发布求助
文献互助 智能选刊 最新文献

Journal of organ dysfunction最新文献

筛选
英文 中文
Hypotension and multiple organ dysfunction syndrome 低血压和多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701200386
S. Sharma, G. Eschun
{"title":"Hypotension and multiple organ dysfunction syndrome","authors":"S. Sharma, G. Eschun","doi":"10.1080/17471060701200386","DOIUrl":"https://doi.org/10.1080/17471060701200386","url":null,"abstract":"Multiple organ dysfunction syndrome (MODS) is characterized by progressive but potentially reversible physiologic dysfunction of two or more organ systems following resuscitation from an acute life-threatening event. Improved understanding of the pathogenesis of MODS has led to the development of new therapies that place importance on early identification and aggressive management. Our understanding of MODS has grown enormously over the past two decades. Presently MODS is deemed to be as much a disease paradigm as a syndrome that follows systemic activation of an adaptive host stress response to a catastrophic event. The exaggerated systemic inflammatory host response, induced by the infecting organisms or a non-infective insult, unleashes inflammatory mediators that are the key players in the pathogenesis of systemic inflammatory response syndrome (SIRS) and MODS. Sepsis, SIRS and their sequela, MODS, represent a continuum of clinical syndromes encompassing systemic inflammation, coagulopathy and hemodyn...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"107 1","pages":"130-144"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75986360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small interfering RNA technology in pancreatic ductal epithelial cells: future cancer therapy 小干扰RNA技术在胰腺导管上皮细胞:未来的癌症治疗
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701275354
J. Chow, J. Carethers, C. Cho
{"title":"Small interfering RNA technology in pancreatic ductal epithelial cells: future cancer therapy","authors":"J. Chow, J. Carethers, C. Cho","doi":"10.1080/17471060701275354","DOIUrl":"https://doi.org/10.1080/17471060701275354","url":null,"abstract":"Firstly, we have to thank the Nobel Prize winners of Physiology or Medicine 2006, Drs. Andrew Fire at Stanford University and Craig Mello at the University of Massachusetts Medical School, for their pioneering work in RNA interference (RNAi). Without their discovery, we may not have been able to understand the role of RNAs in regulating gene expression today. RNAi is a process that is initiated by the introduction of RNA into a cell and ends with the degradation of complementary messenger RNA, thus stopping or otherwise affecting gene expression. In this review, we will describe the mechanisms involved in the processing of the RNA and how gene expression can be regulated. Since its discovery, RNAi has been widely studied and therapeutic investigations are ongoing. It is becoming increasingly apparent that RNAi has potential for cancer treatment in the future. This review focuses on the evolving development of the RNAi technique in plants, worms, fruit flies, and mammalian cells and particular attention is...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"249-256"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79323059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of phosphodiesterase inhibition in sepsis 磷酸二酯酶抑制在脓毒症中的作用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060801932573
Todd W. Costantini, J. Deree, W. Loomis, James G. Putnam, D. Hoyt, R. Coimbra
{"title":"Effects of phosphodiesterase inhibition in sepsis","authors":"Todd W. Costantini, J. Deree, W. Loomis, James G. Putnam, D. Hoyt, R. Coimbra","doi":"10.1080/17471060801932573","DOIUrl":"https://doi.org/10.1080/17471060801932573","url":null,"abstract":"Acute endotoxemia is characterized by the activation of inflammatory cells and the generation of proinflammatory cytokines. This systemic inflammatory response can lead to tissue damage, and end-organ injury. Modulation of this enhanced inflammatory response may have clinical utility in the treatment of sepsis. Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, has been studied for its immunomodulatory effects. PTX has previously been shown to decrease neutrophil activation, cytokine production, and organ injury following sepsis and hemorrhagic shock. This review will outline the research done in our laboratory to elucidate the effects of phosphodiesterase inhibition with PTX in endotoxemia.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"71 1","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83340883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage migration inhibitory factor in the immune response 巨噬细胞迁移抑制因子在免疫应答中的作用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701200436
D. Männel
