ISRN endocrinology最新文献_第3页

A clinical review of the association of thyroid stimulating hormone and cognitive impairment. 促甲状腺激素与认知障碍相关性的临床研究综述。

ISRN endocrinology Pub Date : 2013-09-23 DOI: 10.1155/2013/856017

Sylvia Annerbo, Johan Lökk

{"title":"A clinical review of the association of thyroid stimulating hormone and cognitive impairment.","authors":"Sylvia Annerbo, Johan Lökk","doi":"10.1155/2013/856017","DOIUrl":"https://doi.org/10.1155/2013/856017","url":null,"abstract":"Clinical and subclinical hypothyroidism as well as overt hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning as memory, reaction time, and visuospatial organization. Subclinical hyperthyroidism (SH) or low serum concentrations of TSH concentrations have been associated with dementia in previous epidemiological studies, but the association in the elderly has not been established. There is little or no consensus regarding how thyroid function is associated with cognitive performance in the elderly. In this focused review, we have performed an examination between eleven studies from the last five years examining the association between thyroid function and cognitive performance in elderly people, a group who is overrepresented among individuals with minor abnormalities in serum TSH and thyroid hormone concentration. Six of the studies showed a consistent finding of an association between SH with cognitive impairment or dementia. In general, taking into account the largest and most powerfully designed studies, there is a strong body of evidence supporting the association between SH and cognitive impairment. The scarce number of publications on these topics indicates the need of more research especially regarding longitudinal and interventional studies thus hopefully enabling confirmation or rejection of causality between TSH abnormalities and dementia. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"856017"},"PeriodicalIF":0.0,"publicationDate":"2013-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/856017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40276974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Aryl hydrocarbon receptor ligands inhibit igf-ii and adipokine stimulated breast cancer cell proliferation. 芳烃受体配体抑制igf-ii和脂肪因子刺激的乳腺癌细胞增殖。

ISRN endocrinology Pub Date : 2013-09-23 eCollection Date: 2013-01-01 DOI: 10.1155/2013/104850

Travis B Salisbury, Gary Z Morris, Justin K Tomblin, Ateeq R Chaudhry, Carla R Cook, Nalini Santanam

{"title":"Aryl hydrocarbon receptor ligands inhibit igf-ii and adipokine stimulated breast cancer cell proliferation.","authors":"Travis B Salisbury, Gary Z Morris, Justin K Tomblin, Ateeq R Chaudhry, Carla R Cook, Nalini Santanam","doi":"10.1155/2013/104850","DOIUrl":"https://doi.org/10.1155/2013/104850","url":null,"abstract":"Obesity increases human cancer risk and the risk for cancer recurrence. Adipocytes secrete paracrine factors termed adipokines that stimulate signaling in cancer cells that induce proliferation. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays roles in tumorigenesis, is regulated by exogenous lipophilic chemicals, and has been explored as a therapeutic target for cancer therapy. Whether exogenous AHR ligands modulate adipokine stimulated breast cancer cell proliferation has not been investigated. We provide evidence that adipocytes secrete insulin-like growth factor 2 (IGF-2) at levels that stimulate the proliferation of human estrogen receptor (ER) positive breast cancer cells. Using highly specific AHR ligands and AHR short interfering RNA (AHR-siRNA), we show that specific ligand-activated AHR inhibits adipocyte secretome and IGF-2-stimulated breast cancer cell proliferation. We also report that a highly specific AHR agonist significantly (P < 0.05) inhibits the expression of E2F1, CCND1 (known as Cyclin D1), MYB, SRC, JAK2, and JUND in breast cancer cells. Collectively, these data suggest that drugs that target the AHR may be useful for treating cancer in human obesity. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"104850"},"PeriodicalIF":0.0,"publicationDate":"2013-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/104850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40276973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Diagnostic value of the combined measurement of serum hcy, serum cys C, and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy. 血清hcy、血清cys、尿微量白蛋白联合检测对2型糖尿病合并早期糖尿病肾病的诊断价值。

ISRN endocrinology Pub Date : 2013-09-18 eCollection Date: 2013-01-01 DOI: 10.1155/2013/407452

