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Journal of organ dysfunction最新文献

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Identification of novel in vitro protein kinase A phosphorylation sites on recombinant non-muscle myosin light chain kinase: Nano-liquid chromatography tandem mass spectrometry methodology 重组非肌球蛋白轻链激酶新型体外蛋白激酶A磷酸化位点的鉴定:纳米液相色谱串联质谱法
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.3109/17471060802409712
Jing Zhao, S. Camp, E. Chiang, A. Schilling, S. Dudek, Joe G. N. Garcia
{"title":"Identification of novel in vitro protein kinase A phosphorylation sites on recombinant non-muscle myosin light chain kinase: Nano-liquid chromatography tandem mass spectrometry methodology","authors":"Jing Zhao, S. Camp, E. Chiang, A. Schilling, S. Dudek, Joe G. N. Garcia","doi":"10.3109/17471060802409712","DOIUrl":"https://doi.org/10.3109/17471060802409712","url":null,"abstract":"Protein phosphorylation is a key event in endothelial cell signaling and barrier regulation. We previously demonstrated that the non-muscle myosin light chain kinase (nmMLCK) isoform present in endothelium (1914aa) is a multi-functional enzyme which drives the participation of the actin cytoskeleton in vascular barrier regulation, trafficking of inflammatory cells into the lung, and susceptibility to sepsis-induced acute lung injury. The activity of the nmMLCK isoform is differentially regulated by both Ser/Thr and Tyr phosphorylation; however, cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA)-mediated nmMLCK phosphorylation exerts paradoxical effects on kinase activity depending on the exact Ser/Thr sites. To address this conundrum, we mapped in vitro phosphorylation sites of nmMLCK catalyzed by the catalytic unit of PKA using data-dependent nano-liquid chromatography tandem mass spectrometry. High mass-accuracy MS and optimized biochemical protocols identified 26 novel nmMLCK1 PKA p...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"29 1","pages":"242-253"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81202836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Post-burn organ dysfunction: an overview 烧伤后器官功能障碍综述
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060801931732
M. Mosier, R. Gamelli
{"title":"Post-burn organ dysfunction: an overview","authors":"M. Mosier, R. Gamelli","doi":"10.1080/17471060801931732","DOIUrl":"https://doi.org/10.1080/17471060801931732","url":null,"abstract":"The etiology of multiple organ failure (MOF) remains inadequately understood and it remains a significant cause of mortality in thermally injured patients. Many factors may drive or lead to MOF, such as relative immunosuppression and infection from the thermal injury itself, further immunosuppression from multiple blood transfusions required by excisional debridement, an impaired gastrointestinal barrier, hypoperfusion, and infection; but ultimately MOF appears to be a result of an uncontrolled inflammatory state. An appropriate burn resuscitation coupled with diligent care in the intensive care unit can decrease the incidence of MOF, but have not been able to fully eradicate it. Ongoing research in nutritional, non-specific, and specific immunomodulation holds promise of potential improvement in our ability to care for critically ill burn patients and scoring systems allow us to better predict patients at greatest risk of MOF and death.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"39 1","pages":"184-192"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83486739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation after renal transplantation: Role in the development of graft dysfunction and potential therapies 肾移植后炎症:在移植物功能障碍发展中的作用和潜在的治疗方法
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.3109/17471060802302339
D. Silverstein
{"title":"Inflammation after renal transplantation: Role in the development of graft dysfunction and potential therapies","authors":"D. Silverstein","doi":"10.3109/17471060802302339","DOIUrl":"https://doi.org/10.3109/17471060802302339","url":null,"abstract":"Inflammation is the response of the body to various stimuli. Mediators of inflammation include complements, pro-coagulants, cytokines, and fibrinolytics. In renal transplantation (RT), immediately after a kidney is procured, ischemia then reperfusion (I-R) occurs, involving immunologic and non-immunologic mechanisms. Inflammation causes the generation of reactive oxygen species, lipid peroxidation, and simultaneous cell necrosis and apoptosis. The mediators of I-R injury include leukocytes, platelets, and pro-coagulants. Eventually, inflammation may cause extensive tissue destruction. Attenuation of the inflammatory process is achieved by use of an interleukin (IL)-6 antibody, zinc pretreatment, and in P-selectin knockouts. The relationship between inflammation and acute rejection (AR) is present before grafting. Pre-RT serum C-reactive protein, IL-2, and interferon (IFN)-γ concentrations before, and at 1 and 2 weeks after, RT are higher in patients who develop AR. Furthermore, renal IL-6 expression is fo...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"369 1","pages":"233-241"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76758647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Static and dynamic preload indicators in multiple organ dysfunction syndrome 多器官功能障碍综合征的静态和动态预负荷指标
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701281949
S. Marghli, S. Nouira