{"title":"Macrophage migration inhibitory factor in the immune response","authors":"D. Männel","doi":"10.1080/17471060701200436","DOIUrl":"https://doi.org/10.1080/17471060701200436","url":null,"abstract":"Macrophage migration inhibitory factor (MIF) exerts a plethora of biological functions. Pro-inflammatory functions can clearly be attributed to the highly purified recombinant MIF protein. Therefore, MIF endangers the infected organism by acting synergistically with microbial substances, thereby enhancing the inflammatory reaction and causing exaggerated inflammation that can lead to tissue damage and shock. However, experimental evidence is provided to suggest that MIF might be able to partially reconstitute the defective immune defense in post-septic patients. As an immune-compromised organism, e.g. after sepsis, is protected from hyper-inflammatory shock, MIF can safely be applied without increasing the risk of shock. Thus, MIF does not act like a conventional cytokine but, rather, indirectly modulates and supports the immune response.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"12 1","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80794155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin, glucose control and multiple organ dysfunction syndrome 胰岛素、血糖控制与多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060802339695
M. Schetz, I. Vanhorebeek, G. Berghe
{"title":"Insulin, glucose control and multiple organ dysfunction syndrome","authors":"M. Schetz, I. Vanhorebeek, G. Berghe","doi":"10.1080/17471060802339695","DOIUrl":"https://doi.org/10.1080/17471060802339695","url":null,"abstract":"Hyperglycemia in critically ill patients is frequently associated with an adverse clinical outcome but used to be considered an adaptive stress response and a marker of illness severity. Recent clinical and experimental studies, however, suggest a causal relationship. Tight glycemic control with an insulin infusion reduces mortality and improves the organ function of critically ill subjects. Experimental data point to the importance of glycemic control, irrespective of the insulin level. Potential underlying mechanisms include the reduction of oxidative stress and inflammation, the protection of endothelial and mitochondrial function and the prevention of apoptosis.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"59 1","pages":"195-207"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89833399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pentoxifylline-supplemented resuscitation attenuates both early and late mediators of hepatic inflammation after hemorrhagic shock 己酮可可碱补充复苏减弱失血性休克后肝脏炎症的早期和晚期介质
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060801931641
J. Deree, W. Loomis, James G. Putnam, P. Wolf, R. Coimbra
{"title":"Pentoxifylline-supplemented resuscitation attenuates both early and late mediators of hepatic inflammation after hemorrhagic shock","authors":"J. Deree, W. Loomis, James G. Putnam, P. Wolf, R. Coimbra","doi":"10.1080/17471060801931641","DOIUrl":"https://doi.org/10.1080/17471060801931641","url":null,"abstract":"Objective. After hemorrhage, resuscitation with racemic Ringer's lactate (RL) results in hepatic injury and an increase in pro-inflammatory mediator synthesis. The aim of this study was to determine the effect of resuscitation including pentoxifylline (PTX) on mediators of hepatic inflammation after hypovolemic shock. Material and methods. Male Sprague–Dawley rats underwent 1 h of hypotension followed by resuscitation with RL or RL+PTX (25 mg/kg). Liver sections were scored for injury histologically. Nitric oxide and pro-inflammatory cytokines were measured using an enzyme-linked immunosorbent assay. Inducible nitric oxide synthase (iNOS) and high mobility group box 1 (HMGB1) content were evaluated by means of Western blotting. Results. In the presence of PTX, histologic hepatic injury was markedly less than with RL resuscitation (p<0.05). Furthermore, the addition of PTX to RL significantly attenuated the hepatic concentrations of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, iNOS, NO and HMGB1 (p<...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"47 1","pages":"177-183"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90988893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of enteral ebselen and ethylhydroxyethyl cellulose in pancreatitis-associated multiple-organ dysfunction in humans 肠内布selen和乙基羟乙基纤维素在人类胰腺炎相关多器官功能障碍中的作用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701486209
Hong-Guang Lu, Yuanlu Shi, L. Zhao, C. Bai, Xiangdong Wang
{"title":"Role of enteral ebselen and ethylhydroxyethyl cellulose in pancreatitis-associated multiple-organ dysfunction in humans","authors":"Hong-Guang Lu, Yuanlu Shi, L. Zhao, C. Bai, Xiangdong Wang","doi":"10.1080/17471060701486209","DOIUrl":"https://doi.org/10.1080/17471060701486209","url":null,"abstract":"Objective. Acute pancreatitis (AP) remains a severe disease responsible for the development of multiple organ dysfunction, and is associated with high mortality and morbidity. Early enteral nutrition has been suggested to have therapeutic potential for improving the outcome of AP patients. The aim of this study was to investigate whether supplementation of enteral nutrition with ebselen and ethylhydroxyethyl cellulose (EHEC) can attenuate the acute-phase responses and the severity of organ dysfunction in AP patients with either single- or multiple-organ dysfunction. Material and methods. AP patients with single-organ dysfunction (acute lung dysfunction) were treated with either vehicle (n=43) or the combination of ebselen and EHEC (n=48). AP patients with multiple-organ dysfunction (more than two organs) were treated with either vehicle (n=52) or the combination of ebselen and EHEC (n=55). Results. The combination of ebselen and EHEC significantly reduced the occurrence of infection (as indicated by a low...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"9 1","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77701159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Estrogen and multiple organ dysfunction syndrome in critical illness: From bench to bedside 危重疾病中的雌激素与多器官功能障碍综合征:从实验台到床边
