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Journal of organ dysfunction最新文献

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Clinical utility of lung mechanics measurements 肺力学测量的临床应用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060601151887
B. Jonson, U. Bitzén
{"title":"Clinical utility of lung mechanics measurements","authors":"B. Jonson, U. Bitzén","doi":"10.1080/17471060601151887","DOIUrl":"https://doi.org/10.1080/17471060601151887","url":null,"abstract":"Although routine lung function tests, such as spirometry, can be used to diagnose bronchial and parenchymal disease, lung mechanics studies are often required to differentiate between the two forms of disease. The flow regulator method allows analysis of parenchymal mechanics in terms of the elastic recoil pressure versus volume curve and of bronchial properties in terms of the elastic recoil pressure versus resistance curve. In this report the clinical utility of lung mechanics measurements is illustrated by means of two cases. A complete battery of lung function tests allows diagnosis and comprehension of the patient's symptoms for many diseases which are difficult to diagnose using only spirometry.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"62 23 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87881536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Stem cell proliferation within the adult liver 成体肝脏内的干细胞增殖
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060601137423
S. Koenig, P. Krause
{"title":"Stem cell proliferation within the adult liver","authors":"S. Koenig, P. Krause","doi":"10.1080/17471060601137423","DOIUrl":"https://doi.org/10.1080/17471060601137423","url":null,"abstract":"Our understanding of the process of self-renewal has both progressed and changed over the last few decades. For many years, the assumption was that the liver regenerates primarily through the division of hepatocytes. However, over the last few years there has been increasing evidence of the participation of immature cells. Stem cell-fed liver regeneration comprising extensive cell proliferation within the portal areas of the liver lobules occurs when the proliferation of mature hepatocytes is massively impaired, as seen in chronic and severe liver injury. The tissue-determined progenitor cells, termed “oval cells” owing to their predominant morphology, may develop from dormant stem cells located in the canal of Hering. They proliferate and extend into the surrounding parenchyma, differentiating into hepatocytes and bile duct cells. The variable antigen profiles imply that the intrahepatic progenitor cells constitute a dynamic cell compartment, which contains a multitude of cells expressing not only hepati...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87277478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrathoracic blood volume and extravascular lung water in critical illness: methods of measurement, clinical applications and limitations 危重病人胸内血容量和血管外肺水:测量方法、临床应用和局限性
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701200428
J. Moore, M. Nirmalan
{"title":"Intrathoracic blood volume and extravascular lung water in critical illness: methods of measurement, clinical applications and limitations","authors":"J. Moore, M. Nirmalan","doi":"10.1080/17471060701200428","DOIUrl":"https://doi.org/10.1080/17471060701200428","url":null,"abstract":"The limitations of central venous pressure and pulmonary artery occlusion pressure as measures of cardiac preload are widely recognized. In this context, measuring intrathoracic blood volume (ITBV) using transpulmonary indicator dilution technology offers an alternative approach to haemodynamic monitoring. This review summarizes some of the theoretical and practical limitations of ITBV as a measure of cardiac preload. The added benefit of estimating extravascular lung water using this technology is highlighted, with particular emphasis being placed on current clinical trends that favour a more conservative approach to fluid resuscitation in patients with acute lung injury or acute respiratory distress syndrome.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"27 1","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75994106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of acute brain injury on distant organ function in intensive care patients 急性脑损伤对重症患者远端脏器功能的影响
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/02841860701324291
E. Piacentini, L. Blanch
