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Journal of organ dysfunction最新文献

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A multidisciplinary approach to a better understanding of and therapy for chronic obstructive pulmonary disease 多学科的方法，以更好地了解和治疗慢性阻塞性肺疾病
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600580631
S. Shapiro, E. Silverman, C. Westin, C. Gerard, E. Ingenito, J. Reilly
{"title":"A multidisciplinary approach to a better understanding of and therapy for chronic obstructive pulmonary disease","authors":"S. Shapiro, E. Silverman, C. Westin, C. Gerard, E. Ingenito, J. Reilly","doi":"10.1080/17471060600580631","DOIUrl":"https://doi.org/10.1080/17471060600580631","url":null,"abstract":"The overall premise of this project is that COPD is a syndrome with considerable heterogeneity regarding the relative contributions of the mechanisms of airflow obstruction. Moreover, differing mechanisms underlying airflow obstruction will have different pathobiology, genetic determinants and responses to therapy and the grouping of all of these patients under the umbrella “COPD” therefore impedes future progress in research and therapy. The best progress will be made when groups of investigators from a variety of basic and clinical research disciplines work together to approach these issues.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"9 1","pages":"176-182"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87170032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut lymph hypothesis of early shock and trauma-induced multiple organ dysfunction syndrome: A new look at gut origin sepsis 早期休克和创伤性多器官功能障碍综合征的肠淋巴假说:肠源性败血症的新视角
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600551772
E. Deitch, Da-zhong Xu, Q. Lu
{"title":"Gut lymph hypothesis of early shock and trauma-induced multiple organ dysfunction syndrome: A new look at gut origin sepsis","authors":"E. Deitch, Da-zhong Xu, Q. Lu","doi":"10.1080/17471060600551772","DOIUrl":"https://doi.org/10.1080/17471060600551772","url":null,"abstract":"Trauma is the leading cause of death in people aged < 40 years and multiple organ dysfunction syndrome (MODS) is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma/hemorrhagic shock (T/HS) leads to acute (non-infectious) MODS is of major health importance in the USA. One of the major hypotheses being studied to explain the development of sepsis and MODS after trauma is the gut hypothesis of MODS. Additionally, there is recent experimental and clinical information that the response to injury and sepsis may differ between males and females. Thus, the overall global hypothesis of this review is that T/HS-induced early distant organ injury and cellular dysfunction is secondary to gut injury and is primarily mediated by factors exiting the gut via the mesenteric lymphatics. A secondary major hypothesis which will be presented is that gender and sex hormones modulate gut and hence distant organ and cellular dysfunction after T/HS. These hypotheses are ...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"81 1","pages":"70-79"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85775111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Functional ambivalence of phospholipid hydrolysis in lung: Implications for surfactant alteration and bacterial killing 肺磷脂水解的功能矛盾:表面活性剂改变和细菌杀灭的意义
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600737066
L. Touqui
{"title":"Functional ambivalence of phospholipid hydrolysis in lung: Implications for surfactant alteration and bacterial killing","authors":"L. Touqui","doi":"10.1080/17471060600737066","DOIUrl":"https://doi.org/10.1080/17471060600737066","url":null,"abstract":"Hydrolysis and reorganization of membrane or extracellular phospholipids are important processes in cell death or activation. These processes involve the participation of various types of enzymes, including phospholipase A2 (PLA2). Among these enzymes, type IIA secreted PLA2 (sPLA2-IIA) is secreted by various inflammatory cells, including macrophages and neutrophils, and has been suggested to play a role in the pathogenesis of a number of inflammatory diseases. sPLA2-IIA is involved in the release of arachidonic acid, the precursor of proinflammatory eicosanoids, and has been found to bind to specific receptors located on cell surface membranes. However, the most pertinent roles of this enzyme are its ability to kill bacteria and to hydrolyze pulmonary surfactant phospholipids. This hydrolysis, which alters the tensioactive properties of surfactant, potentially contributes to the pathogenesis of acute respiratory distress syndrome. The bactericidal effect of sPLA2-IIA is mainly due to the hydrolysis of ba...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"20 1","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86887163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The acute respiratory distress syndrome: Evolution of concepts and progress 急性呼吸窘迫综合征:概念的演变与进展
