, John A Bauer

{"title":"Effects of glucose control and variability on endothelial function and repair in adolescents with type 1 diabetes.","authors":"Robert P Hoffman, Amanda S Dye, Hong Huang, John A Bauer","doi":"10.1155/2013/876547","DOIUrl":"https://doi.org/10.1155/2013/876547","url":null,"abstract":"Background. Endothelial dysfunction and increased inflammation are precursors of cardiovascular disease in type 1 diabetes (T1D) and occur even in adolescents with T1D. The goal of this study was to determine the relationship of endothelial dysfunction to various measures of glycemia. Research Design and Methods. Forearm blood flow (FBF, venous occlusion plethysmography) was measured before and after 5 min of upper arm vascular occlusion in 17 adolescents with uncomplicated type 1 diabetes. Endothelial function was assessed as postocclusion FBF and forearm vascular resistance (FVR, mean arterial pressure/FBF). Fasting glucose, 72 hour mean glucose and standard deviation from continuous glucose monitoring, hemoglobin A1c, and hemoglobin A1c by duration area under the curve were used to assess immediate, short-term, and intermediate- and long-term glycemia. Results. Postocclusion FBF (r = -0.53, P = 0.030) negatively correlated and postocclusion FVR positively correlated (r = 0.52, P = 0.031) with hemoglobin A1c levels. FVR was positively associated with log 3 day mean glucose (r = 0.55, P = 0.027). Postocclusion FBF (2.8 ± 1.1 versus 3.4 ± 0.5 mL/dL/min, mean ± SE, P = 0.084) tended to be lower and FVR (31.4 ± 10.4 versus 23.9 ± 4.4 mmHg dL min/mL, P = 0.015) was significantly higher in subjects with hemoglobin A1c above the median (8.3%) compared to those with lower hemoglobin A1c levels. Conclusions. These results demonstrate that poor intermediate-term glycemic control is associated with impaired endothelial function. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"876547"},"PeriodicalIF":0.0,"publicationDate":"2013-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/876547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32083856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Carotid atherosclerosis as a surrogate maker of cardiovascular disease in diabetic patients. 颈动脉粥样硬化是糖尿病患者心血管疾病的替代标志物。

ISRN endocrinology Pub Date : 2013-11-10 eCollection Date: 2013-01-01 DOI: 10.1155/2013/979481

Ryuichi Kawamoto, Tateaki Katoh, Tomo Kusunoki, Nobuyuki Ohtsuka

{"title":"Carotid atherosclerosis as a surrogate maker of cardiovascular disease in diabetic patients.","authors":"Ryuichi Kawamoto, Tateaki Katoh, Tomo Kusunoki, Nobuyuki Ohtsuka","doi":"10.1155/2013/979481","DOIUrl":"https://doi.org/10.1155/2013/979481","url":null,"abstract":"Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on the presence of CVD. We cross-sectionally assessed the ability of carotid IMT to identify CVD corresponding to treatment that was examined by receiver-operating characteristic (ROC) curve analyses. Among the 271 diabetic patients, 199 non-CVD and 72 CVD patients were examined. Multiple linear regression analysis using the presence of CVD as an objective variable showed that carotid IMT (β = 0.259, P < 0.001) as well as other confounding factors was a significant independent contributing factor. The ROC curve analysis showed that the best marker of CVD was carotid IMT, with an area under the ROC curve of 0.718 (95% confidence interval (CI), 0.650-0.785). The greatest sensitivity and specificity were obtained when the cut-off value of mean carotid IMT was set at 0.95 mm (sensitivity = 0.71, specificity = 0.60, and accuracy = 0.627). Our study suggests that carotid IMT may be useful for screening diabetic patients with CVD. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"979481"},"PeriodicalIF":0.0,"publicationDate":"2013-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/979481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31939447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Insulin sensitivity assessed by stable isotopes with oral glucose administration: validation with euglycaemic clamp. 稳定同位素评估胰岛素敏感性与口服葡萄糖给药:验证与血糖钳。

ISRN endocrinology Pub Date : 2013-11-03 eCollection Date: 2013-01-01 DOI: 10.1155/2013/189412

