Bioelectromagnetics最新文献

{"title":"A Rationally Designed Building Block of the Putative Magnetoreceptor MagR","authors":"Peilin Yang,&nbsp;Tiantian Cai,&nbsp;Lei Zhang,&nbsp;Daqi Yu,&nbsp;Zhen Guo,&nbsp;Yuebin Zhang,&nbsp;Guohui Li,&nbsp;Xin Zhang,&nbsp;Can Xie","doi":"10.1002/bem.22413","DOIUrl":"10.1002/bem.22413","url":null,"abstract":"<p>The ability of animals to perceive guidance cues from Earth's magnetic field for orientation and navigation has been supported by a wealth of behavioral experiments, yet the nature of this sensory modality remains fascinatingly unresolved and wide open for discovery. MagR has been proposed as a putative magnetoreceptor based on its intrinsic magnetism and its complexation with a previously suggested key protein in magnetosensing, cryptochrome, to form a rod-like polymer structure. Here, we report a rationally designed single-chain tetramer of MagR (SctMagR), serving as the building block of the hierarchical assembly of MagR polymer. The magnetic trapping experiment and direct magnetic measurement of SctMagR demonstrated the possibility of magnetization of nonmagnetic cells via overexpressing a single protein, which has great potential in various applications. SctMagR, as reported in this study, serves as a prototype of designed magnetic biomaterials inspired by animal magnetoreception. The features of SctMagR provide insights into the unresolved origin of the intrinsic magnetic moment, which is of considerable interest in both biology and physics. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 5","pages":"317-326"},"PeriodicalIF":1.9,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49567867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Long-Term and Multigeneration Exposure of Caenorhabditis elegans to 9.4 GHz Microwaves","authors":"Aihua Sun,&nbsp;Xuelong Zhao,&nbsp;Zhihui Li,&nbsp;Yan Gao,&nbsp;Qi Liu,&nbsp;Hongmei Zhou,&nbsp;Guofu Dong,&nbsp;Changzhen Wang","doi":"10.1002/bem.22409","DOIUrl":"10.1002/bem.22409","url":null,"abstract":"<p>A large number of studies on the biological effects of microwaves are carried out using rodents and cells, but the conditions are difficult to control, and the irradiation period is short; the results obtained have always been controversial and difficult to reproduce. In this study, we expose nematodes to an electromagnetic environment for a long-term and multigeneration period to explore the possible biological effects. Wild-type N2 strains of <i>Caenorhabditis elegans</i> are exposed to 9.4 GHz microwaves at a specific adsorption rate of 4 W/kg for 10 h per day from L1 larvae to adults. Then, adult worms are washed off, and the laid eggs are kept to hatch L1 larvae, which are continuously exposed to microwaves until passing through 20 generations. The worms of the 10th, 15th, and 20th generations are collected for index detection. Interestingly, we found that the fecundity of <i>C. elegans</i> decreased significantly in the exposed group from the 15th generation. At the same time, we found that the growth of <i>C. elegans</i> decreased, motility decreased, and oxidative stress occurred in the exposed group from the 10th generation, which may play roles in the decreased spawning in worms. We preliminarily believe that the microwave energy received by worms leads to oxidative stress, which causes a decrease in the spawning rate, and the underlying mechanism needs to be further studied. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 5","pages":"336-346"},"PeriodicalIF":1.9,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45624722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Action of the Pulsed Electric Field of the Subnanosecond Range on Human Tumor Cells","authors":"Aleksey A. Petrov,&nbsp;Anastasiya A. Moraleva,&nbsp;Nadezhda V. Antipova,&nbsp;Ravil Kh. Amirov,&nbsp;Igor S. Samoylov,&nbsp;Sergey Y. Savinov","doi":"10.1002/bem.22408","DOIUrl":"10.1002/bem.22408","url":null,"abstract":"<p>The action of the pulsed electric field of the subnanosecond range on Jurkat, HEK 293, and U-87 MG human cell lines was studied. The cells were treated in a waveguide in 0.18 ml electrodeless Teflon cuvettes. The electric field strength in the cell culture medium was ~2 kV/cm, the pulse duration was ~1 ns, the leading edge was 150 ps, the frequency was 100 Hz, and the treatment time was 5 min. According to estimates, the change of the transmembrane potential during the pulse was ~20 mV and we assume that it was insufficient for electroporation. Jurkat and HEK 293 cells appeared to be more resistant to the treatment than U-87 MG cells. We have observed that the impulses with the above-mentioned parameters can cause a noticeable change in the mitochondrial activity of U-87 MG cells. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 5","pages":"327-335"},"PeriodicalIF":1.9,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46580827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Page","authors":"","doi":"10.1002/bem.22410","DOIUrl":"10.1002/bem.22410","url":null,"abstract":"","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"213-215"},"PeriodicalIF":1.9,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48910830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Moderate to High Static Magnetic Fields on Reproduction","authors":"Chao Song,&nbsp;Biao Yu,&nbsp;Junjun Wang,&nbsp;Yiming Zhu,&nbsp;Xin Zhang","doi":"10.1002/bem.22404","DOIUrl":"10.1002/bem.22404","url":null,"abstract":"<p>With the wide application of magnetic resonance imaging in hospitals and permanent magnets in household items, people have increased exposure to various types of static magnetic fields (SMFs) with moderate and high intensities, which has caused a considerable amount of public concern. Studies have shown that some aspects of gametogenesis and early embryonic development can be significantly affected by SMFs, while others have shown no effects. This review summarizes the experimental results of moderate to high-intensity SMFs (1 mT–16.7 T) on the reproductive development of different model animals, and we find that the effects of SMFs are variable depending on experimental conditions. In general, the effects of inhomogeneous SMFs seem to be more significant compared to that of homogeneous SMFs, which is likely due to magnetic forces generated by the magnetic field gradient. Moreover, some electromagnetic fields may have induced bioeffects because of nonnegligible gradient and heat effect, which are much reduced in superconducting magnets. We hope this review can provide a starting point for more in-depth analysis of various SMFs on reproduction, which is indispensable for evaluating the safety and potential applications of SMFs on living organisms in the future. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"278-291"},"PeriodicalIF":1.9,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45421127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Functional Ultrasound (fUS) Real-Time Imaging and Dosimetry of Mice Brain Under Radiofrequency Exposure","authors":"Rosa Orlacchio,&nbsp;Yann Percherancier,&nbsp;Florence Poulletier De Gannes,&nbsp;Annabelle Hurtier,&nbsp;Isabelle Lagroye,&nbsp;Philippe Leveque,&nbsp;Delia Arnaud-Cormos","doi":"10.1002/bem.22403","DOIUrl":"10.1002/bem.22403","url":null,"abstract":"<p>This study aims to analyze in real-time the potential modifications induced by low-level continuous-wave and Global System for Mobile Communications radiofrequency (RF) exposure at 1.8 GHz on brain activation in anesthetized mice. A specific in vivo experimental setup consisting of a dipole antenna for the local exposure of the brain was fully characterized. A unique neuroimaging technique based on a functional ultrasound (fUS) probe was used to observe the areas of mice brain activation simultaneously to the RF exposure with unprecedented spatial and temporal resolution (~100 μm, 1 ms) following manual whisker stimulation using a brush. Numerical and experimental dosimetry was carried out to characterize the exposure and to guarantee the validity of the biological results. Our results show that the fUS probe can be efficiently used during in vivo exposure without interference with the dipole. In addition, we conclude that exposure to brain-averaged specific absorption rate levels of 2 and 6 W/kg does not introduce significant changes in the time course of the evoked fUS response in the left barrel field cortex. The proposed technique represents a valuable instrument for providing new insights into the possible effects induced on brain activation under RF exposure. For the first time, brain activity under mobile phone exposure was evaluated in vivo with fUS imaging, paving the way for more realistic exposure configurations, i.e. awake mice and new signals such as the 5 G networks. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"257-267"},"PeriodicalIF":1.9,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41292136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LF-EMF Compound Block Type Signal Activates Human Neutrophilic Granulocytes In Vivo","authors":"Jan J. M. Cuppen,&nbsp;Cristian Gradinaru,&nbsp;Bregje E. Raap - van Sleuwen,&nbsp;Anna C. E. de Wit,&nbsp;Ton A. A. J. van der Vegt,&nbsp;Huub F. J. Savelkoul","doi":"10.1002/bem.22406","DOIUrl":"10.1002/bem.22406","url":null,"abstract":"<p>This research aims to demonstrate in a randomized, placebo-controlled crossover design study that a nominal 5 μT low-frequency electromagnetic field (LF-EMF) signal for 30 min activates neutrophils in vivo in humans. Granularity of neutrophils was measured in blood samples of healthy human volunteers (<i>n</i> = 32) taken before and after exposure for both the exposure and control sessions. A significant decrease in the granularity, indicative of neutrophil activation, was observed both in the exposure measurements and the exposure minus control measurements. Earlier EMF publications show immune function increase in isolated cells and more effective immune responses in animals with infections. This result, therefore, supports the thesis that the exposure can activate the innate immune system in humans, speed up the innate immune response, and may have potential beneficial effects in infectious disease. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 5","pages":"309-316"},"PeriodicalIF":1.9,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43971233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Atopic Dermatitis Improvement Caused by Low-Level, Low-Frequency Pulsed Electromagnetic Fields","authors":"Jun-Young Kim,&nbsp;Ji-Young Lee,&nbsp;Ja-Woo Lee,&nbsp;Soo-Kyung Lee,&nbsp;Chang-Soon Park,&nbsp;Se-Jung Yang,&nbsp;Yong-Heum Lee","doi":"10.1002/bem.22405","DOIUrl":"10.1002/bem.22405","url":null,"abstract":"<p>This study aimed to evaluate the effectiveness of using low-level, low-frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Twenty 6-week-old hairless mice were randomly divided into Normal (<i>n</i> = 5), PEMF 15 Hz (<i>n</i> = 5), PEMF 75 Hz (<i>n</i> = 5), and Sham (<i>n</i> = 5) groups. Following the onset of atopic dermatitis symptoms, PEMF groups (15 and 75 Hz) were stimulated with LLLF_PEMF (15 mT) for 8 h per day for 1 week. Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (<i>P</i> &lt; 0.05), but these differences were not visually obvious. While both the PEMF and Sham groups had atopic dermatitis lesions, lesion size was significantly smaller in the two PEMF groups than in the Sham group (<i>P</i> &lt; 0.001). Additionally, changes in epithelial thickness because of skin inflammation significantly decreased for both PEMF groups, compared with the Sham group (<i>P</i> &lt; 0.001). In conclusion, these results suggest that PEMF stimulation in vivo triggers electro-chemical reactions that affect immune response. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"268-277"},"PeriodicalIF":1.9,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41093311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An International Collaborative Animal Study of the Carcinogenicity of Mobile Phone Radiofrequency Radiation: Considerations for Preparation of a Global Project","authors":"Young Hwan Ahn,&nbsp;Katsumi Imaida,&nbsp;Yong-Bum Kim,&nbsp;Kang-Hyun Han,&nbsp;Jeong-Ki Pack,&nbsp;Nam Kim,&nbsp;Sang Bong Jeon,&nbsp;Ae-Kyoung Lee,&nbsp;Hyung Do Choi,&nbsp;Jianqing Wang,&nbsp;Mayumi Kawabe,&nbsp;Hye Sun Kim","doi":"10.1002/bem.22407","DOIUrl":"10.1002/bem.22407","url":null,"abstract":"<p>Radiofrequency radiation (RFR) was classified as a “possible” human carcinogen in 2011, which caused great public concern. A carcinogenicity study by the National Toxicology Program (NTP) found Code Division Multiple Access—and Global System for Mobile Communications—modulated mobile phone RFR to be carcinogenic to the brain and heart of male rats. As part of an investigation of mobile phone carcinogenesis, and to verify the NTP study results, a 5-year collaborative animal project was started in Korea and Japan in 2019. An international animal study of this type has two prerequisites: use of the same study protocol and the same RF-exposure system. This article discusses our experience in the design of this global study on radiofrequency electromagnetic fields (RF-EMFs). Bioelectromagnetics. 43:218–224, 2022. © 2022 The Authors. Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"218-224"},"PeriodicalIF":1.9,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45585079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bioelectromagnetics Journal","authors":"James C. Lin PhD","doi":"10.1002/bem.22402","DOIUrl":"10.1002/bem.22402","url":null,"abstract":"<p><i>Bioelectromagnetics</i> (BEM) is published for the Bioelectromagnetics Society (BEMS) by John Wiley &amp; Sons. It is a peer-reviewed, internationally circulated scientific journal that specializes in reporting original data on biological effects and applications of electric, magnetic, and electromagnetic fields and radiations that range in frequency from zero hertz (static fields) to terahertz oscillations and visible light. Both experimental and clinical studies are of interest to the journal's readers as are theoretical papers or reviews that offer novel insights into or criticism of contemporary concepts and theories of field–body interactions.</p><p>I have been serving as the BEM Editor-in-Chief (EiC) since 2006. The most recent 3-year term of my tenure as EiC of the BEM journal ended on June 30, 2021. At the beginning of 2021, I informed the Board of Directors of the Bioelectromagnetics Society (BEMS) that I did not intend to continue another 3-year term as BEM EiC. The BEMS Board of Directors asked me to stay and serve for one more year so that a new EiC of the BEM journal can be named. I agreed. Currently, the search for a new EiC for BEM journal is underway.</p><p>All manuscript submission and editorial operations were transferred to the brand-new online manuscript handling system in January 2007. Soon after, the Journal ushered in an online version in addition to the traditional print version to enable publication using both platforms for each issue. The Journal moved to online publication only in January 2018. It now has a completely digital submission, review, and production process. The current BEM journal's impact factor is 2.01 and it reached an all-time high of 2.76 in 2010.</p><p>I wish to take this opportunity to express my earnest thanks and sincere appreciation to members of the scientific community who have responded affirmatively to my invitation to serve on the BEM Editorial Board, during different time frames, since 2006. With special gratitude to the Associate Editors, I wish to say thank you so much for all you have done for the <i>Bioelectromagnetics</i> journal and our research community.</p><p>To the many authors, engineers, and scientists, we are incredibly grateful for your research, submission, review, and feedback as they all contribute to disseminating knowledge and advance science that move our research space forward. It is my sincere hope that you will continue to do so in the years to come.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"217"},"PeriodicalIF":1.9,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47609628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}