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600610628
T. Petty
{"title":"The acute respiratory distress syndrome: Evolution of concepts and progress","authors":"T. Petty","doi":"10.1080/17471060600610628","DOIUrl":"https://doi.org/10.1080/17471060600610628","url":null,"abstract":"The acute respiratory distress syndrome (ARDS) is a common and catastrophic form of acute respiratory failure, caused by a number of direct and indirect insults to the lung. Inflammatory pulmonary edema and alveolar collapse are central to ARDS. Numerous redundant mechanisms are involved which include oxidants neutrophils products and other inflammatory mediators. Surfactant is damaged or destroyed. Supportive treatment with low tidal volume ventilation and positive end expiratory pressure is the standard of care. No specific pharmacologic agent has been shown to alter the course of disease. Survivors may have varying degrees of pulmonary insufficiency, or may be normal. Most survivors have a good prognosis and quality of life.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82790309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Diagnostics of pulmonary embolism with emphasis of ventilation/perfusion scintigraphy and dead space analysis 肺栓塞的诊断，重点是通气/灌注显像和死腔分析
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600580649
B. Jonson, M. Bajc
{"title":"Diagnostics of pulmonary embolism with emphasis of ventilation/perfusion scintigraphy and dead space analysis","authors":"B. Jonson, M. Bajc","doi":"10.1080/17471060600580649","DOIUrl":"https://doi.org/10.1080/17471060600580649","url":null,"abstract":"Ventilation/perfusion scintigraphy, a first hand method for diagnosis of pulmonary embolism, PE, is challenged by tomography of the pulmonary arteries, CT. An additional method is based upon dead space analysis. Tomographic ventilation/perfusion scintigraphy, V/PSPECT is superior to planar technique. Important is interpretation criteria based upon pattern recognition and clinical information. With optimal strategy, the rate of non-diagnostic findings is only about 1%. The sensitivity of CT is too low to exclude subsegmental PE,. The radiation dose is for CT is several times higher than for V/PSPECT. Quantification of PE, only offered by V/PSPECT has impact on therapy and is vital for follow up. Limited availability of V/PSPECT makes CT an essential element in a strategy for diagnosis of PE. The single breath test for CO2 offers an alternative when imaging techniques are not available or when radiation is a particular problem in early pregnancy.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"42 1","pages":"237-243"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90875660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Intestinal mucosal epithelium: the barrier to sepsis 肠黏膜上皮:脓毒症的屏障
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600765018
A. Blikslager
{"title":"Intestinal mucosal epithelium: the barrier to sepsis","authors":"A. Blikslager","doi":"10.1080/17471060600765018","DOIUrl":"https://doi.org/10.1080/17471060600765018","url":null,"abstract":"The intestinal epithelium provides a critical barrier to pathogens and their toxins within the intestinal lumen. The epithelium is capable of directly interacting with intestinal pathogens such as Salmonella species, resulting in a release of cytokines beneath the epithelium that likely play a role in sepsis. More directly, the epithelium expresses Toll-like receptors so that it can directly respond to luminal lipopolysaccharide. Breaching of the epithelial barrier is likely the principal cause of sepsis in patients with compromised intestinal circulation. However, a number of reparative mechanisms have developed to rapidly repair epithelial defects, including epithelial migration (restitution) and closure of injured tight junctions. Therefore, barrier function and prevention of sepsis are related to the ability of the epithelium to react in an appropriate manner to luminal bacteria, prevent passage of bacteria across the barrier, and rapidly repair the barrier when it is damaged.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"15 1","pages":"250-253"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85101364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pancreatic dysfunction in acute pancreatitis 急性胰腺炎的胰腺功能障碍
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600776775
E. Andersson, R. Andersson
