Gut lymph hypothesis of early shock and trauma-induced multiple organ dysfunction syndrome: A new look at gut origin sepsis

Abstract

Trauma is the leading cause of death in people aged < 40 years and multiple organ dysfunction syndrome (MODS) is the leading cause of death in intensive care units. Consequently, understanding the mechanisms by which trauma/hemorrhagic shock (T/HS) leads to acute (non-infectious) MODS is of major health importance in the USA. One of the major hypotheses being studied to explain the development of sepsis and MODS after trauma is the gut hypothesis of MODS. Additionally, there is recent experimental and clinical information that the response to injury and sepsis may differ between males and females. Thus, the overall global hypothesis of this review is that T/HS-induced early distant organ injury and cellular dysfunction is secondary to gut injury and is primarily mediated by factors exiting the gut via the mesenteric lymphatics. A secondary major hypothesis which will be presented is that gender and sex hormones modulate gut and hence distant organ and cellular dysfunction after T/HS. These hypotheses are ...