Tengkai Wang, Qian Wang, Zhimei Wang, Zuomin Xiao, Lunqin Liu

{"title":"Diagnostic value of the combined measurement of serum hcy, serum cys C, and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy.","authors":"Tengkai Wang, Qian Wang, Zhimei Wang, Zuomin Xiao, Lunqin Liu","doi":"10.1155/2013/407452","DOIUrl":"https://doi.org/10.1155/2013/407452","url":null,"abstract":"Diabetic nephropathy (DN) is a major cause of end-stage kidney disease, and therefore early diagnosis and intervention may help reverse renal damage. One hundred and sixty-eight patients with T2DM and 56 healthy volunteers (control group) were enrolled at Shandong University Qilu Hospital between April 2010 and October 2012. All subjects underwent blood sampling for sera homocysteine (Hcy) and cystatin C (Cys C) assays and a urine microalbumin test. The patients were divided into three groups according to the urine microalbumin excretion rate (UMAER): the simple DM group (SDM group, n = 51), the early-stage DN group (EDN group, n = 60), and the clinical DN and renal failure group (CDN group, n = 57). Correlation analysis was performed to examine the association between sera Hcy and Cys C levels with UMAER. Our findings showed that sera Hcy level, Cys C level, and UMAER increased significantly in the SDM group (P < 0.05, P < 0.01), the EDN group (P < 0.01), and the CDN group (P < 0.01) as compared with the control group. These three biochemical markers also increased significantly with DN progression (P < 0.01). Correlation analysis showed that sera Hcy and Cys C levels were positively correlated with UMAER (r = 0.702, P < 0.01; r = 0.873, P < 0.01). In conclusion, our results showed that sera Hcy and Cys C levels increased consistently with the development and progression of DN as indicated by UMAER. Sera Hcy and Cys C are sensitive biomarkers for the detection of early-stage DN and monitoring its progression. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":" ","pages":"407452"},"PeriodicalIF":0.0,"publicationDate":"2013-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/407452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40265109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Gestational diabetes mellitus: screening and outcomes in southern italian pregnant women. 妊娠糖尿病：意大利南部孕妇的筛查和结果。

ISRN endocrinology Pub Date : 2013-09-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/387495

Carmelo Capula, Eusebio Chiefari, Anna Vero, Biagio Arcidiacono, Stefania Iiritano, Luigi Puccio, Vittorio Pullano, Daniela P Foti, Antonio Brunetti, Raffaella Vero

{"title":"Gestational diabetes mellitus: screening and outcomes in southern italian pregnant women.","authors":"Carmelo Capula, Eusebio Chiefari, Anna Vero, Biagio Arcidiacono, Stefania Iiritano, Luigi Puccio, Vittorio Pullano, Daniela P Foti, Antonio Brunetti, Raffaella Vero","doi":"10.1155/2013/387495","DOIUrl":"10.1155/2013/387495","url":null,"abstract":"Recent Italian guidelines exclude women <35 years old, without risk factors for gestational diabetes mellitus (GDM), from screening for GDM. To determine the effectiveness of these measures with respect to the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria, we evaluated 2,448 pregnant women retrospectively enrolled in Calabria, southern Italy. GDM was diagnosed following the IADPSG 2010 criteria. Among 538 women <35 years old, without risk factors, who would have not been tested according to the Italian guidelines, we diagnosed GDM in 171 (31.8%) pregnants (7.0% of total pregnants). Diagnosis was made at baseline (55.6%), 1 hour (39.8%), or 2 hours (4.7%) during OGTT. Despite of appropriate treatment, GDM represented a risk factor for cesarean section, polyhydramnios, increased birth weight, admission to neonatal intensive care units, and large for gestational age. These outcomes were similar to those observed in GDM women at high risk for GDM. In conclusion, Italian recommendations failed to identify 7.0% of women with GDM, when compared to IADPSG criteria. The risk for adverse hyperglycaemic-related outcomes is similar in low-risk and high-risk pregnants with GDM. To limit costs of GDM screening, our data suggest to restrict OGTT to two steps (baseline and 1 hour). ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"387495"},"PeriodicalIF":0.0,"publicationDate":"2013-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31780440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of neonatal manipulation of androgen receptor function on endocrine-metabolic programming in the juvenile female rat. 雄性激素受体功能对幼年雌性大鼠内分泌代谢程序的影响。

ISRN endocrinology Pub Date : 2013-08-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/181950