{"title":"Static and dynamic preload indicators in multiple organ dysfunction syndrome","authors":"S. Marghli, S. Nouira","doi":"10.1080/17471060701281949","DOIUrl":"https://doi.org/10.1080/17471060701281949","url":null,"abstract":"In patients with multiple organ dysfunction syndrome, early optimization of cardiac preload is required to improve outcome. This review describes available static and dynamic indices used as bedside indicators of cardiac preload and fluid responsiveness in critically ill patients. Static indices (mostly derived from a pulmonary artery catheter or echocardiography) are based on measurements of cardiac pressures and volumes. Dynamic indices are based on a functional assessment of the pressure–volume relationship and the heart–lung interaction. Available data demonstrated that dynamic indices such as pulse pressure variation and stroke volume variation were more reliable predictors of fluid responsiveness than static indices. Dynamic indices using non-invasive devices are also proposed and it is expected that they will be used more often in future. However, spontaneous breathing movements and arrhythmia are the major limitations to the use of dynamic indices in clinical practice. In this respect, new volumet...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"731 1","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85545019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of intestinal mucus and pancreatic proteases in the pathogenesis of trauma–hemorrhagic shock-induced gut barrier failure and multiple organ dysfunction syndrome 肠粘液和胰腺蛋白酶在创伤失血性休克引起的肠屏障功能衰竭和多器官功能障碍综合征发病机制中的作用
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060801931211
Susan M. Sharpe, Danielle Doucet, X. Qin, E. Deitch
{"title":"Role of intestinal mucus and pancreatic proteases in the pathogenesis of trauma–hemorrhagic shock-induced gut barrier failure and multiple organ dysfunction syndrome","authors":"Susan M. Sharpe, Danielle Doucet, X. Qin, E. Deitch","doi":"10.1080/17471060801931211","DOIUrl":"https://doi.org/10.1080/17471060801931211","url":null,"abstract":"The development of the multiple organ dysfunction syndrome (MODS) is one of the leading causes of death in critically ill patients. Owing to its clinical importance, MODS, as well as acute respiratory distress syndrome and systemic inflammatory response syndrome, has been the focus of significant research to delineate its causes as well as potential therapies for it. A large body of research has focused on the role of the gut in the pathogenesis of MODS, with a special focus on the mechanisms of gut injury as well as the processes by which a localized or limited gut injury is transduced into a systemic inflammatory state. Previous studies have focused on the systemic arm of gut ischemia–reperfusion injury and have largely ignored the non-bacterial intraluminal contents of the gut. The current review will present the hypothesis that the luminal contents of the gut, including the mucus gel layer and intraluminal pancreatic proteases as well as the gut flora, are critically involved in the pathogenesis of is...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"25 1","pages":"168-176"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76454082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Hypothalamic–pituitary–adrenal axis multiple and organ dysfunction syndrome in critical illness: A special focus on arginine-vasopressin and apelin 危重疾病的下丘脑-垂体-肾上腺轴多发性和器官功能障碍综合征:特别关注精氨酸-加压素和apelin
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060802339711
N. Gallo‐Payet, Jean-François Roussy, F. Chagnon, C. Roberge, O. Lesur
{"title":"Hypothalamic–pituitary–adrenal axis multiple and organ dysfunction syndrome in critical illness: A special focus on arginine-vasopressin and apelin","authors":"N. Gallo‐Payet, Jean-François Roussy, F. Chagnon, C. Roberge, O. Lesur","doi":"10.1080/17471060802339711","DOIUrl":"https://doi.org/10.1080/17471060802339711","url":null,"abstract":"The hypothalamic–pituitary–adrenal axis is essential for the adaptive response and for the maintenance of homeostasis during critical illness. Relative adrenocortical dysfunction as well as hypotension are often observed in septic shock and multiple organ dysfunction syndrome (MODS). This review highlights angiotensin II (Ang II), vasopressin (AVP) and apelin (APL) as ‘new’ factors that are potentially involved in the secretion of adrenocorticotrophic hormone (ACTH) and cortisol in critical illness. Indeed, Ang II is involved in all phases of the stress response, while exogenous infusion of AVP is generally effective at controlling intractable hypotension. Finally, APL can directly release ACTH and reduce plasma AVP. All of the proposed mechanisms by which these three neuropeptides could be involved in sepsis and MODS are discussed herein.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"121 1","pages":"216-229"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79440902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Three-dimensional culture systems for differentiation of mice embryonic stem cells into hepatocyte-like cells 小鼠胚胎干细胞向肝细胞样细胞分化的三维培养系统
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701295311
Tetsuya Imamura, Y. Kinebuchi, O. Ishizuka, S. Seki, Y. Igawa, O. Nishizawa