Leslie Bluck, Rachel Williams, Sarah Jackson, Burak Salgin, Carlo Acerini, David Dunger

引用次数: 1

No Association between Glycemia and Wound Healing in an Experimental db/db Mouse Model. 在实验性db/db小鼠模型中，血糖与伤口愈合无关联。

ISRN endocrinology Pub Date : 2013-10-22 eCollection Date: 2013-01-01 DOI: 10.1155/2013/307925

Margrete Berdal, Trond Jenssen

{"title":"No Association between Glycemia and Wound Healing in an Experimental db/db Mouse Model.","authors":"Margrete Berdal, Trond Jenssen","doi":"10.1155/2013/307925","DOIUrl":"https://doi.org/10.1155/2013/307925","url":null,"abstract":"Impaired wound healing is a frequent problem in diabetes. Hyperglycemia may be an operative mechanism, but a link between glycemic control and wound healing has never been established. Wounds in db/db mice have been extensively studied. This study was undertaken to see if plasma glucose was a predictor of wound healing. An excisional wound was made (149 db/db mice). Wound closure was studied versus metabolic variables. The animals were 11.8 ± 0.2 weeks (mean ± standard error of the mean), obese (38.1 ± 0.5 g), and hyperglycemic (fasting plasma glucose 21.0 ± 0.7 mmol/L). Wound closure at day 13 was 30.1 ± 1.6%. In linear mixed model analyses neither fasting plasma glucose nor its change from start to end of experiment was a significant predictor of wound closure (β = 0.15, P = 0.07, 95% CI: -0.01 to 0.31 and β = 0.06, P = 0.5, 95% CI: -0.11 to 0.23, resp.). However, increase in body weight significantly and independently predicted wound closure (for weight change, β = 0.22, P = 0.008, 95% CI: 0.06 to 0.38). This study strongly suggests that wound healing in db/db mice is independent of prevailing glycemia but dependent on anabolic changes such as weight gain over time. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"307925"},"PeriodicalIF":0.0,"publicationDate":"2013-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/307925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31881166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Hypovitaminosis d in patients with type 2 diabetes mellitus: a relation to disease control and complications. 2型糖尿病患者维生素d缺乏症与疾病控制及并发症的关系

ISRN endocrinology Pub Date : 2013-10-22 eCollection Date: 2013-01-01 DOI: 10.1155/2013/641098

Hala Ahmadieh, Sami T Azar, Najla Lakkis, Asma Arabi

{"title":"Hypovitaminosis d in patients with type 2 diabetes mellitus: a relation to disease control and complications.","authors":"Hala Ahmadieh, Sami T Azar, Najla Lakkis, Asma Arabi","doi":"10.1155/2013/641098","DOIUrl":"https://doi.org/10.1155/2013/641098","url":null,"abstract":"Aims. This study aims at assessing the relationship between 25 (OH) vitamin D (25-OHD) levels and microvascular complications in patients with type 2 diabetes mellitus (DM2). Methods. 136 patients (59 ± 11 years) with DM2 (disease duration 8.6 ± 7 years) participated in this cross-sectional study. Anthropometric data, HbA1c, 25-OHD levels, serum creatinine, and urine microalbumin/creatinine ratio were collected. Dilated retinal exam was performed, and diabetic neuropathy was assessed using the United Kingdom Screening Score. Results. Serum 25-OHD correlated negatively with HbA1c (r = -0.20, P = 0.049). Mean 25-OHD levels were lower in subjects with diabetic retinopathy compared to those without retinopathy (12.3 ± 5.5 versus 21.8 ± 13.7, P < 0.001) and lower in subjects with diabetic neuropathy compared to those without neuropathy (16.4 ± 10.4 versus 23.5 ± 14.5, P = 0.004). After adjustment for BMI, diabetes duration, and smoking, 25-OHD was an independent predictor of HbA1c ( β -0.14; P = 0.03). After adjustment for HbA1c, age, smoking, BMI and disease duration, 25-OHD were independent predictors for diabetic retinopathy: OR 2.8 [95% CI 2.1-8.0] and neuropathy: OR 4.5 [95% CI 1.6-12] for vitamin D < 20 versus vitamin D ≥ 20 ng/mL. Conclusion. Low serum 25-OHD level was an independent predictor of HbA1c, diabetic neuropathy, and diabetic retinopathy in patients with DM2. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"641098"},"PeriodicalIF":0.0,"publicationDate":"2013-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/641098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31879488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 98

