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Journal of organ dysfunction最新文献

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In vitro effect of interleukin-3 and -6 on the hepatocyte-specific metabolic capacity of adult bone marrow-derived liver stem cells 白细胞介素-3和-6对成体骨髓源性肝干细胞肝细胞特异性代谢能力的体外影响
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060600986143
D. Inderbitzin, D. Sidler, I. Avital, D. Candinas
{"title":"In vitro effect of interleukin-3 and -6 on the hepatocyte-specific metabolic capacity of adult bone marrow-derived liver stem cells","authors":"D. Inderbitzin, D. Sidler, I. Avital, D. Candinas","doi":"10.1080/17471060600986143","DOIUrl":"https://doi.org/10.1080/17471060600986143","url":null,"abstract":"Objective. Bone marrow-derived adult liver stem cells (BALSC) represent a potential target for future cell-based therapies. For a salvage therapy in conditions such as liver failure, it is imperative to render BALSC functional in a timely manner. The aim of this study was to investigate whether interleukin (IL)-3 and -6 are capable of enhancing the liver-specific metabolic capacity of BALSC. Material and methods. Rat BALSC were cultured alone or with syngeneic hepatocytes. IL-3 and/or -6 were used to stimulate BALSC in cultures. The urea formation capacity of cultured BALSC was then determined. Results. When compared to BALSC in culture alone, urea metabolism was enhanced by 60.0% in co-cultures (p<0.0001). IL-3 and -6 increased urea formation in BALSC by 124.0% (p<0.0001). Conclusions. IL-3 and -6 enhance urea metabolism in BALSC. These cytokines may be used to prime BALSC prior to clinical application in bioartificial liver systems or cell transplantation.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"12 1","pages":"137-142"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77748412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sources of hepatocytes for transplantation in hepatic dysfunction 肝功能障碍患者肝细胞移植的来源
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060701324327
K. Ralphs, Wan-Chun Li, Zoë D. Burke, Shifaan Thowfeequ, Amani M Al-Adsani, D. Tosh
{"title":"Sources of hepatocytes for transplantation in hepatic dysfunction","authors":"K. Ralphs, Wan-Chun Li, Zoë D. Burke, Shifaan Thowfeequ, Amani M Al-Adsani, D. Tosh","doi":"10.1080/17471060701324327","DOIUrl":"https://doi.org/10.1080/17471060701324327","url":null,"abstract":"Hepatocyte transplantation provides an alternative cellular therapy to orthotopic liver transplantation for the treatment of fulminant hepatic failure and hereditary liver disease. Unfortunately there is a serious limitation to the treatment of liver diseases by both liver and hepatocyte transplantation, namely the shortage of organ donors. Therefore, to overcome the problem of organ shortage, additional sources of hepatocytes must be found. Alternative sources of hepatocytes for transplantation have been proposed and these include immortalized cells, stem cells (both embryonic and adult) and differentiated cell types from non-hepatic sources (e.g. the pancreas). The aim of this review is to summarize current knowledge of embryonic and adult stem cell differentiation towards the hepatic phenotype and to examine sources of hepatocytes from developmentally related tissues (e.g. the pancreas).","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"150-163"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89845690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging of hyperparathyroidism: Comparing combined technetium-99m sestamibi/high-resolution ultrasound with technetium-99m sestamibi or high-resolution ultrasound alone 甲状旁腺功能亢进的影像学:99m超声联合高分辨率超声与99m超声联合高分辨率超声的比较
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060600837049
Y. Y. Ho, Y. Chan, W. Cheah
{"title":"Imaging of hyperparathyroidism: Comparing combined technetium-99m sestamibi/high-resolution ultrasound with technetium-99m sestamibi or high-resolution ultrasound alone","authors":"Y. Y. Ho, Y. Chan, W. Cheah","doi":"10.1080/17471060600837049","DOIUrl":"https://doi.org/10.1080/17471060600837049","url":null,"abstract":"Objective. Ultrasound (US) and technetium-99m sestamibi scintigraphy (MIBI) are frequently used to detect abnormal parathyroid glands in hyperparathyroidism, as this allows the option of minimally invasive parathyroidectomy. This retrospective study compares US, MIBI and combined MIBI/US for detecting uni- and multiglandular disease of the parathyroid. Material and methods. A total of 29 patients with biochemically proven hyperparathyroidism were evaluated. Each parathyroid focus was considered individually. Comparison was made with histopathology. Results. When all cases were considered, combined MIBI/US imaging was significantly superior in terms of excluding parathyroid abnormality to either US or MIBI alone. When only uniglandular disease was considered, MIBI/US was again found to be superior. There was no statistical difference between techniques in terms of excluding multiglandular disease. When all cases were considered, both MIBI/US and MIBI were superior in terms of positively diagnosing unigland...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"27 1","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81672818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinctive signaling pathways in the induction of airway MUC5B and -AC expression by phorbol 12-myristate 13-acetate and their implication in lung diseases 12-肉豆蔻酸13-乙酸佛波诱导气道MUC5B和-AC表达的独特信号通路及其在肺部疾病中的意义