{"title":"Influence of acute brain injury on distant organ function in intensive care patients","authors":"E. Piacentini, L. Blanch","doi":"10.1080/02841860701324291","DOIUrl":"https://doi.org/10.1080/02841860701324291","url":null,"abstract":"In the last decade it has become clear that the acutely injured brain has profound interrelations with other failing organs in critically ill patients. In fact, non-neurologic organ dysfunction in patients with severe traumatic brain injury is independently associated with worse outcome. Moreover, the brain itself can be considered an initiator of multiple organ dysfunction syndrome (MODS). The intrinsic mechanisms behind these interactions are not well known but several recent animal and clinical studies have provided important information about the mechanisms underlying brain injury-induced MODS. Catecholamines, neurokinins, and cytokines are potentially injurious substances secreted secondary to brain injury. As acute brain injury is accompanied by neuroinflammation, it is natural to speculate that circulating inflammatory factor(s) originating in the brain may enter the circulation, pass through the disrupted blood–brain barrier, and mediate the inflammatory and cytotoxic effects in other organs. A be...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"170 1","pages":"145-150"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77988867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation and cardiovascular complications in chronic kidney disease 慢性肾脏疾病的炎症和心血管并发症
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.3109/17471060802302321
D. Weaver, M. Mitsnefes
{"title":"Inflammation and cardiovascular complications in chronic kidney disease","authors":"D. Weaver, M. Mitsnefes","doi":"10.3109/17471060802302321","DOIUrl":"https://doi.org/10.3109/17471060802302321","url":null,"abstract":"Cardiovascular disease is a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD), accounting for 50% of deaths of patients on dialysis, even young adults. The etiology of accelerated cardiovascular disease in these patients is likely multifactorial. Although patients with CKD demonstrate a high prevalence of traditional risk factors for cardiovascular disease, these risk factors alone cannot explain the high burden of cardiovascular disease in this patient population. One of several uremia-related risk factors thought to contribute to disease progression is low-grade systemic inflammation. This review summarizes the current literature on the role of inflammation in promoting cardiovascular disease in this patient population as well as potential therapies to address this non-traditional risk factor.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"60 1","pages":"208-217"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84877074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In utero as a potential location for cell transplantation 子宫内作为细胞移植的潜在位置
Journal of organ dysfunction Pub Date : 2007-10-03 DOI: 10.1080/17471060601137464
M. Suckow, E. Rosen
{"title":"In utero as a potential location for cell transplantation","authors":"M. Suckow, E. Rosen","doi":"10.1080/17471060601137464","DOIUrl":"https://doi.org/10.1080/17471060601137464","url":null,"abstract":"A variety of diseases, including some which affect the hemostatic and blood coagulation systems, result from dysfunction of specific cell types. Attempts to ameliorate such diseases by implantation of healthy donor cells typically fail due to immune rejection of the donor cells. One method to possibly overcome this limitation is to administer donor cells prior to immune competence, thus inducing immune tolerance to the donated cells. To accomplish this, donor cells must be administered in utero, relatively early in the developmental process. We describe herein studies in which engraftments of fetal hepatocytes and a hepatoblast line were successfully accomplished by in utero administration of cells in mice. This approach reversed the clinical outcome of Factor X (FX) deficiency, increasing the survival time of FX null mice. Further, engraftment of donor cells was observed in the liver, as well as the spleen, brain, interstitium of the gonad, and lung. These results demonstrate the potential for applicatio...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"50 3","pages":"143-149"},"PeriodicalIF":0.0,"publicationDate":"2007-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17471060601137464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72368011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventilatory strategies to reduce pulmonary morbidity and mortality in intensive care 降低重症监护中肺部发病率和死亡率的通气策略
Journal of organ dysfunction Pub Date : 2007-06-07 DOI: 10.1080/17471060601151853
P. Papadakos, B. Lachmann
{"title":"Ventilatory strategies to reduce pulmonary morbidity and mortality in intensive care","authors":"P. Papadakos, B. Lachmann","doi":"10.1080/17471060601151853","DOIUrl":"https://doi.org/10.1080/17471060601151853","url":null,"abstract":"The use of ventilatory management protocols for the ventilation of acutely ill patients in the intensive care unit has been continually evolving and improving. One of the most important recent areas of research and clinical interest concerns the strategy of lung recruitment, or the open lung concept (OLC). In this paper we review the pathophysiologic basis and clinical role of lung recruitment maneuvers and present our extensive clinical experience with the technique. Two modes of ventilation that prevent ventilation-induced lung injury are described: pressure-controlled ventilation and the OLC.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"94 21 1","pages":"95-99"},"PeriodicalIF":0.0,"publicationDate":"2007-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81280347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mechanisms of ageing in chronic allograft nephropathy 慢性同种异体肾病的衰老机制
