Pancreatic dysfunction in acute pancreatitis

Abstract

In the normal setting, the release of digestive substances and hormones from the pancreas is closely regulated. However, a variety of diseases, such as acute pancreatitis (AP), may disturb this balance. A limited number of studies on exocrine function in the acute phase of pancreatitis have been performed, most of them in animals. In the convalescent phase of AP, a substantial number of patients will have abnormal results of pancreatic function tests. Many patients with AP develop temporary hyperglycemia requiring insulin treatment and some will end up requiring long-term insulin therapy. The aim of this review is to summarize current knowledge of exocrine and endocrine dysfunction of the pancreas during both the acute and recovery phases of AP. Pancreatic function in the normal setting, dysfunction associated with AP and follow-up studies are presented.