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601152364
D. M. Wu, R. Wu, S. Reddy, Y. Lee, M. M. Chang
{"title":"Distinctive signaling pathways in the induction of airway MUC5B and -AC expression by phorbol 12-myristate 13-acetate and their implication in lung diseases","authors":"D. M. Wu, R. Wu, S. Reddy, Y. Lee, M. M. Chang","doi":"10.1080/17471060601152364","DOIUrl":"https://doi.org/10.1080/17471060601152364","url":null,"abstract":"Elevated expression of gel-forming MUC5AC and -5B genes is a major pathological feature of various airway diseases. Normally, MUC5B is expressed predominantly by submucosal gland mucous cells. However, trans-differentiation of MUC5B expression by surface airway epithelial cells occurs in various lung-diseased tissues. The nature of this phenomenon is not known. Phorbol 12-myristate 13-acetate (PMA) was found to be a potent stimulator of MUC5B gene expression under air–liquid interface conditions in three airway epithelial cell systems: primary cultures of normal human bronchial epithelial cells; an immortalized normal human bronchial epithelial cell line, HBE1; and a human lung adenocarcinoma cell line, A549. Stimulation was time- and dose-dependent, could be demonstrated by promoter–reporter gene transfection, and was sensitive to mithramycin A, suggesting the involvement of a specificity protein 1-based transcriptional mechanism in the stimulation. Both PMA-induced MUC5B message and promoter–reporter ge...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"3 1","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78504539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New aspects of chronic obstructive pulmonary disease 慢性阻塞性肺疾病的新认识
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060701214338
P. Barnes
{"title":"New aspects of chronic obstructive pulmonary disease","authors":"P. Barnes","doi":"10.1080/17471060701214338","DOIUrl":"https://doi.org/10.1080/17471060701214338","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability, but has only recently been extensively explored from a cellular and molecular perspective. In COPD there is a chronic inflammation that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This is characterized by increased numbers of alveolar macrophages, neutrophils and cytotoxic T lymphocytes, and the release of multiple inflammatory mediators (lipids, chemokines, cytokines and growth factors). A high level of oxidative stress may amplify this inflammation. There is also increased elastolysis and evidence of the involvement of several elastolytic enzymes, including serine proteases, cathepsins and matrix metalloproteinases. The inflammation and proteolysis observed in COPD are an amplification of the normal inflammatory response to cigarette smoke. This inflammation, in marked contrast to asthma, appears to be resistant to corticosteroids, prompting a search for novel anti-inflammato...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"34 1","pages":"240-249"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82779621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-based therapies for acute liver failure: human tissue engineering, pure cell implantation and stem cell application 急性肝衰竭的细胞治疗:人体组织工程、纯细胞植入和干细胞应用
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060600804130
R. Andersson, Xiangdong Wang
{"title":"Cell-based therapies for acute liver failure: human tissue engineering, pure cell implantation and stem cell application","authors":"R. Andersson, Xiangdong Wang","doi":"10.1080/17471060600804130","DOIUrl":"https://doi.org/10.1080/17471060600804130","url":null,"abstract":"Improving the survival rate and quality of life of patients with acute and chronic hepatic dysfunction still represents a challenge. Cell-based therapeutic hepatocyte transplantation has great potential to serve as a temporary support and “bridge” prior to a donor organ becoming available, or even as therapy for replacing a compromised liver. In this review we describe potential applications of human tissue engineering, compare therapeutic effects of transplanted hepatocytes, with or without tissue engineering and highlight the exciting progress of stem cell transplantation in hepatic dysfunction. Hepatocytes can be transplanted in the form of pure cells or as cells engineered with devices (with or without pretreatment with growth factors), freshly isolated or preserved cells or adult matured or stem cells. The efficacy of different forms of cell-based therapy may be associated with the severity and duration of the disease and with the therapeutic strategy used to treat it.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"110 1","pages":"194-203"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79613094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of endogenous catecholamine on alveolar fluid balance in acute pancreatitis and hypoxia in rats 内源性儿茶酚胺对急性胰腺炎和缺氧大鼠肺泡液平衡的保护作用
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601151739
T. Sakuma