Journal of organ dysfunction Pub Date : 2007-03-19 DOI: 10.1080/17471060600756058
D. Susa, R. Bruin, Jay Mitchell, H. Roest, J. Hoeijmakers, J. Ijzermans
{"title":"Mechanisms of ageing in chronic allograft nephropathy","authors":"D. Susa, R. Bruin, Jay Mitchell, H. Roest, J. Hoeijmakers, J. Ijzermans","doi":"10.1080/17471060600756058","DOIUrl":"https://doi.org/10.1080/17471060600756058","url":null,"abstract":"Background. Chronic allograft nephropathy (CAN) is the single most important cause of late graft loss. Histologic signs of CAN overlap with the histology of normally ageing kidneys. Clinical observations show an inverse relationship between either donor age or ischemia time and long-term graft survival. The mechanisms by which donor age or ischemia lead to reduced functional lifespan are currently unknown. Material and methods. A review of the current literature on renal transplantation, ageing mechanisms and advances in the molecular pathogenesis of CAN was performed. Results and conclusions. Ischemia time and donor age have been identified as major allo-antigen-independent risk factors. Following transplantation, reactive oxygen species cause oxidative DNA and telomeric damage. Evidence for a molecular connection between oxidative DNA damage and ageing has increased, and suggests that the mechanisms causing normal ageing and long-term organ dysfunction may be fundamentally the same. The accelerated appe...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"12 1","pages":"7-17"},"PeriodicalIF":0.0,"publicationDate":"2007-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75258622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Paediatric oncology: role of 18 F-fluorodeoxyglucose positron emission tomography/computerized tomography 儿科肿瘤学:18f -氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的作用
Journal of organ dysfunction Pub Date : 2007-03-19 DOI: 10.1080/17471060600889834
D. Rubello, C. Nanni, L. Rampin, M. Gross, A. Al-Nahhas, S. Fanti
{"title":"Paediatric oncology: role of 18 F-fluorodeoxyglucose positron emission tomography/computerized tomography","authors":"D. Rubello, C. Nanni, L. Rampin, M. Gross, A. Al-Nahhas, S. Fanti","doi":"10.1080/17471060600889834","DOIUrl":"https://doi.org/10.1080/17471060600889834","url":null,"abstract":"This review deals with the usefulness of combined 18F-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) imaging for the diagnosis and follow-up of extracranial paediatric tumours. After a discussion of the pathophysiologic biodistribution of 18F-FDG, the main indications for 18F-FDG PET/CT imaging in paediatric malignancies are outlined. Moreover, the normal variants of physiologic biodistribution of 18F-FDG and its potential related pitfalls are pointed out.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82136767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficient gas exchange with low tidal volume ventilation in acute respiratory distress syndrome 低潮气量通气在急性呼吸窘迫综合征中的有效气体交换
Journal of organ dysfunction Pub Date : 2007-01-01 DOI: 10.1080/17471060601152430
B. Jonson, L. Uttman
{"title":"Efficient gas exchange with low tidal volume ventilation in acute respiratory distress syndrome","authors":"B. Jonson, L. Uttman","doi":"10.1080/17471060601152430","DOIUrl":"https://doi.org/10.1080/17471060601152430","url":null,"abstract":"The immediate and ultimate objectives of mechanical ventilation in the acute respiratory distress syndrome (ARDS) are to maintain gas exchange, ensure survival and allow the patient to regain a high quality of life. To achieve these goals, ventilation must be adequate and ventilator-induced lung injury minimal. A trade-off between the immediate and ultimate goals is required in order to secure adequate gas exchange with respect to CO2 and O2, and this can be achieved with lung-protective ventilation (LPV). LPV is achieved with low tidal volume ventilation, an adequate positive end-expiratory pressure (PEEP) and a limited plateau pressure. These features tend to compromise gas exchange. Dead space is large in ARDS. In this review, methods to enhance gas exchange, even at low tidal volume, by decreasing the huge dead space in ARDS are discussed. Optimizing the ventilator setting involves combining the best values for respiratory rate, minute ventilation and tidal volume, PEEP, the flow or pressure pattern o...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"137 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80391769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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