Luisina Ongaro, Andres Giovambattista, Eduardo Spinedi

{"title":"Impact of neonatal manipulation of androgen receptor function on endocrine-metabolic programming in the juvenile female rat.","authors":"Luisina Ongaro, Andres Giovambattista, Eduardo Spinedi","doi":"10.1155/2013/181950","DOIUrl":"https://doi.org/10.1155/2013/181950","url":null,"abstract":"The impact of neonatal androgen receptor (AR) stimulation/blockage, due to testosterone propionate (TP)/AR antagonist treatment, on individual anthropometry and neuroendocrine-metabolic function was evaluated in the juvenile female rat. Pups (age 5 days) were s.c. injected with TP (1.25 mg), flutamide (F; 1.75 mg), and TP + F or vehicle (control, CT) and studied on day 30 of age. Body weight (BW), parametrial adipose tissue (PMAT) mass, food intake, adipoinsular axis, and steroidogenic functions were examined. Opposite to TP-rats, F-treated rats developed hypophagia, grew slowly (BW and PMAT), and displayed heightened peripheral insulin sensitivity. These F effects were abrogated in TP + F animals. Accordingly, TP rats displayed hyperleptinemia, an effect fully prevented by F cotreatment. Finally, androgen-treated animals bore an irreversible ovarian dysfunction (reduced circulating levels of 17HOP4 and ovary 17HOP4 content and P450c17 mRNA abundance). These data indicate that early stimulation of AR enhanced energy store, blockage of AR activity resulted in some beneficial metabolic effects, and neonatally androgenized rats developed a severe ovarian dysfunction. Our study highlights the important role of AR in the early organizational programming of metabolic and neuroendocrine functions. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"181950"},"PeriodicalIF":0.0,"publicationDate":"2013-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/181950","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31758978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Comparison of in vitro and in situ methods for studying lipolysis. 比较体外和原位研究脂肪分解的方法。

ISRN endocrinology Pub Date : 2013-08-19 DOI: 10.1155/2013/205385

Ahmad Ghorbani, Mahmood Abedinzade

引用次数: 0

Liraglutide suppresses the plasma levels of active and des-acyl ghrelin independently of active glucagon-like Peptide-1 levels in mice. 利拉鲁肽能独立抑制小鼠血浆中胰高血糖素样肽-1活性水平的活性和去酰基胃饥饿素水平。

ISRN endocrinology Pub Date : 2013-08-13 eCollection Date: 2013-01-01 DOI: 10.1155/2013/184753

Katsunori Nonogaki, Marina Suzuki

引用次数: 4

Predictors of postpartum glucose tolerance testing in italian women with gestational diabetes mellitus. 意大利妊娠期糖尿病妇女产后糖耐量试验的预测因素。

ISRN endocrinology Pub Date : 2013-07-17 eCollection Date: 2013-01-01 DOI: 10.1155/2013/182505

Carmelo Capula, Eusebio Chiefari, Anna Vero, Stefania Iiritano, Biagio Arcidiacono, Luigi Puccio, Vittorio Pullano, Daniela Foti, Antonio Brunetti, Raffaella Vero

{"title":"Predictors of postpartum glucose tolerance testing in italian women with gestational diabetes mellitus.","authors":"Carmelo Capula, Eusebio Chiefari, Anna Vero, Stefania Iiritano, Biagio Arcidiacono, Luigi Puccio, Vittorio Pullano, Daniela Foti, Antonio Brunetti, Raffaella Vero","doi":"10.1155/2013/182505","DOIUrl":"https://doi.org/10.1155/2013/182505","url":null,"abstract":"Postpartum screening is critical for early identification of type 2 diabetes in women previously diagnosed with gestational diabetes mellitus (GDM). Nevertheless, its rate remains disappointingly low. Thus, we plan to examine the rate of postpartum glucose tolerance test (ppOGTT) for Italian women with GDM, before and after counseling, and identify demographic, clinical, and/or biochemical predictors of adherence. With these aims, we retrospectively enrolled 1159 women with GDM, in Calabria, Southern Italy, between 2004 and 2011. During the last year, verbal and written counseling on the importance of followup was introduced. Data were analyzed by multiple regression analysis. A significant increase of the return rate was observed following introduction of the counseling [adjusted odds ratio (AOR) 5.17 (95% CI, 3.83-6.97), P < 0.001]. Interestingly, previous diagnosis of polycystic ovary syndrome (PCOS) emerged as the major predictor of postpartum followup [AOR 5.27 (95% CI, 3.51-8.70), P < 0.001], even after stratification for the absence of counseling. Previous diagnosis of GDM, higher educational status, and insulin treatment were also relevant predictors. Overall, our data indicate that counseling intervention is effective, even if many women fail to return, whereas PCOS represents a new strong predictor of adherence to postpartum testing. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"182505"},"PeriodicalIF":0.0,"publicationDate":"2013-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/182505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31666760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Paradoxically Low Levels of Total and HMW Adiponectin in Relation to Metabolic Parameters in a Tongan Population. 汤加人群中与代谢参数相关的总脂联素和HMW脂联素矛盾低水平。