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060802345874
E. Nickel, M. Schwacha, I. Chaudry
{"title":"Estrogen and multiple organ dysfunction syndrome in critical illness: From bench to bedside","authors":"E. Nickel, M. Schwacha, I. Chaudry","doi":"10.1080/17471060802345874","DOIUrl":"https://doi.org/10.1080/17471060802345874","url":null,"abstract":"For>100 years, researchers and medical professionals have been aware of a gender difference in immune responsiveness following insults like trauma, shock, burn or sepsis. Strong experimental evidence indicates that female animals are protected under such conditions compared to their male counterparts. 17β-estradiol (estrogen) is reported to be responsible for those protective effects as studies have shown that estrogen administration plays a major role in the restoration and maintenance of cellular and organ function following injury. Numerous experimental studies have also shown a variety of salutary effects of estrogen under low-flow conditions; however, clinical studies are rare and observational studies are inconclusive, even though a trend towards an advantage for females has been shown. Nonetheless, further clinical studies are needed as estrogen administration is simple and a single-dose administration of this hormone is not expected to produce any adverse effects. Thus, treatment of traumatized pa...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"66 1","pages":"230-238"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83918785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human recombinant interleukin-12 and circulating CD4 and CD8 T cells in patients with mild allergic asthma 人重组白细胞介素-12和循环CD4和CD8 T细胞在轻度过敏性哮喘患者中的作用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701505214
L. Loh, B. Vyas, D. Kemeny, B. O'connor
{"title":"Human recombinant interleukin-12 and circulating CD4 and CD8 T cells in patients with mild allergic asthma","authors":"L. Loh, B. Vyas, D. Kemeny, B. O'connor","doi":"10.1080/17471060701505214","DOIUrl":"https://doi.org/10.1080/17471060701505214","url":null,"abstract":"Objective. Recombinant human (rHu) interleukin (IL)-12 has been shown to reduce levels of blood and sputum eosinophils in patients with mild allergic asthma in a randomized controlled study. The aim of the study was to investigate whether four escalating weekly subcutaneous injections of rHuIL-12 in allergic asthmatic patients could induce changes in the intracellular cytokine profile of the circulating blood CD4+ and CD8+ T cells. Material and methods. Purified CD4+ and CD8+ T cells from peripheral blood mononuclear cells of 11 patients (six received rHuIL-12 and five received placebo) were collected before and after 4 weeks of treatment, and cultured in the presence of phorbol myristate acetate for 4 days, with or without the addition of IL-12 in vitro. Expression of various intracellular cytokines was determined using flow cytometry following treatment with brefeldin-A and saponin. Results. Compared to placebo, the proportions of peripheral blood interferon-γ-, IL-4-, IL-2- or IL-10-producing CD4+ or C...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77193987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal glands/corticosteroids and multiple organ dysfunction syndrome 肾上腺/皮质类固醇与多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060802339703
A. Polito, D. Annane
{"title":"Adrenal glands/corticosteroids and multiple organ dysfunction syndrome","authors":"A. Polito, D. Annane","doi":"10.1080/17471060802339703","DOIUrl":"https://doi.org/10.1080/17471060802339703","url":null,"abstract":"The hypothalamic–pituitary–adrenal axis is part of a complex system that includes the autonomic nervous system, the vasopressinergic system and the γ-aminobutyric acid (GABA)ergic system. The integration of these systems along with the immune system is the key to the maintenance of life and homeostasis under conditions of daily stress. Dissonance of these system following an exogenous attack, such as infection, trauma, surgery, burns or drug abuse, or an endogenous danger, such as acute myocardial infarction, stroke or pancreatitis, results in critical illness. Adrenal insufficiency is one clinical manifestation of such a disruption in the homeostatic response to stress that may contribute to the development of organ failure and eventually death. In the intensive care unit, persisting hypotension or organ failure should prompt the performance of a corticotrophin test. If basal cortisol is<10µg/dl or the increase in cortisol is<9µg/dl then physicians should consider the presence of adrenal insufficiency. W...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"561 1","pages":"208-215"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77609662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书