A Longitudinal Study of Changes in Thyroid Related Hormones among Pregnant Women Residing in an Iodine Deficient Urban Area. 居住在缺碘城市地区孕妇甲状腺相关激素变化的纵向研究。

ISRN endocrinology Pub Date : 2013-10-21 eCollection Date: 2013-01-01 DOI: 10.1155/2013/234031

Shan Elahi, Zaib Hussain

{"title":"A Longitudinal Study of Changes in Thyroid Related Hormones among Pregnant Women Residing in an Iodine Deficient Urban Area.","authors":"Shan Elahi, Zaib Hussain","doi":"10.1155/2013/234031","DOIUrl":"https://doi.org/10.1155/2013/234031","url":null,"abstract":"Problem Statement. Thyroid gland in women undergoes functional changes during pregnancy. A few studies have described such changes in pregnant women residing in iodine deficient areas. Objective. To document these changes in pregnant women residing in Lahore, a low iodine intake urban area of Pakistan. Patients and Methods. In 254 pregnant women, data of FT4, FT3, and TSH during the first and subsequent trimesters were obtained and compared with those of 110 nonpregnant women. These hormones were determined in serum by radioimmunoassay (RIA) techniques using commercial kits. Results. Compared to nonpregnant women mean FT4 level was decreased, and FT3 and TSH increased significantly (P < 0.05) in pregnant women. A negative correlation of FT4 with TSH was observed in all three trimesters. Serum FT3 was positively correlated with TSH only during the third trimester. As a function of gestation time, FT4 levels progressively decreased, and FT3 and TSH levels increased significantly (one-way ANOVA F = 108.2, 17.3, and 44.8, resp.; all P < 0.05) exhibiting thyroid gland adaptations. Conclusion. Pregnancy is associated with significant alterations in thyroid function due to low iodine intake in women residing in study area. The compensated thyroid function poses a risk of thyroid failure in a number of pregnant women. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"234031"},"PeriodicalIF":0.0,"publicationDate":"2013-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/234031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31867161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Improving compliance with screening of diabetic patients for microalbuminuria in primary care practice. 提高初级保健中糖尿病患者微量白蛋白尿筛查的依从性。

ISRN endocrinology Pub Date : 2013-10-09 eCollection Date: 2013-01-01 DOI: 10.1155/2013/893913

Abeer Anabtawi, L Mary Mathew

引用次数: 13

Risk of cancer in diabetes: the effect of metformin. 糖尿病患者患癌症的风险:二甲双胍的作用。

ISRN endocrinology Pub Date : 2013-09-24 DOI: 10.1155/2013/636927

Mojtaba Malek, Rokhsareh Aghili, Zahra Emami, Mohammad E Khamseh

{"title":"Risk of cancer in diabetes: the effect of metformin.","authors":"Mojtaba Malek, Rokhsareh Aghili, Zahra Emami, Mohammad E Khamseh","doi":"10.1155/2013/636927","DOIUrl":"https://doi.org/10.1155/2013/636927","url":null,"abstract":"Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer response to cancer treatment, and excess mortality related to diabetes are among the most important explanations. Although diabetes appear to be a risk factor for cancer and is associated with the mortality risk in cancer patients, several factors such as diabetes duration, multiple drug therapy, and the presence of diabetes comorbidities make the assessment of the effect of diabetes treatment on cancer risk and mortality difficult. Metformin is the drug of choice for the treatment of type 2 diabetes. The available evidence from basic science, clinical, and population-based research supports the anticancer effect of metformin. However, randomized controlled clinical trials do not provide enough evidence for a strong protective effect of metformin on cancer incidence or mortality. One of the most important limitations of these trials is the short duration of the followup. Further long-term randomized controlled clinical trials specifically designed to determine metformin effect on cancer risk are needed to provide the best answer to this challenge. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"636927"},"PeriodicalIF":0.0,"publicationDate":"2013-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/636927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72