{"title":"Three-dimensional culture systems for differentiation of mice embryonic stem cells into hepatocyte-like cells","authors":"Tetsuya Imamura, Y. Kinebuchi, O. Ishizuka, S. Seki, Y. Igawa, O. Nishizawa","doi":"10.1080/17471060701295311","DOIUrl":"https://doi.org/10.1080/17471060701295311","url":null,"abstract":"The demand for donated livers for transplantation far exceeds the supply. One potential way to relieve this shortage is by developing bioartificial and secondary livers. These innovative approaches will require a large number of high-quality hepatocytes. Pluripotent embryonic stem (ES) cells are likely to be the best source to serve this requirement. This review describes recent progress with mice ES cells which, when placed in a three-dimensional culture system within an environment of liver regeneration, can form hepatocyte-like cells and hepatic lobule-like aggregates. The combination of ES cells and culture systems imitating in vivo environments has the potential to induce high-quality hepatocytes and to develop into liver systems that can compensate for the insufficient supply of donor organs.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"13 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91358646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Outcome issues of mechanical ventilator settings in acute respiratory distress syndrome patients from Québec ICUs after the 2000 Acute Respiratory Distress Syndrome Network trial 2000年急性呼吸窘迫综合征网络试验后，来自quimac icu的急性呼吸窘迫综合征患者机械呼吸机设置的结局问题
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701505164
Y. Poulin, Marc-André Leclair, F. Lauzier, Y. Berthiaume, Y. Skrobik, J. Bellemare, O. Lesur
{"title":"Outcome issues of mechanical ventilator settings in acute respiratory distress syndrome patients from Québec ICUs after the 2000 Acute Respiratory Distress Syndrome Network trial","authors":"Y. Poulin, Marc-André Leclair, F. Lauzier, Y. Berthiaume, Y. Skrobik, J. Bellemare, O. Lesur","doi":"10.1080/17471060701505164","DOIUrl":"https://doi.org/10.1080/17471060701505164","url":null,"abstract":"Objective. To undertake a retrospective assessment of a knowledge translation of how a low tidal volume setting has affected the overall outcome of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) patients in Quebec ICUs. Material and methods. This was a study of case files from five Quebec ICUs, separated into two groups: those from before and after November 2000 (i.e. 6 months after the publication of the first ARDS Network trial). The primary outcome was changes in tidal volume. Secondary outcomes comprised mortality, number of days without organ dysfunction/failure, positive end-expiratory pressure (PEEP) level, respiratory rate and partial pressure of CO2 (PaCO2). Results. Of 105 patients, 55 were studied before and 50 after the landmark trial. Compared to the situation before November 2000: (i) tidal volume (normalized to predicted ideal body weight) fell; (ii) PEEP, respiratory rate and PaCO2 rose; and (iii) in-hospital mortality decreased and days without organ failure increased ...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"6 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88701959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The endocrine cutting edge of critical illness 内分泌危重疾病的前沿
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060802574119
O. Lesur, D. Annane
{"title":"The endocrine cutting edge of critical illness","authors":"O. Lesur, D. Annane","doi":"10.1080/17471060802574119","DOIUrl":"https://doi.org/10.1080/17471060802574119","url":null,"abstract":"","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"431 17","pages":"194-194"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17471060802574119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72436838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide spectrum of presentation and variable mechanisms of compromised cardiac function in multiple organ dysfunction syndrome 多器官功能障碍综合征心功能受损的广泛表现和可变机制
Journal of organ dysfunction Pub Date : 2008-01-01 DOI: 10.1080/17471060701200394
Jun Ren
{"title":"Wide spectrum of presentation and variable mechanisms of compromised cardiac function in multiple organ dysfunction syndrome","authors":"Jun Ren","doi":"10.1080/17471060701200394","DOIUrl":"https://doi.org/10.1080/17471060701200394","url":null,"abstract":"Clinical and experimental evidence has demonstrated the development of cardiac dysfunction and heart failure in patients with advanced viral or bacterial infection, severe trauma, burns and allograft rejection involving multiple organ dysfunction syndrome (MODS) or systemic inflammatory response syndrome (SIRS). Although a number of scenarios, including elevated levels of inflammatory cytokines such as tumor necrosis factor-α have been speculated to contribute to the pathogenesis of MODS- or SIRS-associated cardiac dysfunction, the precise link between MODS or SIRS and cardiac contractile dysfunction is still proving to be elusive, limiting the optimization of therapeutic strategies against this devastating health problem. Recent investigations support the contributions of nitric oxide/nitrosative damage, Toll-like receptor, endothelin-1, insulin insensitivity, ceramide, adhesion molecules and oxidative stress in the pathogenesis of MODS- or SIRS-associated cardiac dysfunction. Identification of these cel...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"30 1","pages":"239-248"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84637017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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