ISRN endocrinology Pub Date : 2013-07-09 Print Date: 2013-01-01 DOI: 10.1155/2013/873507

Philip Peake, Stephen Colagiuri, Lesley V Campbell, Yvonne Shen

{"title":"Paradoxically Low Levels of Total and HMW Adiponectin in Relation to Metabolic Parameters in a Tongan Population.","authors":"Philip Peake, Stephen Colagiuri, Lesley V Campbell, Yvonne Shen","doi":"10.1155/2013/873507","DOIUrl":"https://doi.org/10.1155/2013/873507","url":null,"abstract":"Aim. Adiponectin has demonstrated anti-inflammatory and insulin sensitising properties, and low circulating levels may be an important risk factor for diabetes. We examined levels of adiponectin and its insulin-sensitising HMW isoform and their relationship with metabolic parameters in Tongans, a population prone to type II diabetes. Methods. Adiponectin and its HMW isoform were quantitated by Elisa in specimens from a randomly recruited, multistage cluster population survey of Tongans and from a group of Caucasians. Anthropometric, clinical, and biochemical data were collected on each subject. Results. Both male and female Tongans had lower levels of total and HMW adiponectin than their Caucasian counterparts. Levels of total and HMW adiponectin were higher in females than males in each group. Adiponectin levels were inversely related to BMI, weight, and HOMA in Tongan males and females, as well as to dyslipidemia in both sexes. Conclusion. Tongans had lower levels of both total and HMW adiponectin than Caucasians population, even after matching Tongans to their Caucasian counterparts based on BMI, age, and sex. These findings may reflect differences in body composition between the populations not adequately assessed by BMI, lifestyle factors, or a genetic variant likely in a genetically homogenous population. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"873507"},"PeriodicalIF":0.0,"publicationDate":"2013-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/873507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy. 雌激素信号传导与大脑老化：绝经后激素治疗的环境依赖性考虑。

ISRN endocrinology Pub Date : 2013-07-07 Print Date: 2013-01-01 DOI: 10.1155/2013/814690

Natasha N Mott, Toni R Pak

{"title":"Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy.","authors":"Natasha N Mott, Toni R Pak","doi":"10.1155/2013/814690","DOIUrl":"10.1155/2013/814690","url":null,"abstract":"Recent clinical studies have spurred rigorous debate about the benefits of hormone therapy (HT) for postmenopausal women. Controversy first emerged based on a sharp increase in the risk of cardiovascular disease in participants of the Women's Health Initiative (WHI) studies, suggesting that decades of empirical research in animal models was not necessarily applicable to humans. However, a reexamination of the data from the WHI studies suggests that the timing of HT might be a critical factor and that advanced age and/or length of estrogen deprivation might alter the body's ability to respond to estrogens. Dichotomous estrogenic effects are mediated primarily by the actions of two high-affinity estrogen receptors alpha and beta (ER α & ER β ). The expression of the ERs can be overlapping or distinct, dependent upon brain region, sex, age, and exposure to hormone, and, during the time of menopause, there may be changes in receptor expression profiles, post-translational modifications, and protein:protein interactions that could lead to a completely different environment for E2 to exert its effects. In this review, factors affecting estrogen-signaling processes will be discussed with particular attention paid to the expression and transcriptional actions of ER β in brain regions that regulate cognition and affect. ","PeriodicalId":89576,"journal":{"name":"ISRN endocrinology","volume":"2013 ","pages":"814690"},"PeriodicalIF":0.0,"publicationDate":"2013-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0