{"title":"Protective effects of endogenous catecholamine on alveolar fluid balance in acute pancreatitis and hypoxia in rats","authors":"T. Sakuma","doi":"10.1080/17471060601151739","DOIUrl":"https://doi.org/10.1080/17471060601151739","url":null,"abstract":"Fluid accumulation in the alveolar spaces is a characteristic of a number of pulmonary diseases. In such diseases, excess alveolar fluid causes a deterioration in alveolar gas exchange and exposes patients to hypoxemia. If therapy is unsuccessful, there is a high risk that the patient will die. This paper reviews the effect of β-adrenergic agonists on alveolar fluid clearance in human lungs and the protective effects of endogenous catecholamine on alveolar fluid balance in acute pancreatitis and hypoxia in rats. It is shown that administration of exogenous β-adrenergic agonists into the distal airspaces can be a potent therapy for patients with pulmonary edema and that endogenous catecholamine does have a protective effect on alveolar fluid balance in acute pancreatitis and hypoxia in rats.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"27 1","pages":"90-94"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87399202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocyte transplantation for treating chronic hepatic dysfunction 肝细胞移植治疗慢性肝功能障碍
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601137456
D. Zamora‐Valdés, E. Guibert, Joaquín V. Rodríguez, M. Uribe, N. Méndez-Sánchez
{"title":"Hepatocyte transplantation for treating chronic hepatic dysfunction","authors":"D. Zamora‐Valdés, E. Guibert, Joaquín V. Rodríguez, M. Uribe, N. Méndez-Sánchez","doi":"10.1080/17471060601137456","DOIUrl":"https://doi.org/10.1080/17471060601137456","url":null,"abstract":"Chronic liver dysfunction is a major cause of morbidity and mortality worldwide. Orthotopic liver transplantation is positioned as first-line therapy for these patients. However, the limited availability of organ donors has forced scientists around the world to seek bridging or alternative therapies. After more than two decades of preclinical research, hepatocyte transplantation has been initiated. Hepatocyte transplantation has been assessed in experimental models of chronic liver dysfunction and some human cases have been reported. We review the technical, experimental, and clinical aspects of hepatocyte transplantation and assess its future potential as therapy for patients with chronic liver dysfunction.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"266 1","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76383893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Spirometric determination of chronic obstructive pulmonary disease 慢性阻塞性肺疾病的肺活量测定
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601152273
G. Ruppel
{"title":"Spirometric determination of chronic obstructive pulmonary disease","authors":"G. Ruppel","doi":"10.1080/17471060601152273","DOIUrl":"https://doi.org/10.1080/17471060601152273","url":null,"abstract":"The forced expiratory volume in 1 s (FEV1):forced vital capacity (FVC) ratio is probably the most important spirometric parameter measured as it defines whether or not airway obstruction is present. An FEV1/FVC ratio below the lower limit of normal (LLN) is diagnostic of airway obstruction. However, there is controversy surrounding the use of a fixed ratio of 70% for discriminating between obstructed and non-obstructed patients, and significant differences in the diagnosis of obstruction can occur depending on whether an FEV1/FVC ratio of 70% or the LLN is used. Using an appropriate LLN for the FEV1/FVC ratio is extremely important in order to avoid false-positives in older healthy adults and false-negatives in younger adults who may have early chronic obstructive pulmonary disease.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"46 1","pages":"221-223"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90258251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Human fetal hepatocyte behavior in dynamic 3D perfusion culture bioreactors 人胎儿肝细胞在动态3D灌注培养生物反应器中的行为
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601180779
S. Monga, J. Gerlach
{"title":"Human fetal hepatocyte behavior in dynamic 3D perfusion culture bioreactors","authors":"S. Monga, J. Gerlach","doi":"10.1080/17471060601180779","DOIUrl":"https://doi.org/10.1080/17471060601180779","url":null,"abstract":"Extracorporeal liver support has been used to bridge patients with acute liver failure to orthotopic liver transplantation. However, the limited functional sustainability of adult hepatocytes in bioreactors mandates the investigation of alternate cell sources. Owing to their plasticity, fetal hepatocytes are an attractive source for use in bioartificial liver devices. Establishing a renewable in vitro source of fetal hepatocytes would also be of interest with regard to possible hepatic cell transplantation studies. Herein, we discuss the use of single-cell suspensions of murine and human fetal liver cells in a dynamic 3D perfusion bioreactor based on artificial capillary beds which form four interwoven compartments. Histology showed neo-tissue formation in between the artificial capillaries. Further immunohistochemical characterization using proliferating cell nuclear antigen and Ki-67 demonstrated ongoing cell proliferation and survival. These tissues were comprised of albumin-positive hepatocytes, while...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"4 1","pages":"183-192"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88250562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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