{"title":"Pancreatic dysfunction in acute pancreatitis","authors":"E. Andersson, R. Andersson","doi":"10.1080/17471060600776775","DOIUrl":"https://doi.org/10.1080/17471060600776775","url":null,"abstract":"In the normal setting, the release of digestive substances and hormones from the pancreas is closely regulated. However, a variety of diseases, such as acute pancreatitis (AP), may disturb this balance. A limited number of studies on exocrine function in the acute phase of pancreatitis have been performed, most of them in animals. In the convalescent phase of AP, a substantial number of patients will have abnormal results of pancreatic function tests. Many patients with AP develop temporary hyperglycemia requiring insulin treatment and some will end up requiring long-term insulin therapy. The aim of this review is to summarize current knowledge of exocrine and endocrine dysfunction of the pancreas during both the acute and recovery phases of AP. Pancreatic function in the normal setting, dysfunction associated with AP and follow-up studies are presented.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"28 1","pages":"135-141"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87831005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute lung injury in 2005: A mini-review 2005年急性肺损伤:综述
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600580714
R. Spragg
{"title":"Acute lung injury in 2005: A mini-review","authors":"R. Spragg","doi":"10.1080/17471060600580714","DOIUrl":"https://doi.org/10.1080/17471060600580714","url":null,"abstract":"As management strategies for acute lung injury (ALI) are shown to have a significant impact on outcome, it is important to understand the biology, epidemiology, and clinical presentation of that injury. Although no effective pharmacologic interventions have reached the clinic, use of a low-ventilation strategy is of clear benefit. Surfactant replacement continues to be a topic of study, while use of nitric oxide, prone positioning, extracorporeal gas exchange, and high-frequency oscillatory ventilation have not been shown, in prospective randomized studies, to provide added benefit. Measures such as rigorous control of blood glucose levels and glucocorticoid replacement have a well-established role in certain settings. There are many challenges for clinical studies of ALI, including precise definition of target study populations and surrogate endpoints, adequate blinding, and standardization of supportive care measures.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"80 9 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86115252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New insights into airway mucous cell differentiation 气道黏液细胞分化的新认识
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600580672
R. Wu, R. Harper, Cheng-Yuan Kao, Philip Thai, D. M. Wu, Yin Chen, M. M. Chang
{"title":"New insights into airway mucous cell differentiation","authors":"R. Wu, R. Harper, Cheng-Yuan Kao, Philip Thai, D. M. Wu, Yin Chen, M. M. Chang","doi":"10.1080/17471060600580672","DOIUrl":"https://doi.org/10.1080/17471060600580672","url":null,"abstract":"Chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis are characterized by persistent airway inflammation and the overproduction of mucus in airways. So-called “goblet (mucous) cell metaplasia/hyperplasia” is the pathologic feature in these diseased airways, in which the normal mucociliary epithelium is replaced by goblet/mucous cells. The nature of the goblet/mucous cell population which arises in these diseased airways is unknown. Our recent studies have shown that trans-differentiation of surface epithelial cells occurs so that they express the submucosal gland-type mucin gene, MUC5B, in addition to a general elevation of all mucin gene products in surface epithelial cells as well as in the submucosal area. In contrast to MUC5B, the surface type of mucin gene, MUC5AC, is restrictedly expressed in the surface epithelium. Using a panel of cytokines—interleukin (IL)-1α, -1β, -2, -3, -4, -5, -6, -7, -8, -9, -10, -11, -12, -13, -15, -16, -17, -18, and -19, a...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"70 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74626170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Proteomics in organ dysfunction today: A new way to understand the disease 器官功能障碍中的蛋白质组学:了解疾病的新方法
Journal of organ dysfunction Pub Date : 2006-01-01 DOI: 10.1080/17471060600782633
Jing Yang, Xiangdong Wang
{"title":"Proteomics in organ dysfunction today: A new way to understand the disease","authors":"Jing Yang, Xiangdong Wang","doi":"10.1080/17471060600782633","DOIUrl":"https://doi.org/10.1080/17471060600782633","url":null,"abstract":"Proteomic analysis is a powerful tool used to investigate protein profiles of cells, biopsies and fluids, explore protein-based mechanisms of human diseases, identify novel biomarkers for diagnosis...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"8 1","pages":"66-67"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74878196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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